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8I93
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BU of 8i93 by Molmil
ACE2-B0AT1 complex bound with methionine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Li, Y.N, Zhang, Y.Y, Shen, Y.P, Yan, R.H.
Deposit date:2023-02-06
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B 0 AT1 and ACE2-SIT1.
Cell Discov, 9, 2023
8I92
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BU of 8i92 by Molmil
ACE2-B0AT1 complex bound with glutamine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Li, Y.N, Zhang, Y.Y, Shen, Y.P, Yan, R.H.
Deposit date:2023-02-06
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B 0 AT1 and ACE2-SIT1.
Cell Discov, 9, 2023
8I91
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BU of 8i91 by Molmil
ACE2-SIT1 complex bound with proline
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:Li, Y.N, Zhang, Y.Y, Shen, Y.P, Yan, R.H.
Deposit date:2023-02-06
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B 0 AT1 and ACE2-SIT1.
Cell Discov, 9, 2023
8FT5
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BU of 8ft5 by Molmil
Crystal structure of LeuT soaked with Crown-5
Descriptor: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
Authors:Karasawa, A, Liu, H, Quick, M, Hendrickson, A.H, Liu, Q.
Deposit date:2023-01-11
Release date:2023-11-22
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystallographic characterization of sodium ions in a bacterial leucine/sodium symporter
To be Published
8FT4
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BU of 8ft4 by Molmil
Multicrystal structure of Na+, leucine-bound LeuT determined at 5 keV
Descriptor: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
Authors:Karasawa, A, Liu, H, Quick, M, Hendrickson, A.H, Liu, Q.
Deposit date:2023-01-11
Release date:2023-11-22
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystallographic characterization of sodium ions in a bacterial leucine/sodium symporter
To be Published
8GNK
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BU of 8gnk by Molmil
CryoEM structure of cytosol-facing, substrate-bound ratGAT1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CHOLESTEROL, ...
Authors:Nayak, S.R, Joseph, D, Penmatsa, A.
Deposit date:2022-08-24
Release date:2023-05-31
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism.
Nat.Struct.Mol.Biol., 30, 2023
7Y7W
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BU of 7y7w by Molmil
Cryo-EM structure of human GABA transporter GAT1 bound with GABA in NaCl solution in an inward-occluded state at 2.4 angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C.
Deposit date:2022-06-22
Release date:2023-04-26
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Molecular basis for substrate recognition and transport of human GABA transporter GAT1.
Nat.Struct.Mol.Biol., 30, 2023
7Y7Z
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BU of 7y7z by Molmil
Cryo-EM structure of human GABA transporter GAT1 bound with tiagabine in NaCl solution in an inward-open state at 3.2 angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1, ...
Authors:Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C.
Deposit date:2022-06-22
Release date:2023-04-26
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular basis for substrate recognition and transport of human GABA transporter GAT1.
Nat.Struct.Mol.Biol., 30, 2023
7Y7Y
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BU of 7y7y by Molmil
Cryo-EM structure of human GABA transporter GAT1 bound with nipecotic acid in NaCl solution in an inward-occluded state at 2.4 angstrom
Descriptor: (3R)-piperidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C.
Deposit date:2022-06-22
Release date:2023-04-26
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Molecular basis for substrate recognition and transport of human GABA transporter GAT1.
Nat.Struct.Mol.Biol., 30, 2023
7Y7V
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BU of 7y7v by Molmil
Cryo-EM structure of human apo GABA transporter GAT1 in an inward-open state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1
Authors:Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C.
Deposit date:2022-06-22
Release date:2023-04-26
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Molecular basis for substrate recognition and transport of human GABA transporter GAT1.
Nat.Struct.Mol.Biol., 30, 2023
7Y75
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BU of 7y75 by Molmil
SIT1-ACE2-BA.2 RBD
Descriptor: 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Shen, Y.P, Li, Y.N, Zhang, Y.Y, Yan, R.H.
Deposit date:2022-06-21
Release date:2022-11-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of ACE2-SIT1 recognized by Omicron variants of SARS-CoV-2.
Cell Discov, 8, 2022
7Y76
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BU of 7y76 by Molmil
SIT1-ACE2-BA.5 RBD
Descriptor: 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Shen, Y.P, Li, Y.N, Zhang, Y.Y, Yan, R.H.
Deposit date:2022-06-21
Release date:2023-01-04
Last modified:2023-02-08
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of ACE2-SIT1 recognized by Omicron variants of SARS-CoV-2.
Cell Discov, 8, 2022
8DE3
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BU of 8de3 by Molmil
Native serotonin transporter in complex with 15B8 Fab antibody in the presence of cocaine
Descriptor: 15B8 Fab heavy chain variable domain, 15B8 Fab light chain variable domain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yang, D, Gouaux, E.
Deposit date:2022-06-19
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Native serotonin transporter in complex with 15B8 Fab antibody in the presence of cocaine
To Be Published
8DE4
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BU of 8de4 by Molmil
Native serotonin transporter in complex with 15B8 Fab in the presence of methamphetamine
Descriptor: (2S)-N-methyl-1-phenylpropan-2-amine, 15B8 Fab heavy chain variable domain, 15B8 Fab light chain variable domain, ...
Authors:Yang, D, Gouaux, E.
Deposit date:2022-06-19
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Native serotonin transporter in complex with 15B8 Fab in the presence of methamphetamine
To be published
7TXT
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BU of 7txt by Molmil
Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl
Descriptor: 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine, 15B8 Fab heavy chain, 15B8 Fab light chain, ...
Authors:Singh, I, Seth, A, Billesboelle, C.B, Braz, J, Rodriguiz, R.M, Roy, K, Bekele, B, Craik, V, Huang, X.P, Boytsov, D, Lak, P, O'Donnell, H, Sandtner, W, Roth, B.L, Basbaum, A.I, Wetsel, W.C, Manglik, A, Shoichet, B.K, Rudnick, G.
Deposit date:2022-02-09
Release date:2023-03-15
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.
Cell, 186, 2023
7WLW
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BU of 7wlw by Molmil
X-ray structure of thermostabilized Drosophila dopamine transporter with GABA transporter1-like substitutions in the binding site, in complex with SKF89976a
Descriptor: (3S)-1-(4,4-diphenylbut-3-enyl)piperidine-3-carboxylic acid, Antibody Fragment heavy chain, Antibody fragment light chain, ...
Authors:Penmatsa, A, Joseph, D.
Deposit date:2022-01-13
Release date:2022-06-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter.
Embo J., 41, 2022
7WGT
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BU of 7wgt by Molmil
X-ray structure of thermostabilized Drosophila dopamine transporter with GABA transporter1-like substitutions in the binding site, in complex with NO711.
Descriptor: 1-(2-{[(diphenylmethylidene)amino]oxy}ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid, Antibody fragment (9D5) heavy chain, Antibody fragment (9D5) light chain, ...
Authors:Joseph, D, Penmatsa, A.
Deposit date:2021-12-28
Release date:2022-06-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter.
Embo J., 41, 2022
7WGD
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BU of 7wgd by Molmil
X-ray structure of thermostabilized Drosophila dopamine transporter with GABA transporter1-like substitutions in the binding site, in substrate-free form.
Descriptor: Antibody fragment (9D5) Light Chain, Antibody fragment (9D5) heavy chain, CHLORIDE ION, ...
Authors:Joseph, D, Penmatsa, A.
Deposit date:2021-12-28
Release date:2022-06-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter.
Embo J., 41, 2022
7SK2
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BU of 7sk2 by Molmil
Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation
Descriptor: Sodium- and chloride-dependent GABA transporter 1, Tiagabine
Authors:Gati, C, Motiwala, Z, Aduri, N.G, Shaye, H, Han, G.W, Cherezov, V.
Deposit date:2021-10-19
Release date:2022-06-08
Last modified:2022-07-06
Method:ELECTRON MICROSCOPY (3.82 Å)
Cite:Structural basis of GABA reuptake inhibition.
Nature, 606, 2022
7V61
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BU of 7v61 by Molmil
ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3E8, ...
Authors:Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q.
Deposit date:2021-08-18
Release date:2022-06-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.
Signal Transduct Target Ther, 6, 2021
7MGW
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BU of 7mgw by Molmil
5-HT bound serotonin transporter reconstituted in lipid nanodisc in NaCl in occluded conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CHOLESTEROL, ...
Authors:Yang, D, Gouaux, E.
Deposit date:2021-04-13
Release date:2021-12-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Illumination of serotonin transporter mechanism and role of the allosteric site.
Sci Adv, 7, 2021
7LWD
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BU of 7lwd by Molmil
Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, ...
Authors:Yang, D, Kalenderoglou, I.E, Gouaux, E, Coleman, J.A, Loland, C.J.
Deposit date:2021-03-01
Release date:2021-08-11
Last modified:2021-09-01
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
Nat Commun, 12, 2021
7LQJ
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BU of 7lqj by Molmil
Crystal structure of LeuT bound to L-Alanine
Descriptor: ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ...
Authors:Font, J, Aguilar, J, Galli, A, Ryan, R.
Deposit date:2021-02-13
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.144 Å)
Cite:Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife, 10, 2021
7LQK
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BU of 7lqk by Molmil
Crystal structure of the R375A mutant of LeuT
Descriptor: ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ...
Authors:Font, J, Aguilar, J, Galli, A, Ryan, R.
Deposit date:2021-02-13
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife, 10, 2021
7LQL
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BU of 7lql by Molmil
Crystal structure of the R375D mutant of LeuT
Descriptor: ALANINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ...
Authors:Font, J, Aguilar, J, Galli, A, Ryan, R.
Deposit date:2021-02-13
Release date:2021-05-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia.
Elife, 10, 2021

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