4QCL
| Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and dCTP | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA TEMPLATE, ... | Authors: | Baranovskiy, A.G, Suwa, Y, Babayeva, N.D, Gu, J, Tahirov, T.H. | Deposit date: | 2014-05-12 | Release date: | 2014-11-26 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Activity and fidelity of human DNA polymerase alpha depend on primer structure J.Biol.Chem., 2018
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6FWK
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5EXR
| Crystal structure of human primosome | Descriptor: | DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ... | Authors: | Tahirov, T.H, Baranovskiy, A.G, Babayeva, N.D. | Deposit date: | 2015-11-24 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome. J.Biol.Chem., 291, 2016
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6AS7
| CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF HUMAN DNA POLYMERASE ALPHA IN TERNARY COMPLEX WITH AN DNA-PRIMED DNA TEMPLATE AND DCTP | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, COBALT (II) ION, DNA (5'-D(*AP*GP*GP*CP*GP*CP*TP*CP*CP*AP*GP*GP*C)-3'), ... | Authors: | Tahirov, T.H, Baranovskiy, A.G, Babayeva, N.D. | Deposit date: | 2017-08-23 | Release date: | 2018-03-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Activity and fidelity of human DNA polymerase alpha depend on primer structure. J. Biol. Chem., 293, 2018
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1CLQ
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5H12
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1D5A
| CRYSTAL STRUCTURE OF AN ARCHAEBACTERIAL DNA POLYMERASE D.TOK. DEPOSITION OF SECOND NATIVE STRUCTURE AT 2.4 ANGSTROM | Descriptor: | MAGNESIUM ION, PROTEIN (DNA POLYMERASE), SULFATE ION | Authors: | Zhao, Y, Jeruzalmi, D, Leighton, L, Lasken, R, Kuriyan, J. | Deposit date: | 1999-10-06 | Release date: | 2000-03-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of an archaebacterial DNA polymerase. Structure Fold.Des., 7, 1999
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1IH7
| High-Resolution Structure of Apo RB69 DNA Polymerase | Descriptor: | DNA POLYMERASE, GUANOSINE, POTASSIUM ION | Authors: | Franklin, M.C, Wang, J, Steitz, T.A. | Deposit date: | 2001-04-18 | Release date: | 2001-06-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structure of the Replicating Complex of a Pol alpha Family DNA Polymerase Cell(Cambridge,Mass.), 105, 2001
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2GV9
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1IG9
| Structure of the Replicating Complex of a Pol Alpha Family DNA Polymerase | Descriptor: | 5'-D(*AP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*(DOC))-3', CALCIUM ION, ... | Authors: | Franklin, M.C, Wang, J, Steitz, T.A. | Deposit date: | 2001-04-17 | Release date: | 2001-06-11 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the Replicating Complex of a Pol Alpha Family DNA Polymerase Cell(Cambridge,Mass.), 105, 2001
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7F4Y
| Crystal structure of replisomal dimer of DNA polymerase from bacteriophage RB69 with DNA duplexes | Descriptor: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*AP*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3'), ... | Authors: | Youn, H.-S, Park, J, An, J.Y, Lee, Y, Eom, S.H, Wang, J. | Deposit date: | 2021-06-21 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of New Binary and Ternary DNA Polymerase Complexes From Bacteriophage RB69. Front Mol Biosci, 8, 2021
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5IUD
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2JGU
| crystal structure of DNA-directed DNA polymerase | Descriptor: | DNA POLYMERASE, MANGANESE (II) ION | Authors: | Kim, D.U, Cho, H.S. | Deposit date: | 2007-02-15 | Release date: | 2008-04-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of Pfu, the High Fidelity DNA Polymerase from Pyrococcus Furiosus. Int.J.Biol.Macromol., 42, 2008
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7KC0
| Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp | Descriptor: | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*CP*AP*TP*GP*AP*TP*TP*AP*CP*GP*AP*AP*TP*TP*GP*C)-3'), ... | Authors: | Zheng, F, Georgescu, R, Li, H, O'Donnell, M.E. | Deposit date: | 2020-10-04 | Release date: | 2020-12-02 | Last modified: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of eukaryotic DNA polymerase delta bound to the PCNA clamp while encircling DNA. Proc.Natl.Acad.Sci.USA, 117, 2020
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6WJV
| Structure of the Saccharomyces cerevisiae polymerase epsilon holoenzyme | Descriptor: | DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit B, DNA polymerase epsilon subunit C, ... | Authors: | Yuan, Z, Georgescu, R, Schauer, G.D, O'Donnell, M, Li, H. | Deposit date: | 2020-04-14 | Release date: | 2020-07-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the polymerase epsilon holoenzyme and atomic model of the leading strand replisome. Nat Commun, 11, 2020
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5OMF
| Closed, ternary structure of KOD DNA polymerase | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*C)-3'), ... | Authors: | Kropp, H.M, Betz, K, Wirth, J, Diederichs, K, Marx, A. | Deposit date: | 2017-07-31 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.092 Å) | Cite: | Crystal structures of ternary complexes of archaeal B-family DNA polymerases. PLoS ONE, 12, 2017
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6WYA
| RTX (Reverse Transcription Xenopolymerase) in complex with a DNA duplex and dAMPNPP | Descriptor: | 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Choi, W.S, He, P, Pothukuchy, A, Gollihar, J, Ellington, A.D, Yang, W. | Deposit date: | 2020-05-12 | Release date: | 2020-08-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | How a B family DNA polymerase has been evolved to copy RNA. Proc.Natl.Acad.Sci.USA, 117, 2020
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5OMQ
| Ternary complex of 9N DNA polymerase in the replicative state with three metal ions in the active site | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA Primer, DNA Template, ... | Authors: | Betz, K, Marx, A, Diederichs, K. | Deposit date: | 2017-08-01 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.199 Å) | Cite: | Crystal structures of ternary complexes of archaeal B-family DNA polymerases. PLoS ONE, 12, 2017
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6WYB
| RTX (Reverse Transcription Xenopolymerase) in complex with an RNA/DNA hybrid | Descriptor: | 1,2-ETHANEDIOL, 3,3',3''-phosphanetriyltripropanoic acid, DNA polymerase, ... | Authors: | Choi, W.S, He, P, Pothukuchy, A, Gollihar, J, Ellington, A.D, Yang, W. | Deposit date: | 2020-05-12 | Release date: | 2020-08-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | How a B family DNA polymerase has been evolved to copy RNA. Proc.Natl.Acad.Sci.USA, 117, 2020
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5OMV
| Ternary complex of 9N DNA polymerase in the replicative state with two metal ions in the active site | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA polymerase, DNA primer, ... | Authors: | Betz, K, Marx, A, Diederichs, K. | Deposit date: | 2017-08-01 | Release date: | 2017-12-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.003 Å) | Cite: | Crystal structures of ternary complexes of archaeal B-family DNA polymerases. PLoS ONE, 12, 2017
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2VWK
| Uracil Recognition in Archaeal DNA Polymerases Captured by X-ray Crystallography. V93Q polymerase variant | Descriptor: | DNA POLYMERASE, SODIUM ION, SULFATE ION | Authors: | Firbank, S.J, Wardle, J, Heslop, P, Lewis, R.J, Connolly, B.A. | Deposit date: | 2008-06-26 | Release date: | 2008-07-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Uracil Recognition in Archaeal DNA Polymerases Captured by X-Ray Crystallography. J.Mol.Biol., 381, 2008
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2VWJ
| Uracil Recognition in Archaeal DNA Polymerases Captured by X-ray Crystallography. | Descriptor: | 5'-D(*AP*AP*UP*GP*GP*AP*GP*AP*CP*GP *GP*CP*TP*TP*TP*TP*GP*CP*CP*GP*TP*GP*TP*C)-3', DNA POLYMERASE, POTASSIUM ION | Authors: | Firbank, S.J, Wardle, J, Heslop, P, Lewis, R.J, Connolly, B.A. | Deposit date: | 2008-06-25 | Release date: | 2008-07-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Uracil Recognition in Archaeal DNA Polymerases Captured by X-Ray Crystallography. J.Mol.Biol., 381, 2008
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7LUF
| HSV1 polymerase ternary complex with dsDNA and PNU-183792 | Descriptor: | DNA (5'-D(*CP*GP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3'), DNA (5'-D(P*AP*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*CP*G)-3'), DNA polymerase, ... | Authors: | Hayes, R.P, Klein, D. | Deposit date: | 2021-02-22 | Release date: | 2021-04-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase. Nat Commun, 12, 2021
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7LXD
| Structure of yeast DNA Polymerase Zeta (apo) | Descriptor: | DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ... | Authors: | Truong, C.D, Craig, T.A, Cui, G, Botuyan, M.V, Serkasevich, R.A, Chan, K.-Y, Mer, G, Chiu, P.-L, Kumar, R. | Deposit date: | 2021-03-03 | Release date: | 2021-06-30 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.11 Å) | Cite: | Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta. J.Biol.Chem., 297, 2021
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2ATQ
| RB69 single-stranded DNA binding protein-DNA polymerase fusion | Descriptor: | DNA polymerase, GUANOSINE-5'-DIPHOSPHATE, ZINC ION, ... | Authors: | Sun, S, Geng, L, Shamoo, Y. | Deposit date: | 2005-08-25 | Release date: | 2006-05-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure and enzymatic properties of a chimeric bacteriophage RB69 DNA polymerase and single-stranded DNA binding protein with increased processivity. Proteins, 65, 2006
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