9PAP
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STRUCTURE OF PAPAIN REFINED AT 1.65 ANGSTROMS RESOLUTION
Descriptor:PAPAIN, METHANOL
Authors:Kamphuis, I.G., Drenth, J.
Deposit date:1986-03-31
Release date:1986-10-24
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of papain refined at 1.65 A resolution
J.Mol.Biol., 179, 1984
8PCH
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CRYSTAL STRUCTURE OF PORCINE CATHEPSIN H DETERMINED AT 2.1 ANGSTROM RESOLUTION: LOCATION OF THE MINI-CHAIN C-TERMINAL CARBOXYL GROUP DEFINES CATHEPSIN H AMINOPEPTIDASE FUNCTION
Descriptor:CATHEPSIN H, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Guncar, G., Podobnik, M., Pungercar, J., Strukelj, B., Turk, V., Turk, D.
Deposit date:1997-11-07
Release date:1998-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function.
Structure, 6, 1998
7PCK
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CRYSTAL STRUCTURE OF WILD TYPE HUMAN PROCATHEPSIN K
Descriptor:PROTEIN (PROCATHEPSIN K)
Authors:Sivaraman, J., Lalumiere, M., Menard, R., Cygler, M.
Deposit date:1998-10-21
Release date:1999-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of wild-type human procathepsin K.
Protein Sci., 8, 1999
6PAD
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BINDING OF CHLOROMETHYL KETONE SUBSTRATE ANALOGUES TO CRYSTALLINE PAPAIN
Descriptor:PAPAIN, Nalpha-[(benzyloxy)carbonyl]-N-[(1S)-3-chloro-1-methyl-2-oxopropyl]-L-phenylalaninamide
Authors:Drenth, J., Kalk, K.H., Swen, H.M.
Deposit date:1976-11-01
Release date:1977-04-12
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding of chloromethyl ketone substrate analogues to crystalline papain.
Biochemistry, 15, 1976
6MIS
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NATIVE ANANAIN IN COMPLEX WITH E-64
Descriptor:Ananain, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE
Authors:Yongqing, T., Wilmann, P.G., Pike, R.N., Wijeyewickrema, L.C.
Deposit date:2018-09-20
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Determination of the Crystal Structure and Substrate Specificity of Ananain
To be published
6MIR
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NATIVE ANANAIN FROM ANANAS COMOSUS
Descriptor:Ananain
Authors:Yongqing, T., Wilmann, P.G., Pike, R.N., Wijeyewickrema, L.C.
Deposit date:2018-09-19
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.731 Å)
Cite:Determination of the Crystal Structure and Substrate Specificity of Ananain
To be published
6H8T
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CRYSTAL STRUCTURE OF PAPAIN MODIFY BY ACHIRAL RU(II)COMPLEX
Descriptor:Papain, ACETATE ION, CHLORIDE ION, ...
Authors:Cherrier, M.V., Amara, P., Talbi, B., Salmin, M., Fontecilla-Camps, J.C.
Deposit date:2018-08-03
Release date:2018-09-12
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate.
Metallomics, 10, 2018
6F06
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CATHEPSIN L IN COMPLEX WITH (3S,14E)-8-(AZETIDIN-3-YL)-19-CHLORO-N-(1-CYANOCYCLOPROPYL)-5-OXO-12,17-DIOXA-4-AZATRICYCLO[16.2.2.06,11]DOCOSA-1(21),6,8,10,14,18(22),19-HEPTAENE-3-CARBOXAMIDE
Descriptor:Cathepsin L1, (3~{S},14~{E})-8-(azetidin-3-yl)-19-chloranyl-~{N}-(1-cyanocyclopropyl)-5-oxidanylidene-12,17-dioxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(21),6(11),7,9,14,18(22),19-heptaene-3-carboxamide, ZINC ION, ...
Authors:Kuglstatter, A., Stihle, M.
Deposit date:2017-11-17
Release date:2018-04-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
J. Med. Chem., 61, 2018
6EZX
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CATHEPSIN L IN COMPLEX WITH (3S,14E)-19-CHLORO-N-(1-CYANOCYCLOPROPYL)-5-OXO-17-OXA-4-AZATRICYCLO[16.2.2.06,11]DOCOSA-1(21),6,8,10,14,18(22),19-HEPTAENE-3-CARBOXAMIDE
Descriptor:Cathepsin L1, (3~{S},14~{E})-19-chloranyl-~{N}-[1-(iminomethyl)cyclopropyl]-5-oxidanylidene-17-oxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(21),6,8,10,14,18(22),19-heptaene-3-carboxamide
Authors:Banner, D.W., Benz, J., Kuglstatter, A.
Deposit date:2017-11-16
Release date:2018-04-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
J. Med. Chem., 61, 2018
6EZP
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CATHEPSIN L IN COMPLEX WITH (3S,14E)-19-CHLORO-N-(1-CYANOCYCLOPROPYL)-5-OXO-12,17-DIOXA-4-AZATRICYCLO[16.2.2.06,11]DOCOSA-1(21),6(11),7,9,14,18(22),19-HEPTAENE-3-CARBOXAMIDE
Descriptor:Cathepsin L1, (3~{S},14~{E})-19-chloranyl-~{N}-(1-cyanocyclopropyl)-5-oxidanylidene-12,17-dioxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(21),6(11),7,9,14,18(22),19-heptaene-3-carboxamide, GLYCEROL
Authors:Banner, D.W., Benz, J., Kuglstatter, A.
Deposit date:2017-11-16
Release date:2018-04-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
J. Med. Chem., 61, 2018
6EXQ
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CRYSTAL STRUCTURE OF RHODESAIN IN COMPLEX WITH A MACROLACTAM INHIBITOR
Descriptor:Cysteine protease, 1,2-ETHANEDIOL, (3~{S})-19-chloranyl-~{N}-(1-cyanocyclopropyl)-8-methoxy-5-oxidanylidene-12,17-dioxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(20),6(11),7,9,18,21-hexaene-3-carboxamide
Authors:Dietzel, U., Kisker, C.
Deposit date:2017-11-08
Release date:2018-04-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
J. Med. Chem., 61, 2018
6EXO
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CRYSTAL STRUCTURE OF RHODESAIN IN COMPLEX WITH A MACROLACTAM INHIBITOR
Descriptor:Cysteine protease, 1,2-ETHANEDIOL, (3~{S},14~{E})-19-chloranyl-~{N}-(1-cyanocyclopropyl)-5-oxidanylidene-12,17-dioxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(21),6(11),7,9,14,18(22),19-heptaene-3-carboxamide
Authors:Dietzel, U., Kisker, C.
Deposit date:2017-11-08
Release date:2018-04-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
J. Med. Chem., 61, 2018
6EX8
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CRYSTAL STRUCTURE OF RHODESAIN IN COMPLEX WITH A MACROLACTAM INHIBITOR
Descriptor:Cysteine protease, (3~{S})-~{N}-[1-(aminomethyl)cyclopropyl]-19-chloranyl-5-oxidanylidene-9-(trifluoromethyl)-12,17-dioxa-4-azatricyclo[16.2.2.0^{6,11}]docosa-1(20),6(11),7,9,18,21-hexaene-3-carboxamide, 1,2-ETHANEDIOL
Authors:Dietzel, U., Kisker, C.
Deposit date:2017-11-07
Release date:2018-04-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
J. Med. Chem., 61, 2018
6CZS
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CRYSTAL STRUCTURE OF HUMAN PRO-CATHEPSIN H C26S MUTANT
Descriptor:Pro-cathepsin H, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Huang, X., Hao, Y.
Deposit date:2018-04-09
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Crystal structures of human procathepsin H.
PLoS ONE, 13, 2018
6CZK
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CRYSTAL STRUCTURE OF WILD-TYPE HUMAN PRO-CATHEPSIN H
Descriptor:Pro-cathepsin H, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Huang, X., Hao, Y.
Deposit date:2018-04-09
Release date:2018-08-08
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Crystal structures of human procathepsin H.
PLoS ONE, 13, 2018
6AY2
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STRUCTURE OF CATHB WITH COVALENTLY LINKED COMPOUND 28
Descriptor:Cathepsin B, N~1~-[(2S)-1-amino-5-(carbamoylamino)pentan-2-yl]-N'~1~-[(1R)-1-(thiophen-3-yl)ethyl]cyclobutane-1,1-dicarboxamide
Authors:Kiefer, J.R., Steinbacher, S.
Deposit date:2017-09-07
Release date:2017-12-27
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J. Med. Chem., 61, 2018
6ASH
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CRYSTAL STUCTURE OF HUMAN CATHEPSIN K WITH A NON-ACTIVE SITE INHIBITOR AT 1.42 ANGSTROM RESOLUTION
Descriptor:Cathepsin K, 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid
Authors:Law, S., Aguda, A., Nguyen, N., Brayer, G., Bromme, D.
Deposit date:2017-08-24
Release date:2018-08-29
Method:X-RAY DIFFRACTION (1.423 Å)
Cite:Crystal stucture of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution.
To Be Published
5Z5O
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STRUCTURE OF PYCNONODYSOSTOSIS DISEASE RELATED I249T MUTANT OF HUMAN CATHEPSIN K
Descriptor:Cathepsin K, GLYCEROL, 1,2-ETHANEDIOL, ...
Authors:Biswas, S., Roy, S.
Deposit date:2018-01-19
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Not all pycnodysostosis-related mutants of human cathepsin K are inactive: Crystal structure and biochemical studies of an active mutant I249T.
FEBS J., 2018
5VPL
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CRYSTAL STRUCTURE OF DER F 1 COMPLEXED WITH FAB 4C1
Descriptor:Der f 1 variant, 4C1 - LIGHT CHAIN, 4C1 - HEAVY CHAIN, ...
Authors:Chruszcz, M., Vailes, L.D., Chapman, M.D., Pomes, A., Minor, W.
Deposit date:2017-05-05
Release date:2017-05-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular Determinants For Antibody Binding On Group 1 House Dust Mite Allergens.
J.Biol.Chem., 287, 2012
5VPK
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CRYSTAL STRUCTURE OF MITE ALLERGEN DER F 1
Descriptor:Der f 1 variant, SULFATE ION, N-ACETYL-D-GLUCOSAMINE
Authors:Chruszcz, M., Chapman, M.D., Vailes, L.D., Pomes, A., Minor, W.
Deposit date:2017-05-05
Release date:2017-05-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures Of Mite Allergens Der F 1 And Der P 1 Reveal Differences In Surface-Exposed Residues That May Influence Antibody Binding
J.Mol.Biol., 386, 2009
5VPH
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CRYSTAL STRUCTURE OF DER P 1 COMPLEXED WITH FAB 4C1
Descriptor:Der p 1 allergen, FAB 4C1 - LIGHT CHAIN, FAB 4C1 - HEAVY CHAIN, ...
Authors:Chruszcz, M., Vailes, L.D., Chapman, M.D., Pomes, A., Minor, W.
Deposit date:2017-05-05
Release date:2017-05-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Determinants For Antibody Binding On Group 1 House Dust Mite Allergens.
J.Biol.Chem., 287, 2012
5VPG
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CRYSTAL STRUCTURE OF DER P 1 COMPLEXED WITH FAB 4C1
Descriptor:Der p 1 allergen, FAB 4C1 - LIGHT CHAIN, FAB 4C1 - HEAVY CHAIN, ...
Authors:Chruszcz, M., Vailes, L.D., Chapman, M.D., Pomes, A., Minor, W.
Deposit date:2017-05-05
Release date:2017-05-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Determinants For Antibody Binding On Group 1 House Dust Mite Allergens.
J.Biol.Chem., 287, 2012
5VCO
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THE CRYSTAL STRUCTURE OF DER P 1 ALLERGEN COMPLEXED WITH FAB FRAGMENT OF MAB 10B9
Descriptor:LIGHT CHAIN OF FAB FRAGMENT OF 10B9 ANTIBODY, HEAVY CHAIN OF FAB FRAGMENT OF 10B9 ANTIBODY, PEPTIDASE 1, ...
Authors:Osinski, T., Majorek, K.A., Pomes, A., Offermann, L.R., Osinski, S., Glesner, J., Vailes, L.D., Chapman, M.D., Minor, W., Chruszcz, M.
Deposit date:2017-03-31
Release date:2017-04-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structural Analysis of Der p 1-Antibody Complexes and Comparison with Complexes of Proteins or Peptides with Monoclonal Antibodies.
J. Immunol., 195, 2015
5VCN
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THE CRYSTAL STRUCTURE OF DER P 1 ALLERGEN COMPLEXED WITH FAB FRAGMENT OF MAB 5H8
Descriptor:PEPTIDASE 1, LIGHT CHAIN OF FAB FRAGMENT OF MAB 5H8, HEAVY CHAIN OF FAB FRAGMENT OF MAB 5H8, ...
Authors:Osinski, T., Majorek, K.A., Pomes, A., Offermann, L.R., Osinski, S., Glesner, J., Vailes, L.D., Chapman, M.D., Minor, W., Chruszcz, M.
Deposit date:2017-03-31
Release date:2017-04-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Analysis of Der p 1-Antibody Complexes and Comparison with Complexes of Proteins or Peptides with Monoclonal Antibodies.
J. Immunol., 195, 2015
5TUN
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CRYSTAL STRUCTURE OF UNINHIBITED HUMAN CATHEPSIN K AT 1.62 ANGSTROM RESOLUTION
Descriptor:Cathepsin K
Authors:Aguda, A.H., Kruglyak, N., Nguyen, N.T., Law, S., Bromme, D., Brayer, G.D.
Deposit date:2016-11-06
Release date:2017-01-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib.
Biochem. J., 474, 2017
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