1BU2
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X-RAY STRUCTURE OF A VIRAL CYCLIN FROM HERPESVIRUS SAIMIRI
Descriptor:CYCLIN HOMOLOG
Authors:Schulze-Gahmen, U., Jung, J.U., Kim, S.-H.
Deposit date:1998-09-10
Release date:1999-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a viral cyclin, a positive regulator of cyclin-dependent kinase 6.
Structure Fold.Des., 7, 1999
1ZP2
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STRUCTURE OF THE MEDIATOR SUBUNIT CYCLIN C
Descriptor:RNA polymerase II holoenzyme cyclin-like subunit
Authors:Hoeppner, S., Baumli, S., Cramer, P.
Deposit date:2005-05-16
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Mediator Subunit Cyclin C and its Implications for CDK8 Function.
J.Mol.Biol., 350, 2005
2I53
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CRYSTAL STRUCTURE OF CYCLIN K
Descriptor:Cyclin K, ACETATE ION
Authors:Baek, K., Brown, R.S., Birrane, G., Ladias, J.A.A.
Deposit date:2006-08-23
Release date:2007-01-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9.
J.Mol.Biol., 366, 2007
2IVX
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CRYSTAL STRUCTURE OF HUMAN CYCLIN T2 AT 1.8 A RESOLUTION
Descriptor:CYCLIN-T2, 1,2-ETHANEDIOL
Authors:Debreczeni, J.E., Bullock, A.N., Fedorov, O., Savitsky, P., Berridge, G., Das, S., Pike, A.C.W., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Gorrec, F., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
Deposit date:2006-06-21
Release date:2006-07-19
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
EMBO J., 27, 2008
2PK2
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CYCLIN BOX STRUCTURE OF THE P-TEFB SUBUNIT CYCLIN T1 DERIVED FROM A FUSION COMPLEX WITH EIAV TAT
Descriptor:Cyclin-T1, Protein Tat
Authors:Anand, K., Schulte, A., Fujinaga, K., Scheffzek, K., Geyer, M.
Deposit date:2007-04-17
Release date:2007-07-03
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat.
J.Mol.Biol., 370, 2007
2W2H
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STRUCTURAL BASIS OF TRANSCRIPTION ACTIVATION BY THE CYCLIN T1-TAT-TAR RNA COMPLEX FROM EIAV
Descriptor:CYCLIN-T1, PROTEIN TAT, 5'-R(*GP*CP*UP*CP*AP*GP*AP*UP*CP*UP *GP*CP*GP*GP*UP*CP*UP*GP*AP*GP*C)-3', ...
Authors:Anand, K., Geyer, M.
Deposit date:2008-10-30
Release date:2008-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural Insights Into the Cyclin T1-Tat-Tar RNA Transcription Activation Complex from Eiav.
Nat.Struct.Mol.Biol., 15, 2008
1JKW
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STRUCTURE OF CYCLIN MCS2
Descriptor:CYCLIN H
Authors:Andersen, G., Poterszman, A., Moras, D., Thierry, J.C.
Deposit date:1996-10-11
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of human cyclin H.
FEBS Lett., 397, 1996
1JOW
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CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN CDK6 AND A VIRAL CYCLIN
Descriptor:CYCLIN HOMOLOG, CELL DIVISION PROTEIN KINASE 6
Authors:Schulze-Gahmen, U., Kim, S.H.
Deposit date:2001-07-31
Release date:2002-02-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for CDK6 activation by a virus-encoded cyclin.
Nat.Struct.Biol., 9, 2002
1KXU
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CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE
Descriptor:CYCLIN H
Authors:Kim, K.K., Chamberin, H.M., Morgan, D.O., Kim, S.-H.
Deposit date:1996-08-08
Release date:1997-01-27
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase.
Nat.Struct.Biol., 3, 1996
1VIN
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BOVINE CYCLIN A3
Descriptor:CYCLIN A
Authors:Noble, M.E.M., Endicott, J.A.E., Brown, N.R.
Deposit date:1996-03-15
Release date:1996-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of cyclin A.
Structure, 3, 1995
1XO2
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CRYSTAL STRUCTURE OF A HUMAN CYCLIN-DEPENDENT KINASE 6 COMPLEX WITH A FLAVONOL INHIBITOR, FISETIN
Descriptor:Cyclin, Cell division protein kinase 6, 3,7,3',4'-TETRAHYDROXYFLAVONE
Authors:Lu, H.S., Chang, D.J., Baratte, B., Meijer, L., Schulze-Gahmen, U.
Deposit date:2004-10-05
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of a Human Cyclin-Dependent Kinase 6 Complex with a Flavonol Inhibitor, Fisetin.
J.Med.Chem., 48, 2005
2B9R
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CRYSTAL STRUCTURE OF HUMAN CYCLIN B1
Descriptor:Human cyclin B1
Authors:Basavappa, R., Petri, E.
Deposit date:2005-10-12
Release date:2006-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Crystal Structure of Human Cyclin B.
Cell Cycle, 6, 2007
2EUF
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X-RAY STRUCTURE OF HUMAN CDK6-VCYCLIN IN COMPLEX WITH THE INHIBITOR PD0332991
Descriptor:viral Cyclin, Cell division protein kinase 6, CALCIUM ION, ...
Authors:Schulze-Gahmen, U., Lu, H.
Deposit date:2005-10-28
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.
J.Med.Chem., 49, 2006
2F2C
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X-RAY STRUCTURE OF HUMAN CDK6-VCYCLINWITH THE INHIBITOR AMINOPURVALANOL
Descriptor:Cyclin homolog, Cell division protein kinase 6, SULFATE ION, ...
Authors:Schulze-Gahmen, U., Lu, H.
Deposit date:2005-11-16
Release date:2006-06-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition.
J.Med.Chem., 49, 2006
2W96
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CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4, GLYCEROL
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., McMenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-21
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W99
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CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., McMenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-22
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W9F
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CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., McMenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-23
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2W9Z
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CRYSTAL STRUCTURE OF CDK4 IN COMPLEX WITH A D-TYPE CYCLIN
Descriptor:G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4
Authors:Day, P.J., Cleasby, A., Tickle, I.J., Reilly, M.O., Coyle, J.E., Holding, F.P., McMenamin, R.L., Yon, J., Chopra, R., Lengauer, C., Jhoti, H.
Deposit date:2009-01-30
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.
Proc.Natl.Acad.Sci.USA, 106, 2009
4TTH
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CRYSTAL STRUCTURE OF A CDK6/VCYCLIN COMPLEX WITH INHIBITOR BOUND
Descriptor:Cyclin homolog, Cyclin-dependent kinase 6, 9-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine
Authors:Piper, D.E., Walker, N., Wang, Z.
Deposit date:2014-06-20
Release date:2014-08-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
J.Med.Chem., 57, 2014
4UN0
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CRYSTAL STRUCTURE OF THE HUMAN CDK12-CYCLINK COMPLEX
Descriptor:CYCLIN-K, CYCLIN-DEPENDENT KINASE 12
Authors:Dixon Clarke, S.E., Elkins, J.M., Pike, A.C.W., Chaikuad, A., Goubin, S., Krojer, T., Sorrell, F.J., Nowak, R., Williams, E., Kopec, J., Mahajan, R.P., Burgess-Brown, N., Carpenter, E.P., Knapp, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2014-05-22
Release date:2014-06-04
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structures of the Cdk12/Cyck Complex with AMP-Pnp Reveal a Flexible C-Terminal Kinase Extension Important for ATP Binding.
Sci.Rep., 5, 2015
5ACB
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CRYSTAL STRUCTURE OF THE HUMAN CDK12-CYCLINK COMPLEX
Descriptor:CYCLIN-K, CYCLIN-DEPENDENT KINASE 12, N-[4-[(3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide
Authors:Dixon Clarke, S.E., Elkins, J.M., Pike, A.C.W., Mackenzie, A., Goubin, S., Strain-Damerell, C., Mahajan, P., Tallant, C., Chalk, R., Wiggers, H., Kopec, J., Fitzpatrick, F., Burgess-Brown, N., Carpenter, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2015-08-14
Release date:2016-06-15
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Covalent Targeting of Remote Cysteine Residues to Develop Cdk12 and Cdk13 Inhibitors.
Nat.Chem.Biol., 12, 2016
1E9H
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THR 160 PHOSPHORYLATED CDK2 - HUMAN CYCLIN A3 COMPLEX WITH THE INHIBITOR INDIRUBIN-5-SULPHONATE BOUND
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A3, 2',3-DIOXO-1,1',2',3-TETRAHYDRO-2,3'-BIINDOLE-5'-SULFONIC ACID
Authors:Davies, T.G., Tunnah, P., Noble, M.E.M., Endicott, J.A.
Deposit date:2000-10-16
Release date:2001-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Inhibitor Binding to Active and Inactive Cdk2: The Crystal Structure of Cdk2-Cyclin A/Indirubin-5-Sulphonate
Structure, 9, 2001
1F5Q
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CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2
Descriptor:CYCLIN DEPENDENT KINASE 2, GAMMA HERPESVIRUS CYCLIN, CHLORIDE ION
Authors:Card, G.L., Knowles, P., Laman, H., Jones, N., McDonald, N.Q.
Deposit date:2000-06-15
Release date:2000-12-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a gamma-herpesvirus cyclin-cdk complex.
EMBO J., 19, 2000
1FIN
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CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
Descriptor:CYCLIN-DEPENDENT KINASE 2, CYCLIN A, ADENOSINE-5'-TRIPHOSPHATE
Authors:Jeffrey, P.D., Russo, A.A., Pavletich, N.P.
Deposit date:1996-07-14
Release date:1997-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
Nature, 376, 1995
1FVV
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THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR
Descriptor:CYCLIN-DEPENDENT KINASE 2, CYCLIN A, 4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE
Authors:Davis, S.T., Benson, B.G., Bramson, H.N., Chapman, D.E., Dickerson, S.H., Dold, K.M., Eberwein, D.J., Edelstein, M., Frye, S.V., Gampe Jr., R.T., Griffin, R.J., Harris, P.A., Hassell, A.M., Holmes, W.D., Hunter, R.N., Knick, V.B., Lackey, K., Lovejoy, B., Luzzio, M.J., Murray, D., Parker, P., Rocque, W.J., Shewchuk, L., Veal, J.M., Walker, D.H., Kuyper, L.K.
Deposit date:2000-09-20
Release date:2001-01-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.
Science, 291, 2001
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