Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8I7P
DownloadVisualize
BU of 8i7p by Molmil
Crystal structure of Ricin A chain bound with N2-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-tyrosine
Descriptor: 6-(2-ethyl-4-hydroxyphenyl)-1H-indazole-3-carboxamide, Ricin A chain, SULFATE ION
Authors:Goto, M, Sakamoto, N, Higashi, S, Kawata, R, Nagatsu, K, Saito, R.
Deposit date:2023-02-01
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor.
J Enzyme Inhib Med Chem, 38, 2023
8GCW
DownloadVisualize
BU of 8gcw by Molmil
Stx2A1(Y77A)-P6 peptide
Descriptor: P stalk protein, rRNA N-glycosylase
Authors:Rudolph, M.J, Li, X.P.
Deposit date:2023-03-03
Release date:2024-03-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the Stx2A1(Y77A) in complex with P6 peptide.
To Be Published
8CX8
DownloadVisualize
BU of 8cx8 by Molmil
Stx2A1-BTB13086
Descriptor: 1,2-ETHANEDIOL, 5-(4-chlorophenyl)furan-2-carboxylic acid, CHLORIDE ION, ...
Authors:Rudolph, M.J, Li, X.P.
Deposit date:2022-05-20
Release date:2024-03-06
Method:X-RAY DIFFRACTION (1.905 Å)
Cite:Stx2A1-BTB13086
To Be Published
7Y4M
DownloadVisualize
BU of 7y4m by Molmil
Crystal structure of Ricin A chain bound with N2-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanyl-N6-((benzyloxy)carbonyl)-L-lysine
Descriptor: (2S)-2-[[(2S)-2-[2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-6-(phenylmethoxycarbonylamino)hexanoic acid, Ricin A chain, SULFATE ION
Authors:Katakura, S, Goto, M, Ohba, T, Kawata, R, Nagatsu, K, Higashi, S, Matsumoto, K, Kurisu, K, Ohtsuka, K, Saito, R.
Deposit date:2022-06-15
Release date:2022-11-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Pterin-based small molecule inhibitor capable of binding to the secondary pocket in the active site of ricin-toxin A chain.
Plos One, 17, 2022
7Y4K
DownloadVisualize
BU of 7y4k by Molmil
Crystal structure of Ricin A chain bound with N2-(2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanyl-N6-((benzyloxy)carbonyl)-L-ornitine
Descriptor: (2S)-2-[[(2S)-2-[2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-5-(phenylmethoxycarbonylamino)pentanoic acid, Ricin A chain, SULFATE ION
Authors:Katakura, S, Goto, M, Ohba, T, Kawata, R, Nagatsu, K, Higashi, S, Matsumoto, K, Kurisu, K, Ohtsuka, K, Saito, R.
Deposit date:2022-06-15
Release date:2022-11-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Pterin-based small molecule inhibitor capable of binding to the secondary pocket in the active site of ricin-toxin A chain.
Plos One, 17, 2022
7Y08
DownloadVisualize
BU of 7y08 by Molmil
Crystal structure of Ricin A chain bound with (2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)glycyl-L-phenylalanine
Descriptor: N-[(2-amino-4-oxo-1,4-dihydropteridin-7-yl)carbonyl]glycyl-L-phenylalanine, Ricin A chain, SULFATE ION
Authors:Goto, M, Higashi, S, Ohba, T, Kawata, R, Nagatsu, K, Suzuki, S, Saito, R.
Deposit date:2022-06-03
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.
Biochem.Biophys.Res.Commun., 627, 2022
7Y07
DownloadVisualize
BU of 7y07 by Molmil
Crystal structure of Ricin A chain bound with (S)-2-amino-N-(1-hydroxy-3-phenylpropan-2-yl)-4-oxo-3,4-dihydropteridine-7-carboxamide
Descriptor: 2-azanyl-4-oxidanylidene-N-[(2S)-1-oxidanyl-3-phenyl-propan-2-yl]-3H-pteridine-7-carboxamide, Ricin A chain, SULFATE ION
Authors:Goto, M, Higashi, S, Ohba, T, Kawata, R, Nagatsu, K, Suzuki, S, Saito, R.
Deposit date:2022-06-03
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.
Biochem.Biophys.Res.Commun., 627, 2022
7Y06
DownloadVisualize
BU of 7y06 by Molmil
Crystal structure of Ricin A chain bound with (S)-2-(2-amino-4-oxo-3,4-dihydropteridine-7-carboxamido)-4-phenylbutanoic acid
Descriptor: (2S)-2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]-4-phenyl-butanoic acid, Ricin A chain, SULFATE ION
Authors:Goto, M, Higashi, S, Ohba, T, Kawata, R, Nagatsu, K, Suzuki, S, Saito, R.
Deposit date:2022-06-03
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.
Biochem.Biophys.Res.Commun., 627, 2022
7Y05
DownloadVisualize
BU of 7y05 by Molmil
Crystal structure of Ricin A chain bound with (R)-2-(2-amino-4-oxo-3,4-dihydropteridine-7-carboxamido)-2-phenylacetic acid
Descriptor: (2R)-2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]-2-phenyl-ethanoic acid, Ricin A chain, SULFATE ION
Authors:Goto, M, Higashi, S, Ohba, T, Kawata, R, Nagatsu, K, Suzuki, S, Saito, R.
Deposit date:2022-06-03
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.
Biochem.Biophys.Res.Commun., 627, 2022
7Y03
DownloadVisualize
BU of 7y03 by Molmil
Crystal structure of Ricin A chain bound with (S)-2-(2-amino-4-oxo-3,4-dihydropteridine-7-carboxamido)-2-phenylacetic acid
Descriptor: (2S)-2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]-2-phenyl-ethanoic acid, Ricin A chain, SULFATE ION
Authors:Goto, M, Higashi, S, Ohba, T, Kawata, R, Nagatsu, K, Suzuki, S, Saito, R.
Deposit date:2022-06-03
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.
Biochem.Biophys.Res.Commun., 627, 2022
7Y02
DownloadVisualize
BU of 7y02 by Molmil
Crystal structure of Ricin A chain bound with (S)-2-(2-amino-4-oxo-3,4-dihydropteridine-7-carboxamido)-3-(4-fluorophenyl)propanoic acid
Descriptor: (2S)-2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]-3-(4-fluorophenyl)propanoic acid, Ricin A chain, SULFATE ION
Authors:Goto, M, Higashi, S, Ohba, T, Kawata, R, Nagatsu, K, Suzuki, S, Saito, R.
Deposit date:2022-06-03
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.
Biochem.Biophys.Res.Commun., 627, 2022
7XZW
DownloadVisualize
BU of 7xzw by Molmil
Crystal structure of Ricin A chain bound with (2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-D-phenylalanine
Descriptor: (2R)-2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]-3-phenyl-propanoic acid, Ricin A chain, SULFATE ION
Authors:Goto, M, Higashi, S, Ohba, T, Kawata, R, Nagatsu, K, Suzuki, S, Saito, R.
Deposit date:2022-06-03
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.
Biochem.Biophys.Res.Commun., 627, 2022
7XZU
DownloadVisualize
BU of 7xzu by Molmil
Crystal structure of Ricin A chain bound with (2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-phenylalanine
Descriptor: (2S)-2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]-3-phenyl-propanoic acid, Ricin A chain, SULFATE ION
Authors:Goto, M, Higashi, S, Ohba, T, Kawata, R, Nagatsu, K, Suzuki, S, Saito, R.
Deposit date:2022-06-03
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.
Biochem.Biophys.Res.Commun., 627, 2022
7XZT
DownloadVisualize
BU of 7xzt by Molmil
Crystal structure of Ricin A chain bound with (2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-D-tyrosine
Descriptor: (2R)-2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]-3-(4-hydroxyphenyl)propanoic acid, Ricin A chain, SULFATE ION
Authors:Goto, M, Higashi, S, Ohba, T, Kawata, R, Nagatsu, K, Suzuki, S, Saito, R.
Deposit date:2022-06-03
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.
Biochem.Biophys.Res.Commun., 627, 2022
7XZS
DownloadVisualize
BU of 7xzs by Molmil
Crystal structure of Ricin A chain bound with (2-amino-4-oxo-3,4-dihydropteridine-7-carbonyl)-L-tyrosine
Descriptor: (2S)-2-[(2-azanyl-4-oxidanylidene-3H-pteridin-7-yl)carbonylamino]-3-(4-hydroxyphenyl)propanoic acid, Ricin A chain, SULFATE ION
Authors:Goto, M, Higashi, S, Ohba, T, Kawata, R, Nagatsu, K, Suzuki, S, Saito, R.
Deposit date:2022-06-03
Release date:2022-12-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.
Biochem.Biophys.Res.Commun., 627, 2022
7VHF
DownloadVisualize
BU of 7vhf by Molmil
Crystal structure of the STX2a complexed with RRA peptide
Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, GLYCEROL, RRA peptide, ...
Authors:Senda, M, Takahashi, M, Nishikawa, K, Senda, T.
Deposit date:2021-09-22
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin.
Sci Rep, 12, 2022
7VHE
DownloadVisualize
BU of 7vhe by Molmil
Crystal structure of the STX2a complexed with RRRA peptide
Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, GLYCEROL, RRRA peptide, ...
Authors:Senda, M, Takahashi, M, Nishikawa, K, Senda, T.
Deposit date:2021-09-22
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin.
Sci Rep, 12, 2022
7VHD
DownloadVisualize
BU of 7vhd by Molmil
Crystal structure of the STX2a complexed with R4A peptide
Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, ARG-ARG-ARG-ARG-ALA, Shiga toxin 2 B subunit, ...
Authors:Senda, M, Takahashi, M, Nishikawa, K, Senda, T.
Deposit date:2021-09-22
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin.
Sci Rep, 12, 2022
7VHC
DownloadVisualize
BU of 7vhc by Molmil
Crystal structure of the STX2a complexed with AR4A peptide
Descriptor: 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, Shiga toxin 2 B subunit, inhibitor peptide, ...
Authors:Senda, M, Takahashi, M, Nishikawa, K, Senda, T.
Deposit date:2021-09-22
Release date:2022-07-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin.
Sci Rep, 12, 2022
7UJJ
DownloadVisualize
BU of 7ujj by Molmil
Stx2a and DARPin complex
Descriptor: 1,2-ETHANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, DARPin, ...
Authors:Jiang, M, Zhang, J.
Deposit date:2022-03-30
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:A Multi-Specific DARPin Potently Neutralizes Shiga Toxin 2 via Simultaneous Modulation of Both Toxin Subunits.
Bioengineering (Basel), 9, 2022
7U6V
DownloadVisualize
BU of 7u6v by Molmil
Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk
Descriptor: C-terminal domain (CTD) from the Ribosomal P-stalk, Shiga toxin 2a subunit A (Stx2A), Shiga toxin 2a subunit B (Stx2B)
Authors:Kulczyk, A.W.
Deposit date:2022-03-06
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction.
J.Biol.Chem., 299, 2022
7TH3
DownloadVisualize
BU of 7th3 by Molmil
Single-domain VHH intrabodies neutralize ricin toxin
Descriptor: Ricin chain A, VHH antibody
Authors:Rudolph, M.J.
Deposit date:2022-01-10
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins.
J.Biol.Chem., 298, 2022
7TH2
DownloadVisualize
BU of 7th2 by Molmil
Single-domain VHH intrabodies neutralize ricin toxin
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ...
Authors:Rudolph, M.J, Mantis, N.
Deposit date:2022-01-10
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.838 Å)
Cite:Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins.
J.Biol.Chem., 298, 2022
7TGI
DownloadVisualize
BU of 7tgi by Molmil
Single-domain VHH intrabodies neutralize ricin toxin
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Ricin chain A, ...
Authors:Rudolph, M.J.
Deposit date:2022-01-07
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins.
J.Biol.Chem., 298, 2022
7TGF
DownloadVisualize
BU of 7tgf by Molmil
Single-domain VHH intrabodies neutralize ricin toxin.
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Ricin chain A, ...
Authors:Rudolph, M.J, Mantis, N.
Deposit date:2022-01-07
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.347 Å)
Cite:Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins.
J.Biol.Chem., 298, 2022

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon