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2A65
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BU of 2a65 by Molmil
Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
Descriptor: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
Authors:Yamashita, A, Singh, S.K, Kawate, T, Jin, Y, Gouaux, E.
Deposit date:2005-07-01
Release date:2005-08-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of a bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters.
Nature, 437, 2005
2Q72
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BU of 2q72 by Molmil
Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and imipramine
Descriptor: 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ...
Authors:Singh, S.K, Yamashita, A, Gouaux, E.
Deposit date:2007-06-05
Release date:2007-08-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2Q6H
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BU of 2q6h by Molmil
Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and clomipramine
Descriptor: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ...
Authors:Singh, S.K, Yamashita, A, Gouaux, E.
Deposit date:2007-06-05
Release date:2007-08-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2QB4
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BU of 2qb4 by Molmil
Crystal Structure Analysis of LeuT complexed with L-leucine, sodium and desipramine
Descriptor: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ...
Authors:Singh, S.K, Yamashita, A, Gouaux, E.
Deposit date:2007-06-15
Release date:2007-08-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2QEI
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BU of 2qei by Molmil
Crystal structure analysis of LeuT complexed with L-alanine, sodium, and clomipramine
Descriptor: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, ALANINE, SODIUM ION, ...
Authors:Singh, S.K, Yamashita, A, Gouaux, E.
Deposit date:2007-06-25
Release date:2007-08-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2QJU
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BU of 2qju by Molmil
Crystal Structure of an NSS Homolog with Bound Antidepressant
Descriptor: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, LEUCINE, ...
Authors:Zhou, Z, Karpowich, N.K, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2007-07-09
Release date:2007-08-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Science, 317, 2007
3F3A
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BU of 3f3a by Molmil
Crystal Structure of LeuT bound to L-Tryptophan and Sodium
Descriptor: SODIUM ION, TETRADECANE, TRYPTOPHAN, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F3D
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BU of 3f3d by Molmil
Crystal structure of LeuT bound to L-Methionine and sodium
Descriptor: METHIONINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F3E
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BU of 3f3e by Molmil
Crystal structure of LeuT bound to L-leucine (30 mM) and sodium
Descriptor: LEUCINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F3C
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BU of 3f3c by Molmil
Crystal structure of LeuT bound to 4-Fluoro-L-Phenylalanine and sodium
Descriptor: 4-FLUORO-L-PHENYLALANINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-30
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F4I
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BU of 3f4i by Molmil
Crystal Structure of LeuT bound to L-selenomethionine and sodium
Descriptor: SELENOMETHIONINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-31
Release date:2008-12-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F4J
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BU of 3f4j by Molmil
Crystal structure of LeuT bound to glycine and sodium
Descriptor: GLYCINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-31
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3F48
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BU of 3f48 by Molmil
Crystal structure of LeuT bound to L-alanine and sodium
Descriptor: ALANINE, SODIUM ION, Transporter, ...
Authors:Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E.
Deposit date:2008-10-31
Release date:2008-12-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
3GJD
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BU of 3gjd by Molmil
Crystal Structure of LeuT with bound OG
Descriptor: CHLORIDE ION, LEUCINE, SODIUM ION, ...
Authors:Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P.
Deposit date:2009-03-08
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Proc.Natl.Acad.Sci.USA, 106, 2009
3GJC
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BU of 3gjc by Molmil
Crystal Structure of the E290S mutant of LeuT with bound OG
Descriptor: LEUCINE, SODIUM ION, Transporter, ...
Authors:Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P.
Deposit date:2009-03-08
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
Proc.Natl.Acad.Sci.USA, 106, 2009
3GWV
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BU of 3gwv by Molmil
Leucine transporter LeuT in complex with R-fluoxetine
Descriptor: (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ...
Authors:Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWU
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BU of 3gwu by Molmil
Leucine transporter LeuT in complex with sertraline
Descriptor: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, LEUCINE, SODIUM ION, ...
Authors:Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3GWW
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BU of 3gww by Molmil
Leucine transporter LeuT in complex with S-fluoxetine
Descriptor: (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ...
Authors:Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N.
Deposit date:2009-04-01
Release date:2009-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
Nat.Struct.Mol.Biol., 16, 2009
3MPQ
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BU of 3mpq by Molmil
I204R1 mutant of LeuT
Descriptor: CHLORIDE ION, LEUCINE, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, ...
Authors:Kroncke, B.M.
Deposit date:2010-04-27
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural origins of nitroxide side chain dynamics on membrane protein alpha-helical sites.
Biochemistry, 49, 2010
3MPN
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BU of 3mpn by Molmil
F177R1 mutant of LeuT
Descriptor: CHLORIDE ION, LEUCINE, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, ...
Authors:Kroncke, B.M.
Deposit date:2010-04-27
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural origins of nitroxide side chain dynamics on membrane protein alpha-helical sites.
Biochemistry, 49, 2010
3QS5
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BU of 3qs5 by Molmil
Crystal structure of LeuT mutant I359Q bound to sodium and L-tryptophan
Descriptor: Na(+):neurotransmitter symporter (Snf family), SODIUM ION, TRYPTOPHAN, ...
Authors:Piscitelli, C.L, Gouaux, E.
Deposit date:2011-02-19
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into transport mechanism from LeuT engineered to transport tryptophan.
Embo J., 31, 2012
3QS6
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BU of 3qs6 by Molmil
Crystal structure of LeuT mutant F259V,I359Q bound to sodium and L-tryptophan
Descriptor: Na(+):neurotransmitter symporter (Snf family), SODIUM ION, TRYPTOPHAN, ...
Authors:Piscitelli, C.L, Gouaux, E.
Deposit date:2011-02-19
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Insights into transport mechanism from LeuT engineered to transport tryptophan.
Embo J., 31, 2012
3QS4
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BU of 3qs4 by Molmil
Crystal structure of LeuT mutant F259V bound to sodium and L-tryptophan
Descriptor: Na(+):neurotransmitter symporter (Snf family), SODIUM ION, TRYPTOPHAN, ...
Authors:Piscitelli, C.L, Gouaux, E.
Deposit date:2011-02-19
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.631 Å)
Cite:Insights into transport mechanism from LeuT engineered to transport tryptophan.
Embo J., 31, 2012
3TT3
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BU of 3tt3 by Molmil
Crystal Structure of LeuT in the inward-open conformation in complex with Fab
Descriptor: Leucine transporter LeuT, mouse monoclonal 1gG1 Fab fragment, heavy chain, ...
Authors:Krishnamurthy, H, Gouaux, E.
Deposit date:2011-09-13
Release date:2012-01-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:X-ray structures of LeuT in substrate-free outward-open and apo inward-open states.
Nature, 481, 2012
3TT1
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BU of 3tt1 by Molmil
Crystal Structure of LeuT in the outward-open conformation in complex with Fab
Descriptor: Leucine transporter LeuT, SODIUM ION, mouse monoclonal 1gG2a Fab fragment, ...
Authors:Krishnamurthy, H, Gouaux, E.
Deposit date:2011-09-13
Release date:2012-01-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.099 Å)
Cite:X-ray structures of LeuT in substrate-free outward-open and apo inward-open states.
Nature, 481, 2012

217705

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