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8RKI
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BU of 8rki by Molmil
Molecular basis of ZP3/ZP1 heteropolymerization: crystal structure of a native vertebrate egg coat filament fragment
Descriptor: Choriogenin H, YTTERBIUM (III) ION, Zona pellucida sperm-binding protein 3, ...
Authors:Wiseman, B, Zamora-Caballero, S, de Sanctis, D, Yasumasu, S, Jovine, L.
Deposit date:2023-12-25
Release date:2024-03-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat.
Cell, 187, 2024
8BQU
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BU of 8bqu by Molmil
Molecular basis of ZP3/ZP1 heteropolymerization: crystal structure of a native vertebrate egg coat filament
Descriptor: Choriogenin H, Zona pellucida sperm-binding protein 3, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Bokhove, M, de Sanctis, D, Yasumasu, S, Jovine, L.
Deposit date:2022-11-21
Release date:2024-03-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat.
Cell, 187, 2024
8DC0
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BU of 8dc0 by Molmil
Rat Betaglycan Zona Pellucida Domain (ZPC) in complex with mini monomer TGFb2 (mmTGF-b2-7M2R)
Descriptor: Transforming growth factor beta receptor type 3, Transforming growth factor beta-2
Authors:Wieteska, L, Taylor, A.B, Hinck, A.P.
Deposit date:2022-06-15
Release date:2023-06-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Rat Betaglycan Zona Pellucida Domain (ZPC) in complex with mini monomer TGFb2 (mmTGF-b2-7M2R)
To Be Published
7Q3N
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BU of 7q3n by Molmil
Cryo-EM of the complex between human uromodulin (UMOD)/Tamm-Horsfall protein (THP) and the FimH lectin domain from uropathogenic E. coli
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Type 1 fimbiral adhesin FimH, ...
Authors:Jovine, L, Xu, C, Stsiapanava, A, Carroni, M, Tunyasuvunakool, K, Jumper, J, Wu, B.
Deposit date:2021-10-28
Release date:2022-03-16
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Nat.Struct.Mol.Biol., 29, 2022
7PFP
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BU of 7pfp by Molmil
Full-length cryo-EM structure of the native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jovine, L, Xu, C, Stsiapanava, A, Carroni, M, Tunyasuvunakool, K, Jumper, J, Wu, B.
Deposit date:2021-08-11
Release date:2022-03-16
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.
Nat.Struct.Mol.Biol., 29, 2022
7LBG
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BU of 7lbg by Molmil
CryoEM structure of the HCMV Trimer gHgLgO in complex with human Transforming growth factor beta receptor type 3 and neutralizing fabs 13H11 and MSL-109
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein H, ...
Authors:Kschonsak, M, Rouge, L, Arthur, C.P, Hoangdung, H, Patel, N, Kim, I, Johnson, M, Kraft, E, Rohou, A.L, Gill, A, Martinez-Martin, N, Payandeh, J, Ciferri, C.
Deposit date:2021-01-07
Release date:2021-03-10
Last modified:2021-03-17
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry.
Cell, 184, 2021
6ZYA
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BU of 6zya by Molmil
Extended human uromodulin filament core at 3.5 A resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R.
Deposit date:2020-07-31
Release date:2020-09-02
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.
Elife, 9, 2020
6ZS5
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BU of 6zs5 by Molmil
3.5 A cryo-EM structure of human uromodulin filament core
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R.
Deposit date:2020-07-15
Release date:2020-09-02
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.
Elife, 9, 2020
6TQL
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BU of 6tql by Molmil
Cryo-EM of elastase-treated human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Stsiapanava, A, Xu, C, Carroni, M, Wu, B, Jovine, L.
Deposit date:2019-12-16
Release date:2020-11-04
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.
Embo J., 39, 2020
6TQK
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BU of 6tqk by Molmil
Cryo-EM of native human uromodulin (UMOD)/Tamm-Horsfall protein (THP) filament.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, ...
Authors:Stsiapanava, A, Xu, C, Carroni, M, Wu, B, Jovine, L.
Deposit date:2019-12-16
Release date:2020-11-04
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Cryo-EM structure of native human uromodulin, a zona pellucida module polymer.
Embo J., 39, 2020
5OSQ
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BU of 5osq by Molmil
ZP-N domain of mammalian sperm receptor ZP3 (crystal form II, processed in P21221)
Descriptor: CALCIUM ION, Maltose-binding periplasmic protein,Zona pellucida sperm-binding protein 3, TRIETHYLENE GLYCOL, ...
Authors:Jovine, L, Monne, M.
Deposit date:2017-08-18
Release date:2017-09-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats
Nature, 456, 2008
5BUP
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BU of 5bup by Molmil
Crystal structure of the ZP-C domain of mouse ZP2
Descriptor: ACETATE ION, Zona pellucida sperm-binding protein 2
Authors:Nishimura, K, Jovine, L.
Deposit date:2015-06-04
Release date:2016-01-27
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:A structured interdomain linker directs self-polymerization of human uromodulin.
Proc.Natl.Acad.Sci.USA, 113, 2016
4WRN
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BU of 4wrn by Molmil
Crystal structure of the polymerization region of human uromodulin/Tamm-Horsfall protein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Maltose-binding periplasmic protein,Uromodulin, ZINC ION, ...
Authors:Bokhove, M, De Sanctis, D, Jovine, L.
Deposit date:2014-10-24
Release date:2016-01-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A structured interdomain linker directs self-polymerization of human uromodulin.
Proc.Natl.Acad.Sci.USA, 113, 2016
4AJV
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BU of 4ajv by Molmil
Structure of mouse ZP-C domain of TGF-Beta-Receptor-3
Descriptor: TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 3
Authors:Diestel, U, Resch, M, Meinhardt, K, Weiler, S, Hellmann, T.V, Nickel, J, Eichler, J, Muller, Y.A.
Deposit date:2012-02-20
Release date:2013-02-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Identification of a Novel Tgf-Beta-Binding Site in the Zona Pellucida C-Terminal (Zp-C) Domain of Tgf-Beta-Receptor-3 (Tgfr-3).
Plos One, 8, 2013
3QW9
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BU of 3qw9 by Molmil
Crystal structure of betaglycan ZP-C domain
Descriptor: Transforming growth factor beta receptor type 3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Lin, S.J, Jardetzky, T.S.
Deposit date:2011-02-27
Release date:2011-04-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-{beta} binding.
Proc.Natl.Acad.Sci.USA, 108, 2011
3NK4
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BU of 3nk4 by Molmil
Crystal structure of full-length sperm receptor ZP3 at 2.0 A resolution
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, CITRATE ANION, Zona pellucida 3
Authors:Monne, M, Jovine, L.
Deposit date:2010-06-18
Release date:2010-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into Egg Coat Assembly and Egg-Sperm Interaction from the X-Ray Structure of Full-Length ZP3.
Cell(Cambridge,Mass.), 143, 2010
3NK3
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BU of 3nk3 by Molmil
Crystal structure of full-length sperm receptor ZP3 at 2.6 A resolution
Descriptor: CITRATE ANION, Zona pellucida 3, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose
Authors:Monne, M, Jovine, L.
Deposit date:2010-06-18
Release date:2010-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into Egg Coat Assembly and Egg-Sperm Interaction from the X-Ray Structure of Full-Length ZP3.
Cell(Cambridge,Mass.), 143, 2010
3EF7
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BU of 3ef7 by Molmil
ZP-N domain of mammalian sperm receptor ZP3 (crystal form III)
Descriptor: CALCIUM ION, Maltose-binding periplasmic protein, LINKER, ...
Authors:Monne, M, Jovine, L.
Deposit date:2008-09-08
Release date:2008-12-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats
Nature, 456, 2008
3D4G
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BU of 3d4g by Molmil
ZP-N domain of mammalian sperm receptor ZP3 (crystal form II)
Descriptor: CALCIUM ION, Maltose-binding periplasmic protein, LINKER, ...
Authors:Jovine, L, Monne, M.
Deposit date:2008-05-14
Release date:2008-12-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats
Nature, 456, 2008
3D4C
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BU of 3d4c by Molmil
ZP-N domain of mammalian sperm receptor ZP3 (crystal form I)
Descriptor: CADMIUM ION, Maltose-binding periplasmic protein, LINKER, ...
Authors:Jovine, L, Monne, M.
Deposit date:2008-05-14
Release date:2008-12-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats
Nature, 456, 2008

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PDB entries from 2024-03-27

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