5ZLP
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CRYSTAL STRUCTURE OF GLUTAMINE SYNTHETASE FROM HELICOBACTER PYLORI
Descriptor:Glutamine synthetase, ADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Joo, H.K., Lee, J.Y.
Deposit date:2018-03-29
Release date:2018-08-29
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural Analysis of Glutamine Synthetase from Helicobacter pylori.
Sci Rep, 8, 2018
5ZLI
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CRYSTAL STRUCTURE OF GLUTAMINE SYNTHETASE FROM HELICOBACTER PYLORI
Descriptor:Glutamine synthetase
Authors:Joo, H.K., Lee, J.Y.
Deposit date:2018-03-28
Release date:2018-08-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Analysis of Glutamine Synthetase from Helicobacter pylori.
Sci Rep, 8, 2018
5LDF
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MALTOSE BINDING PROTEIN GENETICALLY FUSED TO DODECAMERIC GLUTAMINE SYNTHETASE
Descriptor:Glutamine synthetase, Maltose-binding periplasmic protein, MALTOSE
Authors:Coscia, F., Petosa, C., Schoehn, G.
Deposit date:2016-06-25
Release date:2016-08-10
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Fusion to a homo-oligomeric scaffold allows cryo-EM analysis of a small protein.
Sci Rep, 6, 2016
5DM3
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CRYSTAL STRUCTURE OF GLUTAMINE SYNTHETASE FROM CHROMOHALOBACTER SALEXIGENS DSM 3043(CSAL_0679, TARGET EFI-550015) WITH BOUND ADP
Descriptor:L-glutamine synthetase, ADENOSINE-5'-DIPHOSPHATE
Authors:Yadava, U., Vetting, M.W., Al Obaidi, N.F., Toro, R., Morisco, L.L., Benach, J., Koss, J., Wasserman, S.R., Attonito, J.D., Scott Glenn, A., Chamala, S., Chowdhury, S., Lafleur, J., Love, J., Seidel, R.D., Whalen, K.L., Gerlt, J.A., Almo, S.C., Enzyme Function Initiative (EFI)
Deposit date:2015-09-07
Release date:2015-09-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Glutamine Synthetase from Chromohalobacter salexigens DSM 3043(Csal_0679, TARGET EFI-550015) with bound ADP
To be published
4XYC
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NANOMOLAR INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE 1: SYNTHESIS, BIOLOGICAL EVALUATION AND X-RAY CRYSTALLOGRAPHIC STUDIES
Descriptor:Glutamine synthetase 1, 9-phenyl-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one
Authors:Couturier, C., Silve, S., Morales, R., Ppessegue, B., Llopart, S., Nair, A., Bauer, A., Scheiper, B., poeverlein, c., Ganzhorn, A., Lagrange, S., Bacque, E.
Deposit date:2015-02-02
Release date:2015-03-25
Last modified:2015-04-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: Synthesis, biological evaluation and X-ray crystallographic studies.
Bioorg.Med.Chem.Lett., 25, 2015
4S17
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THE CRYSTAL STRUCTURE OF GLUTAMINE SYNTHETASE FROM BIFIDOBACTERIUM ADOLESCENTIS ATCC 15703
Descriptor:Glutamine synthetase, MAGNESIUM ION, ACETATE ION
Authors:Cuff, M., Tan, K., Mack, J., Clancy, S., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
Deposit date:2015-01-08
Release date:2015-01-28
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of glutamine synthetase from Bifidobacterium adolescentis ATCC 15703
To be Published
4S0R
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STRUCTURE OF GS-TNRA COMPLEX
Descriptor:Glutamine synthetase, TnrA peptide, GLUTAMINE, ...
Authors:Schumacher, M.A., Chinnam, N.G., Cuthbert, B., Tonthat, N.K.
Deposit date:2015-01-04
Release date:2015-03-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis.
Genes Dev., 29, 2015
4LNO
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B. SUBTILIS GLUTAMINE SYNTHETASE STRUCTURES REVEAL LARGE ACTIVE SITE CONFORMATIONAL CHANGES AND BASIS FOR ISOENZYME SPECIFIC REGULATION: FORM TWO OF GS-1
Descriptor:Glutamine synthetase, MAGNESIUM ION, GLUTAMINE
Authors:Schumacher, M.A., Chinnam, N., Tonthat, N., Fisher, S., Wray, L.
Deposit date:2013-07-11
Release date:2013-11-13
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism.
J.Biol.Chem., 288, 2013
4LNN
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B. SUBTILIS GLUTAMINE SYNTHETASE STRUCTURES REVEAL LARGE ACTIVE SITE CONFORMATIONAL CHANGES AND BASIS FOR ISOENZYME SPECIFIC REGULATION: STRUCTURE OF APO FORM OF GS
Descriptor:Glutamine synthetase, MAGNESIUM ION, SULFATE ION
Authors:Schumacher, M.A., Chinnam, N., Tonthat, N., Fisher, S., Wray, L.
Deposit date:2013-07-11
Release date:2013-11-13
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism.
J.Biol.Chem., 288, 2013
4LNK
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B. SUBTILIS GLUTAMINE SYNTHETASE STRUCTURES REVEAL LARGE ACTIVE SITE CONFORMATIONAL CHANGES AND BASIS FOR ISOENZYME SPECIFIC REGULATION: STRUCTURE OF GS-GLUTAMATE-AMPPCP COMPLEX
Descriptor:Glutamine synthetase, GLUTAMIC ACID, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Schumacher, M.A., Chinnam, N., Tonthat, N., Fisher, S., Wray, L.
Deposit date:2013-07-11
Release date:2013-10-30
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism.
J.Biol.Chem., 288, 2013
4LNI
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B. SUBTILIS GLUTAMINE SYNTHETASE STRUCTURES REVEAL LARGE ACTIVE SITE CONFORMATIONAL CHANGES AND BASIS FOR ISOENZYME SPECIFIC REGULATION: STRUCTURE OF THE TRANSITION STATE COMPLEX
Descriptor:Glutamine synthetase, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Schumacher, M.A., Chinnam, N., Tonthat, N., Fisher, S., Wray, L.
Deposit date:2013-07-11
Release date:2013-11-06
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.5793 Å)
Cite:Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism.
J.Biol.Chem., 288, 2013
4LNF
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B. SUBTILIS GLUTAMINE SYNTHETASE STRUCTURES REVEAL LARGE ACTIVE SITE CONFORMATIONAL CHANGES AND BASIS FOR ISOENZYME SPECIFIC REGULATION: STRUCTURE OF GS-Q
Descriptor:Glutamine synthetase, MAGNESIUM ION, GLUTAMINE, ...
Authors:Schumacher, M.A., Chinnam, N., Tonthat, N., Fisher, S., Wray, L.
Deposit date:2013-07-11
Release date:2013-11-13
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.949 Å)
Cite:Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism.
J.Biol.Chem., 288, 2013
4IS4
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THE GLUTAMINE SYNTHETASE FROM THE DICOTYLEDONOUS PLANT M. TRUNCATULA IS A DECAMER
Descriptor:Glutamine synthetase
Authors:Seabra, A.R., Carvalho, H., Pereira, P.J.B.
Deposit date:2013-01-16
Release date:2014-04-09
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The structures of cytosolic and plastid-located glutamine synthetases from Medicago truncatula reveal a common and dynamic architecture.
Acta Crystallogr.,Sect.D, 70, 2014
4HPP
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CRYSTAL STRUCTURE OF NOVEL GLUTAMINE SYNTHASE HOMOLOG
Descriptor:Probable glutamine synthetase, MAGNESIUM ION, CALCIUM ION, ...
Authors:Ladner, J.E., Atanasova, V., Dolezelova, Z., Parsons, J.F.
Deposit date:2012-10-24
Release date:2012-12-26
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and Activity of PA5508, a Hexameric Glutamine Synthetase Homologue.
Biochemistry, 51, 2012
4BAX
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CRYSTAL STRUCTURE OF GLUTAMINE SYNTHETASE FROM STREPTOMYCES COELICOLOR
Descriptor:GLUTAMINE SYNTHETASE, SODIUM ION
Authors:Zeth, K.
Deposit date:2012-09-16
Release date:2013-03-27
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of Glutamine Synthetase from Streptomyces Coelicolor
To be Published
4ACF
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH IMIDAZOPYRIDINE INHIBITOR ((4-(6-BROMO-3-(BUTYLAMINO)IMIDAZO(1,2-A)PYRIDIN-2-YL)PHENOXY) ACETIC ACID) AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE.
Descriptor:GLUTAMINE SYNTHETASE 1, {4-[6-BROMO-3-(BUTYLAMINO)IMIDAZO[1,2-A]PYRIDIN-2-YL]PHENOXY}ACETIC ACID, MAGNESIUM ION, ...
Authors:Nilsson, M.T., Mowbray, S.L.
Deposit date:2011-12-15
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis, Biological Evaluation and X-Ray Crystallographic Studies of Imidazo(1,2-A)Pyridine-Based Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors
Medchemcomm, 3, 2012
3ZXV
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH TRI-SUBSTITUTED IMIDAZOLE INHIBITOR (4-(2-TERT-BUTYL- 4-(6-METHOXYNAPHTHALEN-2-YL)-1H-IMIDAZOL-5-YL)PYRIDIN-2-AMINE) AND L- METHIONINE-S-SULFOXIMINE PHOSPHATE
Descriptor:GLUTAMINE SYNTHETASE 1, 4-(2-TERT-BUTYL-4-(6-METHOXYNAPHTHALEN-2-YL)-3H-IMIDAZOL-4-YL)PYRIDIN-2-AMINE, MAGNESIUM ION, ...
Authors:Nilsson, M.T., Mowbray, S.L.
Deposit date:2011-08-16
Release date:2012-04-04
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Trisubstituted Imidazoles as Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors.
J.Med.Chem., 55, 2012
3ZXR
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH TRI-SUBSTITUTED IMIDAZOLE INHIBITOR (3-(2-TERT-BUTYL- 5-(PYRIDIN-4-YL)-1H-IMIDAZOL-4-YL)QUINOLINE) AND L-METHIONINE-S- SULFOXIMINE PHOSPHATE.
Descriptor:GLUTAMINE SYNTHETASE 1, 3-(2-TERT-BUTYL-5-(PYRIDIN-4-YL)-1H-IMIDAZOL-4-YL)QUINOLINE, MAGNESIUM ION, ...
Authors:Nilsson, M.T., Mowbray, S.L.
Deposit date:2011-08-15
Release date:2012-04-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Trisubstituted Imidazoles as Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors.
J.Med.Chem., 55, 2012
3O6X
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CRYSTAL STRUCTURE OF THE TYPE III GLUTAMINE SYNTHETASE FROM BACTEROIDES FRAGILIS
Descriptor:Glutamine synthetase, MAGNESIUM ION, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ...
Authors:van Rooyen, J.M., Belrhali, H., Abratt, V.R., Sewell, B.T.
Deposit date:2010-07-29
Release date:2011-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal Structure of Type III Glutamine Synthetase: Surprising Reversal of the Inter-Ring Interface.
Structure, 19, 2011
3NG0
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CRYSTAL STRUCTURE OF GLUTAMINE SYNTHETASE FROM SYNECHOCYSTIS SP. PCC 6803
Descriptor:Glutamine synthetase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MANGANESE (II) ION
Authors:Saelices, L., Cascio, D., Florencio, F.J., Muro-Pastor, M.I.
Deposit date:2010-06-10
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Glutamine Synthetase from Synechocystis sp. PCC 6803
To be Published
3FKY
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CRYSTAL STRUCTURE OF THE GLUTAMINE SYNTHETASE GLN1DELTAN18 FROM THE YEAST SACCHAROMYCES CEREVISIAE
Descriptor:Glutamine synthetase, CITRATE ANION
Authors:He, Y.X., Gui, L., Liu, Y.Z., Du, Y., Zhou, Y.Y., Li, P., Zhou, C.Z.
Deposit date:2008-12-18
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly
Proteins, 76, 2009
2WHI
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH A PURINE ANALOGUE INHIBITOR AND L-METHIONINE-S- SULFOXIMINE PHOSPHATE.
Descriptor:GLUTAMINE SYNTHETASE 1, 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, MAGNESIUM ION, ...
Authors:Nilsson, M.T., Krajewski, W.W., Jones, T.A., Mowbray, S.L.
Deposit date:2009-05-05
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors.
J.Mol.Biol., 393, 2009
2WGS
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH A PURINE ANALOGUE INHIBITOR.
Descriptor:GLUTAMINE SYNTHETASE 1, 1-(3,4-dichlorobenzyl)-3,7-dimethyl-8-morpholin-4-yl-3,7-dihydro-1H-purine-2,6-dione, CHLORIDE ION
Authors:Nilsson, M.T., Krajewski, W.W., Jones, T.A., Mowbray, S.L.
Deposit date:2009-04-27
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Basis for the Inhibition of Mycobacterium Tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors.
J.Mol.Biol., 393, 2009
2UU7
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CRYSTAL STRUCTURE OF APO GLUTAMINE SYNTHETASE FROM DOG (CANIS FAMILIARIS)
Descriptor:GLUTAMINE SYNTHETASE, MAGNESIUM ION, CHLORIDE ION
Authors:Krajewski, W.W., Jones, T.A., Mowbray, S.L.
Deposit date:2007-02-28
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design.
J.Mol.Biol., 375, 2008
2QC8
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CRYSTAL STRUCTURE OF HUMAN GLUTAMINE SYNTHETASE IN COMPLEX WITH ADP AND METHIONINE SULFOXIMINE PHOSPHATE
Descriptor:Glutamine synthetase, MANGANESE (II) ION, CHLORIDE ION, ...
Authors:Karlberg, T., Lehtio, L., Arrowsmith, C.H., Berglund, H., Busam, R.D., Collins, R., Dahlgren, L.G., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hogbom, M., Johansson, I., Kallas, A., Kotenyova, T., Moche, M., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Sundstrom, M., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Holmberg-Schiavone, L., Structural Genomics Consortium (SGC)
Deposit date:2007-06-19
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.
J.Mol.Biol., 375, 2008
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