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8TNR
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BU of 8tnr by Molmil
Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 2
Descriptor: 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ...
Authors:Roy Burman, S.S, Hunkeler, M, Fischer, E.S.
Deposit date:2023-08-02
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Continuous evolution of compact protein degradation tags regulated by selective molecular glues
to be published
8TNP
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BU of 8tnp by Molmil
Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40
Descriptor: DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ...
Authors:Roy Burman, S.S, Hunkeler, M, Fischer, E.S.
Deposit date:2023-08-02
Release date:2024-03-13
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Continuous evolution of compact protein degradation tags regulated by selective molecular glues
to be published
8TNQ
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BU of 8tnq by Molmil
Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1
Descriptor: 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ...
Authors:Roy Burman, S.S, Hunkeler, M, Fischer, E.S.
Deposit date:2023-08-02
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (2.41 Å)
Cite:Continuous evolution of compact protein degradation tags regulated by selective molecular glues
to be published
8VG3
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BU of 8vg3 by Molmil
Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure
Descriptor: ZINC ION, Zinc finger protein 711
Authors:Rua, A.J, Alexandrescu, A.T.
Deposit date:2023-12-22
Release date:2024-01-17
Method:SOLUTION NMR
Cite:Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure
To Be Published
8U17
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BU of 8u17 by Molmil
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide
Descriptor: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ...
Authors:Clifton, M.C, Ma, X, Ornelas, E.
Deposit date:2023-08-30
Release date:2023-12-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Sci Rep, 13, 2023
8U15
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BU of 8u15 by Molmil
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to CC-220
Descriptor: (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DDB1, Protein cereblon, ...
Authors:Clifton, M.C, Ma, X, Ornelas, E.
Deposit date:2023-08-30
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Sci Rep, 13, 2023
8U16
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BU of 8u16 by Molmil
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to Pomalidomide
Descriptor: 1,2-ETHANEDIOL, DNA damage-binding protein 1, Protein cereblon, ...
Authors:Clifton, M.C, Ma, X, Ornelas, E.
Deposit date:2023-08-30
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Sci Rep, 13, 2023
7YSF
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BU of 7ysf by Molmil
Crystal structure of ZNF524 ZF1-4 in complex with telomeric DNA
Descriptor: D-MALATE, DNA (5'-D(*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*CP*CP*C)-3'), ...
Authors:Li, F.D, Xu, Z.Y.
Deposit date:2022-08-12
Release date:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of ZNF524 ZF1-4 in complex with telomeric DNA
To Be Published
8SSS
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BU of 8sss by Molmil
ZnFs 1-7 of CCCTC-binding factor (CTCF) Complexed with 23mer
Descriptor: 1,2-ETHANEDIOL, DNA Strand (23mer) I, DNA Strand (23mer) II, ...
Authors:Horton, J.R, Yang, J, Cheng, X.
Deposit date:2023-05-08
Release date:2023-08-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of CTCF-DNA complexes including all 11 zinc fingers.
Nucleic Acids Res., 51, 2023
8SSQ
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BU of 8ssq by Molmil
ZnFs 3-11 of CCCTC-binding factor (CTCF) Complexed with 35mer DNA 35-4
Descriptor: DNA (35-MER) Strand 2, DNA (35-MER) Strand I, SODIUM ION, ...
Authors:Horton, J.R, Yang, J, Cheng, X.
Deposit date:2023-05-08
Release date:2023-08-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Structures of CTCF-DNA complexes including all 11 zinc fingers.
Nucleic Acids Res., 51, 2023
8SSR
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BU of 8ssr by Molmil
ZnFs 3-11 of CCCTC-binding factor (CTCF) Complexed with 35mer DNA 35-20
Descriptor: DNA (35-MER) Strand I, DNA (35-MER) Strand II, SODIUM ION, ...
Authors:Horton, J.R, Yang, J, Cheng, X.
Deposit date:2023-05-08
Release date:2023-08-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Structures of CTCF-DNA complexes including all 11 zinc fingers.
Nucleic Acids Res., 51, 2023
8SST
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BU of 8sst by Molmil
ZnFs 1-7 of CCCTC-binding factor (CTCF) K365T Mutant Complexed with 23mer
Descriptor: 1,2-ETHANEDIOL, DNA Strand (23mer) I, DNA Strand (23mer) II, ...
Authors:Horton, J.R, Yang, J, Cheng, X.
Deposit date:2023-05-08
Release date:2023-08-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structures of CTCF-DNA complexes including all 11 zinc fingers.
Nucleic Acids Res., 51, 2023
8SSU
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BU of 8ssu by Molmil
ZnFs 3-11 of CCCTC-binding factor (CTCF) Complexed with 19mer DNA
Descriptor: 1,2-ETHANEDIOL, DNA (19-MER) Strand I, DNA (19-MER) Strand II, ...
Authors:Horton, J.R, Yang, J, Cheng, X.
Deposit date:2023-05-08
Release date:2023-08-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structures of CTCF-DNA complexes including all 11 zinc fingers.
Nucleic Acids Res., 51, 2023
8FFZ
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BU of 8ffz by Molmil
TFIIIA-TFIIIC-Brf1-TBP complex bound to 5S rRNA gene
Descriptor: DNA (151-MER), Transcription factor IIIA, Transcription factor IIIB 70 kDa subunit,TATA-box-binding protein, ...
Authors:Talyzina, A, He, Y.
Deposit date:2022-12-11
Release date:2023-06-21
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of TFIIIC-dependent RNA polymerase III transcription initiation.
Mol.Cell, 83, 2023
7W1M
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BU of 7w1m by Molmil
Cryo-EM structure of human cohesin-CTCF-DNA complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit SA-1, ...
Authors:Shi, Z.B, Bai, X.C, Yu, H.
Deposit date:2021-11-19
Release date:2023-05-31
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:CTCF and R-loops are boundaries of cohesin-mediated DNA looping.
Mol.Cell, 83, 2023
8CUC
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BU of 8cuc by Molmil
Crystal structure analysis of SALL4 zinc finger domain in complex with DNA
Descriptor: DNA (5'-D(P*CP*GP*AP*AP*AP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*TP*AP*TP*TP*TP*CP*G)-3'), Sal-like protein 4, ...
Authors:Seo, H.S, Dhe-Paganon, S.
Deposit date:2022-05-17
Release date:2023-05-24
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal Structure Analysis of SALL4 Zinc Finger domain in complex with DNA
To Be Published
8H9H
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BU of 8h9h by Molmil
Crystal structure of ZBTB7A in complex with GACCC-containing sequence
Descriptor: DNA (5'-D(*TP*AP*AP*GP*GP*AP*CP*CP*CP*AP*GP*AP*T)-3'), DNA (5'-D(P*AP*AP*TP*CP*TP*GP*GP*GP*TP*CP*CP*TP*T)-3'), ZINC ION, ...
Authors:Yang, Y.
Deposit date:2022-10-25
Release date:2023-04-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:ZBTB7A regulates primed-to-naive transition of pluripotent stem cells via recognition of the PNT-associated sequence by zinc fingers 1-2 and recognition of gamma-globin -200 gene element by zinc fingers 1-4.
Febs J., 290, 2023
8DEY
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BU of 8dey by Molmil
Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709
Descriptor: (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ...
Authors:Ma, X, Ornelas, E, Clifton, M.C.
Deposit date:2022-06-21
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.
Cell Chem Biol, 30, 2023
7U8F
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BU of 7u8f by Molmil
Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue DKY709
Descriptor: (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA damage-binding protein 1, ...
Authors:Ma, X, Ornelas, E, Clifton, M.C.
Deposit date:2022-03-08
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.
Cell Chem Biol, 30, 2023
8E3E
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BU of 8e3e by Molmil
ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#10)
Descriptor: DNA (5'-D(*CP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*A)-3'), ZINC ION, ...
Authors:Horton, J.R, Ren, R, Cheng, X.
Deposit date:2022-08-17
Release date:2023-02-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia.
J.Biol.Chem., 299, 2023
8E3D
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BU of 8e3d by Molmil
ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#11)
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*AP*TP*TP*TP*GP*GP*GP*GP*AP*GP*GP*GP*GP*TP*CP*TP*TP*TP*AP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*AP*AP*AP*AP*GP*AP*CP*CP*CP*CP*TP*CP*CP*CP*CP*AP*AP*AP*T)-3'), ...
Authors:Horton, J.R, Ren, R, Cheng, X.
Deposit date:2022-08-17
Release date:2023-02-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia.
J.Biol.Chem., 299, 2023
8DTU
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BU of 8dtu by Molmil
The complex of nanobody 5344N74D with BCL11A ZF6.
Descriptor: B-cell lymphoma/leukemia 11A, Nanobody 5344N74D, ZINC ION
Authors:Yin, M, Tenglin, K, Zhai, L, Dassama, L.M, Orkin, S.H.
Deposit date:2022-07-26
Release date:2023-02-01
Method:X-RAY DIFFRACTION (2.447 Å)
Cite:Evolution of nanobodies specific for BCL11A.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DTN
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BU of 8dtn by Molmil
The complex of nanobody 6101 with BCL11A ZF6
Descriptor: B-cell lymphoma/leukemia 11A, MAGNESIUM ION, Nanobody 6101, ...
Authors:Yin, M, Tenglin, K, Zhai, L, Dassama, L.M, Orkin, S.H.
Deposit date:2022-07-26
Release date:2023-02-01
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Evolution of nanobodies specific for BCL11A.
Proc.Natl.Acad.Sci.USA, 120, 2023
8A4I
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BU of 8a4i by Molmil
Crystal structure of SALL4 zinc finger cluster 4 with AT-rich DNA
Descriptor: DNA (5'-D(*GP*AP*TP*AP*TP*TP*AP*AP*TP*AP*TP*C)-3'), MAGNESIUM ION, Sal-like protein 4, ...
Authors:Watson, J.A, Pantier, R, Jayachandran, U, Chhatbar, K, Alexander-Howden, B, Kruusvee, V, Prendecki, M, Bird, A, Cook, A.G.
Deposit date:2022-06-11
Release date:2023-01-11
Last modified:2023-01-25
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndrome.
Life Sci Alliance, 6, 2023
7Y3I
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BU of 7y3i by Molmil
Structure of DNA bound SALL4
Descriptor: DNA (12-mer), Sal-like protein 4, ZINC ION
Authors:Ru, W, Xu, C.
Deposit date:2022-06-10
Release date:2022-10-26
Last modified:2022-11-30
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif.
J.Biol.Chem., 298, 2022

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PDB entries from 2024-03-27

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