1A06
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CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE
Authors:Kuriyan, J., Goldberg, J.
Deposit date:1997-12-09
Release date:1998-04-08
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I.
Cell(Cambridge,Mass.), 84, 1996
1A9U
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THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580
Descriptor:MAP KINASE P38, 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
Authors:Wang, Z., Canagarajah, B., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.
Deposit date:1998-04-10
Release date:1999-04-20
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1APM
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2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT
Descriptor:CAMP-DEPENDENT PROTEIN KINASE (E.C.2.7.1.37) (C/APK) (CATALYTIC SUBUNIT) "ALPHA" ISOENZYME MUTANT WITH SER 139 REPLACED BY ALA (S139A) COMPLEX WITH THE PEPTIDE INHIBITOR PKI(5-24) AND THE DETERGENT MEGA-8
Authors:Knighton, D.R., Bell, S.M., Zheng, J., Teneyck, L.F., Xuong, N.-H., Taylor, S.S., Sowadski, J.M.
Deposit date:1993-01-18
Release date:1993-04-15
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent.
Acta Crystallogr.,Sect.D, 49, 1993
1AQ1
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE
Descriptor:CYCLIN-DEPENDENT PROTEIN KINASE 2, STAUROSPORINE
Authors:Endicott, J.A., Noble, M.E.M., Johnson, L.N., Lawrie, A., Tunnah, P., Brown, N.R.
Deposit date:1997-08-05
Release date:1997-11-12
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Nat.Struct.Biol., 4, 1997
1ATP
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2.2 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH MNATP AND A PEPTIDE INHIBITOR
Descriptor:CAMP-DEPENDENT PROTEIN KINASE (E.C.2.7.1.37) (C/APK) (CATALYTIC SUBUNIT) COMPLEX WITH THE PEPTIDE INHIBITOR PKI(5-24) AND MNATP (A TERNARY COMPLEX OF CAPK)
Authors:Zheng, J., Trafny, E.A., Knighton, D.R., Xuong, N.-H., Taylor, S.S., Teneyck, L.F., Sowadski, J.M.
Deposit date:1993-01-08
Release date:1993-04-15
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor.
Acta Crystallogr.,Sect.D, 49, 1993
1B38
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HUMAN CYCLIN-DEPENDENT KINASE 2
Descriptor:CELL DIVISION PROTEIN KINASE 2
Authors:Brown, N.R., Noble, M.E.M., Lawrie, A.M., Morris, M.C., Tunnah, P., Divita, G., Johnson, L.N., Endicott, J.A.
Deposit date:1998-12-17
Release date:1998-12-23
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity.
J.Biol.Chem., 274, 1999
1B39
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HUMAN CYCLIN-DEPENDENT KINASE 2 PHOSPHORYLATED ON THR 160
Descriptor:CELL DIVISION PROTEIN KINASE 2
Authors:Brown, N.R., Noble, M.E.M., Lawrie, A.M., Morris, M.C., Tunnah, P., Divita, G., Johnson, L.N., Endicott, J.A.
Deposit date:1998-12-17
Release date:1998-12-23
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity.
J.Biol.Chem., 274, 1999
1BI7
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MECHANISM OF G1 CYCLIN DEPENDENT KINASE INHIBITION FROM THE STRUCTURE OF THE CDK6-P16INK4A TUMOR SUPPRESSOR COMPLEX
Descriptor:CYCLIN-DEPENDENT KINASE 6, MULTIPLE TUMOR SUPPRESSOR
Authors:Russo, A.A., Tong, L., Lee, J.O., Jeffrey, P.D., Pavletich, N.P.
Deposit date:1998-06-22
Release date:1999-01-13
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Nature, 395, 1998
1BKX
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A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND ADENOSINE FURTHER DEFINES CONFORMATIONAL FLEXIBILITY
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, ADENOSINE-5'-MONOPHOSPHATE
Authors:Narayana, N., Cox, S., Xuong, N., Ten Eyck, L.F., Taylor, S.S.
Deposit date:1997-07-01
Release date:1998-03-18
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility.
Structure, 5, 1997
1BL6
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THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995
Descriptor:PROTEIN (MAP KINASE P38) MUTANT (19 RESIDUES INSERTED AT N-TERMINUS)
Authors:Wang, Z., Canagarajah, B.J., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.
Deposit date:1998-07-11
Release date:1999-07-26
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1BL7
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THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025
Descriptor:PROTEIN (MAP KINASE P38) MUTANT (19 RESIDUES INSERTED AT N-TERMINUS)
Authors:Wang, Z., Canagarajah, B.J., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.
Deposit date:1998-07-23
Release date:1999-07-26
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1BMK
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THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655
Descriptor:PROTEIN (MAP KINASE P38) MUTANT (19 RESIDUES INSERTED AT N-TERMINUS)
Authors:Wang, Z., Canagarajah, B., Boehm, J.C., Kassis, S., Cobb, M.H., Young, P.R., Abdel-Meguid, S., Adams, J.L., Goldsmith, E.J.
Deposit date:1998-07-23
Release date:1999-07-23
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1BX6
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CRYSTAL STRUCTURE OF THE POTENT NATURAL PRODUCT INHIBITOR BALANOL IN COMPLEX WITH THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, BALANOL
Authors:Narayana, N., Xuong, N.-H., Ten Eyck, L.F., Taylor, S.S.
Deposit date:1998-10-13
Release date:1999-04-27
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase.
Biochemistry, 38, 1999
1CDK
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CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C
Descriptor:CAMP-DEPENDENT PROTEIN KINASE, PROTEIN KINASE INHIBITOR, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MYRISTIC ACID
Authors:Bossemeyer, D., Engh, R.A., Kinzel, V., Ponstingl, H., Huber, R.
Deposit date:1994-07-04
Release date:1995-10-15
Last modified:2012-08-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).
EMBO J., 12, 1993
1CKI
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RECOMBINANT CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317
Descriptor:CASEIN KINASE I DELTA
Authors:Longenecker, K.L., Roach, P.J., Hurley, T.D.
Deposit date:1995-08-25
Release date:1995-12-07
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.
J.Mol.Biol., 257, 1996
1CKJ
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CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317 COMPLEX WITH BOUND TUNGSTATE
Descriptor:RECOMBINANT CASEIN KINASE I DELTA
Authors:Longenecker, K.L., Roach, P.J., Hurley, T.D.
Deposit date:1995-08-25
Release date:1995-12-07
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.
J.Mol.Biol., 257, 1996
1CKP
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR PURVALANOL B
Descriptor:PROTEIN (CYCLIN-DEPENDENT PROTEIN KINASE 2) (2.7.1.37)
Authors:Gray, N.S., Thunnissen, A.M.W.H., Schultz, P.G., Kim, S.H.
Deposit date:1998-07-14
Release date:1999-01-13
Last modified:2010-03-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Science, 281, 1998
1CM8
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PHOSPHORYLATED MAP KINASE P38-GAMMA
Descriptor:MAP KINASE P38-GAMMA
Authors:Bellon, S., Fitzgibbon, M.J., Fox, T., Hsiao, H.M., Wilson, K.P.
Deposit date:1999-05-17
Release date:2000-05-17
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation.
Structure Fold.Des., 7, 1999
1CMK
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CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS
Descriptor:CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37)
Authors:Zheng, J., Knighton, D.R., Xuong, N.-H., Taylor, S.S., Sowadski, J.M., Ten Eyck, L.F.
Deposit date:1993-11-18
Release date:1994-05-31
Last modified:2012-08-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations.
Protein Sci., 2, 1993
1CSN
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BINARY COMPLEX OF CASEIN KINASE-1 WITH MGATP
Descriptor:CASEIN KINASE-1, ADENOSINE-5'-TRIPHOSPHATE
Authors:Xu, R.-M., Cheng, X.
Deposit date:1995-04-25
Release date:1995-07-31
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of casein kinase-1, a phosphate-directed protein kinase.
EMBO J., 14, 1995
1CTP
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STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION
Descriptor:CAMP-DEPENDENT PROTEIN KINASE (E.C.2.7.1.37) (CAPK) (CATALYTIC SUBUNIT)
Authors:Karlsson, R., Zheng, J., Xuong, N.H., Taylor, S.S., Sowadski, J.M.
Deposit date:1993-04-08
Release date:1994-01-31
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation.
Acta Crystallogr.,Sect.D, 49, 1993
1DAW
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CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP
Descriptor:PROTEIN KINASE CK2
Authors:Niefind, K., Puetter, M., Guerra, B., Issinger, O.G., Schomburg, D.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
1DAY
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CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP
Descriptor:PROTEIN KINASE CK2
Authors:Niefind, K., Puetter, M., Guerra, B., Issinger, O.G., Schomburg, D.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
1DI8
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THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE
Descriptor:CYCLIN-DEPENDENT KINASE 2 (E.C.2.7.1.-)
Authors:Shewchuk, L., Hassell, A., Kuyper, L.F.
Deposit date:1999-11-29
Release date:2000-11-29
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.
J.Med.Chem., 43, 2000
1DI9
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THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE
Descriptor:P38 KINASE (E.C.2.7.1.-)
Authors:Shewchuk, L., Hassell, A., Kuyper, L.F.
Deposit date:1999-11-29
Release date:2000-11-29
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.
J.Med.Chem., 43, 2000
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