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4QCL
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BU of 4qcl by Molmil
Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and dCTP
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA TEMPLATE, ...
Authors:Baranovskiy, A.G, Suwa, Y, Babayeva, N.D, Gu, J, Tahirov, T.H.
Deposit date:2014-05-12
Release date:2014-11-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Activity and fidelity of human DNA polymerase alpha depend on primer structure
J.Biol.Chem., 2018
6FWK
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BU of 6fwk by Molmil
The crystal structure of Pol2CORE-M644G in complex with DNA and an incoming nucleotide
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3'), ...
Authors:Parkash, V, Johansson, E.
Deposit date:2018-03-06
Release date:2019-01-30
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Nat Commun, 10, 2019
5EXR
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BU of 5exr by Molmil
Crystal structure of human primosome
Descriptor: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ...
Authors:Tahirov, T.H, Baranovskiy, A.G, Babayeva, N.D.
Deposit date:2015-11-24
Release date:2016-03-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.
J.Biol.Chem., 291, 2016
6AS7
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BU of 6as7 by Molmil
CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF HUMAN DNA POLYMERASE ALPHA IN TERNARY COMPLEX WITH AN DNA-PRIMED DNA TEMPLATE AND DCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, COBALT (II) ION, DNA (5'-D(*AP*GP*GP*CP*GP*CP*TP*CP*CP*AP*GP*GP*C)-3'), ...
Authors:Tahirov, T.H, Baranovskiy, A.G, Babayeva, N.D.
Deposit date:2017-08-23
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Activity and fidelity of human DNA polymerase alpha depend on primer structure.
J. Biol. Chem., 293, 2018
1CLQ
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BU of 1clq by Molmil
CRYSTAL STRUCTURE OF A REPLICATION FORK DNA POLYMERASE EDITING COMPLEX AT 2.7 A RESOLUTION
Descriptor: CALCIUM ION, DNA (5'-D(*AP*GP*TP*AP*GP*TP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*AP*CP*TP*AP*CP*T)-3'), ...
Authors:Shamoo, Y, Steitz, T.A.
Deposit date:1999-04-30
Release date:1999-10-28
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex.
Cell(Cambridge,Mass.), 99, 1999
5H12
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BU of 5h12 by Molmil
Crystal structure of Deep Vent DNA Polymerase
Descriptor: Deep Vent DNA Polymerase
Authors:Hikida, Y, Kimoto, M, Hirao, I, Yokoyama, S.
Deposit date:2016-10-07
Release date:2017-01-25
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Crystal structure of Deep Vent DNA polymerase.
Biochem. Biophys. Res. Commun., 483, 2017
1D5A
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BU of 1d5a by Molmil
CRYSTAL STRUCTURE OF AN ARCHAEBACTERIAL DNA POLYMERASE D.TOK. DEPOSITION OF SECOND NATIVE STRUCTURE AT 2.4 ANGSTROM
Descriptor: MAGNESIUM ION, PROTEIN (DNA POLYMERASE), SULFATE ION
Authors:Zhao, Y, Jeruzalmi, D, Leighton, L, Lasken, R, Kuriyan, J.
Deposit date:1999-10-06
Release date:2000-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of an archaebacterial DNA polymerase.
Structure Fold.Des., 7, 1999
1IH7
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BU of 1ih7 by Molmil
High-Resolution Structure of Apo RB69 DNA Polymerase
Descriptor: DNA POLYMERASE, GUANOSINE, POTASSIUM ION
Authors:Franklin, M.C, Wang, J, Steitz, T.A.
Deposit date:2001-04-18
Release date:2001-06-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of the Replicating Complex of a Pol alpha Family DNA Polymerase
Cell(Cambridge,Mass.), 105, 2001
2GV9
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BU of 2gv9 by Molmil
Crystal structure of the Herpes Simplex virus type 1 DNA polymerase
Descriptor: DNA polymerase, GUANIDINE, MERCURY (II) ION, ...
Authors:Liu, S.
Deposit date:2006-05-02
Release date:2006-05-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal structure of the herpes simplex virus 1 DNA polymerase.
J.Biol.Chem., 281, 2006
1IG9
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BU of 1ig9 by Molmil
Structure of the Replicating Complex of a Pol Alpha Family DNA Polymerase
Descriptor: 5'-D(*AP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*(DOC))-3', CALCIUM ION, ...
Authors:Franklin, M.C, Wang, J, Steitz, T.A.
Deposit date:2001-04-17
Release date:2001-06-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the Replicating Complex of a Pol Alpha Family DNA Polymerase
Cell(Cambridge,Mass.), 105, 2001
7F4Y
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BU of 7f4y by Molmil
Crystal structure of replisomal dimer of DNA polymerase from bacteriophage RB69 with DNA duplexes
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*AP*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3'), ...
Authors:Youn, H.-S, Park, J, An, J.Y, Lee, Y, Eom, S.H, Wang, J.
Deposit date:2021-06-21
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of New Binary and Ternary DNA Polymerase Complexes From Bacteriophage RB69.
Front Mol Biosci, 8, 2021
5IUD
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BU of 5iud by Molmil
Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer
Descriptor: DNA polymerase alpha catalytic subunit, DNA primer, DNA template
Authors:Coloma, J, Aggarwal, A.K.
Deposit date:2016-03-17
Release date:2016-04-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer.
Sci Rep, 6, 2016
2JGU
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BU of 2jgu by Molmil
crystal structure of DNA-directed DNA polymerase
Descriptor: DNA POLYMERASE, MANGANESE (II) ION
Authors:Kim, D.U, Cho, H.S.
Deposit date:2007-02-15
Release date:2008-04-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Pfu, the High Fidelity DNA Polymerase from Pyrococcus Furiosus.
Int.J.Biol.Macromol., 42, 2008
7KC0
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BU of 7kc0 by Molmil
Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp
Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*CP*AP*TP*GP*AP*TP*TP*AP*CP*GP*AP*AP*TP*TP*GP*C)-3'), ...
Authors:Zheng, F, Georgescu, R, Li, H, O'Donnell, M.E.
Deposit date:2020-10-04
Release date:2020-12-02
Last modified:2020-12-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of eukaryotic DNA polymerase delta bound to the PCNA clamp while encircling DNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WJV
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BU of 6wjv by Molmil
Structure of the Saccharomyces cerevisiae polymerase epsilon holoenzyme
Descriptor: DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit B, DNA polymerase epsilon subunit C, ...
Authors:Yuan, Z, Georgescu, R, Schauer, G.D, O'Donnell, M, Li, H.
Deposit date:2020-04-14
Release date:2020-07-08
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the polymerase epsilon holoenzyme and atomic model of the leading strand replisome.
Nat Commun, 11, 2020
5OMF
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BU of 5omf by Molmil
Closed, ternary structure of KOD DNA polymerase
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*C)-3'), ...
Authors:Kropp, H.M, Betz, K, Wirth, J, Diederichs, K, Marx, A.
Deposit date:2017-07-31
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Crystal structures of ternary complexes of archaeal B-family DNA polymerases.
PLoS ONE, 12, 2017
6WYA
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BU of 6wya by Molmil
RTX (Reverse Transcription Xenopolymerase) in complex with a DNA duplex and dAMPNPP
Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Choi, W.S, He, P, Pothukuchy, A, Gollihar, J, Ellington, A.D, Yang, W.
Deposit date:2020-05-12
Release date:2020-08-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:How a B family DNA polymerase has been evolved to copy RNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
5OMQ
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BU of 5omq by Molmil
Ternary complex of 9N DNA polymerase in the replicative state with three metal ions in the active site
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA Primer, DNA Template, ...
Authors:Betz, K, Marx, A, Diederichs, K.
Deposit date:2017-08-01
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Crystal structures of ternary complexes of archaeal B-family DNA polymerases.
PLoS ONE, 12, 2017
6WYB
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BU of 6wyb by Molmil
RTX (Reverse Transcription Xenopolymerase) in complex with an RNA/DNA hybrid
Descriptor: 1,2-ETHANEDIOL, 3,3',3''-phosphanetriyltripropanoic acid, DNA polymerase, ...
Authors:Choi, W.S, He, P, Pothukuchy, A, Gollihar, J, Ellington, A.D, Yang, W.
Deposit date:2020-05-12
Release date:2020-08-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:How a B family DNA polymerase has been evolved to copy RNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
5OMV
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BU of 5omv by Molmil
Ternary complex of 9N DNA polymerase in the replicative state with two metal ions in the active site
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA polymerase, DNA primer, ...
Authors:Betz, K, Marx, A, Diederichs, K.
Deposit date:2017-08-01
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Crystal structures of ternary complexes of archaeal B-family DNA polymerases.
PLoS ONE, 12, 2017
2VWK
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BU of 2vwk by Molmil
Uracil Recognition in Archaeal DNA Polymerases Captured by X-ray Crystallography. V93Q polymerase variant
Descriptor: DNA POLYMERASE, SODIUM ION, SULFATE ION
Authors:Firbank, S.J, Wardle, J, Heslop, P, Lewis, R.J, Connolly, B.A.
Deposit date:2008-06-26
Release date:2008-07-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Uracil Recognition in Archaeal DNA Polymerases Captured by X-Ray Crystallography.
J.Mol.Biol., 381, 2008
2VWJ
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BU of 2vwj by Molmil
Uracil Recognition in Archaeal DNA Polymerases Captured by X-ray Crystallography.
Descriptor: 5'-D(*AP*AP*UP*GP*GP*AP*GP*AP*CP*GP *GP*CP*TP*TP*TP*TP*GP*CP*CP*GP*TP*GP*TP*C)-3', DNA POLYMERASE, POTASSIUM ION
Authors:Firbank, S.J, Wardle, J, Heslop, P, Lewis, R.J, Connolly, B.A.
Deposit date:2008-06-25
Release date:2008-07-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Uracil Recognition in Archaeal DNA Polymerases Captured by X-Ray Crystallography.
J.Mol.Biol., 381, 2008
7LUF
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BU of 7luf by Molmil
HSV1 polymerase ternary complex with dsDNA and PNU-183792
Descriptor: DNA (5'-D(*CP*GP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3'), DNA (5'-D(P*AP*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*CP*G)-3'), DNA polymerase, ...
Authors:Hayes, R.P, Klein, D.
Deposit date:2021-02-22
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.
Nat Commun, 12, 2021
7LXD
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BU of 7lxd by Molmil
Structure of yeast DNA Polymerase Zeta (apo)
Descriptor: DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ...
Authors:Truong, C.D, Craig, T.A, Cui, G, Botuyan, M.V, Serkasevich, R.A, Chan, K.-Y, Mer, G, Chiu, P.-L, Kumar, R.
Deposit date:2021-03-03
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.11 Å)
Cite:Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta.
J.Biol.Chem., 297, 2021
2ATQ
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BU of 2atq by Molmil
RB69 single-stranded DNA binding protein-DNA polymerase fusion
Descriptor: DNA polymerase, GUANOSINE-5'-DIPHOSPHATE, ZINC ION, ...
Authors:Sun, S, Geng, L, Shamoo, Y.
Deposit date:2005-08-25
Release date:2006-05-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and enzymatic properties of a chimeric bacteriophage RB69 DNA polymerase and single-stranded DNA binding protein with increased processivity.
Proteins, 65, 2006

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