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8W9J
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Crystal structure of human CLEC12A ectodomain complexed with 50C1 Fab
Descriptor: Anti-human CLEC12A antibody 50C1 heavy chain, Anti-human CLEC12A antibody 50C1 light chain, C-type lectin domain family 12 member A
Authors:Mori, S, Nagae, M, Yamasaki, S.
Deposit date:2023-09-05
Release date:2024-03-06
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands.
Int.Immunol., 2024
8W8T
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BU of 8w8t by Molmil
Crystal structure of human CLEC12A CRD
Descriptor: C-type lectin domain family 12 member A, SULFATE ION
Authors:Mori, S, Nagae, M, Yamasaki, S.
Deposit date:2023-09-04
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands.
Int.Immunol., 2024
8UMO
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BU of 8umo by Molmil
Murine CD94-NKG2A receptor in complex with Qa-1b presenting AMAPRTLLL
Descriptor: BROMIDE ION, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ...
Authors:MacLachlan, B.J, Rossjohn, J, Vivian, J.P.
Deposit date:2023-10-18
Release date:2024-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the murine CD94-NKG2A receptor in complex with Qa-1 b presenting an MHC-I leader peptide.
Febs J., 2023
8SE6
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NKG2D complexed with inhibitor 36
Descriptor: N-[(1S)-2-(dimethylamino)-2-oxo-1-{3-[3-(2,2,2-trifluoroethyl)azetidin-1-yl]phenyl}ethyl]-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, NKG2-D type II integral membrane protein, TETRAETHYLENE GLYCOL, ...
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2023-04-08
Release date:2023-10-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D).
Bioorg.Med.Chem.Lett., 96, 2023
8SE5
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NKG2D complexed with inhibitor 14
Descriptor: DI(HYDROXYETHYL)ETHER, N-{(1S)-2-[(1R,5S,6S)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, NKG2-D type II integral membrane protein, ...
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2023-04-08
Release date:2023-10-11
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D).
Bioorg.Med.Chem.Lett., 96, 2023
8JAH
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BU of 8jah by Molmil
Crystal structure of human CLEC12A C-type lectin domain
Descriptor: C-type lectin domain family 12 member A, POTASSIUM ION, SULFATE ION
Authors:Lei, Q, Tang, H, Dong, X.
Deposit date:2023-05-06
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Mechanistic insights into the C-type lectin receptor CLEC12A-mediated immune recognition of monosodium urate crystal.
J.Biol.Chem., 2024
8IVD
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BU of 8ivd by Molmil
COMPLEX STRUCTURE OF CD93-IGFBP7
Descriptor: Insulin-like growth factor-binding protein 7,Complement component C1q receptor
Authors:Xu, Y.M, Song, G.J.
Deposit date:2023-03-27
Release date:2024-01-17
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:structural insight into CD93 recognition by IGFBP7
To Be Published
8HGG
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BU of 8hgg by Molmil
Structure of 2:2 PAPP-A.ProMBP complex
Descriptor: Bone marrow proteoglycan, Pappalysin-1, ZINC ION
Authors:Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J.
Deposit date:2022-11-14
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.
Cell Discov, 8, 2022
8HBC
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Crystal structure of the CysR-CTLD3 fragment of human DEC205
Descriptor: Lymphocyte antigen 75
Authors:Kong, D, Yu, B, Hu, Z, Cheng, C, Cao, L, He, Y.
Deposit date:2022-10-28
Release date:2023-11-01
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Interaction of human dendritic cell receptor DEC205/CD205 with keratins.
J.Biol.Chem., 300, 2024
8HB5
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Crystal structure of Mincle in complex with HD-275
Descriptor: (2~{R},3~{R},4~{S},5~{S},6~{R})-6-(methoxymethyl)oxane-2,3,4,5-tetrol, C-type lectin domain family 4 member E, CALCIUM ION
Authors:Ishizuka, S, Nagae, M, Yamasaki, S.
Deposit date:2022-10-27
Release date:2023-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand.
Acs Cent.Sci., 9, 2023
8H4V
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Mincle CRD complex with PGL trisaccharide
Descriptor: (2~{R},3~{R},4~{S},5~{S},6~{R})-6-(methoxymethyl)oxane-2,3,4,5-tetrol-(1-4)-6-deoxy-2,3-di-O-methyl-alpha-L-mannopyranose-(1-2)-3-O-methyl-alpha-L-rhamnopyranose, C-type lectin domain family 4 member E, CALCIUM ION
Authors:Ishizuka, S, Nagae, M, Yamasaki, S.
Deposit date:2022-10-11
Release date:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand.
Acs Cent.Sci., 9, 2023
8G94
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Structure of CD69-bound S1PR1 coupled to heterotrimeric Gi
Descriptor: Early activation antigen CD69, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Chen, H, Li, X.
Deposit date:2023-02-21
Release date:2023-04-19
Last modified:2023-04-26
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Transmembrane protein CD69 acts as an S1PR1 agonist.
Elife, 12, 2023
8EAB
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BU of 8eab by Molmil
NKG2D complexed with inhibitor 4f
Descriptor: DI(HYDROXYETHYL)ETHER, N-[(1S)-2-oxo-1-[3-(trifluoromethyl)phenyl]-2-({4-[4-(trifluoromethyl)phenyl]pyridin-3-yl}amino)ethyl]-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-05-10
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EAA
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NKG2D complexed with inhibitor 4e
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, N-{(1S)-2-(dimethylamino)-1-[3-methyl-5-(trifluoromethyl)phenyl]-2-oxoethyl}-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, ...
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA9
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NKG2D complexed with inhibitor 4d
Descriptor: DI(HYDROXYETHYL)ETHER, N-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-(dimethylamino)-2-oxoethyl]-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein, ...
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-05-10
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA8
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NKG2D complexed with inhibitor 4a
Descriptor: DI(HYDROXYETHYL)ETHER, N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein, ...
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA7
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NKG2D complexed with inhibitor 3g
Descriptor: (4M)-N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4-(1-methyl-1H-pyrazol-5-yl)-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, DI(HYDROXYETHYL)ETHER, NKG2-D type II integral membrane protein
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-05-10
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA6
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NKG2D complexed with inhibitor 3e
Descriptor: N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, NKG2-D type II integral membrane protein
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8EA5
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NKG2D complexed with inhibitor 1a
Descriptor: (3S,5aS,8aR)-3-benzyl-6-[(3,5-dichlorophenyl)methyl]-1,4-dimethyloctahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione, NKG2-D type II integral membrane protein, TRIETHYLENE GLYCOL
Authors:Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S.
Deposit date:2022-08-28
Release date:2023-05-03
Last modified:2023-05-10
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc.Natl.Acad.Sci.USA, 120, 2023
8A59
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BU of 8a59 by Molmil
C-type lectin-like domain (CTLD) and Sushi-like domain of human CD93
Descriptor: Complement component C1q receptor, GLYCEROL, SULFATE ION
Authors:Tassone, G, Barbera, S, Raucci, L, Orlandini, M, Pozzi, C.
Deposit date:2022-06-14
Release date:2022-11-02
Last modified:2022-12-28
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Dimerization of the C-type lectin-like receptor CD93 promotes its binding to Multimerin-2 in endothelial cells.
Int.J.Biol.Macromol., 224, 2023
7YTQ
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BU of 7ytq by Molmil
Human langerin carbohydrate recognition domain in complex with an alpha-mannoside ligand
Descriptor: CALCIUM ION, CD207 molecule, CHLORIDE ION, ...
Authors:Wangkanont, K.
Deposit date:2022-08-16
Release date:2022-09-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Human langerin carbohydrate recognition domain in complex with an alpha-mannoside ligand
To Be Published
7Y5N
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Structure of 1:1 PAPP-A.ProMBP complex(half map)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone marrow proteoglycan, ...
Authors:Zhong, Q.H, Chu, H.L, Wang, G.P, Zhang, C, Wei, Y, Qiao, J, Hang, J.
Deposit date:2022-06-17
Release date:2023-01-11
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2.
Cell Discov, 8, 2022
7XMP
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BU of 7xmp by Molmil
High resolution structure of lectin-like Ox-LDL receptor 1 in space group P 32 2 1
Descriptor: Oxidized low-density lipoprotein receptor 1
Authors:Tomar, A, Varughese, K.I, Arockiasamy, A.
Deposit date:2022-04-26
Release date:2023-05-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:High resolution structure of lectin like Ox-LDL receptor 1 in space group P 32 2 1
To Be Published
7WZ8
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Structure of human langerin complex in Birbeck granules
Descriptor: SNAP-tag,C-type lectin domain family 4 member K
Authors:Oda, T, Yanagisawa, H.
Deposit date:2022-02-17
Release date:2022-06-22
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation.
Elife, 11, 2022
7W5D
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High resolution structure of lectin-ike Ox-LDL Receptor 1
Descriptor: Oxidized low-density lipoprotein receptor 1
Authors:Tomar, A, Arockiasamy, A.
Deposit date:2021-11-30
Release date:2022-12-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.141 Å)
Cite:High Resolution Structure of Lectin-Like Ox-LDL Receptor 1
To Be Published

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PDB entries from 2024-03-27

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