5ZMC
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STRUCTURAL BASIS FOR REACTIVATION OF -146C>T MUTANT TERT PROMOTER BY COOPERATIVE BINDING OF P52 AND ETS1/2
Descriptor:DNA (5'-D(P*CP*GP*GP*GP*GP*AP*CP*CP*CP*GP*GP*AP*AP*GP*GP*G)-3'), DNA (5'-D(P*GP*CP*CP*CP*TP*TP*CP*CP*GP*GP*GP*TP*CP*CP*CP*C)-3'), Protein C-ets-1, ...
Authors:Xu, X., Bharath, S.R., Song, H.
Deposit date:2018-04-02
Release date:2018-09-19
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1.
Nat Commun, 9, 2018
5YBC
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X-RAY STRUCTURE OF NATIVE ETS-DOMAIN DOMAIN OF ERGP55
Descriptor:Transcriptional regulator ERG, GLYCEROL
Authors:Saxena, A.K., Gangwar, S.P.
Deposit date:2017-09-04
Release date:2018-09-19
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence
Acta Crystallogr F Struct Biol Commun, 74, 2018
5W3G
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SOLUTION STRUCTURE OF ETS TRANSCRIPTION FACTOR PU.1
Descriptor:Transcription factor PU.1
Authors:Lau, D.K.W., Okon, M., McIntosh, L.P.
Deposit date:2017-06-07
Release date:2018-06-13
Method:SOLUTION NMR
Cite:Conserved protein dynamics within the ETS transcription factor family
To be published
5JVT
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CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF TRANSCRIPTION FACTOR FLI1 IN COMPLEX WITH AN 11-MER DNA GACCGGAAGTG
Descriptor:Friend leukemia integration 1 transcription factor, DNA (5'-D(*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP*C)-3'), ...
Authors:Hou, C., Tsodikov, O.V.
Deposit date:2016-05-11
Release date:2016-09-14
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.
Nucleic Acids Res., 44, 2016
5ILS
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AUTOINHIBITED ETV1
Descriptor:ETS translocation variant 1
Authors:Whitby, F.G., Currie, S.L.
Deposit date:2016-03-04
Release date:2017-02-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Nucleic Acids Res., 45, 2017
5ILU
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AUTOINHIBITED ETV4
Descriptor:ETS translocation variant 4
Authors:Whitby, F.G., Currie, S.L.
Deposit date:2016-03-04
Release date:2017-02-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.101 Å)
Cite:Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Nucleic Acids Res., 45, 2017
5ILV
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UNINHIBITED ETV5
Descriptor:ETS translocation variant 5
Authors:Whitby, F.G., Currie, S.L.
Deposit date:2016-03-04
Release date:2017-02-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Nucleic Acids Res., 45, 2017
5E8G
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CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF HUMAN TRANSCRIPTION FACTOR FLI1
Descriptor:Friend leukemia integration 1 transcription factor, COBALT (II) ION
Authors:Hou, C., Tsodikov, O.V.
Deposit date:2015-10-14
Release date:2015-12-09
Last modified:2015-12-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Dimerization and DNA Binding of Transcription Factor FLI1.
Biochemistry, 54, 2015
5E8I
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CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF HUMAN TRANSCRIPTION FACTOR FLI1 IN COMPLEX WITH A 10-MER DNA ACCGGAAGTG
Descriptor:Friend leukemia integration 1 transcription factor, DNA (5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), ...
Authors:Hou, C., Tsodikov, O.V.
Deposit date:2015-10-14
Release date:2015-12-09
Last modified:2015-12-30
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Structural Basis for Dimerization and DNA Binding of Transcription Factor FLI1.
Biochemistry, 54, 2015
4UUV
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STRUCTURE OF THE DNA BINDING ETS DOMAIN OF HUMAN ETV4 IN COMPLEX WITH DNA
Descriptor:ETS TRANSLOCATION VARIANT 4, 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3'
Authors:Newman, J.A., Cooper, C.D.O., Kopec, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O.
Deposit date:2014-07-31
Release date:2014-08-13
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
4UNO
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CRYSTAL STRUCTURE OF THE ETS DOMAIN OF HUMAN ETV5 IN COMPLEX WITH DNA
Descriptor:ETS TRANSLOCATION VARIANT 5, 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3', ...
Authors:Newman, J.A., Aitkenhead, H., Cooper, C.D.O., Pinkas, D.M., Shrestha, L., Burgess-Brown, N., Kopec, J., Fitzpatrick, F., Tallant, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Gileadi, O.
Deposit date:2014-05-29
Release date:2014-06-11
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
3WTS
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CRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF ETS1, RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
Descriptor:Runt-related transcription factor 1, Core-binding factor subunit beta, Protein C-ets-1, ...
Authors:Shiina, M., Hamada, K., Ogata, K.
Deposit date:2014-04-21
Release date:2014-08-13
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions
J.Mol.Biol., 2014
3WTT
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CRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF PHOSPHORYLATED ETS1, RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
Descriptor:Runt-related transcription factor 1, Core-binding factor subunit beta, Protein C-ets-1, ...
Authors:Shiina, M., Hamada, K., Ogata, K.
Deposit date:2014-04-21
Release date:2014-08-13
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions
J.Mol.Biol., 2014
3WTU
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CRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF ETS1 (V170A), RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
Descriptor:Runt-related transcription factor 1, Core-binding factor subunit beta, Protein C-ets-1, ...
Authors:Shiina, M., Hamada, K., Ogata, K.
Deposit date:2014-04-21
Release date:2014-08-13
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions
J.Mol.Biol., 2014
3WTV
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CRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF ETS1(V170G), RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
Descriptor:Runt-related transcription factor 1, Core-binding factor subunit beta, Protein C-ets-1, ...
Authors:Shiina, M., Hamada, K., Ogata, K.
Deposit date:2014-04-21
Release date:2014-08-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions
J.Mol.Biol., 2014
3WTW
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CRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF ETS1(K167A), RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
Descriptor:Runt-related transcription factor 1, Core-binding factor subunit beta, Protein C-ets-1, ...
Authors:Shiina, M., Hamada, K., Ogata, K.
Deposit date:2014-04-21
Release date:2014-08-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions
J.Mol.Biol., 2014
3WTX
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CRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF ETS1(Y329A), RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
Descriptor:Runt-related transcription factor 1, Core-binding factor subunit beta, Protein C-ets-1, ...
Authors:Shiina, M., Hamada, K., Ogata, K.
Deposit date:2014-04-21
Release date:2014-08-13
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions
J.Mol.Biol., 2014
3WTY
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CRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF ETS1(G333P), RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
Descriptor:Runt-related transcription factor 1, Core-binding factor subunit beta, Protein C-ets-1, ...
Authors:Shiina, M., Hamada, K., Ogata, K.
Deposit date:2014-04-21
Release date:2014-08-13
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions
J.Mol.Biol., 2014
3WTZ
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CRYSTAL STRUCTURE OF ETS-1 DNA BINDING AND AUTOINHIBITORY DOMAINS (276-441)
Descriptor:Protein C-ets-1
Authors:Shiina, M., Hamada, K., Ogata, K.
Deposit date:2014-04-21
Release date:2014-08-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions
J.Mol.Biol., 2014
3WU0
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CRYSTAL STRUCTURE OF PHOSPHORYLATED ETS-1 DNA BINDING AND AUTOINHIBITORY DOMAINS (276-441)
Descriptor:Protein C-ets-1
Authors:Shiina, M., Hamada, K., Ogata, K.
Deposit date:2014-04-21
Release date:2014-08-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions
J.Mol.Biol., 2014
3WU1
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CRYSTAL STRUCTURE OF THE ETS1-RUNX1-DNA TERNARY COMPLEX
Descriptor:Runt-related transcription factor 1, Protein C-ets-1, DNA (5'-D(*GP*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*T)-3'), ...
Authors:Tahirov, T.H., Ogata, K.
Deposit date:2014-04-21
Release date:2014-08-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions
J.Mol.Biol., 2014
4CO8
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STRUCTURE OF THE DNA BINDING ETS DOMAIN OF HUMAN ETV4
Descriptor:ETS TRANSLOCATION VARIANT 4, 1,2-ETHANEDIOL
Authors:Newman, J.A., Cooper, C.D.O., Shrestha, L., Burgess-Brown, N., Kopec, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O.
Deposit date:2014-01-27
Release date:2014-02-05
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
2MD5
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STRUCTURE OF UNINHIBITED ETV6 ETS DOMAIN
Descriptor:Transcription factor ETV6
Authors:De, S., Mcintosh, L.P., Chan, A.C., Coyne, H.J., Okon, M., Graves, B.J., Murphy, M.E.
Deposit date:2013-08-29
Release date:2013-12-25
Last modified:2014-04-02
Method:SOLUTION NMR
Cite:Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6.
J.Mol.Biol., 426, 2014
4MHG
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CRYSTAL STRUCTURE OF ETV6 BOUND TO A SPECIFIC DNA SEQUENCE
Descriptor:Specific 14 bp DNA, Complimentary Specific 14 bp DNA, Transcription factor ETV6
Authors:Chan, A.C., De, S., Coyne III, H.J., Okon, M., Murphy, M.E., Graves, B.J., McIntosh, L.P.
Deposit date:2013-08-29
Release date:2014-01-08
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6.
J.Mol.Biol., 426, 2014
4LG0
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STRUCTURE OF A TERNARY FOXO1-ETS1 DNA COMPLEX
Descriptor:Forkhead box protein O1, Protein C-ets-1, DNA (5'-D(*DTP*DTP*DCP*DAP*DCP*DGP*DGP*DTP*DTP*DTP*DCP*DCP*DTP*DGP*DTP*DTP*DAP*DTP*DTP*DGP*DT)-3'), ...
Authors:Birrane, G., Choy, W.C., Datta, D., Geiger, C.A., Grant, M.A.
Deposit date:2013-06-27
Release date:2014-07-02
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structure of a ternary FOXO1-ETS1 DNA complex
To be Published
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