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1ICF
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BU of 1icf by Molmil
CRYSTAL STRUCTURE OF MHC CLASS II ASSOCIATED P41 II FRAGMENT IN COMPLEX WITH CATHEPSIN L
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (CATHEPSIN L: HEAVY CHAIN), PROTEIN (CATHEPSIN L: LIGHT CHAIN), ...
Authors:Guncar, G, Pungercic, G, Klemencic, I, Turk, V, Turk, D.
Deposit date:1999-01-07
Release date:2000-01-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.
EMBO J., 18, 1999
1L3H
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BU of 1l3h by Molmil
NMR structure of P41icf, a potent inhibitor of human cathepsin L
Descriptor: MHC CLASS II-ASSOCIATED P41 INVARIANT CHAIN FRAGMENT (P41icf)
Authors:Chiva, C, Barthe, P, Codina, A, Giralt, E.
Deposit date:2002-02-27
Release date:2003-03-04
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Synthesis and NMR structure of P41ICF, a potent inhibitor of human cathepsin L
J.Am.Chem.Soc., 125, 2003
1RMJ
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BU of 1rmj by Molmil
C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II
Descriptor: Insulin-like growth factor binding protein 6
Authors:Headey, S.J, Keizer, D.W, Yao, S, Brasier, G, Kantharidis, P, Bach, L.A, Norton, R.S.
Deposit date:2003-11-28
Release date:2004-09-14
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II.
Mol.Endocrinol., 18, 2004
1ZT3
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BU of 1zt3 by Molmil
C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid
Descriptor: 1,4-DIETHYLENE DIOXIDE, Insulin-like growth factor binding protein 1
Authors:Sala, A, Capaldi, S, Campagnoli, M, Faggion, B, Labo, S, Perduca, M, Romano, A, Carrizo, M.E, Valli, M, Visai, L, Minchiotti, L, Galliano, M, Monaco, H.L.
Deposit date:2005-05-26
Release date:2005-06-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and Properties of the C-terminal Domain of Insulin-like Growth Factor-binding Protein-1 Isolated from Human Amniotic Fluid
J.Biol.Chem., 280, 2005
1ZT5
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BU of 1zt5 by Molmil
C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid complexed with Iron(II)
Descriptor: 1,4-DIETHYLENE DIOXIDE, FE (II) ION, Insulin-like growth factor binding protein 1
Authors:Sala, A, Capaldi, S, Campagnoli, M, Faggion, B, Labo, S, Perduca, M, Romano, A, Carrizo, M.E, Valli, M, Visai, L, Minchiotti, L, Galliano, M, Monaco, H.L.
Deposit date:2005-05-26
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.818 Å)
Cite:Structure and Properties of the C-terminal Domain of Insulin-like Growth Factor-binding Protein-1 Isolated from Human Amniotic Fluid
J.Biol.Chem., 280, 2005
2DSQ
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BU of 2dsq by Molmil
Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins
Descriptor: Insulin-like growth factor IB, Insulin-like growth factor-binding protein 1, Insulin-like growth factor-binding protein 4
Authors:Sitar, T, Popowicz, G.M, Siwanowicz, I, Huber, R, Holak, T.A.
Deposit date:2006-07-05
Release date:2006-08-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2DSR
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BU of 2dsr by Molmil
Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins
Descriptor: Insulin-like growth factor IB, Insulin-like growth factor-binding protein 4
Authors:Sitar, T, Popowicz, G.M, Siwanowicz, I, Huber, R, Holak, T.A.
Deposit date:2006-07-05
Release date:2006-08-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2H7T
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BU of 2h7t by Molmil
Solution Structure of the C-terminal Domain of Insulin-like Growth Factor Binding Protein 2 (IGFBP-2)
Descriptor: Insulin-like growth factor-binding protein 2
Authors:Kuang, Z.
Deposit date:2006-06-03
Release date:2007-04-24
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)
J.Mol.Biol., 364, 2006
4MZV
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BU of 4mzv by Molmil
Crystal structure of extracellular part of human EpCAM
Descriptor: DECYL-BETA-D-MALTOPYRANOSIDE, Epithelial cell adhesion molecule
Authors:Pavsic, M, Guncar, G, Djinovic-Carugo, K, Lenarcic, B.
Deposit date:2013-09-30
Release date:2014-08-27
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.865 Å)
Cite:Crystal structure and its bearing towards an understanding of key biological functions of EpCAM.
Nat Commun, 5, 2014
6I07
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BU of 6i07 by Molmil
Crystal structure of EpCAM in complex with scFv
Descriptor: Epithelial cell adhesion molecule, GLYCEROL, Single chain Fv
Authors:Casaletto, J.B, Geddie, M.L, Abu-Yousif, A.O, Masson, K, Fulgham, A, Boudot, A, Maiwald, T, Kearns, J.D, Kohli, N, Su, S, Razlog, M, Raue, A, Kalra, A, Hakansson, M, Logan, D.T, Welin, M, Chattopadhyay, S, Harms, B.D, Nielsen, U.B, Schoeberl, B, Lugovskoy, A.A, MacBeath, G.
Deposit date:2018-10-25
Release date:2019-03-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.
Proc.Natl.Acad.Sci.USA, 116, 2019
6O0D
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BU of 6o0d by Molmil
Saxiphilin Apo structure
Descriptor: Saxiphilin
Authors:Yen, T.J, Lolicato, M, Minor, D.L.
Deposit date:2019-02-16
Release date:2019-07-10
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv, 5, 2019
6O0E
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BU of 6o0e by Molmil
Saxiphilin:STX complex, soaking
Descriptor: Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
Authors:Yen, T.J, Lolicato, M, Minor, D.L.
Deposit date:2019-02-16
Release date:2019-07-10
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv, 5, 2019
6O0F
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BU of 6o0f by Molmil
Saxiphilin:STX complex, co-crystal
Descriptor: Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
Authors:Yen, T.J, Lolicato, M, Minor, D.L.
Deposit date:2019-02-16
Release date:2019-07-10
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Sci Adv, 5, 2019
6SCJ
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BU of 6scj by Molmil
The structure of human thyroglobulin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Thyroglobulin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Coscia, F, Turk, D, Lowe, J.
Deposit date:2019-07-24
Release date:2020-02-12
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The structure of human thyroglobulin.
Nature, 578, 2020
7B75
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BU of 7b75 by Molmil
Cryo-EM Structure of Human Thyroglobulin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thyroglobulin, ...
Authors:Adaixo, R, Righetto, R, Steiner, E.M, Taylor, N.M.I, Stahlberg, H.
Deposit date:2020-12-09
Release date:2021-12-29
Last modified:2022-01-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of native human thyroglobulin.
Nat Commun, 13, 2022
7E5M
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BU of 7e5m by Molmil
crystal structure of trans assembled human TROP-2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor-associated calcium signal transducer 2
Authors:Sun, M, Zhang, H, Chai, Y, Qi, J, Gao, G.F, Tan, S.
Deposit date:2021-02-19
Release date:2021-12-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2.
Iscience, 24, 2021
7E5N
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BU of 7e5n by Molmil
crystal structure of cis assembled TROP-2
Descriptor: Tumor-associated calcium signal transducer 2
Authors:Sun, M, Zhang, H, Chai, Y, Qi, J, Gao, G.F, Tan, S.
Deposit date:2021-02-19
Release date:2021-12-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2.
Iscience, 24, 2021
7N4Y
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BU of 7n4y by Molmil
The structure of bovine thyroglobulin with iodinated tyrosines
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kim, K, Clarke, O.B.
Deposit date:2021-06-04
Release date:2021-11-10
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.61 Å)
Cite:The structure of natively iodinated bovine thyroglobulin.
Acta Crystallogr D Struct Biol, 77, 2021
7PEE
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BU of 7pee by Molmil
Crystal structure of extracellular part of human Trop2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ...
Authors:Pavsic, M.
Deposit date:2021-08-09
Release date:2021-10-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Trop2 Forms a Stable Dimer with Significant Structural Differences within the Membrane-Distal Region as Compared to EpCAM.
Int J Mol Sci, 22, 2021
7QTQ
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BU of 7qtq by Molmil
Structure of Native, iodinated bovine thyroglobulin solved on strepavidin affinity grids.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thyroglobulin, ...
Authors:Marechal, N, Weitz, J.C, Serrano, B.P, Zhang, X.
Deposit date:2022-01-15
Release date:2022-05-04
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin.
Nat Commun, 13, 2022
7UFG
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BU of 7ufg by Molmil
Cryo-EM structure of PAPP-A in complex with IGFBP5
Descriptor: Insulin-like growth factor-binding protein 5, Pappalysin-1, ZINC ION
Authors:Judge, R.A, Jain, R, Hao, Q, Ouch, C, Sridar, J, Smith, C.L, Wang, J.C.K, Eaton, D.
Deposit date:2022-03-22
Release date:2022-09-28
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
Nat Commun, 13, 2022
7WRQ
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BU of 7wrq by Molmil
Structure of Human IGF1/IGFBP3/ALS Ternary Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor-binding protein 3, Insulin-like growth factor-binding protein complex acid labile subunit, ...
Authors:Kim, H, Fu, Y, Kim, H.M.
Deposit date:2022-01-27
Release date:2022-08-10
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex
Nat Commun, 13, 2022
8D6P
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BU of 8d6p by Molmil
Rana catesbeiana saxiphilin mutant - Y558A
Descriptor: Saxiphilin
Authors:Chen, Z, Zakrzewska, S, Minor, D.L.
Deposit date:2022-06-06
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D6Q
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BU of 8d6q by Molmil
Rana catesbeiana saxiphilin mutant - Y558I
Descriptor: Saxiphilin
Authors:Chen, Z, Zakrzewska, S, Minor, D.L.
Deposit date:2022-06-06
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D6S
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BU of 8d6s by Molmil
Rana catesbeiana saxiphilin mutant - Y558A:STX (co-crystal)
Descriptor: Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
Authors:Chen, Z, Zakrzewska, S, Minor, D.L.
Deposit date:2022-06-06
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022

 

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