3ICD
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STRUCTURE OF A BACTERIAL ENZYME REGULATED BY PHOSPHORYLATION, ISOCITRATE DEHYDROGENASE
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Hurley, J.H., Thorsness, P.E., Ramalingam, V., Helmers, N.H., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1989-12-28
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase.
Proc.Natl.Acad.Sci.USA, 86, 1989
4ICD
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REGULATION OF ISOCITRATE DEHYDROGENASE BY PHOSPHORYLATION INVOLVES NO LONG-RANGE CONFORMATIONAL CHANGE IN THE FREE ENZYME
Descriptor:PHOSPHORYLATED ISOCITRATE DEHYDROGENASE
Authors:Hurley, J.H., Dean, A.M., Thorsness, P.E., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1989-12-28
Release date:1991-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme.
J.Biol.Chem., 265, 1990
5ICD
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REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID
Authors:Hurley, J.H., Dean, A.M., Sohl, J.L., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1990-05-30
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulation of an enzyme by phosphorylation at the active site.
Science, 249, 1990
6ICD
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REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Hurley, J.H., Dean, A.M., Sohl, J.L., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1990-05-30
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulation of an enzyme by phosphorylation at the active site.
Science, 249, 1990
7ICD
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REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Hurley, J.H., Dean, A.M., Sohl, J.L., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1990-05-30
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Regulation of an enzyme by phosphorylation at the active site.
Science, 249, 1990
8ICD
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REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID
Authors:Hurley, J.H., Dean, A.M., Sohl, J.L., Koshlandjunior, D.E., Stroud, R.M.
Deposit date:1990-05-30
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Regulation of an enzyme by phosphorylation at the active site.
Science, 249, 1990
9ICD
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CATALYTIC MECHANISM OF NADP+-DEPENDENT ISOCITRATE DEHYDROGENASE: IMPLICATIONS FROM THE STRUCTURES OF MAGNESIUM-ISOCITRATE AND NADP+ COMPLEXES
Descriptor:ISOCITRATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Hurley, J.H., Dean, A.M., Koshland Jr., D.E., Stroud, R.M.
Deposit date:1991-07-29
Release date:1991-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes.
Biochemistry, 30, 1991
1IPD
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THREE-DIMENSIONAL STRUCTURE OF A HIGHLY THERMOSTABLE ENZYME, 3-ISOPROPYLMALATE DEHYDROGENASE OF THERMUS THERMOPHILUS AT 2.2 ANGSTROMS RESOLUTION
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE, SULFATE ION
Authors:Imada, K., Sato, M., Tanaka, N., Katsube, Y., Matsuura, Y., Oshima, T.
Deposit date:1992-01-29
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of a highly thermostable enzyme, 3-isopropylmalate dehydrogenase of Thermus thermophilus at 2.2 A resolution.
J.Mol.Biol., 222, 1991
1IKA
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STRUCTURE OF ISOCITRATE DEHYDROGENASE WITH ALPHA-KETOGLUTARATE AT 2.7 ANGSTROMS RESOLUTION: CONFORMATIONAL CHANGES INDUCED BY DECARBOXYLATION OF ISOCITRATE
Descriptor:ISOCITRATE DEHYDROGENASE, CALCIUM ION, 2-OXOGLUTARIC ACID
Authors:Stoddard, B.L., Koshland Junior, D.E.
Deposit date:1993-06-15
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of isocitrate dehydrogenase with alpha-ketoglutarate at 2.7-A resolution: conformational changes induced by decarboxylation of isocitrate.
Biochemistry, 32, 1993
1HEX
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STRUCTURE OF 3-ISOPROPYLMALATE DEHYDROGENASE IN COMPLEX WITH NAD+: LIGAND-INDUCED LOOP-CLOSING AND MECHANISM FOR COFACTOR SPECIFICITY
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Hurley, J.H.
Deposit date:1994-09-09
Release date:1994-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of 3-isopropylmalate dehydrogenase in complex with NAD+: ligand-induced loop closing and mechanism for cofactor specificity.
Structure, 2, 1994
1IDM
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3-ISOPROPYLMALATE DEHYDROGENASE, LOOP-DELETED CHIMERA
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE
Authors:Sakurai, M., Ohzeki, M., Moriyama, H., Sato, M., Tanaka, N.
Deposit date:1995-05-19
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a loop-deleted variant of 3-isopropylmalate dehydrogenase from Thermus thermophilus: an internal reprieve tolerance mechanism.
Acta Crystallogr.,Sect.D, 52, 1996
1IDC
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ISOCITRATE DEHYDROGENASE FROM E.COLI (MUTANT K230M), STEADY-STATE INTERMEDIATE COMPLEX DETERMINED BY LAUE CRYSTALLOGRAPHY
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, 2-OXALOSUCCINIC ACID
Authors:Bolduc, J.M., Dyer, D.H., Scott, W.G., Singer, P., Sweet, R.M., Koshland Junior, D.E., Stoddard, B.L.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1IDD
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ISOCITRATE DEHYDROGENASE Y160F MUTANT APO ENZYME
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Lee, M.E., Dyer, D.H., Klein, O.D., Bolduc, J.M., Stoddard, B.L., Koshland Junior, D.E.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1IDE
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ISOCITRATE DEHYDROGENASE Y160F MUTANT STEADY-STATE INTERMEDIATE COMPLEX (LAUE DETERMINATION)
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID, ...
Authors:Bolduc, J.M., Dyer, D.H., Scott, W.G., Singer, P., Sweet, R.M., Koshland Junior, D.E., Stoddard, B.L.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1IDF
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ISOCITRATE DEHYDROGENASE K230M MUTANT APO ENZYME
Descriptor:ISOCITRATE DEHYDROGENASE
Authors:Bolduc, J.M., Dyer, D.H., Scott, W.G., Singer, P., Sweet, R.M., Koshland Junior, D.E., Stoddard, B.L.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1GRO
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REGULATORY AND CATALYTIC MECHANISMS IN ESCHERICHIA COLI ISOCITRATE DEHYDROGENASE: MULTIPLE ROLES FOR N115
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID
Authors:Grobler, J.A., Hurley, J.H.
Deposit date:1995-10-12
Release date:1996-04-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Second-site suppression of regulatory phosphorylation in Escherichia coli isocitrate dehydrogenase.
Protein Sci., 5, 1996
1GRP
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REGULATORY AND CATALYTIC MECHANISMS IN ESCHERICHIA COLI ISOCITRATE DEHYDROGENASE: MULTIPLE ROLES FOR N115
Descriptor:ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ISOCITRIC ACID
Authors:Grobler, J.A., Hurley, J.H.
Deposit date:1995-10-12
Release date:1996-04-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Second-site suppression of regulatory phosphorylation in Escherichia coli isocitrate dehydrogenase.
Protein Sci., 5, 1996
1XAA
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3-ISOPROPYLMALATE DEHYDROGENASE, LOW TEMPERATURE (100K) STRUCTURE
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE
Authors:Nagata, C., Moriyama, H., Tanaka, N.
Deposit date:1995-11-09
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cryocrystallography of 3-Isopropylmalate dehydrogenase from Thermus thermophilus and its chimeric enzyme.
Acta Crystallogr.,Sect.D, 52, 1996
1XAB
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3-ISOPROPYLMALATE DEHYDROGENASE, LOW TEMPERATURE (150K) STRUCTURE
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE
Authors:Nagata, C., Moriyama, H., Tanaka, N.
Deposit date:1995-11-09
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cryocrystallography of 3-Isopropylmalate dehydrogenase from Thermus thermophilus and its chimeric enzyme.
Acta Crystallogr.,Sect.D, 52, 1996
1XAC
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CHIMERA ISOPROPYLMALATE DEHYDROGENASE BETWEEN BACILLUS SUBTILIS (M) AND THERMUS THERMOPHILUS (T) FROM N-TERMINAL: 20% T MIDDLE 20% M RESIDUAL 60% T, MUTATED AT S82R. LOW TEMPERATURE (100K) STRUCTURE.
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE 2T2M6T S82R
Authors:Nagata, C., Moriyama, H., Tanaka, N.
Deposit date:1995-11-09
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cryocrystallography of 3-Isopropylmalate dehydrogenase from Thermus thermophilus and its chimeric enzyme.
Acta Crystallogr.,Sect.D, 52, 1996
1XAD
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CHIMERA ISOPROPYLMALATE DEHYDROGENASE BETWEEN BACILLUS SUBTILIS (M) AND THERMUS THERMOPHILUS (T) FROM N-TERMINAL: 20% T MIDDLE 20% M RESIDUAL 60% T, MUTATED AT S82R. LOW TEMPERATURE (150K) STRUCTURE.
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE 2T2M6T S82R
Authors:Nagata, C., Moriyama, H., Tanaka, N.
Deposit date:1995-11-09
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cryocrystallography of 3-Isopropylmalate dehydrogenase from Thermus thermophilus and its chimeric enzyme.
Acta Crystallogr.,Sect.D, 52, 1996
1ISO
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ISOCITRATE DEHYDROGENASE: STRUCTURE OF AN ENGINEERED NADP+--> NAD+ SPECIFICITY-REVERSAL MUTANT
Descriptor:ISOCITRATE DEHYDROGENASE, SULFATE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Hurley, J.H.
Deposit date:1996-03-01
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ --> NAD+ specificity-reversal mutant.
Biochemistry, 35, 1996
1OSI
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STRUCTURE OF 3-ISOPROPYLMALATE DEHYDROGENASE
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE
Authors:Qu, C., Akanuma, S., Moriyama, H., Tanaka, N., Oshima, T.
Deposit date:1996-10-22
Release date:1997-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A mutation at the interface between domains causes rearrangement of domains in 3-isopropylmalate dehydrogenase.
Protein Eng., 10, 1997
1OSJ
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STRUCTURE OF 3-ISOPROPYLMALATE DEHYDROGENASE
Descriptor:3-ISOPROPYLMALATE DEHYDROGENASE
Authors:Qu, C., Akanuma, S., Moriyama, H., Tanaka, N., Oshima, T.
Deposit date:1996-10-22
Release date:1997-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A mutation at the interface between domains causes rearrangement of domains in 3-isopropylmalate dehydrogenase.
Protein Eng., 10, 1997
1AI2
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ISOCITRATE DEHYDROGENASE COMPLEXED WITH ISOCITRATE, NADP+, AND CALCIUM (FLASH-COOLED)
Descriptor:ISOCITRATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRATE CALCIUM COMPLEX
Authors:Stoddard, B.L., Mesecar, A., Koshland Junior, D.E.
Deposit date:1997-04-30
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences.
Science, 277, 1997
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