1A2Q
 
 | | SUBTILISIN BPN' MUTANT 7186 | | Descriptor: | ACETONE, CALCIUM ION, SUBTILISIN BPN' | | Authors: | Gilliland, G.L, Whitlow, M, Howard, A.J. | | Deposit date: | 1998-01-08 | | Release date: | 1998-04-29 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding.
Biochemistry, 28, 1989
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1AF4
 | | CRYSTAL STRUCTURE OF SUBTILISIN CARLSBERG IN ANHYDROUS DIOXANE | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, CALCIUM ION, SUBTILISIN CARLSBERG | | Authors: | Schmitke, J.L, Stern, L.J, Klibanov, A.M. | | Deposit date: | 1997-03-21 | | Release date: | 1997-06-16 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The crystal structure of subtilisin Carlsberg in anhydrous dioxane and its comparison with those in water and acetonitrile.
Proc.Natl.Acad.Sci.USA, 94, 1997
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1AH2
 | | SERINE PROTEASE PB92 FROM BACILLUS ALCALOPHILUS, NMR, 18 STRUCTURES | | Descriptor: | SERINE PROTEASE PB92 | | Authors: | Boelens, R, Schipper, D, Martin, J.R, Karimi-Nejad, Y, Mulder, F, Zwan, J.V.D, Mariani, M. | | Deposit date: | 1997-04-11 | | Release date: | 1998-04-15 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | The solution structure of serine protease PB92 from Bacillus alcalophilus presents a rigid fold with a flexible substrate-binding site.
Structure, 5, 1997
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1AK9
 | | SUBTILISIN MUTANT 8321 | | Descriptor: | CALCIUM ION, ISOPROPYL ALCOHOL, SODIUM ION, ... | | Authors: | Whitlow, M, Howard, A.J, Wood, J.F. | | Deposit date: | 1997-05-30 | | Release date: | 1997-11-12 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding.
Biochemistry, 28, 1989
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1AQN
 | | SUBTILISIN MUTANT 8324 | | Descriptor: | CALCIUM ION, ISOPROPYL ALCOHOL, SUBTILISIN 8324, ... | | Authors: | Whitlow, M, Howard, A.J, Wood, J.F. | | Deposit date: | 1997-07-31 | | Release date: | 1998-01-14 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Large increases in general stabilityfor subtilisin BPN' through incremental changes in the free energy of unfolding
To be published
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1AU9
 | | SUBTILISIN BPN' MUTANT 8324 IN CITRATE | | Descriptor: | CALCIUM ION, ISOPROPYL ALCOHOL, SUBTILISIN BPN', ... | | Authors: | Whitlow, M, Howard, A.J, Wood, J.F. | | Deposit date: | 1997-09-12 | | Release date: | 1997-12-31 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding.
Biochemistry, 28, 1989
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1AV7
 | | SUBTILISIN CARLSBERG L-NAPHTHYL-1-ACETAMIDO BORONIC ACID INHIBITOR COMPLEX | | Descriptor: | SODIUM ION, SUBTILISIN CARLSBERG, TYPE VIII | | Authors: | Stoll, V.S, Eger, B.T, Hynes, R.C, Martichonok, V, Jones, J.B, Pai, E.F. | | Deposit date: | 1997-09-29 | | Release date: | 1998-04-01 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes.
Biochemistry, 37, 1998
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1AVT
 | | SUBTILISIN CARLSBERG D-PARA-CHLOROPHENYL-1-ACETAMIDO BORONIC ACID INHIBITOR COMPLEX | | Descriptor: | SODIUM ION, SUBTILISIN CARLSBERG, TYPE VIII | | Authors: | Stoll, V.S, Eger, B.T, Hynes, R.C, Martichonok, V, Jones, J.B, Pai, E.F. | | Deposit date: | 1997-09-19 | | Release date: | 1998-03-25 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes.
Biochemistry, 37, 1998
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1BE6
 | | TRANS-CINNAMOYL-SUBTILISIN IN ANHYDROUS ACETONITRILE | | Descriptor: | ACETONITRILE, CALCIUM ION, PHENYLETHYLENECARBOXYLIC ACID, ... | | Authors: | Schmitke, J.L, Stern, L.J, Klibanov, A.M. | | Deposit date: | 1998-05-20 | | Release date: | 1998-10-14 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Comparison of x-ray crystal structures of an acyl-enzyme intermediate of subtilisin Carlsberg formed in anhydrous acetonitrile and in water.
Proc.Natl.Acad.Sci.USA, 95, 1998
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1BE8
 | | TRANS-CINNAMOYL-SUBTILISIN IN WATER | | Descriptor: | CALCIUM ION, PHENYLETHYLENECARBOXYLIC ACID, SUBTILISIN CARLSBERG | | Authors: | Schmitke, J.L, Stern, L.J, Klibanov, A.M. | | Deposit date: | 1998-05-20 | | Release date: | 1998-10-28 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Comparison of x-ray crystal structures of an acyl-enzyme intermediate of subtilisin Carlsberg formed in anhydrous acetonitrile and in water.
Proc.Natl.Acad.Sci.USA, 95, 1998
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1BFK
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1BFU
 | | SUBTILISIN CARLSBERG IN 20% DIOXANE | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, CALCIUM ION, SUBTILISIN CARLSBERG | | Authors: | Schmitke, J.L, Stern, L.J, Klibanov, A.M. | | Deposit date: | 1998-05-22 | | Release date: | 1998-10-28 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Organic solvent binding to crystalline subtilisin1 in mostly aqueous media and in the neat solvents.
Biochem.Biophys.Res.Commun., 248, 1998
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1BH6
 | | SUBTILISIN DY IN COMPLEX WITH THE SYNTHETIC INHIBITOR N-BENZYLOXYCARBONYL-ALA-PRO-PHE-CHLOROMETHYL KETONE | | Descriptor: | CALCIUM ION, N-BENZYLOXYCARBONYL-ALA-PRO-3-AMINO-4-PHENYL-BUTAN-2-OL, SODIUM ION, ... | | Authors: | Eschenburg, S, Genov, N, Wilson, K.S, Betzel, C. | | Deposit date: | 1998-06-15 | | Release date: | 1998-11-04 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structure of subtilisin DY, a random mutant of subtilisin Carlsberg.
Eur.J.Biochem., 257, 1998
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1BJR
 | | COMPLEX FORMED BETWEEN PROTEOLYTICALLY GENERATED LACTOFERRIN FRAGMENT AND PROTEINASE K | | Descriptor: | CALCIUM ION, LACTOFERRIN, PROTEINASE K | | Authors: | Singh, T.P, Sharma, S, Karthikeyan, S, Betzel, C, Bhatia, K.L. | | Deposit date: | 1998-06-27 | | Release date: | 1998-11-04 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Crystal structure of a complex formed between proteolytically-generated lactoferrin fragment and proteinase K.
Proteins, 33, 1998
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1C3L
 | | SUBTILISIN-CARLSBERG COMPLEXED WITH XENON (8 BAR) | | Descriptor: | CALCIUM ION, FORMIC ACID, SUBTILISIN-CARLSBERG, ... | | Authors: | Prange, T, Schiltz, M, Pernot, L, Colloc'h, N, Longhi, S. | | Deposit date: | 1999-07-28 | | Release date: | 1999-08-04 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Exploring hydrophobic sites in proteins with xenon or krypton.
Proteins, 30, 1998
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1C9J
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1C9M
 | | BACILLUS LENTUS SUBTILSIN (SER 87) N76D/S103A/V104I | | Descriptor: | CALCIUM ION, SERINE PROTEASE, SULFATE ION | | Authors: | Bott, R. | | Deposit date: | 1999-08-02 | | Release date: | 1999-10-06 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Engineered Bacillus lentus subtilisins having altered flexibility.
J.Mol.Biol., 292, 1999
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1C9N
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1CNM
 | | ENHANCEMENT OF CATALYTIC EFFICIENCY OF PROTEINASE K THROUGH EXPOSURE TO ANHYDROUS ORGANIC SOLVENT AT 70 DEGREES CELSIUS | | Descriptor: | ACETONITRILE, CALCIUM ION, PROTEIN (PROTEINASE K) | | Authors: | Gupta, M.N, Tyagi, R, Sharma, S, Karthikeyan, S, Singh, T.P. | | Deposit date: | 1999-05-20 | | Release date: | 1999-05-27 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Enhancement of catalytic efficiency of enzymes through exposure to anhydrous organic solvent at 70 degrees C. Three-dimensional structure of a treated serine proteinase at 2.2 A resolution.
Proteins, 39, 2000
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1CSE
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1DBI
 | | CRYSTAL STRUCTURE OF A THERMOSTABLE SERINE PROTEASE | | Descriptor: | AK.1 SERINE PROTEASE, CALCIUM ION, SODIUM ION | | Authors: | Smith, C.A, Toogood, H.S, Baker, H.M, Daniel, R.M, Baker, E.N. | | Deposit date: | 1999-11-02 | | Release date: | 1999-11-18 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Calcium-mediated thermostability in the subtilisin superfamily: the crystal structure of Bacillus Ak.1 protease at 1.8 A resolution.
J.Mol.Biol., 294, 1999
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1DUI
 | | Subtilisin BPN' from Bacillus amyloliquefaciens, crystal growth mutant | | Descriptor: | DIISOPROPYL PHOSPHONATE, PROTEIN (SUBTILISIN BPN'), SODIUM ION | | Authors: | Pan, Q, Gallagher, D.T. | | Deposit date: | 2000-01-17 | | Release date: | 2000-01-28 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Probing Protein Interaction Chemistry Through Crystal Growth: Structure, Mutation, and Mechanism in Subtilisin s88
J.Cryst.Growth, 212, 2000
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1EA7
 | | Sphericase | | Descriptor: | CALCIUM ION, SERINE PROTEASE | | Authors: | Almog, O, Gonzalez, A, Klein, D, Braun, S, Shoham, G. | | Deposit date: | 2001-07-10 | | Release date: | 2002-07-04 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (0.93 Å) | | Cite: | The 0.93A Crystal Structure of Sphericase: A Calcium-Loaded Serine Protease from Bacillus Sphaericus
J.Mol.Biol., 332, 2003
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1EGQ
 | | ENHANCEMENT OF ENZYME ACTIVITY THROUGH THREE-PHASE PARTITIONING: CRYSTAL STRUCTURE OF A MODIFIED SERINE PROTEINASE AT 1.5 A RESOLUTION | | Descriptor: | ACETIC ACID, CALCIUM ION, PROTEINASE K | | Authors: | Singh, R.K, Gourinath, S, Sharma, S, Ray, I, Gupta, M.N, Singh, T.P. | | Deposit date: | 2000-02-16 | | Release date: | 2001-02-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Enhancement of enzyme activity through three-phase partitioning: crystal structure of a modified serine proteinase at 1.5 A resolution.
Protein Eng., 14, 2001
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1GA1
 | | CRYSTAL STRUCTURE ANALYSIS OF PSCP (PSEUDOMONAS SERINE-CARBOXYL PROTEINASE) COMPLEXED WITH A FRAGMENT OF IODOTYROSTATIN (THIS ENZYME RENAMED "SEDOLISIN" IN 2003) | | Descriptor: | CALCIUM ION, CHLORIDE ION, FRAGMENT OF IODOTYROSTATIN, ... | | Authors: | Dauter, Z, Li, M, Wlodawer, A. | | Deposit date: | 2000-11-29 | | Release date: | 2000-12-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Practical experience with the use of halides for phasing macromolecular structures: a powerful tool for structural genomics.
Acta Crystallogr.,Sect.D, 57, 2001
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