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8R4I
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BU of 8r4i by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP)
Descriptor: Islet amyloid polypeptide
Authors:Ooi, S.A, Valli, D, Maj, M.
Deposit date:2023-11-13
Release date:2024-03-06
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.01 Å)
Cite:Improving cryo-EM grids for amyloid fibrils using interface-active solutions and spectator proteins.
Biophys.J., 123, 2024
5MGQ
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BU of 5mgq by Molmil
Solution structure of oxidized and amidated human IAPP (1-37), the diabetes II peptide.
Descriptor: Islet amyloid polypeptide
Authors:Rodriguez Camargo, D.C, Tripsianes, K, Reif, B.
Deposit date:2016-11-21
Release date:2017-03-29
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
Sci Rep, 7, 2017
1FB9
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BU of 1fb9 by Molmil
EFFECTS OF S-SULFONATION ON THE SOLUTION STRUCTURE OF SALMON CALCITONIN
Descriptor: CALCITONIN ANALOGUE
Authors:Wu, H, Mao, J, Wang, Y, Dou, H.
Deposit date:2000-07-14
Release date:2003-07-01
Last modified:2018-06-27
Method:SOLUTION NMR
Cite:Solution structure and biological activity of recombinant salmon calcitonin S-sulfonated analog
Biochem.Biophys.Res.Commun., 306, 2003
5K5G
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BU of 5k5g by Molmil
Structure of human islet amyloid polypeptide in complex with an engineered binding protein
Descriptor: HI18, Islet amyloid polypeptide
Authors:Mirecka, E.A, Feuerstein, S, Gremer, L, Schroeder, G.F, Stoldt, M, Willbold, D, Hoyer, W.
Deposit date:2016-05-23
Release date:2016-10-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:beta-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor.
Sci Rep, 6, 2016
1BKU
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BU of 1bku by Molmil
EFFECTS OF GLYCOSYLATION ON THE STRUCTURE AND DYNAMICS OF EEL CALCITONIN, NMR, 10 STRUCTURES
Descriptor: CALCITONIN
Authors:Hashimoto, Y, Nishikido, J, Toma, K, Yamamoto, K, Haneda, K, Inazu, T, Valentine, K, Opella, S.J.
Deposit date:1998-07-13
Release date:1999-01-13
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Effects of glycosylation on the structure and dynamics of eel calcitonin in micelles and lipid bilayers determined by nuclear magnetic resonance spectroscopy.
Biochemistry, 38, 1999
1BYV
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BU of 1byv by Molmil
GLYCOSYLATED EEL CALCITONIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (CALCITONIN)
Authors:Hashimoto, Y, Toma, K, Nishikido, J, Yamamoto, K, Haneda, K, Inazu, T, Valentine, K.G, Opella, S.J.
Deposit date:1998-10-16
Release date:1998-10-28
Last modified:2020-07-29
Method:SOLUTION NMR
Cite:Effects of glycosylation on the structure and dynamics of eel calcitonin in micelles and lipid bilayers determined by nuclear magnetic resonance spectroscopy.
Biochemistry, 38, 1999
1BZB
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GLYCOSYLATED EEL CALCITONIN
Descriptor: PROTEIN (CALCITONIN), alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Hashimoto, Y, Toma, K, Nishikido, J, Yamamoto, K, Haneda, K, Inazu, T, Valentine, K, Opella, S.J.
Deposit date:1998-10-27
Release date:1998-11-11
Last modified:2020-07-29
Method:SOLUTION NMR
Cite:Effects of glycosylation on the structure and dynamics of eel calcitonin in micelles and lipid bilayers determined by nuclear magnetic resonance spectroscopy.
Biochemistry, 38, 1999
6Y1A
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BU of 6y1a by Molmil
Amyloid fibril structure of islet amyloid polypeptide
Descriptor: AMINO GROUP, Islet amyloid polypeptide
Authors:Roeder, C, Kupreichyk, T, Gremer, L, Schaefer, L.U, Pothula, K.R, Ravelli, R.B.G, Willbold, D, Hoyer, W, Schroder, G.F.
Deposit date:2020-02-11
Release date:2020-03-04
Last modified:2020-07-22
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-beta fibrils.
Nat.Struct.Mol.Biol., 27, 2020
7M64
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Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 3
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
7M61
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BU of 7m61 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 1
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
7M65
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BU of 7m65 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 4
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
7M62
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BU of 7m62 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 2
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
6ZRF
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BU of 6zrf by Molmil
amyloid structure of amylin (IAPP - islet amyloid polypeptide)
Descriptor: Islet amyloid polypeptide
Authors:Gallardo, R.U, Iadanza, M.G, Ranson, N.A, Radford, S.E.
Deposit date:2020-07-13
Release date:2020-09-30
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly.
Nat.Struct.Mol.Biol., 27, 2020
6ZRQ
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BU of 6zrq by Molmil
two-protofilament amyloid structure of S20G variant of human amylin (IAPP - islet amyloid polypeptide)
Descriptor: Islet amyloid polypeptide
Authors:Gallardo, R.U, Iadanza, M.G, Ranson, N.A, Radford, S.E.
Deposit date:2020-07-14
Release date:2020-09-30
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly.
Nat.Struct.Mol.Biol., 27, 2020
6ZRR
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BU of 6zrr by Molmil
three-protofilament amyloid structure of S20G variant of human amylin (IAPP - Islet Amyloid Polypeptide)
Descriptor: Islet amyloid polypeptide
Authors:Gallardo, R.U, Iadanza, M.G, Ranson, N.A, Radford, S.E.
Deposit date:2020-07-14
Release date:2020-09-30
Last modified:2020-11-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly.
Nat.Struct.Mol.Biol., 27, 2020
7YL0
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BU of 7yl0 by Molmil
Structure of hIAPP-TF-type2
Descriptor: Islet amyloid polypeptide
Authors:Li, D, Zhang, X, Wang, Y, Zhu, P.
Deposit date:2022-07-25
Release date:2022-12-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A new polymorphism of human amylin fibrils with similar protofilaments and a conserved core
Iscience, 25, 2022
7YL3
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BU of 7yl3 by Molmil
Structure of hIAPP-TF-type1
Descriptor: Islet amyloid polypeptide
Authors:Li, D, Zhang, X, Wang, Y, Zhu, P.
Deposit date:2022-07-25
Release date:2022-12-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A new polymorphism of human amylin fibrils with similar protofilaments and a conserved core
Iscience, 25, 2022
7YL7
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BU of 7yl7 by Molmil
Structure of hIAPP-TF-type3
Descriptor: Islet amyloid polypeptide
Authors:Li, D, Zhang, X.
Deposit date:2022-07-25
Release date:2022-12-28
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:A new polymorphism of human amylin fibrils with similar protofilaments and a conserved core
Iscience, 25, 2022
7YKW
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BU of 7ykw by Molmil
Structure of hIAPP fibril at 3.6 Angstroms resolution
Descriptor: Islet amyloid polypeptide
Authors:Li, D, Zhang, X, Wang, Y, Zhu, P.
Deposit date:2022-07-25
Release date:2023-01-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A new polymorphism of human amylin fibrils with similar protofilaments and a conserved core
Iscience, 25, 2022
6UCK
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BU of 6uck by Molmil
proIAPP in DPC Micelles - Two-Conformer Ensemble Refinement, Bent Conformer
Descriptor: Islet amyloid polypeptide
Authors:DeLisle, C.F, Malooley, A.L, Banerjee, I, Lorieau, J.L.
Deposit date:2019-09-16
Release date:2020-02-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Pro-islet amyloid polypeptide in micelles contains a helical prohormone segment.
Febs J., 287, 2020
6UCJ
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BU of 6ucj by Molmil
proIAPP in DPC Micelles - Two-Conformer Ensemble Refinement, Open Conformer
Descriptor: Islet amyloid polypeptide
Authors:DeLisle, C.F, Malooley, A.L, Banerjee, I, Lorieau, J.L.
Deposit date:2019-09-16
Release date:2020-02-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Pro-islet amyloid polypeptide in micelles contains a helical prohormone segment.
Febs J., 287, 2020
2KJ7
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BU of 2kj7 by Molmil
Three-Dimensional NMR Structure of Rat Islet Amyloid Polypeptide in DPC micelles
Descriptor: Islet amyloid polypeptide
Authors:Nanga, R, Brender, J.R, Xu, J, Hartman, K, Subramanian, V, Ramamoorthy, A.
Deposit date:2009-05-22
Release date:2009-06-23
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy.
J.Am.Chem.Soc., 131, 2009
2KB8
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BU of 2kb8 by Molmil
The dynamic alpha-helix structure of micelle-bound human amylin.
Descriptor: Islet amyloid polypeptide
Authors:Patil, S.M, Xu, S, Sheftic, S.R, Alexandrescu, A.T.
Deposit date:2008-11-21
Release date:2009-02-24
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Dynamic alpha-helix structure of micelle-bound human amylin.
J.Biol.Chem., 284, 2009
2L7S
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BU of 2l7s by Molmil
Determination of the three-dimensional structure of adrenomedullin, a first step towards the analysis of its interactions with receptors and small molecules
Descriptor: Adrenomedullin
Authors:Jimenez-Barbero, J, Perez-Castells, J, Nieto, L.
Deposit date:2010-12-21
Release date:2011-09-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules.
Biopolymers, 97, 2012
2L86
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BU of 2l86 by Molmil
Solution NMR structure of human amylin in SDS micelles at pH 7.3
Descriptor: Islet amyloid polypeptide
Authors:Nanga, R, Brender, J.R, Vivekanandan, S, Ramamoorthy, A.
Deposit date:2011-01-04
Release date:2011-07-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment.
Biochim.Biophys.Acta, 1808, 2011

 

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