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4DD5
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BU of 4dd5 by Molmil
Biosynthetic Thiolase (ThlA1) from Clostridium difficile
Descriptor: Acetyl-CoA acetyltransferase
Authors:Filippova, E.V, Wawrzak, Z, Kudritska, M, Edwards, A, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-01-18
Release date:2012-02-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Biosynthetic Thiolase (ThlA1) from Clostridium difficile
To be Published
6PCD
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BU of 6pcd by Molmil
Crystal structure of beta-ketoadipyl-CoA thiolase mutant (C90S-H356A) in complex Octanoyl coenzyme A
Descriptor: Beta-ketoadipyl-CoA thiolase, CHLORIDE ION, COENZYME A, ...
Authors:Sukritee, B, Panjikar, S.
Deposit date:2019-06-17
Release date:2020-05-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase.
J Struct Biol X, 4, 2020
7FEA
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BU of 7fea by Molmil
PY14 in complex with Col-D
Descriptor: (6~{R},7~{R},9~{E})-6,7-bis(oxidanyl)hexadeca-9,15-dien-11,13-diynoic acid, Acetyl-CoA C-acyltransferase
Authors:Lin, C.C, Ko, T.P, Huang, K.F, Yang, Y.L.
Deposit date:2021-07-19
Release date:2022-07-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.
Commun Biol, 5, 2022
8GQM
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BU of 8gqm by Molmil
Crystal structure of Thiolase complexed with acetyl coenzyme A
Descriptor: ACETYL COENZYME *A, GLYCEROL, Thiolase
Authors:Hong, J, Son, H.F, Kim, K.J.
Deposit date:2022-08-30
Release date:2024-03-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of thiolase from Pseudomonas aeruginosa PAO1
To Be Published
6HSJ
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BU of 6hsj by Molmil
Crystal structure of the zebrafish peroxisomal SCP2-thiolase (type-1) in complex with CoA
Descriptor: ACETATE ION, COENZYME A, GLYCEROL, ...
Authors:Wierenga, R.K, Kiema, T.R, Thapa, C.J.
Deposit date:2018-10-01
Release date:2019-01-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.
Biochem. J., 476, 2019
2WU9
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BU of 2wu9 by Molmil
Crystal structure of peroxisomal KAT2 from Arabidopsis thaliana
Descriptor: 1,2-ETHANEDIOL, 3-KETOACYL-COA THIOLASE 2, PEROXISOMAL
Authors:Pye, V.E, Christensen, C.E, Dyer, J.H, Arent, S, Henriksen, A.
Deposit date:2009-10-01
Release date:2010-05-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Peroxisomal Plant 3-Ketoacyl-Coa Thiolases Structure and Activity are Regulated by a Sensitive Redox Switch
J.Biol.Chem., 285, 2010
6BJB
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BU of 6bjb by Molmil
Crystal structure of Acat2-C91S thiolase from Ascaris suum in complex with propionyl-CoA and nitrate
Descriptor: Acetyl-CoA acetyltransferase A, NITRATE ION, propionyl Coenzyme A
Authors:Blaisse, M.R, Fu, B, Chang, M.C.Y.
Deposit date:2017-11-05
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.50000632 Å)
Cite:Structural and Biochemical Studies of Substrate Selectivity in Ascaris suum Thiolases.
Biochemistry, 57, 2018
2VU1
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BU of 2vu1 by Molmil
Biosynthetic thiolase from Z. ramigera. Complex of with O-pantheteine- 11-pivalate.
Descriptor: ACETYL-COA ACETYLTRANSFERASE, PANTOTHENYL-AMINOETHANOL-11-PIVALIC ACID, SODIUM ION, ...
Authors:Kursula, P, Schmitz, W, Wierenga, R.K.
Deposit date:2008-05-19
Release date:2008-10-28
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:The Sulfur Atoms of the Substrate Coa and the Catalytic Cysteine are Required for a Productive Mode of Substrate Binding in Bacterial Biosynthetic Thiolase, a Thioester-Dependent Enzyme.
FEBS J., 275, 2008
4O9A
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BU of 4o9a by Molmil
Crystal structure of Beta-ketothiolase (PhaA) from Ralstonia eutropha H16
Descriptor: Acetyl-CoA acetyltransferase
Authors:Kim, E.J, Kim, J, Kim, S, Kim, K.J.
Deposit date:2014-01-02
Release date:2015-02-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystal structure and biochemical characterization of PhaA from Ralstonia eutropha, a polyhydroxyalkanoate-producing bacterium.
Biochem.Biophys.Res.Commun., 452, 2014
6BJ9
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BU of 6bj9 by Molmil
Crystal structure of Acat2 thiolase from Ascaris suum
Descriptor: Acetyl-CoA acetyltransferase A, POTASSIUM ION
Authors:Blaisse, M.R, Fu, B, Chang, M.C.Y.
Deposit date:2017-11-05
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.53014076 Å)
Cite:Structural and Biochemical Studies of Substrate Selectivity in Ascaris suum Thiolases.
Biochemistry, 57, 2018
1WL4
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BU of 1wl4 by Molmil
Human cytosolic acetoacetyl-CoA thiolase complexed with CoA
Descriptor: COENZYME A, GLYCEROL, SULFATE ION, ...
Authors:Kursula, P, Fukao, T, Kondo, N, Wierenga, R.K.
Deposit date:2004-06-20
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:High Resolution Crystal Structures of Human Cytosolic Thiolase (CT): A Comparison of the Active Sites of Human CT, Bacterial Thiolase, and Bacterial KAS I
J.Mol.Biol., 347, 2005
7CW4
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BU of 7cw4 by Molmil
Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579
Descriptor: Acetyl-CoA acetyltransferase, GLYCEROL
Authors:Hong, J, Kim, K.J.
Deposit date:2020-08-27
Release date:2020-10-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579.
Biochem.Biophys.Res.Commun., 533, 2020
6BJA
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BU of 6bja by Molmil
Crystal structure of Acat5 thiolase from Ascaris suum in complex with coenzyme A
Descriptor: ACETATE ION, Acetyl-CoA acetyltransferase A, COENZYME A
Authors:Blaisse, M.R, Fu, B, Chang, M.C.Y.
Deposit date:2017-11-05
Release date:2018-02-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.60001445 Å)
Cite:Structural and Biochemical Studies of Substrate Selectivity in Ascaris suum Thiolases.
Biochemistry, 57, 2018
6PCB
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BU of 6pcb by Molmil
Crystal structure of beta-ketoadipyl-CoA thiolase mutant (H356A) in complex with COA
Descriptor: Beta-ketoadipyl-CoA thiolase, CHLORIDE ION, COENZYME A, ...
Authors:Sukritee, B, Panjikar, S.
Deposit date:2019-06-17
Release date:2020-05-27
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase.
J Struct Biol X, 4, 2020
6BN2
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BU of 6bn2 by Molmil
Crystal structure of Acetyl-CoA acetyltransferase from Elizabethkingia anophelis NUHP1
Descriptor: Acetyl-CoA acetyltransferase, CALCIUM ION, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-11-15
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of Acetyl-CoA acetyltransferase from Elizabethkingia anophelis NUHP1
To be Published
4XL3
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BU of 4xl3 by Molmil
Crystal structure of reduced form of thiolase from Clostridium acetobutylicum
Descriptor: Acetyl-CoA acetyltransferase, GLYCEROL
Authors:Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J.
Deposit date:2015-01-13
Release date:2015-10-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum
Nat Commun, 6, 2015
3GOA
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BU of 3goa by Molmil
Crystal structure of the Salmonella typhimurium FadA 3-ketoacyl-CoA thiolase
Descriptor: 3-ketoacyl-CoA thiolase, CALCIUM ION, CHLORIDE ION, ...
Authors:Anderson, S.M, Skarina, T, Onopriyenko, O, Wawrzak, Z, Papazisi, L, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2009-03-18
Release date:2009-03-31
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:

3SS6
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BU of 3ss6 by Molmil
Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase
Descriptor: Acetyl-CoA acetyltransferase, POTASSIUM ION, SULFATE ION
Authors:Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-07-07
Release date:2011-07-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase
TO BE PUBLISHED
4YZO
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BU of 4yzo by Molmil
Crystal Structure Analysis of Thiolase-like protein, ST0096 from Sulfolobus Tokodaii
Descriptor: ACETATE ION, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Padmanabhan, B, Manjula, R, Yokoyama, S, Bessho, Y.
Deposit date:2015-03-25
Release date:2016-03-30
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure Analysis of Thiolase-like protein, ST0096 from Sulfolobus Tokodaii
To Be Published
7PYT
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BU of 7pyt by Molmil
Benzoylsuccinyl-CoA thiolase with coenzyme A
Descriptor: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Benzoylsuccinyl-CoA thiolase subunit, ...
Authors:Ermler, U, Heider, J, Weidenweber, S, Demmer, U.
Deposit date:2021-10-11
Release date:2022-04-06
Last modified:2022-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism.
Febs J., 289, 2022
4UBT
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BU of 4ubt by Molmil
Structure of the C93S variant of the 3-ketoacyl-CoA thiolase FadA5 from M. tuberculosis in complex with a steroid and CoA.
Descriptor: (2S)-2-[(8S,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]propanoic acid (non-preferred name), Acetyl-CoA acetyltransferase FadA5, CHLORIDE ION, ...
Authors:Schaefer, C.M, Kisker, C.
Deposit date:2014-08-13
Release date:2014-12-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:FadA5 a Thiolase from Mycobacterium tuberculosis: A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis.
Structure, 23, 2015
6OK1
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BU of 6ok1 by Molmil
Ltp2-ChsH2(DUF35) aldolase
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ChsH2(DUF35), ...
Authors:Kimber, M.S, Mallette, E, Aggett, R, Seah, S.Y.K.
Deposit date:2019-04-12
Release date:2019-06-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The steroid side-chain-cleaving aldolase Ltp2-ChsH2DUF35is a thiolase superfamily member with a radically repurposed active site.
J.Biol.Chem., 294, 2019
7YXM
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BU of 7yxm by Molmil
Benzoylsuccinyl-CoA thiolase with coenzyme A
Descriptor: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Benzoylsuccinyl-CoA thiolase subunit, ...
Authors:Ermler, U, Heider, J, Weidenweber, S.
Deposit date:2022-02-16
Release date:2022-04-06
Last modified:2022-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism.
Febs J., 289, 2022
1M3K
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BU of 1m3k by Molmil
biosynthetic thiolase, inactive C89A mutant
Descriptor: Acetyl-CoA acetyltransferase, GLYCEROL, SULFATE ION
Authors:Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K.
Deposit date:2002-06-28
Release date:2002-11-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes
Biochemistry, 41, 2002
6ARF
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BU of 6arf by Molmil
Aspergillus fumigatus Cytosolic Thiolase: Apo enzyme in complex with potassium ions
Descriptor: Acetyl-CoA acetyltransferase, CHLORIDE ION, GLYCEROL, ...
Authors:Marshall, A.C, Bond, C.S, Bruning, J.B.
Deposit date:2017-08-22
Release date:2018-05-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Structure of Aspergillus fumigatus Cytosolic Thiolase: Trapped Tetrahedral Reaction Intermediates and Activation by Monovalent Cations
Acs Catalysis, 8(3), 2018

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