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7TFC
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BU of 7tfc by Molmil
B. subtilis GS(14)-Q-GlnR peptide
Descriptor: GLUTAMINE, GlnR C-tail peptide, Glutamine synthetase, ...
Authors:Travis, B.A, Peck, J, Schumacher, M.A.
Deposit date:2022-01-06
Release date:2022-06-29
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (1.96 Å)
Cite:Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
Nat Commun, 13, 2022
7CQN
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BU of 7cqn by Molmil
GmaS in complex with AMPPCP
Descriptor: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Type III glutamate--ammonia ligase
Authors:Li, C.Y, Zhang, Y.Z.
Deposit date:2020-08-11
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.962 Å)
Cite:Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7TDP
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BU of 7tdp by Molmil
Structure of Paenibacillus polymyxa GS bound to Met-Sox-P-ADP (Transition state complex) to 1.98 Angstom
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ...
Authors:Schumacher, M.A.
Deposit date:2022-01-02
Release date:2022-06-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
Nat Commun, 13, 2022
8WWU
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BU of 8wwu by Molmil
1-naphthylamine GS in complex with AMP PNP
Descriptor: Glutamine synthetase, MAGNESIUM ION, MANGANESE (II) ION, ...
Authors:Zhang, S.T, Zhou, N.Y.
Deposit date:2023-10-26
Release date:2024-01-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation
To Be Published
8ECY
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BU of 8ecy by Molmil
cryoEM structure of bovine bestrophin-2 and glutamine synthetase complex
Descriptor: Bestrophin, CALCIUM ION, CHLORIDE ION, ...
Authors:Owji, A.P, Kittredge, A.K, Yang, T.
Deposit date:2022-09-02
Release date:2022-11-02
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Bestrophin-2 and glutamine synthetase form a complex for glutamate release.
Nature, 611, 2022
4ACF
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BU of 4acf by Molmil
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH IMIDAZOPYRIDINE INHIBITOR ((4-(6-BROMO-3-(BUTYLAMINO)IMIDAZO(1,2-A)PYRIDIN-2-YL)PHENOXY) ACETIC ACID) AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE.
Descriptor: CHLORIDE ION, GLUTAMINE SYNTHETASE 1, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ...
Authors:Nilsson, M.T, Mowbray, S.L.
Deposit date:2011-12-15
Release date:2012-10-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis, Biological Evaluation and X-Ray Crystallographic Studies of Imidazo(1,2-A)Pyridine-Based Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors
Medchemcomm, 3, 2012
2OJW
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BU of 2ojw by Molmil
Crystal structure of human glutamine synthetase in complex with ADP and phosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLYCEROL, ...
Authors:Karlberg, T, Uppenberg, J, Arrowsmith, C, Berglund, H, Busam, R.D, Collins, R, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hallberg, B.M, Hammarstrom, M, Hogbom, M, Johansson, I, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Wallden, K, Weigelt, J, Holmberg-Schiavone, L, Structural Genomics Consortium (SGC)
Deposit date:2007-01-15
Release date:2007-03-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375, 2008
7CQU
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BU of 7cqu by Molmil
GmaS/ADP/MetSox-P complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, MAGNESIUM ION, ...
Authors:Li, C.Y, Zhang, Y.Z.
Deposit date:2020-08-11
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7TFA
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BU of 7tfa by Molmil
P. polymyxa GS(12)-Q-GlnR peptide
Descriptor: GLUTAMINE, GlnR C-tail peptide, Glutamine synthetase, ...
Authors:Travis, B.A, Peck, J, Schumacher, M.A.
Deposit date:2022-01-06
Release date:2022-06-29
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.07 Å)
Cite:Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
Nat Commun, 13, 2022
2BVC
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BU of 2bvc by Molmil
Crystal structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition state mimic
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ...
Authors:Krajewski, W.W, Jones, T.A, Mowbray, S.L.
Deposit date:2005-06-23
Release date:2005-07-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Mycobacterium Tuberculosis Glutamine Synthetase in Complex with a Transition-State Mimic Provides Functional Insights.
Proc.Natl.Acad.Sci.USA, 102, 2005
7CPR
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BU of 7cpr by Molmil
glutamine synthetase from Drosophila
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase 2 cytoplasmic
Authors:Yin, H.S, Chen, W.T.
Deposit date:2020-08-07
Release date:2021-08-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2.
Biomolecules, 10, 2020
7TF7
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BU of 7tf7 by Molmil
S. aureus GS(12) - apo
Descriptor: Glutamine synthetase
Authors:Travis, B.A, Peck, J, Schumacher, M.A.
Deposit date:2022-01-06
Release date:2022-06-29
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.13 Å)
Cite:Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
Nat Commun, 13, 2022
3ZXR
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BU of 3zxr by Molmil
Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (3-(2-tert-butyl- 5-(pyridin-4-yl)-1H-imidazol-4-yl)quinoline) and L-methionine-S- sulfoximine phosphate.
Descriptor: 3-(2-TERT-BUTYL-5-(PYRIDIN-4-YL)-1H-IMIDAZOL-4-YL)QUINOLINE, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ...
Authors:Nilsson, M.T, Mowbray, S.L.
Deposit date:2011-08-15
Release date:2012-04-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Trisubstituted Imidazoles as Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors.
J.Med.Chem., 55, 2012
7TF6
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BU of 7tf6 by Molmil
S. aureus GS(12)-Q-GlnR peptide
Descriptor: GLUTAMINE, Glutamine synthetase, MAGNESIUM ION, ...
Authors:Travis, B.A, Peck, J, Schumacher, M.A.
Deposit date:2022-01-06
Release date:2022-06-29
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.15 Å)
Cite:Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
Nat Commun, 13, 2022
2WHI
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BU of 2whi by Molmil
Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with a purine analogue inhibitor and L-methionine-S- sulfoximine phosphate.
Descriptor: 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ...
Authors:Nilsson, M.T, Krajewski, W.W, Jones, T.A, Mowbray, S.L.
Deposit date:2009-05-05
Release date:2009-09-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors.
J.Mol.Biol., 393, 2009
3ZXV
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BU of 3zxv by Molmil
Crystal structure of Mycobacterium Tuberculosis Glutamine Synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine) and L- methionine-S-sulfoximine phosphate
Descriptor: 4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE, CHLORIDE ION, GLUTAMINE SYNTHETASE 1, ...
Authors:Nilsson, M.T, Mowbray, S.L.
Deposit date:2011-08-16
Release date:2012-04-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Trisubstituted Imidazoles as Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors.
J.Med.Chem., 55, 2012
7TFB
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BU of 7tfb by Molmil
P. polymyxa GS(14)-Q-GlnR peptide
Descriptor: GLUTAMINE, GlnR C-tail peptide, Glutamine synthetase, ...
Authors:Travis, B.A, Peck, J, Schumacher, M.A.
Deposit date:2022-01-06
Release date:2022-06-29
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.28 Å)
Cite:Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
Nat Commun, 13, 2022
7CQQ
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BU of 7cqq by Molmil
GmaS in complex with AMPPNP and MetSox
Descriptor: (2S)-2-AMINO-4-(METHYLSULFONIMIDOYL)BUTANOIC ACID, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Li, C.Y, Zhang, Y.Z.
Deposit date:2020-08-11
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
7CQW
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BU of 7cqw by Molmil
GmaS/ADP complex-Conformation 1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Type III glutamate--ammonia ligase
Authors:Li, C.Y, Zhang, Y.Z.
Deposit date:2020-08-11
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.297 Å)
Cite:Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
8WWV
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BU of 8wwv by Molmil
1-naphthylamine GS in complex with ADP and MetSox-P
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ...
Authors:Zhang, S.T, Zhou, N.Y.
Deposit date:2023-10-26
Release date:2024-01-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation
To Be Published
8TGE
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BU of 8tge by Molmil
Crystal structure of the Methanosarcina mazei glutamine synthetase in complex with GlnK1
Descriptor: Glutamine synthetase, Nitrogen regulatory protein GlnK1
Authors:Schumacher, M.A.
Deposit date:2023-07-12
Release date:2023-11-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:M. mazei glutamine synthetase and glutamine synthetase-GlnK1 structures reveal enzyme regulation by oligomer modulation.
Nat Commun, 14, 2023
4S17
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BU of 4s17 by Molmil
The crystal structure of glutamine synthetase from Bifidobacterium adolescentis ATCC 15703
Descriptor: ACETATE ION, Glutamine synthetase, MAGNESIUM ION
Authors:Cuff, M, Tan, K, Mack, J, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2015-01-08
Release date:2015-01-28
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of glutamine synthetase from Bifidobacterium adolescentis ATCC 15703
To be Published
7CQX
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BU of 7cqx by Molmil
GmaS/ADP complex-Conformation 2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Type III glutamate--ammonia ligase
Authors:Li, C.Y, Zhang, Y.Z.
Deposit date:2020-08-11
Release date:2020-11-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Crystal structures of gamma-glutamylmethylamide synthetase provide insight into bacterial metabolism of oceanic monomethylamine.
J.Biol.Chem., 296, 2020
4IS4
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BU of 4is4 by Molmil
The glutamine synthetase from the dicotyledonous plant M. truncatula is a decamer
Descriptor: Glutamine synthetase
Authors:Seabra, A.R, Carvalho, H, Pereira, P.J.B.
Deposit date:2013-01-16
Release date:2014-04-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The structures of cytosolic and plastid-located glutamine synthetases from Medicago truncatula reveal a common and dynamic architecture.
Acta Crystallogr.,Sect.D, 70, 2014
1HTO
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BU of 1hto by Molmil
CRYSTALLOGRAPHIC STRUCTURE OF A RELAXED GLUTAMINE SYNTHETASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor: ADENOSINE MONOPHOSPHATE, CITRIC ACID, GLUTAMINE SYNTHETASE, ...
Authors:Gill, H.S, Eisenberg, D, TB Structural Genomics Consortium (TBSGC)
Deposit date:2001-01-01
Release date:2002-07-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation.
Biochemistry, 41, 2002

 

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