1A05
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CRYSTAL STRUCTURE OF THE COMPLEX OF 3-ISOPROPYLMALATE DEHYDROGENASE FROM THIOBACILLUS FERROOXIDANS WITH 3-ISOPROPYLMALATE
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE, MAGNESIUM ION, 3-ISOPROPYLMALIC ACID
Authors:Imada, K., Inagaki, K., Matsunami, H., Kawaguchi, H., Tanaka, H., Tanaka, N., Namba, K.
Deposit date:1997-12-09
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of 3-isopropylmalate dehydrogenase in complex with 3-isopropylmalate at 2.0 A resolution: the role of Glu88 in the unique substrate-recognition mechanism.
Structure, 6, 1998
1AI2
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ISOCITRATE DEHYDROGENASE COMPLEXED WITH ISOCITRATE, NADP+, AND CALCIUM (FLASH-COOLED)
Descriptor:ISOCITRATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRATE CALCIUM COMPLEX
Authors:Stoddard, B.L., Mesecar, A., Koshland Junior, D.E.
Deposit date:1997-04-30
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences.
Science, 277, 1997
1AI3
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ORBITAL STEERING IN THE CATALYTIC POWER OF ENZYMES: SMALL STRUCTURAL CHANGES WITH LARGE CATALYTIC CONSEQUENCES
Descriptor:ISOCITRATE DEHYDROGENASE, NICOTINAMIDE-(6-DEAMINO-6-HYDROXY-ADENINE)-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID, ...
Authors:Stoddard, B.L., Mesecar, A., Koshland Junior, D.E.
Deposit date:1997-04-30
Release date:1997-11-12
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences.
Science, 277, 1997
1BL5
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ISOCITRATE DEHYDROGENASE FROM E. COLI SINGLE TURNOVER LAUE STRUCTURE OF RATE-LIMITED PRODUCT COMPLEX, 10 MSEC TIME RESOLUTION
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, 2-OXOGLUTARIC ACID, ...
Authors:Stoddard, B.L., Cohen, B., Brubaker, M., Mesecar, A., Koshland Junior, D.E.
Deposit date:1998-07-23
Release date:1999-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs.
Nat.Struct.Biol., 5, 1998
1CM7
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3-ISOPROPYLMALATE DEHYDROGENASE FROM ESCHERICHIA COLI
Descriptor:PROTEIN (3-ISOPROPYLMALATE DEHYDROGENASE)
Authors:Wallon, G., Kryger, G., Lovett, S.T., Oshima, T., Ringe, D., Petsko, G.A.
Deposit date:1999-05-17
Release date:1999-07-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structures of Escherichia coli and Salmonella typhimurium 3-isopropylmalate dehydrogenase and comparison with their thermophilic counterpart from Thermus thermophilus.
J.Mol.Biol., 266, 1997
1CNZ
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3-ISOPROPYLMALATE DEHYDROGENASE (IPMDH) FROM SALMONELLA TYPHIMURIUM
Descriptor:PROTEIN (3-ISOPROPYLMALATE DEHYDROGENASE), MANGANESE (II) ION, SULFATE ION
Authors:Wallon, G., Kryger, G., Lovett, S.T., Oshima, T., Ringe, D., Petsko, G.A.
Deposit date:1999-05-24
Release date:1999-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal Structures of Eschericia Coli and Salmonella Typhimurium 3- Isopropylmalate Dehydrogenase and Comparison with Their Thermophilic Counterpart from Thermus Thermophilus
J.Mol.Biol., 266, 1997
1CW1
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CRYSTAL STRUCTURE OF ISOCITRATE DEHYDROGENASE MUTANT K230M BOUND TO ISOCITRATE AND MN2+
Descriptor:ISOCITRATE DEHYDROGENASE, MANGANESE (II) ION, SULFATE ION, ...
Authors:Stroud, R., Finer-Moore, J.
Deposit date:1999-08-25
Release date:1999-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase.
J.Mol.Biol., 295, 2000
1CW4
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CRYSTAL STRUCTURE OF K230M ISOCITRATE DEHYDROGENASE IN COMPLEX WITH ALPHA-KETOGLUTARATE
Descriptor:ISOCITRATE DEHYDROGENASE, MANGANESE (II) ION, SULFATE ION, ...
Authors:Stroud, M.R., Finer-Moore, J.
Deposit date:1999-08-25
Release date:1999-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase.
J.Mol.Biol., 295, 2000
1CW7
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LOW TEMPERATURE STRUCTURE OF WILD-TYPE IDH COMPLEXED WITH MG-ISOCITRATE
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, SULFATE ION, ...
Authors:Stroud, M.R., Finer-Moore, J.
Deposit date:1999-08-25
Release date:1999-09-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase.
J.Mol.Biol., 295, 2000
1G2U
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THE STRUCTURE OF THE MUTANT, A172V, OF 3-ISOPROPYLMALATE DEHYDROGENASE FROM THERMUS THERMOPHILUS HB8 : ITS THERMOSTABILITY AND STRUCTURE.
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE
Authors:Qu, C., Akanuma, S., Tanaka, N., Moriyama, H., Oshima, T.
Deposit date:2000-10-21
Release date:2000-11-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
Acta Crystallogr.,Sect.D, 57, 2001
1GC8
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THE CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS 3-ISOPROPYLMALATE DEHYDROGENASE MUTATED AT 172TH FROM ALA TO PHE
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE
Authors:Qu, C., Akanuma, S., Tanaka, N., Moriyama, H., Oshima, T.
Deposit date:2000-07-27
Release date:2000-09-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
Acta Crystallogr.,Sect.D, 57, 2001
1GC9
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THE CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS 3-ISOPROPYLMALATE DEHYDROGENASE MUTATED AT 172TH FROM ALA TO GLY
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE
Authors:Qu, C., Akanuma, S., Tanaka, N., Moriyama, H., Oshima, T.
Deposit date:2000-07-28
Release date:2000-09-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
Acta Crystallogr.,Sect.D, 57, 2001
1GRO
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REGULATORY AND CATALYTIC MECHANISMS IN ESCHERICHIA COLI ISOCITRATE DEHYDROGENASE: MULTIPLE ROLES FOR N115
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID
Authors:Grobler, J.A., Hurley, J.H.
Deposit date:1995-10-12
Release date:1996-04-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Second-site suppression of regulatory phosphorylation in Escherichia coli isocitrate dehydrogenase.
Protein Sci., 5, 1996
1GRP
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REGULATORY AND CATALYTIC MECHANISMS IN ESCHERICHIA COLI ISOCITRATE DEHYDROGENASE: MULTIPLE ROLES FOR N115
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID
Authors:Grobler, J.A., Hurley, J.H.
Deposit date:1995-10-12
Release date:1996-04-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Second-site suppression of regulatory phosphorylation in Escherichia coli isocitrate dehydrogenase.
Protein Sci., 5, 1996
1HEX
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STRUCTURE OF 3-ISOPROPYLMALATE DEHYDROGENASE IN COMPLEX WITH NAD+: LIGAND-INDUCED LOOP-CLOSING AND MECHANISM FOR COFACTOR SPECIFICITY
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Hurley, J.H.
Deposit date:1994-09-09
Release date:1994-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of 3-isopropylmalate dehydrogenase in complex with NAD+: ligand-induced loop closing and mechanism for cofactor specificity.
Structure, 2, 1994
1HJ6
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ISOCITRATE DEHYDROGENASE S113E MUTANT COMPLEXED WITH ISOPROPYLMALATE, NADP+ AND MAGNESIUM (FLASH-COOLED)
Descriptor:ISOCITRATE DEHYDROGENASE, GLYCEROL, 3-ISOPROPYLMALIC ACID, ...
Authors:Doyle, S.A., Beernink, P.T., Koshland Junior, D.E.
Deposit date:2001-01-08
Release date:2001-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for a Change in Substrate Specificity: Crystal Structure of S113E Isocitrate Dehydrogenase in a Complex with Isopropylmalate, Mg2+ and Nadp
Biochemistry, 40, 2001
1HQS
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CRYSTAL STRUCTURE OF ISOCITRATE DEHYDROGENASE FROM BACILLUS SUBTILIS
Descriptor:ISOCITRATE DEHYDROGENASE, CITRIC ACID, S-1,2-PROPANEDIOL, ...
Authors:Singh, S.K., Matsuno, K., LaPorte, D.C., Banaszak, L.J.
Deposit date:2000-12-19
Release date:2001-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase.
J.Biol.Chem., 276, 2001
1IDC
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ISOCITRATE DEHYDROGENASE FROM E.COLI (MUTANT K230M), STEADY-STATE INTERMEDIATE COMPLEX DETERMINED BY LAUE CRYSTALLOGRAPHY
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, 2-OXALOSUCCINIC ACID
Authors:Bolduc, J.M., Dyer, D.H., Scott, W.G., Singer, P., Sweet, R.M., Koshland Junior, D.E., Stoddard, B.L.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1IDD
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ISOCITRATE DEHYDROGENASE Y160F MUTANT APO ENZYME
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Lee, M.E., Dyer, D.H., Klein, O.D., Bolduc, J.M., Stoddard, B.L., Koshland Junior, D.E.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1IDE
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ISOCITRATE DEHYDROGENASE Y160F MUTANT STEADY-STATE INTERMEDIATE COMPLEX (LAUE DETERMINATION)
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID, ...
Authors:Bolduc, J.M., Dyer, D.H., Scott, W.G., Singer, P., Sweet, R.M., Koshland Junior, D.E., Stoddard, B.L.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1IDF
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ISOCITRATE DEHYDROGENASE K230M MUTANT APO ENZYME
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Bolduc, J.M., Dyer, D.H., Scott, W.G., Singer, P., Sweet, R.M., Koshland Junior, D.E., Stoddard, B.L.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1IDM
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3-ISOPROPYLMALATE DEHYDROGENASE, LOOP-DELETED CHIMERA
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE
Authors:Sakurai, M., Ohzeki, M., Moriyama, H., Sato, M., Tanaka, N.
Deposit date:1995-05-19
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a loop-deleted variant of 3-isopropylmalate dehydrogenase from Thermus thermophilus: an internal reprieve tolerance mechanism.
Acta Crystallogr.,Sect.D, 52, 1996
1IKA
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STRUCTURE OF ISOCITRATE DEHYDROGENASE WITH ALPHA-KETOGLUTARATE AT 2.7 ANGSTROMS RESOLUTION: CONFORMATIONAL CHANGES INDUCED BY DECARBOXYLATION OF ISOCITRATE
Descriptor:ISOCITRATE DEHYDROGENASE, CALCIUM ION, 2-OXOGLUTARIC ACID
Authors:Stoddard, B.L., Koshland Junior, D.E.
Deposit date:1993-06-15
Release date:1994-07-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of isocitrate dehydrogenase with alpha-ketoglutarate at 2.7-A resolution: conformational changes induced by decarboxylation of isocitrate.
Biochemistry, 32, 1993
1IPD
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THREE-DIMENSIONAL STRUCTURE OF A HIGHLY THERMOSTABLE ENZYME, 3-ISOPROPYLMALATE DEHYDROGENASE OF THERMUS THERMOPHILUS AT 2.2 ANGSTROMS RESOLUTION
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE, SULFATE ION
Authors:Imada, K., Sato, M., Tanaka, N., Katsube, Y., Matsuura, Y., Oshima, T.
Deposit date:1992-01-29
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of a highly thermostable enzyme, 3-isopropylmalate dehydrogenase of Thermus thermophilus at 2.2 A resolution.
J.Mol.Biol., 222, 1991
1ISO
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ISOCITRATE DEHYDROGENASE: STRUCTURE OF AN ENGINEERED NADP+--> NAD+ SPECIFICITY-REVERSAL MUTANT
Descriptor:ISOCITRATE DEHYDROGENASE, SULFATE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Hurley, J.H.
Deposit date:1996-03-01
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ --> NAD+ specificity-reversal mutant.
Biochemistry, 35, 1996