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1HUW
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THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION
Descriptor: HUMAN GROWTH HORMONE
Authors:Ultsch, M.H, Somers, W.S, Kossiakoff, A.A, De Vos, A.M.
Deposit date:1993-09-22
Release date:1994-01-31
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of affinity-matured human growth hormone at 2 A resolution.
J.Mol.Biol., 236, 1994
3HHR
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BU of 3hhr by Molmil
HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX
Descriptor: HUMAN GROWTH HORMONE, HUMAN GROWTH HORMONE RECEPTOR (hGHbp)
Authors:De Vos, A.M, Ultsch, M, Kossiakoff, A.A.
Deposit date:1993-12-30
Release date:1994-04-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Science, 255, 1992
1HGU
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BU of 1hgu by Molmil
HUMAN GROWTH HORMONE
Descriptor: HUMAN GROWTH HORMONE
Authors:Chantalat, L, Jones, N, Korber, F, Navaza, J, Pavlovsky, A.G.
Deposit date:1995-05-11
Release date:1995-12-07
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:THE CRYSTAL-STRUCTURE OF WILD-TYPE GROWTH-HORMONE AT 2.5 ANGSTROM RESOLUTION.
Protein Pept.Lett., 2, 1995
1HWH
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BU of 1hwh by Molmil
1:1 COMPLEX OF HUMAN GROWTH HORMONE MUTANT G120R WITH ITS SOLUBLE BINDING PROTEIN
Descriptor: GROWTH HORMONE, GROWTH HORMONE BINDING PROTEIN
Authors:Sundstrom, S.M, Lundqvist, T.
Deposit date:1996-11-13
Release date:1997-11-19
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution.
J.Biol.Chem., 271, 1996
1HWG
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1:2 COMPLEX OF HUMAN GROWTH HORMONE WITH ITS SOLUBLE BINDING PROTEIN
Descriptor: GROWTH HORMONE, GROWTH HORMONE BINDING PROTEIN
Authors:Sundstrom, S.M, Lundqvist, T.
Deposit date:1996-11-13
Release date:1997-11-19
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution.
J.Biol.Chem., 271, 1996
1AXI
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BU of 1axi by Molmil
STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
Descriptor: GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION
Authors:Atwell, S, Ultsch, M, De Vos, A.M, Wells, J.A.
Deposit date:1997-10-15
Release date:1998-01-28
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural plasticity in a remodeled protein-protein interface.
Science, 278, 1997
1A22
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HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR
Descriptor: GROWTH HORMONE, GROWTH HORMONE RECEPTOR
Authors:De Vos, A.M, Ultsch, M.
Deposit date:1998-01-15
Release date:1998-04-29
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
J.Mol.Biol., 277, 1998
1BP3
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THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX
Descriptor: PROTEIN (GROWTH HORMONE), PROTEIN (PROLACTIN RECEPTOR), ZINC ION
Authors:Somers, W, Ultsch, M, De Vos, A.M, Kossiakoff, A.A.
Deposit date:1998-08-12
Release date:1998-08-19
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The X-ray structure of a growth hormone-prolactin receptor complex.
Nature, 372, 1994
1F6F
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX BETWEEN OVINE PLACENTAL LACTOGEN AND THE EXTRACELLULAR DOMAIN OF THE RAT PROLACTIN RECEPTOR
Descriptor: PLACENTAL LACTOGEN, PROLACTIN RECEPTOR
Authors:Elkins, P.A, Christinger, H.W, Sandowski, Y, Sakal, E, Gertler, A, De Vos, A.M, Kossiakoff, A.A.
Deposit date:2000-06-21
Release date:2000-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Nat.Struct.Biol., 7, 2000
1KF9
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PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR
Descriptor: EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238), PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE
Authors:Schiffer, C.A, Ultsch, M, Walsh, S, Somers, W, De Vos, A.M, Kossiakoff, A.A.
Deposit date:2001-11-19
Release date:2002-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites
J.Mol.Biol., 316, 2002
1RW5
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Solution structure of human prolactin
Descriptor: Prolactin
Authors:Teilum, K, Hoch, J, Martial, J.A, Kragelund, B.B.
Deposit date:2003-12-16
Release date:2005-02-22
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of human prolactin
J.Mol.Biol., 351, 2005
1Z7C
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Crystal Structure of Human Placental Lactogen
Descriptor: Chorionic somatomammotropin hormone
Authors:Walsh, S.T.R, Kossiakoff, A.A.
Deposit date:2005-03-24
Release date:2006-03-07
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure and Site 1 Binding Energetics of Human Placental Lactogen.
J.Mol.Biol., 358, 2006
2Q98
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X-ray structure of a prolactin antagonist
Descriptor: Prolactin
Authors:Broutin, I.J.L, Ducruix, A, Jomain, J.B, Goffin, V.
Deposit date:2007-06-12
Release date:2007-09-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL.
J.Biol.Chem., 282, 2007
3D48
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Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor
Descriptor: CARBONATE ION, Prolactin, Prolactin receptor
Authors:Svensson, L.A, Breinholt, J.
Deposit date:2008-05-14
Release date:2008-06-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor
J.Biol.Chem., 283, 2008
3EW3
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the 1:2 complex between a Nterminal elongated prolactin and the extra cellular domain of the rat prolactin receptor
Descriptor: Prolactin, Prolactin receptor
Authors:Broutin, I, Jomain, J.B, England, P, Goffin, V.
Deposit date:2008-10-14
Release date:2009-11-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.
J.Biol.Chem., 285, 2010
3MZG
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BU of 3mzg by Molmil
Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor
Descriptor: CHLORIDE ION, Prolactin, Prolactin receptor, ...
Authors:Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E.
Deposit date:2010-05-12
Release date:2010-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3N06
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BU of 3n06 by Molmil
A mutant human Prolactin receptor antagonist H27A in complex with the extracellular domain of the human prolactin receptor
Descriptor: CHLORIDE ION, Prolactin, Prolactin receptor, ...
Authors:Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E.
Deposit date:2010-05-13
Release date:2010-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3N0P
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BU of 3n0p by Molmil
A mutant human Prolactin receptor antagonist H30A in complex with the extracellular domain of the human prolactin receptor
Descriptor: CHLORIDE ION, Prolactin, Prolactin receptor, ...
Authors:Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E.
Deposit date:2010-05-14
Release date:2010-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3NCE
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BU of 3nce by Molmil
A mutant human Prolactin receptor antagonist H27A in complex with the mutant extracellular domain H188A of the human prolactin receptor
Descriptor: CARBONATE ION, CHLORIDE ION, Prolactin, ...
Authors:Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E.
Deposit date:2010-06-04
Release date:2010-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3NCB
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BU of 3ncb by Molmil
A mutant human Prolactin receptor antagonist H180A in complex with the extracellular domain of the human prolactin receptor
Descriptor: CARBONATE ION, CHLORIDE ION, Prolactin, ...
Authors:Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E.
Deposit date:2010-06-04
Release date:2010-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3NCF
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BU of 3ncf by Molmil
A mutant human Prolactin receptor antagonist H30A in complex with the mutant extracellular domain H188A of the human prolactin receptor
Descriptor: CHLORIDE ION, Prolactin, Prolactin receptor, ...
Authors:Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E.
Deposit date:2010-06-04
Release date:2010-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3NCC
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A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor
Descriptor: CARBONATE ION, CHLORIDE ION, Prolactin, ...
Authors:Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E.
Deposit date:2010-06-04
Release date:2010-09-29
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
3NPZ
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Prolactin Receptor (PRLR) Complexed with the Natural Hormone (PRL)
Descriptor: Prolactin, Prolactin receptor
Authors:Van Agthoven, J, England, P, Goffin, V, Broutin, I.
Deposit date:2010-06-29
Release date:2010-10-06
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone.
J.Mol.Biol., 404, 2010

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