8DFR
  • Download 8dfr
  • View 8dfr
Molmil generated image of 8dfr
REFINED CRYSTAL STRUCTURES OF CHICKEN LIVER DIHYDROFOLATE REDUCTASE. 3 ANGSTROMS APO-ENZYME AND 1.7 ANGSTROMS NADPH HOLO-ENZYME COMPLEX
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Matthews, D.A., Oatley, S.J., Burridge, J., Kaufman, B.T., Xuong, N.-H., Kraut, J.
Deposit date:1989-05-30
Release date:1989-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Refined Crystal Structures of Chicken Liver Dihydrofolate Reductase. 3 Angstroms Apo-Enzyme and 1.7 Angstroms Nadph Holo-Enzyme Complex
To be Published
7DFR
  • Download 7dfr
  • View 7dfr
Molmil generated image of 7dfr
CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE
Descriptor:DIHYDROFOLATE REDUCTASE, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bystroff, C., Oatley, S.J., Kraut, J.
Deposit date:1988-10-21
Release date:1990-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state.
Biochemistry, 29, 1990
6E4E
  • Download 6e4e
  • View 6e4e
Molmil generated image of 6e4e
CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE FROM STAPHYLOCOCCUS AUREUS MW2 BOUND TO NADP AND P218
Descriptor:Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2018-07-17
Release date:2018-07-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of dihydrofolate reductase from Staphylococcus aureus MW2 bound to NADP and p218
To Be Published
6DFR
  • Download 6dfr
  • View 6dfr
Molmil generated image of 6dfr
CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. THE NADP+ HOLOENZYME AND THE FOLATE(DOT)NADP+ TERNARY COMPLEX. SUBSTRATE BINDING AND A MODEL FOR THE TRANSITION STATE
Descriptor:DIHYDROFOLATE REDUCTASE, CALCIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bystroff, C., Oatley, S.J., Kraut, J.
Deposit date:1988-10-21
Release date:1990-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state.
Biochemistry, 29, 1990
6DE4
  • Download 6de4
  • View 6de4
Molmil generated image of 6de4
HOMO SAPIENS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA-NADPH AND 3'-[(2R)-4-(2,4-DIAMINO-6-ETHYLPHENYL)BUT-3-YN-2-YL]-5'-METHOXY-[1,1'-BIPHENYL]-4-CARBOXYLIC ACID
Descriptor:Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid, ...
Authors:Hajian, B., Wright, D.
Deposit date:2018-05-11
Release date:2018-05-23
Method:X-RAY DIFFRACTION (2.411 Å)
Cite:Homo sapiens dihydrofolate reductase complexed with beta-NADPH and 3'-[(2R)-4-(2,4-diamino-6-ethylphenyl)but-3-yn-2-yl]-5'-methoxy-[1,1'-biphenyl]-4-carboxylic acid
To Be Published
6DDW
  • Download 6ddw
  • View 6ddw
Molmil generated image of 6ddw
MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA-NADPH AND N-(4-{[(2-AMINO-4-OXO-3,4-DIHYDROPTERIDIN-6-YL)METHYL]AMINO}-2-HYDROXYBENZENE-1-CARBONYL)-L-GLUTAMIC ACID
Descriptor:Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-2-hydroxybenzene-1-carbonyl)-L-glutamic acid, ...
Authors:Hajian, B., Scocchera, E., Wright, D.
Deposit date:2018-05-10
Release date:2018-05-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-2-hydroxybenzene-1-carbonyl)-L-glutamic acid
To Be Published
6DDS
  • Download 6dds
  • View 6dds
Molmil generated image of 6dds
MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA-NADPH AND 4-[3-[3-[2,4-BIS(AZANYL)-6-ETHYL-PYRIMIDIN-5-YL]PROP-2-YNYL]-5-METHOXY-PHENYL]BENZOIC ACID
Descriptor:Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid, ...
Authors:Hajian, B., Wright, D., Scocchera, E.
Deposit date:2018-05-10
Release date:2018-05-23
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-5-methoxy-phenyl]benzoic acid
To Be Published
6DDP
  • Download 6ddp
  • View 6ddp
Molmil generated image of 6ddp
MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA-NADPH AND 3'-[(2R)-4-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)BUT-3-YN-2-YL]-5'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLIC ACID
Descriptor:Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid
Authors:Hajian, B., Wright, D.
Deposit date:2018-05-10
Release date:2018-05-23
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Propargyl-linked antifolates as inhibitors of Mycobacterium tuberculosis DHFR
To Be Published
6DAV
  • Download 6dav
  • View 6dav
Molmil generated image of 6dav
CRYSTAL STRUCTURE OF HUMAN DHFR COMPLEXED WITH NADP AND N10FORMYLTETRAHYDROFOLATE
Descriptor:Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid, ...
Authors:Mayclin, S.J., Dranow, D.M., Lorimer, D.D.
Deposit date:2018-05-02
Release date:2018-05-16
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate
to be published
6CXM
  • Download 6cxm
  • View 6cxm
Molmil generated image of 6cxm
CRYSTAL STRUCTURE OF A DIHYDROFOLATE REDUCTASE FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH NADP AND P218
Descriptor:Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2018-04-03
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of a dihydrofolate reductase from Mycobacterium smegmatis in complex with NADP and P218
To Be Published
5Z6M
  • Download 5z6m
  • View 5z6m
Molmil generated image of 5z6m
HIGH-PRESSURE CRYSTAL STRUCTURE ANALYSIS OF M20 LOOP CLOSED DHFR AT 800 MPA
Descriptor:Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Watanabe, N., Nagae, T., Yamada, H.
Deposit date:2018-01-23
Release date:2018-09-19
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP.
Acta Crystallogr D Struct Biol, 74, 2018
5Z6L
  • Download 5z6l
  • View 5z6l
Molmil generated image of 5z6l
HIGH-PRESSURE CRYSTAL STRUCTURE ANALYSIS OF M20 LOOP CLOSED DHFR AT 650 MPA
Descriptor:Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Watanabe, N., Nagae, T., Yamada, H.
Deposit date:2018-01-23
Release date:2018-09-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP.
Acta Crystallogr D Struct Biol, 74, 2018
5Z6K
  • Download 5z6k
  • View 5z6k
Molmil generated image of 5z6k
HIGH-PRESSURE CRYSTAL STRUCTURE ANALYSIS OF M20 LOOP CLOSED DHFR AT 400 MPA
Descriptor:Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Watanabe, N., Nagae, T., Yamada, H.
Deposit date:2018-01-23
Release date:2018-09-19
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP.
Acta Crystallogr D Struct Biol, 74, 2018
5Z6J
  • Download 5z6j
  • View 5z6j
Molmil generated image of 5z6j
HIGH-PRESSURE CRYSTAL STRUCTURE ANALYSIS OF M20 LOOP CLOSED DHFR AT 220 MPA
Descriptor:Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Watanabe, N., Nagae, T., Yamada, H.
Deposit date:2018-01-23
Release date:2018-09-19
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP.
Acta Crystallogr D Struct Biol, 74, 2018
5Z6F
  • Download 5z6f
  • View 5z6f
Molmil generated image of 5z6f
HIGH-PRESSURE CRYSTAL STRUCTURE ANALYSIS OF DHFR(0.1 MPA)
Descriptor:Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Watanabe, N., Nagae, T., Yamada, H.
Deposit date:2018-01-22
Release date:2018-09-19
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP.
Acta Crystallogr D Struct Biol, 74, 2018
5W3Q
  • Download 5w3q
  • View 5w3q
Molmil generated image of 5w3q
L28F E.COLI DHFR IN COMPLEX WITH NADPH
Descriptor:Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION
Authors:Oyen, D., Wright, P.E., Wilson, I.A.
Deposit date:2017-06-08
Release date:2017-08-09
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion.
J. Am. Chem. Soc., 139, 2017
5UJX
  • Download 5ujx
  • View 5ujx
Molmil generated image of 5ujx
CRYSTAL STRUCTURE OF DHFR IN 20% ISOPROPANOL
Descriptor:Dihydrofolate reductase, FOLIC ACID, ISOPROPYL ALCOHOL, ...
Authors:Cuneo, M.J., Agarwal, P.K.
Deposit date:2017-01-19
Release date:2017-12-27
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Modulating Enzyme Activity by Altering Protein Dynamics with Solvent.
Biochemistry, 57, 2018
5UJF
  • Download 5ujf
  • View 5ujf
Molmil generated image of 5ujf
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE BOUND P218 INHIBITOR
Descriptor:Dihydrofolate reductase, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-01-17
Release date:2017-02-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor
TO BE PUBLISHED
5UIO
  • Download 5uio
  • View 5uio
Molmil generated image of 5uio
STRUCTURE OF DHFR WITH BOUND DAP, P-ABG AND NADP
Descriptor:Dihydrofolate reductase, PYRIMIDINE-2,4-DIAMINE, N-(4-aminobenzene-1-carbonyl)-L-glutamic acid, ...
Authors:Pedersen, L.C., London, R.E.
Deposit date:2017-01-14
Release date:2017-11-22
Method:X-RAY DIFFRACTION (1.929 Å)
Cite:A Structural Basis for Biguanide Activity.
Biochemistry, 56, 2017
5UIH
  • Download 5uih
  • View 5uih
Molmil generated image of 5uih
STRUCTURE OF DHFR WITH BOUND PHENFORMIN AND NADP
Descriptor:Dihydrofolate reductase, N-(2-phenylethyl)imidodicarbonimidic diamide, SODIUM ION, ...
Authors:Pedersen, L.C., London, R.E.
Deposit date:2017-01-14
Release date:2017-11-22
Method:X-RAY DIFFRACTION (1.647 Å)
Cite:A Structural Basis for Biguanide Activity.
Biochemistry, 56, 2017
5U27
  • Download 5u27
  • View 5u27
Molmil generated image of 5u27
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE BOUND TO NADP AND P65 INHIBITOR
Descriptor:Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2016-11-29
Release date:2016-12-21
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor
TO BE PUBLISHED
5U26
  • Download 5u26
  • View 5u26
Molmil generated image of 5u26
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE BOUND TO NADP AND P218 INHIBITOR
Descriptor:Dihydrofolate reductase, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2016-11-29
Release date:2016-12-21
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor
TO BE PUBLISHED
5T7O
  • Download 5t7o
  • View 5t7o
Molmil generated image of 5t7o
CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE IN COMPLEX WITH (6S)-5,6,7,8-TETRAHYDROFOLATE
Descriptor:Bifunctional dihydrofolate reductase-thymidylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (6S)-5,6,7,8-TETRAHYDROFOLATE, ...
Authors:Di Pisa, F., Dello Iacono, L., Bonucci, A., Mangani, S.
Deposit date:2016-09-05
Release date:2017-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE
To Be Published
5JG0
  • Download 5jg0
  • View 5jg0
Molmil generated image of 5jg0
STAPHYLOCOCCUS AUREUS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA-NADPH AND UCP1191
Descriptor:Dihydrofolate reductase, 4-{6-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-2H-1,3-benzodioxol-4-yl}benzoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Anderson, A.C., Reeve, S.M.
Deposit date:2016-04-19
Release date:2017-04-19
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.879 Å)
Cite:MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.
Cell Chem Biol, 23, 2016
5JA3
  • Download 5ja3
  • View 5ja3
Molmil generated image of 5ja3
MYCOBACTERIUM TUBERCULOSIS DIHYDROFOLATE REDUCTASE COMPLEXED WITH BETA- NADPH AND 3'-(3-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)PROP-2-YN-1-YL)-4'-METHOXY-[1,1'-B IPHENYL]-4-CARBOXYLIC ACID (UCP1106)
Descriptor:Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid
Authors:Hajian, B., Anderson, A.C.
Deposit date:2016-04-11
Release date:2016-08-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.814 Å)
Cite:Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.
Plos One, 11, 2016
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2018 Protein Data Bank Japan