Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8UF7
DownloadVisualize
BU of 8uf7 by Molmil
Cryo-EM structure of POmAb, a Type-I anti-prothrombin antiphospholipid antibody, bound to kringle-1 of human prothrombin
Descriptor: POmAb Heavy Chain, POmAb Light Chain, Prothrombin
Authors:Kumar, S, Summers, B, Basore, K, Pozzi, N.
Deposit date:2023-10-03
Release date:2024-02-14
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure and functional basis of prothrombin recognition by a Type-I anti-prothrombin antiphospholipid antibody.
Blood, 2024
7TPP
DownloadVisualize
BU of 7tpp by Molmil
Cryo-em structure of human prothrombin:prothrombinase at 4.1 Angstrom resolution
Descriptor: Activated factor Xa heavy chain, Coagulation factor Va, Factor X light chain, ...
Authors:Di Cera, E, Ruben, E.A.
Deposit date:2022-01-25
Release date:2022-05-04
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of the prothrombin-prothrombinase complex.
Blood, 139, 2022
7TNG
DownloadVisualize
BU of 7tng by Molmil
Kringle domain of human Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1)
Descriptor: Inactive tyrosine-protein kinase transmembrane receptor ROR1
Authors:Guarino, S.R, Di Bello, A, Palamini, M, Forneris, F.
Deposit date:2022-01-21
Release date:2022-05-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1)
Acta Crystallogr.,Sect.F, 78, 2022
7MOA
DownloadVisualize
BU of 7moa by Molmil
Cryo-EM structure of the c-MET II/HGF I complex bound with HGF II in a rigid conformation
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C.
Deposit date:2021-05-01
Release date:2021-06-09
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
7MOB
DownloadVisualize
BU of 7mob by Molmil
Cryo-EM structure of 2:2 c-MET/NK1 complex
Descriptor: Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C.
Deposit date:2021-05-01
Release date:2021-06-09
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
7MO8
DownloadVisualize
BU of 7mo8 by Molmil
Cryo-EM structure of 1:1 c-MET I/HGF I complex after focused 3D refinement of holo-complex
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C.
Deposit date:2021-05-01
Release date:2021-06-09
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
7MO7
DownloadVisualize
BU of 7mo7 by Molmil
Cryo-EM structure of 2:2 c-MET/HGF holo-complex
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C.
Deposit date:2021-05-01
Release date:2021-06-09
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
7MO9
DownloadVisualize
BU of 7mo9 by Molmil
Cryo-EM map of the c-MET II/HGF I/HGF II (K4 and SPH) sub-complex
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C.
Deposit date:2021-05-01
Release date:2021-06-09
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
7OCM
DownloadVisualize
BU of 7ocm by Molmil
K1K1H6, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hepatocyte growth factor alpha chain,Hepatocyte growth factor alpha chain
Authors:de Jonge, H, de Nola, G, Gherardi, E.
Deposit date:2021-04-27
Release date:2021-07-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist.
Life Sci Alliance, 5, 2022
7OCL
DownloadVisualize
BU of 7ocl by Molmil
K1K1, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic
Descriptor: Hepatocyte growth factor alpha chain,Hepatocyte growth factor alpha chain
Authors:de Jonge, H, de Nola, G, Gherardi, E.
Deposit date:2021-04-27
Release date:2021-07-21
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist.
Life Sci Alliance, 5, 2022
7ME4
DownloadVisualize
BU of 7me4 by Molmil
Structure of the extracellular WNT-binding module in Drosophila Ror2/Nrk
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITOLEIC ACID, Tyrosine-protein kinase transmembrane receptor Ror2
Authors:Mendrola, J.M, Shi, F, Perry, K, Stayrook, S.E, Lemmon, M.A.
Deposit date:2021-04-06
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes.
Cell Rep, 37, 2021
7BZT
DownloadVisualize
BU of 7bzt by Molmil
Cryo-EM structure of mature Coxsackievirus A10 in complex with KRM1 at pH 7.4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein VP1, Capsid protein VP2, ...
Authors:Cui, Y, Peng, R, Song, H, Tong, Z, Gao, G.F, Qi, J.
Deposit date:2020-04-28
Release date:2020-07-22
Last modified:2020-08-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1.
Proc.Natl.Acad.Sci.USA, 117, 2020
7BZU
DownloadVisualize
BU of 7bzu by Molmil
Cryo-EM structure of mature Coxsackievirus A10 in complex with KRM1 at pH 5.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein VP1, Capsid protein VP2, ...
Authors:Cui, Y, Peng, R, Song, H, Tong, Z, Gao, G.F, Qi, J.
Deposit date:2020-04-28
Release date:2020-07-22
Last modified:2020-08-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1.
Proc.Natl.Acad.Sci.USA, 117, 2020
6LZ9
DownloadVisualize
BU of 6lz9 by Molmil
t8E4 antibody Fab complexed with the active form of HGF
Descriptor: Heavy chain of t8E4 Fab fragment, Hepatocyte growth factor, Light chain of t8E4 Fab fragment
Authors:Kitago, Y, Umitsu, M, Takagi, J.
Deposit date:2020-02-18
Release date:2020-03-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:t8E4 antibody Fab complexed with the active form of HGF
To Be Published
6UZ4
DownloadVisualize
BU of 6uz4 by Molmil
Solution structure of AGL55-Kringle 2 complex
Descriptor: M protein, Plasminogen
Authors:Qiu, C, Yuan, Y, Castellino, F.J.
Deposit date:2019-11-14
Release date:2020-12-09
Method:SOLUTION NMR
Cite:Structural evolution of the A-domain in plasminogen-binding Group A streptococcal M-protein reflects improved adaptability of the pathogen to the host
To Be Published
6UZ5
DownloadVisualize
BU of 6uz5 by Molmil
Solution structure of KTI55-Kringle 2 complex
Descriptor: M protein, Plasminogen
Authors:Qiu, C, Yuan, Y, Castellino, F.J.
Deposit date:2019-11-14
Release date:2020-12-09
Method:SOLUTION NMR
Cite:Structural evolution of the A-domain in plasminogen-binding Group A streptococcal M-protein reflects improved adaptability of the pathogen to the host
To Be Published
6SNW
DownloadVisualize
BU of 6snw by Molmil
Structure of Coxsackievirus A10 complexed with its receptor KREMEN1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein VP1, Capsid protein VP3, ...
Authors:Zhao, Y, Zhou, D, Ni, T, Karia, D, Kotecha, A, Wang, X, Rao, Z, Jones, E.Y, Fry, E.E, Ren, J, Stuart, D.I.
Deposit date:2019-08-27
Release date:2020-01-15
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10.
Nat Commun, 11, 2020
6PX5
DownloadVisualize
BU of 6px5 by Molmil
CRYSTAL STRUCTURE OF HUMAN MEIZOTHROMBIN DESF1 MUTANT S195A bound with PPACK
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Prothrombin, ...
Authors:Pelc, L.A, Koester, S.K, Chen, Z, Gistover, N, Di Cera, E.
Deposit date:2019-07-24
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin.
Sci Rep, 9, 2019
6RX7
DownloadVisualize
BU of 6rx7 by Molmil
Structure of the KIV type 2 (KIV-2) domain of lipoprotein (a)
Descriptor: Apolipoprotein(a), GLYCEROL, SULFATE ION
Authors:Santonastaso, A, Maggi, M, Scotti, C.
Deposit date:2019-06-07
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:High resolution structure of human apolipoprotein (a) kringle IV type 2: beyond the lysine binding site.
J.Lipid Res., 61, 2020
6OSV
DownloadVisualize
BU of 6osv by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: Antibody heavy chain variable region, Antibody light chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-02
Release date:2020-04-01
Last modified:2020-05-13
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSH
DownloadVisualize
BU of 6osh by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: Antibody Light chain variable region, Antibody heavy chain variable region, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-01
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.117 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OSN
DownloadVisualize
BU of 6osn by Molmil
Potent and Selective Antitumor Antibody Targeting a Membrane-Proximal Epitope of ROR2
Descriptor: ACETATE ION, Tyrosine-protein kinase transmembrane receptor ROR2
Authors:Park, H, Rader, C.
Deposit date:2019-05-01
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.083 Å)
Cite:Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
J.Biol.Chem., 295, 2020
6OQJ
DownloadVisualize
BU of 6oqj by Molmil
SOLUTION STRUCTURE OF THE COMPLEX OF MUTANT VEK50[RH1/AA] AND PLASMINOGEN KRINGLE 2
Descriptor: Plasminogen kringle 2, Plasminogen-binding group A streptococcal M-like protein PAM
Authors:Yuan, Y, Castellino, F.J.
Deposit date:2019-04-26
Release date:2019-07-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.
J.Struct.Biol., 208, 2019
6OQK
DownloadVisualize
BU of 6oqk by Molmil
SOLUTION STRUCTURE OF THE COMPLEX OF MUTANT VEK50[RH2/AA] AND PLASMINOGEN KRINGLE 2
Descriptor: Plasminogen Kringle 2, Plasminogen-binding group A streptococcal M-like protein PAM
Authors:Yuan, Y, Castellino, F.J.
Deposit date:2019-04-26
Release date:2019-07-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.
J.Struct.Biol., 208, 2019
6OG4
DownloadVisualize
BU of 6og4 by Molmil
plasminogen binding group A streptococcal M protein
Descriptor: Plasminogen, Plasminogen-binding group A streptococcal M-like protein PAM, SULFATE ION
Authors:Law, R.H.P, Quek, A.J, Whisstock, J.C, Caradoc-Davies, T.T.
Deposit date:2019-04-01
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding.
J.Mol.Biol., 431, 2019

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon