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8Q6M
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Human SOD1 low dose data collecton
Descriptor: ACETATE ION, COPPER (II) ION, SULFATE ION, ...
Authors:Antonyuk, S.V, Hossain, A, Agar, J.N, Hasnain, S.S.
Deposit date:2023-08-14
Release date:2023-12-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
Plos Biol., 22, 2024
8JD8
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BU of 8jd8 by Molmil
Crystal structure of Citrus limon Cu-Zn superoxide dismutase
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Utami, R.A, Yoshida, H, Retnoningrum, D.S, Ismaya, W.T.
Deposit date:2023-05-12
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Direct relationship between dimeric form and activity in the acidic copper-zinc superoxide dismutase from lemon.
Acta Crystallogr.,Sect.F, 79, 2023
8IQ1
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BU of 8iq1 by Molmil
Crystal structure of hydrogen sulfide-bound superoxide dismutase in reduced state
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, COPPER (II) ION, ...
Authors:Zhou, J.H, Huang, W.X, Cheng, R.X, Zhang, P.J, Zhu, Y.C.
Deposit date:2023-03-15
Release date:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme.
Cell Rep, 42, 2023
8IQ0
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Crystal structure of hydrogen sulfide-bound superoxide dismutase in oxidized state
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, COPPER (II) ION, ...
Authors:Zhou, J.H, Huang, W.X, Cheng, R.X, Zhang, P.J, Zhu, Y.C.
Deposit date:2023-03-15
Release date:2023-09-06
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme.
Cell Rep, 42, 2023
8GSQ
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BU of 8gsq by Molmil
Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment.
Descriptor: (9~{R})-3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-9-oxidanyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, GLYCEROL, Superoxide dismutase [Cu-Zn], ...
Authors:Aouti, S, Padmanabhan, B.
Deposit date:2022-09-06
Release date:2023-06-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis.
Acta Crystallogr D Struct Biol, 79, 2023
8CCX
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BU of 8ccx by Molmil
Human SOD1 in complex with S-XL6 cross-linker
Descriptor: COPPER (II) ION, DIMETHYL SULFOXIDE, SULFATE ION, ...
Authors:Antonyuk, S.V, Hossain, A, Agar, J.N, Hasnain, S.S.
Deposit date:2023-01-27
Release date:2023-12-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.665 Å)
Cite:Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
Plos Biol., 22, 2024
7YPR
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BU of 7ypr by Molmil
Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1.
Descriptor: COPPER (II) ION, POTASSIUM ION, Superoxide dismutase [Cu-Zn], ...
Authors:Sim, K.-S, Fukuda, Y, Inoue, T.
Deposit date:2022-08-04
Release date:2023-12-06
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1.
Acta Crystallogr.,Sect.F, 79, 2023
7YPP
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Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1.
Descriptor: CALCIUM ION, COPPER (II) ION, Superoxide dismutase [Cu-Zn], ...
Authors:Sim, K.-S, Fukuda, Y, Inoue, T.
Deposit date:2022-08-04
Release date:2023-07-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1.
Acta Crystallogr.,Sect.F, 79, 2023
7XX3
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Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB)
Descriptor: (2~{E},4~{E},6~{S})-4,6-dimethyldeca-2,4-dienoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Padmanabhan, B, Unni, S.
Deposit date:2022-05-28
Release date:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Phialomustin-B a fungal metabolite isolated from Phialophora mustea modulates Superoxide Dismutase 1 (SOD1) aggregation: Therapeutic potential in Amyotrophic lateral sclerosis (ALS)
To Be Published
7WX1
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BU of 7wx1 by Molmil
E40K/M117L variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris)
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Narikiyo, S, Furukawa, Y, Akutsu, M.
Deposit date:2022-02-14
Release date:2023-02-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation.
J.Biol.Chem., 299, 2023
7WX0
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BU of 7wx0 by Molmil
E40K variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris)
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Narikiyo, S, Furukawa, Y, Akutsu, M.
Deposit date:2022-02-14
Release date:2023-02-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation.
J.Biol.Chem., 299, 2023
7WWY
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BU of 7wwy by Molmil
M117L variant of Cu/Zn-superoxide dismutase from dog (Canis familiaris)
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Narikiyo, S, Furukawa, Y, Akutsu, M.
Deposit date:2022-02-14
Release date:2023-02-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation.
J.Biol.Chem., 299, 2023
7WWT
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BU of 7wwt by Molmil
Cu/Zn-superoxide dismutase from dog (Canis familiaris)
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Narikiyo, S, Furukawa, Y, Akutsu, M.
Deposit date:2022-02-14
Release date:2023-02-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation.
J.Biol.Chem., 299, 2023
7VZF
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BU of 7vzf by Molmil
Cryo-EM structure of amyloid fibril formed by full-length human SOD1
Descriptor: Superoxide dismutase [Cu-Zn]
Authors:Wang, L.Q, Ma, Y.Y, Yuan, H.Y, Zhao, K, Zhang, M.Y, Wang, Q, Huang, X, Xu, W.C, Chen, J, Li, D, Zhang, D.L, Zou, L.Y, Yin, P, Liu, C, Liang, Y.
Deposit date:2021-11-16
Release date:2022-06-29
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion.
Nat Commun, 13, 2022
7T8H
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BU of 7t8h by Molmil
G93A mutant of human SOD1 bound with MR6-26-2 in P21 space group
Descriptor: ACETATE ION, SULFATE ION, Superoxide dismutase [Cu-Zn], ...
Authors:Amporndanai, K, Hasnain, S.S.
Deposit date:2021-12-16
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Disease Onset and its course are delayed by on-target Cellular SOD1 Engagement of Organo-selenium drug compounds for Amyotrophic Lateral Sclerosis
To Be Published
7T8G
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BU of 7t8g by Molmil
G93A mutant of human SOD1 bound with MR6-8-2 in P21 space group
Descriptor: ACETATE ION, SELENIUM ATOM, SULFATE ION, ...
Authors:Amporndanai, K, Hasnain, S.S.
Deposit date:2021-12-16
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Disease Onset and its course are delayed by on-target Cellular SOD1 Engagement of Organo-selenium drug compounds for Amyotrophic Lateral Sclerosis
To Be Published
7T8F
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BU of 7t8f by Molmil
G93A mutant of human SOD1 bound with Ebselen in P21 space group
Descriptor: ACETATE ION, N-phenyl-2-selanylbenzamide, Superoxide dismutase [Cu-Zn], ...
Authors:Amporndanai, K, Hasnain, S.S.
Deposit date:2021-12-16
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Disease Onset and its course are delayed by on-target Cellular SOD1 Engagement of Organo-selenium drug compounds for Amyotrophic Lateral Sclerosis
To Be Published
7T8E
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BU of 7t8e by Molmil
G93A mutant of human SOD1 in P21 space group
Descriptor: ACETATE ION, SULFATE ION, Superoxide dismutase [Cu-Zn], ...
Authors:Amporndanai, K, Hasnain, S.S.
Deposit date:2021-12-16
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Disease Onset and its course are delayed by on-target Cellular SOD1 Engagement of Organo-selenium drug compounds for Amyotrophic Lateral Sclerosis
To Be Published
7RH7
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BU of 7rh7 by Molmil
Mycobacterial CIII2CIV2 supercomplex, Telacebec (Q203) bound
Descriptor: (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ...
Authors:Di Trani, J.M, Yanofsky, D.J, Rubinstein, J.L.
Deposit date:2021-07-16
Release date:2021-08-04
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of mycobacterial CIII 2 CIV 2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203).
Elife, 10, 2021
7RH6
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BU of 7rh6 by Molmil
Mycobacterial CIII2CIV2 supercomplex, inhibitor free, -Lpqe cyt cc open
Descriptor: (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ...
Authors:Di Trani, J.M, Yanofsky, D.J, Rubinstein, J.L.
Deposit date:2021-07-16
Release date:2021-08-04
Last modified:2021-11-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of mycobacterial CIII 2 CIV 2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203).
Elife, 10, 2021
7RH5
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BU of 7rh5 by Molmil
Mycobacterial CIII2CIV2 supercomplex, Inhibitor free
Descriptor: (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ...
Authors:Di Trani, J.M, Yanofsky, D.J, Rubinstein, J.L.
Deposit date:2021-07-16
Release date:2021-08-04
Last modified:2021-11-10
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of mycobacterial CIII 2 CIV 2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203).
Elife, 10, 2021
7NXX
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BU of 7nxx by Molmil
Structure of Superoxide Dismutase 1 (SOD1) in complex with nanobody 2 (Nb2).
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION, ...
Authors:Gallardo, R, Rousseau, F, Schymkowitz, J, Ulens, C.
Deposit date:2021-03-19
Release date:2022-09-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.189 Å)
Cite:Identification and rational improvement of a nanobody that suppresses aggregation of mutant SOD1
To Be Published
7FB9
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BU of 7fb9 by Molmil
Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1)
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Baek, Y, Ha, N.-C.
Deposit date:2021-07-08
Release date:2022-10-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation.
Commun Biol, 5, 2022
7FB6
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BU of 7fb6 by Molmil
C57D/C146D mutant of Human Cu, Zn Superoxide Dismutase (SOD1)
Descriptor: CHLORIDE ION, COPPER (II) ION, Superoxide dismutase [Cu-Zn], ...
Authors:Baek, Y, Ha, N.-C.
Deposit date:2021-07-08
Release date:2022-10-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation.
Commun Biol, 5, 2022
7CJW
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BU of 7cjw by Molmil
Solution structure of monomeric superoxide dismutase 1 with an additional mutation H46W in a crowded environment
Descriptor: Monomeric Human Cu,Zn Superoxide dismutase
Authors:Iwakawa, N, Morimoto, D, Walinda, E, Danielsson, J, Shirakawa, M, Sugase, K.
Deposit date:2020-07-14
Release date:2021-05-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 beta-Barrel.
J.Phys.Chem.B, 125, 2021

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PDB entries from 2024-03-27

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