PDB: 613 resultsInfo pagesStatus searchChemie searchBIRD

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6UWW	Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with P218 inhibitor Descriptor: 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2019-11-05 Release date: 2020-11-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (0.92 Å) Cite: Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with SDDC-0001565 inhibitor to be published
8UW0	Escherichia coli DHFR bound to NADP+ and folate, 17.2 MGy dose Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Smith, N, Horswill, A.R, Wilson, M.A. Deposit date: 2023-11-05 Release date: 2023-11-15 Method: X-RAY DIFFRACTION (0.93 Å) Cite: X-ray-driven chemistry and conformational heterogeneity in atomic resolution crystal structures of bacterial dihydrofolate reductases To Be Published
8UVZ	Bacillus subtilis DHFR bound to NADP+ and folate Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Smith, N, Horswill, A.R, Wilson, M.A. Deposit date: 2023-11-05 Release date: 2023-11-15 Method: X-RAY DIFFRACTION (0.93 Å) Cite: Bacillus subtilis DHFR bound to NADP+ and folate To Be Published
6CW7	E. coli DHFR product complex with (6S)-5,6,7,8-TETRAHYDROFOLATE Descriptor: (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, Dihydrofolate reductase, ... Authors: Cao, H, Rodrigues, J, Benach, J, Frommelt, A, Morisco, L, Koss, J, Shakhnovich, E, Skolnick, J. Deposit date: 2018-03-30 Release date: 2019-01-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.03 Å) Cite: The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release. Commun Biol, 1, 2018
7FPQ	DHFR:NADP+:FOL complex at 280 K (multi-crystal) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-09 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.03 Å) Cite: DHFR:NADP+:FOL complex at 280 K To Be Published
7FPP	DHFR:NADP+:FOL complex at 280 K (crystal 5) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-09 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.03 Å) Cite: DHFR:NADP+:FOL complex at 280 K To Be Published
7FPW	DHFR:NADP+:FOL complex at 290 K (multi-crystal) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-10 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.04 Å) Cite: DHFR:NADP+:FOL complex at 290 K To Be Published
7FPM	DHFR:NADP+:FOL complex at 280 K (crystal 2) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-09 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.04 Å) Cite: DHFR:NADP+:FOL complex at 280 K To Be Published
7FPN	DHFR:NADP+:FOL complex at 280 K (crystal 3) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-09 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.04 Å) Cite: DHFR:NADP+:FOL complex at 280 K To Be Published
7FPV	DHFR:NADP+:FOL complex at 290 K (crystal 5) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-10 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.04 Å) Cite: DHFR:NADP+:FOL complex at 290 K To Be Published
7FPU	DHFR:NADP+:FOL complex at 290 K (crystal 4) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-10 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.05 Å) Cite: DHFR:NADP+:FOL complex at 290 K To Be Published
1KMV	HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE Descriptor: (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE, DIHYDROFOLATE REDUCTASE, DIMETHYL SULFOXIDE, ... Authors: Klon, A.E, Heroux, A, Ross, L.J, Pathak, V, Johnson, C.A, Piper, J.R, Borhani, D.W. Deposit date: 2001-12-17 Release date: 2002-07-10 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution. J.Mol.Biol., 320, 2002
5SSW	DHFR:NADP+:FOL complex at 270 K (multi-crystal) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-07-03 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (1.06 Å) Cite: DHFR:NADP+:FOL complex at 270 K To Be Published
7FPX	DHFR:NADP+:FOL complex at 300 K (crystal 1) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-10 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.06 Å) Cite: DHFR:NADP+:FOL complex at 300 K To Be Published
7FPO	DHFR:NADP+:FOL complex at 280 K (crystal 4) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-09 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.06 Å) Cite: DHFR:NADP+:FOL complex at 280 K To Be Published
7FPR	DHFR:NADP+:FOL complex at 290 K (crystal 1) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-10 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.07 Å) Cite: DHFR:NADP+:FOL complex at 290 K To Be Published
7FPT	DHFR:NADP+:FOL complex at 290 K (crystal 3) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-10 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.07 Å) Cite: DHFR:NADP+:FOL complex at 290 K To Be Published
7FQ2	DHFR:NADP+:FOL complex at 300 K (multi-crystal) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-10 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.07 Å) Cite: DHFR:NADP+:FOL complex at 300 K To Be Published
5SST	DHFR:NADP+:FOL complex at 270 K (crystal 2) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-07-03 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (1.07 Å) Cite: DHFR:NADP+:FOL complex at 270 K To Be Published
5SSV	DHFR:NADP+:FOL complex at 270 K (crystal 4) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-07-03 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (1.08 Å) Cite: DHFR:NADP+:FOL complex at 270 K To Be Published
7FQA	DHFR:NADP+:FOL complex (crystal 1, pass 4, 280 K) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-12 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.08 Å) Cite: Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex To Be Published
1KMS	HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9439), A LIPOPHILIC ANTIFOLATE Descriptor: 6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE, DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Klon, A.E, Heroux, A, Ross, L.J, Pathak, V, Johnson, C.A, Piper, J.R, Borhani, D.W. Deposit date: 2001-12-17 Release date: 2002-07-10 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.09 Å) Cite: Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution. J.Mol.Biol., 320, 2002
8F84	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM787 Descriptor: 3-[2-(3-{[2,4-diamino-6-(4-hydroxybutyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-11-21 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM787 To be published
8F80	Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM738 Descriptor: 1,2-ETHANEDIOL, 3-[2-(3-{[2,4-diamino-6-(4-methoxyphenyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-11-21 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor MAM738 To be published
7FQ7	DHFR:NADP+:FOL complex (crystal 1, pass 1, 295 K) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-09-12 Release date: 2023-09-20 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Single-crystal, multi-temperature experiment of DHFR:NADP+:FOL complex To Be Published

 

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