121P
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STRUKTUR UND GUANOSINTRIPHOSPHAT-HYDROLYSEMECHANISMUS DES C-TERMINAL VERKUERZTEN MENSCHLICHEN KREBSPROTEINS P21-H-RAS
Descriptor:H-RAS P21 PROTEIN COMPLEX WITH GUANOSINE-5'-[B,G-METHYLENE] TRIPHOSPHATE
Authors:Krengel, U., Scheffzek, K., Scherer, A., Kabsch, W., Wittinghofer, A., Pai, E.F.
Deposit date:1991-06-06
Release date:1994-01-31
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Struktur Und Guanosintriphosphat-Hydrolysemechanismus Des C-Terminal Verkuerzten Menschlichen Krebsproteins P21-H-Ras
Thesis, 1991
1A2B
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HUMAN RHOA COMPLEXED WITH GTP ANALOGUE
Descriptor:TRANSFORMING PROTEIN RHOA, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Ihara, K., Muraguchi, S., Kato, M., Shimizu, T., Shirakawa, M., Kuroda, S., Kaibuchi, K., Hakoshima, T.
Deposit date:1997-12-26
Release date:1998-06-17
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.
J.Biol.Chem., 273, 1998
1A4R
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G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM
Descriptor:G25K GTP-BINDING PROTEIN, GUANOSINE-5'-DIPHOSPHATE, AMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Rudolph, M.G., Vetter, I.R., Wittinghofer, A.
Deposit date:1998-02-02
Release date:1999-03-02
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.
Protein Sci., 8, 1999
1AA9
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HUMAN C-HA-RAS(1-171)(DOT)GDP, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:C-HA-RAS, GUANOSINE-5'-DIPHOSPHATE
Authors:Ito, Y., Yamasaki, Y., Muto, Y., Kawai, G., Nishimura, S., Miyazawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1997-01-27
Release date:1997-07-29
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein.
Biochemistry, 36, 1997
1AGP
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THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLY-12 MUTANT OF P21-H-RAS
Descriptor:C-H-RAS P21 PROTEIN MUTANT WITH GLY 12 REPLACED BY ASP (G12D) COMPLEXED WITH GUANOSINE-5'-[B,G-IMIDO] TRIPHOSPHATE
Authors:Franken, S.M., Scheidig, A.J., Wittinghofer, A., Goody, R.S.
Deposit date:1993-03-29
Release date:1994-04-30
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras.
Biochemistry, 32, 1993
1AJE
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CDC42 FROM HUMAN, NMR, 20 STRUCTURES
Descriptor:CDC42HS
Authors:Feltham, J.L., Dotsch, V., Raza, S., Manor, D., Cerione, R.A., Sutcliffe, M.J., Wagner, G., Oswald, R.E.
Deposit date:1997-05-02
Release date:1997-11-12
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Definition of the switch surface in the solution structure of Cdc42Hs.
Biochemistry, 36, 1997
1AN0
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CDC42HS-GDP COMPLEX
Descriptor:CDC42HS-GDP, GUANOSINE-5'-DIPHOSPHATE
Authors:Kongsaeree, P., Cerione, R., Clardy, J.
Deposit date:1997-06-26
Release date:1999-01-13
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure Determination of Cdc42Hs and Gdp Complex
To be Published
1BYU
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CANINE GDP-RAN
Descriptor:PROTEIN (RAN)
Authors:Stewart, M., Kent, H.M., Mccoy, A.J.
Deposit date:1998-10-18
Release date:1998-12-02
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2).
J.Mol.Biol., 284, 1998
1CEE
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SOLUTION STRUCTURE OF CDC42 IN COMPLEX WITH THE GTPASE BINDING DOMAIN OF WASP
Descriptor:GTP-BINDING RHO-LIKE PROTEIN, WASP PROTEIN COMPLEX
Authors:Abdul-Manan, N., Aghazadeh, B., Liu, G.A., Majumdar, A., Ouerfelli, O., Rosen, M.K.
Deposit date:1999-03-08
Release date:1999-06-30
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein.
Nature, 399, 1999
1CF4
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CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX
Descriptor:CDC42 HOMOLOG, ACTIVATED P21CDC42HS KINASE
Authors:Mott, H.R., Owen, D., Nietlispach, D., Lowe, P.N., Lim, L., Laue, E.D.
Deposit date:1999-03-23
Release date:1999-06-18
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.
Nature, 399, 1999
1CLU
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H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP
Descriptor:TRANSFORMING PROTEIN P21/H-RAS-1
Authors:Ahmadian, M.R., Zor, T., Vogt, D., Kabsch, W., Selinger, Z., Wittinghofer, A., Scheffzek, K.
Deposit date:1999-05-03
Release date:1999-05-28
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Proc.Natl.Acad.Sci.USA, 96, 1999
1CRP
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THE SOLUTION STRUCTURE AND DYNAMICS OF RAS P21. GDP DETERMINED BY HETERONUCLEAR THREE AND FOUR DIMENSIONAL NMR SPECTROSCOPY
Descriptor:C-H-RAS P21 PROTEIN (CATALYTIC DOMAIN, RESIDUES 1 - 166) COMPLEXED WITH GDP AND MG (NMR, FIRST 20 STRUCTURES)
Authors:Kraulis, P.J., Domaille, P.J., Campbell-Burk, S.L., Van Aken, T., Laue, E.D.
Deposit date:1993-11-24
Release date:1994-07-31
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy.
Biochemistry, 33, 1994
1CRQ
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THE SOLUTION STRUCTURE AND DYNAMICS OF RAS P21. GDP DETERMINED BY HETERONUCLEAR THREE AND FOUR DIMENSIONAL NMR SPECTROSCOPY
Descriptor:C-H-RAS P21 PROTEIN (CATALYTIC DOMAIN, RESIDUES 1 - 166) COMPLEXED WITH GDP AND MG (NMR, RESTRAINED MINIMIZED AVERAGE)
Authors:Kraulis, P.J., Domaille, P.J., Campbell-Burk, S.L., Van Aken, T., Laue, E.D.
Deposit date:1993-11-24
Release date:1994-07-31
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy.
Biochemistry, 33, 1994
1CRR
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THE SOLUTION STRUCTURE AND DYNAMICS OF RAS P21. GDP DETERMINED BY HETERONUCLEAR THREE AND FOUR DIMENSIONAL NMR SPECTROSCOPY
Descriptor:C-H-RAS P21 PROTEIN (CATALYTIC DOMAIN, RESIDUES 1 - 166) COMPLEXED WITH GDP AND MG (NMR, FINAL 20 STRUCTURES)
Authors:Kraulis, P.J., Domaille, P.J., Campbell-Burk, S.L., Van Aken, T., Laue, E.D.
Deposit date:1993-11-24
Release date:1994-07-31
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy.
Biochemistry, 33, 1994
1CTQ
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STRUCTURE OF P21RAS IN COMPLEX WITH GPPNHP AT 100 K
Descriptor:PROTEIN (TRANSFORMING PROTEIN P21/H-RAS-1)
Authors:Scheidig, A., Burmester, C., Goody, R.S.
Deposit date:1999-08-20
Release date:1999-11-15
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins.
Structure Fold.Des., 7, 1999
1CXZ
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CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1
Descriptor:HUMAN RHOA COMPLEXED WITH KINASE PKN/PRK1
Authors:Maesaki, R., Ihara, K., Shimizu, T., Kuroda, S., Kaibuchi, K., Hakoshima, T.
Deposit date:1999-08-31
Release date:1999-10-08
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.
Mol.Cell, 4, 1999
1DPF
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CRYSTAL STRUCTURE OF A MG-FREE FORM OF RHOA COMPLEXED WITH GDP
Descriptor:CRYSTAL STRUCTURE OF A MG-FREE FORM OF RHOA COMPLEXED WITH GDP
Authors:Shimizu, T., Ihara, K., Maesaki, R., Kuroda, S., Kaibuchi, K., Hakoshima, T.
Deposit date:1999-12-27
Release date:2000-06-21
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism.
J.Biol.Chem., 275, 2000
1DS6
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CRYSTAL STRUCTURE OF A RAC-RHOGDI COMPLEX
Descriptor:RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
Authors:Scheffzek, K., Stephan, I., Jensen, O.N., Illenberger, D., Gierschik, P.
Deposit date:2000-01-07
Release date:2000-07-12
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.
Nat.Struct.Biol., 7, 2000
1E0A
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CDC42 COMPLEXED WITH THE GTPASE BINDING DOMAIN OF P21 ACTIVATED KINASE
Descriptor:G25K GTP-BINDING PROTEIN, PLACENTAL ISOFORM (GP), CDC42 HOMOLOG, SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA (E.C.2.7.1.-)
Authors:Morreale, A., Venkatesan, M., Mott, H.R., Owen, D., Nietlispach, D., Lowe, P.N., Laue, E.D.
Deposit date:2000-03-16
Release date:2000-04-18
Last modified:2014-02-05
Method:SOLUTION NMR
Cite:Solution Structure of Cdc42 Bound to the Gtpase Binding Domian of Pak
Nat.Struct.Biol., 7, 2000
1EES
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SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES
Descriptor:GTP-BINDING PROTEIN/P21-ACTIVATED KINASE
Authors:Gizachew, D., Guo, W., Chohan, K.C., Sutcliffe, M.J., Oswald, R.E.
Deposit date:2000-02-02
Release date:2000-03-29
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Structure of the complex of Cdc42Hs with a peptide derived from P-21 activated kinase.
Biochemistry, 39, 2000
1EK0
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GPPNHP-BOUND YPT51 AT 1.48 A RESOLUTION
Descriptor:GTP-BINDING PROTEIN YPT51
Authors:Esters, H., Scheidig, A.J.
Deposit date:2000-03-06
Release date:2000-04-17
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:High-resolution crystal structure of S. cerevisiae Ypt51(DeltaC15)-GppNHp, a small GTP-binding protein involved in regulation of endocytosis.
J.Mol.Biol., 298, 2000
1FTN
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CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX
Descriptor:TRANSFORMING PROTEIN RHOA (H12), GUANOSINE-5'-DIPHOSPHATE
Authors:Wei, Y., Zhang, Y., Derewenda, U., Liu, X., Minor, W., Nakamoto, R.K., Somlyo, A.V., Somlyo, A.P., Derewenda, Z.S.
Deposit date:1997-03-13
Release date:1998-03-18
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of RhoA-GDP and its functional implications.
Nat.Struct.Biol., 4, 1997
1G16
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CRYSTAL STRUCTURE OF SEC4-GDP
Descriptor:RAS-RELATED PROTEIN SEC4
Authors:Stroupe, C., Brunger, A.T.
Deposit date:2000-10-10
Release date:2000-12-11
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of a Rab protein in its inactive and active conformations.
J.Mol.Biol., 304, 2000
1G17
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CRYSTAL STRUCTURE OF SEC4-GUANOSINE-5'-(BETA,GAMMA)-IMIDOTRIPHOSPHATE
Descriptor:RAS-RELATED PROTEIN SEC4
Authors:Stroupe, C., Brunger, A.T.
Deposit date:2000-10-10
Release date:2000-12-11
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of a Rab protein in its inactive and active conformations.
J.Mol.Biol., 304, 2000
1GNP
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X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
Descriptor:C-H-RAS P21 PROTEIN COMPLEXED WITH 3'-O-(N-METHYL-ANTHRANILOYL-2'-DEOXYGUANOSINE-5'-[BETA,GAMMA-IMIDO]-TRIPHOSPHATE (RESIDUES 1 - 166)
Authors:Scheidig, A., Franken, S.M., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Pai, E.F., Goody, R.S.
Deposit date:1995-05-11
Release date:1995-07-31
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
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