Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8YGY
DownloadVisualize
BU of 8ygy by Molmil
Structure of the KLK1 from Biortus.
Descriptor: 1,2-ETHANEDIOL, Kallikrein-1, SULFATE ION, ...
Authors:Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y.
Deposit date:2024-02-27
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Structure of the KLK1 from Biortus.
To Be Published
8VGT
DownloadVisualize
BU of 8vgt by Molmil
Structure of the HKU1 RBD bound to the human TMPRSS2 receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ...
Authors:Park, Y.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:2023-12-27
Release date:2024-03-06
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Human coronavirus HKU1 recognition of the TMPRSS2 host receptor
To Be Published
8ASF
DownloadVisualize
BU of 8asf by Molmil
Crystal structure of Thrombin in complex with macrocycle T1
Descriptor: 5-chloranyl-~{N}-[[(9~{S},15~{R})-8,14,17-tris(oxidanylidene)-3,20-dithia-7,13,16-triazatetracyclo[20.2.2.1^{5,7}.1^{9,13}]octacosa-1(25),22(26),23-trien-15-yl]methyl]thiophene-2-carboxamide, Thrombin heavy chain, Thrombin light chain
Authors:Chinellato, M, Angelini, A, Nielsen, A, Heinis, C, Cendron, L.
Deposit date:2022-08-19
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Crystal structure of Thrombin in complex with optimized macrocycles T1 and T3
To Be Published
8UO7
DownloadVisualize
BU of 8uo7 by Molmil
Bovine trypsin in complex with deacetylated wild type microviridin J
Descriptor: CALCIUM ION, Cationic trypsin, Deacetylated wildtype microviridin J, ...
Authors:Chen, W, Bruner, S.D.
Deposit date:2023-10-19
Release date:2024-02-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Alternative Linkage Chemistries in the Chemoenzymatic Synthesis of Microviridin-Based Cyclic Peptides.
Org.Lett., 26, 2024
8UF7
DownloadVisualize
BU of 8uf7 by Molmil
Cryo-EM structure of POmAb, a Type-I anti-prothrombin antiphospholipid antibody, bound to kringle-1 of human prothrombin
Descriptor: POmAb Heavy Chain, POmAb Light Chain, Prothrombin
Authors:Kumar, S, Summers, B, Basore, K, Pozzi, N.
Deposit date:2023-10-03
Release date:2024-02-14
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure and functional basis of prothrombin recognition by a Type-I anti-prothrombin antiphospholipid antibody.
Blood, 2024
8UTL
DownloadVisualize
BU of 8utl by Molmil
Bovine trypsin in complex with Thr3Dap mutated microviridin J
Descriptor: CALCIUM ION, Cationic trypsin, GLYCEROL, ...
Authors:Chen, W, Bruner, S.D.
Deposit date:2023-10-31
Release date:2024-02-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Alternative Linkage Chemistries in the Chemoenzymatic Synthesis of Microviridin-Based Cyclic Peptides.
Org.Lett., 26, 2024
8V1F
DownloadVisualize
BU of 8v1f by Molmil
TMPRSS2 complexed with the noncovalent inhibitor 6-amidino-2-napthol
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Fraser, B.J, Dong, A, Kutera, M, Seitova, A, Li, Y, Hutchinson, A, Edwards, A, Benard, F, Halabelian, L, Arrowsmith, C, Structural Genomics Consortium (SGC)
Deposit date:2023-11-20
Release date:2024-02-07
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:TMPRSS2 complexed with the noncovalent inhibitor 6-amidino-2-napthol
To Be Published
8G1W
DownloadVisualize
BU of 8g1w by Molmil
Crystal Structure Matriptase (C731S) in Complex with Inhibitor VD4162B
Descriptor: CHLORIDE ION, Cyclic peptide inhibitor (ACE)Y(DTR)(NLE)(KCM), Cyclic peptide inhibitor (ACE)Y(DTR)(NLE)(THZ), ...
Authors:Lovell, S, Kashipathy, M.M, Battaile, K.P, Janetka, J.W.
Deposit date:2023-02-03
Release date:2024-02-07
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Mechanism-Based Macrocyclic Inhibitors of Serine Proteases.
J.Med.Chem., 2024
8V04
DownloadVisualize
BU of 8v04 by Molmil
High resolution TMPRSS2 structure following acylation by nafamostat
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-carbamimidamidobenzoic acid, ...
Authors:Fraser, B.J, Dong, A, Kutera, M, Seitova, A, Li, Y, Hutchinson, A, Edwards, A, Benard, F, Levon, H, Arrowsmith, C.
Deposit date:2023-11-16
Release date:2024-01-31
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:High resolution TMPRSS2 structure following acylation by nafamostat
To Be Published
8VIS
DownloadVisualize
BU of 8vis by Molmil
Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ...
Authors:Fraser, B.J, Dong, A, Ilyassov, O, Kenney, T, Li, Y.Y, Seitova, A, Li, Y, Hejazi, Z, Edwards, A, Benard, F, Arrowsmith, C.
Deposit date:2024-01-05
Release date:2024-01-31
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Human TMPRSS11D complexed with a disulfide-linked autoinhibitory DDDDK peptide
To Be Published
8CN9
DownloadVisualize
BU of 8cn9 by Molmil
Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII
Descriptor: CALCIUM ION, CESIUM ION, Coagulation factor VII, ...
Authors:Schluckebier, G, Johansson, E.
Deposit date:2023-02-22
Release date:2023-12-27
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders
Nat Cardiovasc Res, 2023
8HD8
DownloadVisualize
BU of 8hd8 by Molmil
Crystal structure of TMPRSS2 in complex with 212-148
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-carbamimidamidobenzoic acid, CALCIUM ION, ...
Authors:Wang, H, Liu, X, Sun, L, Yang, H.
Deposit date:2022-11-03
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of TMPRSS2 in complex with 212-148
To Be Published
8R8D
DownloadVisualize
BU of 8r8d by Molmil
Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer)
Descriptor: Coagulation factor XII, Garadacimab heavy chain variable region, Garadacimab light chain variable region, ...
Authors:Drulyte, I.
Deposit date:2023-11-29
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for inhibition of beta-FXIIa by garadacimab
To Be Published
7Y0F
DownloadVisualize
BU of 7y0f by Molmil
Crystal structure of TMPRSS2 in complex with UK-371804
Descriptor: 2-[(1-carbamimidamido-4-chloranyl-isoquinolin-7-yl)sulfonylamino]-2-methyl-propanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Wang, H, Duan, Y, Liu, X, Sun, L, Yang, H.
Deposit date:2022-06-04
Release date:2023-12-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of TMPRSS2 in complex with UK-371804
To Be Published
7XYD
DownloadVisualize
BU of 7xyd by Molmil
Crystal structure of TMPRSS2 in complex with Nafamostat
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-carbamimidamidobenzoic acid, CALCIUM ION, ...
Authors:Wang, H, Liu, X, Duan, Y, Liu, X, Sun, L, Yang, H.
Deposit date:2022-06-01
Release date:2023-12-06
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Crystal structure of TMPRSS2 in complex with Nafamostat
To Be Published
7Y0E
DownloadVisualize
BU of 7y0e by Molmil
Crystal structure of TMPRSS2 in complex with Camostat
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-carbamimidamidobenzoic acid, CALCIUM ION, ...
Authors:Wang, H, Duan, Y, Liu, X, Sun, L, Yang, H.
Deposit date:2022-06-04
Release date:2023-12-06
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Crystal structure of TMPRSS2 in complex with Camostat
To Be Published
8TYP
DownloadVisualize
BU of 8typ by Molmil
Complement Protease C1s Inhibited by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide
Descriptor: 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide, Complement C1s subcomponent, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Geisbrecht, B.V.
Deposit date:2023-08-25
Release date:2023-11-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs.
J Immunol., 212, 2024
8ASE
DownloadVisualize
BU of 8ase by Molmil
Crystal structure of Thrombin in complex with macrocycle T3
Descriptor: (8~{S},14~{S},18~{E})-8-[(4-chlorophenyl)methyl]-3,21-dithia-7,10,16-triazatricyclo[21.2.2.1^{10,14}]octacosa-1(26),18,23(27),24-tetraene-6,9,15-trione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chinellato, M, Angelini, A, Nielsen, A, Heinis, C, Cendron, L.
Deposit date:2022-08-19
Release date:2023-11-29
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of Thrombin in complex with optimized macrocycles T1 and T3
To Be Published
7ZRT
DownloadVisualize
BU of 7zrt by Molmil
Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK970
Descriptor: 1,2-ETHANEDIOL, 1,3,5-tris(bromomethyl)benzene, DI(HYDROXYETHYL)ETHER, ...
Authors:Caregnato, A, Angela, P, Mazzoccato, Y, Frasson, N, Angelini, A, Cendron, L.
Deposit date:2022-05-05
Release date:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK970
To Be Published
7ZRR
DownloadVisualize
BU of 7zrr by Molmil
Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK965
Descriptor: 1,2-ETHANEDIOL, 1,3,5-tris(bromomethyl)benzene, AMINO GROUP, ...
Authors:Caregnato, A, Angela, P, Mazzoccato, Y, Frasson, N, Angelini, A, Cendron, L.
Deposit date:2022-05-05
Release date:2023-11-15
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK965
To Be Published
8B53
DownloadVisualize
BU of 8b53 by Molmil
Structure of porcine pancreatic elastase bound to a fragment of a 4-azaindole inhibitor
Descriptor: 3-methylbenzoic acid, CALCIUM ION, Chymotrypsin-like elastase family member 1, ...
Authors:Ferraroni, M, Gerace, A.
Deposit date:2022-09-21
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:X-ray structural study of human neutrophil elastase inhibition with a series of azaindoles, azaindazoles and isoxazolones
J.Mol.Struct., 1274, 2023
8B04
DownloadVisualize
BU of 8b04 by Molmil
STRUCTURE OF PORCINE PANCREATIC ELASTASE BOUND TO A FRAGMENT OF AN ISOXAZOLONE INHIBITOR
Descriptor: 2-cyclopropylcarbonyl-3-propan-2-yl-1,2-oxazol-5-one, CALCIUM ION, Chymotrypsin-like elastase family member 1, ...
Authors:Ferraroni, M, Giovannoni, P, Masini, V.
Deposit date:2022-09-07
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:X-ray structural study of human neutrophil elastase inhibition with a series of azaindoles, azaindazoles and isoxazolones
J.Mol.Struct., 1274, 2023
8B1Y
DownloadVisualize
BU of 8b1y by Molmil
STRUCTURE OF PORCINE PANCREATIC ELASTASE BOUND TO A FRAGMENT OF A 5-AZAINDAZOLE INHIBITOR
Descriptor: 1-cyclopropylcarbonylpyrazolo[4,3-c]pyridine-3-carbonitrile, CALCIUM ION, Chymotrypsin-like elastase family member 1, ...
Authors:Ferraroni, M, Giovannoni, P, Gerace, A.
Deposit date:2022-09-12
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:X-ray structural study of human neutrophil elastase inhibition with a series of azaindoles, azaindazoles and isoxazolones
J.Mol.Struct., 1274, 2023
8B49
DownloadVisualize
BU of 8b49 by Molmil
STRUCTURE OF PORCINE PANCREATIC ELASTASE BOUND TO A FRAGMENT (m-toluoylcarbonyl group) OF A 5-AZAINDOLE INHIBITOR
Descriptor: 1-(3-methylphenyl)carbonylpyrrolo[3,2-c]pyridine-3-carbonitrile, CALCIUM ION, Chymotrypsin-like elastase family member 1, ...
Authors:Ferraroni, M, Giovannoni, P, Gerace, A.
Deposit date:2022-09-20
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:X-ray structural study of human neutrophil elastase inhibition with a series of azaindoles, azaindazoles and isoxazolones
J.Mol.Struct., 1274, 2023
8BO5
DownloadVisualize
BU of 8bo5 by Molmil
COAGULATION FACTOR XI PROTEASE DOMAIN IN COMPLEX WITH ACTIVE SITE INHIBITOR 3
Descriptor: 2-[4-(3-chlorophenyl)-2,5-bis(oxidanylidene)pyrrolo[3,4-b]pyridin-1-yl]-~{N}-[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]ethanamide, CITRIC ACID, Coagulation factor XIa light chain, ...
Authors:Schaefer, M, Roehrig, S, Ackerstaff, J, Nunez, E.J, Gericke, K.M, Meier, K, Tersteegen, A, Stampfuss, J, Ellerbrock, P, Meibom, D, Lang, D, Heitmeier, S, Hillisch, A.
Deposit date:2022-11-14
Release date:2023-09-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders.
J.Med.Chem., 66, 2023

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon