1BQT
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THREE-DIMENSIONAL STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DETERMINED BY 1H-NMR AND DISTANCE GEOMETRY, 6 STRUCTURES
Descriptor:INSULIN-LIKE GROWTH FACTOR-I
Authors:Sato, A., Nishimura, S., Ohkubo, T., Kyogoku, Y., Koyama, S., Kobayashi, M., Yasuda, T., Kobayashi, Y.
Deposit date:1998-08-18
Release date:1999-05-18
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Three-dimensional structure of human insulin-like growth factor-I (IGF-I) determined by 1H-NMR and distance geometry.
Int.J.Pept.Protein Res., 41, 1993
1GZR
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HUMAN INSULIN-LIKE GROWTH FACTOR; ESRF DATA
Descriptor:INSULIN-LIKE GROWTH FACTOR I
Authors:Brzozowski, A.M., Dodson, E.J., Dodson, G.G., Murshudov, G., Verma, C., Turkenburg, J.P., De Bree, F.M., Dauter, Z.
Deposit date:2002-05-28
Release date:2002-07-25
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
Biochemistry, 41, 2002
1GZY
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HUMAN INSULIN-LIKE GROWTH FACTOR; IN-HOUSE DATA
Descriptor:INSULIN-LIKE GROWTH FACTOR I
Authors:Brzozowski, A.M., Dodson, E.J., Dodson, G.G., Murshudov, G., Verma, C., Turkenburg, J.P., De Bree, F.M., Dauter, Z.
Deposit date:2002-06-10
Release date:2002-07-25
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
Biochemistry, 41, 2002
1GZZ
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HUMAN INSULIN-LIKE GROWTH FACTOR; HAMBURG DATA
Descriptor:INSULIN-LIKE GROWTH FACTOR I
Authors:Brzozowski, A.M., Dodson, E.J., Dodson, G.G., Murshudov, G., Verma, C., Turkenburg, J.P., De Bree, F.M., Dauter, Z.
Deposit date:2002-06-10
Release date:2002-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
Biochemistry, 41, 2002
1H02
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HUMAN INSULIN-LIKE GROWTH FACTOR; SRS DARESBURY DATA
Descriptor:INSULIN-LIKE GROWTH FACTOR I
Authors:Brzozowski, A.M., Dodson, E.J., Dodson, G.G., Murshudov, G., Verma, C., Turkenburg, J.P., De Bree, F.M., Dauter, Z.
Deposit date:2002-06-11
Release date:2002-07-25
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin
Biochemistry, 41, 2002
1H59
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COMPLEX OF IGFBP-5 WITH IGF-I
Descriptor:INSULIN-LIKE GROWTH FACTOR IA, INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5
Authors:Zeslawski, W., Beisel, H.G., Kamionka, M., Kalus, W., Engh, R.A., Huber, R., Holak, T.A.
Deposit date:2001-05-21
Release date:2002-05-16
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Interaction of Insulin-Like Growth Factor-I with the N-Terminal Domain of Igfbp-5
Embo J., 20, 2001
1IGL
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SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR II RELATIONSHIP TO RECEPTOR AND BINDING PROTEIN INTERACTIONS
Descriptor:INSULIN-LIKE GROWTH FACTOR II (IGF-II, IGF-2) (NMR, 20 STRUCTURES)
Authors:Torres, A.M., Forbes, B.E., Aplin, S.E., Wallace, J.C., Francis, G.L., Norton, R.S.
Deposit date:1994-12-29
Release date:1995-02-14
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of human insulin-like growth factor II. Relationship to receptor and binding protein interactions.
J.Mol.Biol., 248, 1995
1IMX
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1.8 ANGSTROM CRYSTAL STRUCTURE OF IGF-1
Descriptor:Insulin-like Growth Factor-1
Authors:Vajdos, F.F., Ultsch, M., Schaffer, M.L., Deshayes, K.D., Liu, J., Skelton, N.J., de Vos, A.M.
Deposit date:2001-05-11
Release date:2001-09-05
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions.
Biochemistry, 40, 2001
1PMX
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INSULIN-LIKE GROWTH FACTOR-I BOUND TO A PHAGE-DERIVED PEPTIDE
Descriptor:INSULIN-LIKE GROWTH FACTOR IB/IGF-1 ANTAGONIST F1-1
Authors:Skelton, N.J.
Deposit date:2003-06-11
Release date:2003-10-21
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Complex with a Phage Display-Derived Peptide Provides Insight into the Function of Insulin-like Growth Factor I
Biochemistry, 42, 2003
2GF1
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SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY
Descriptor:INSULIN-LIKE GROWTH FACTOR (NMR, MINIMUM AVERAGE STRUCTURE)
Authors:Cooke, R.M., Harvey, T.S., Campbell, I.D.
Deposit date:1991-01-23
Release date:1993-04-15
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.
Biochemistry, 30, 1991
2KQP
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NMR STRUCTURE OF PROINSULIN
Descriptor:Insulin
Authors:Yang, Y., Hua, Q.X., Mackin, R.B., Weiss, M.A.
Deposit date:2009-11-12
Release date:2010-01-26
Last modified:2010-05-05
Method:SOLUTION NMR
Cite:Solution structure of proinsulin: connecting domain flexibility and prohormone processing.
J.Biol.Chem., 285, 2010
2L29
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COMPLEX STRUCTURE OF E4 MUTANT HUMAN IGF2R DOMAIN 11 BOUND TO IGF-II
Descriptor:Insulin-like growth factor 2 receptor variant, Insulin-like growth factor II
Authors:Williams, C., Hoppe, H., Rezgui, D., Strickland, M., Frago, S., Ellis, R.Z., Wattana-Amorn, P., Prince, S.N., Zaccheo, O.J., Forbes, B., Jones, E.Y., Crump, M.P., Hassan, A.B.
Deposit date:2010-08-13
Release date:2012-02-15
Last modified:2012-12-12
Method:SOLUTION NMR
Cite:An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
3GF1
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SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY
Descriptor:INSULIN-LIKE GROWTH FACTOR (NMR, 10 STRUCTURES)
Authors:Cooke, R.M., Harvey, T.S., Campbell, I.D.
Deposit date:1991-01-24
Release date:1993-04-15
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.
Biochemistry, 30, 1991
3KR3
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CRYSTAL STRUCTURE OF IGF-II ANTIBODY COMPLEX
Descriptor:Crystal structure of IGF-II antibody complex
Authors:Peat, T.S., Newman, J., Adams, T.E.
Deposit date:2009-11-17
Release date:2010-06-16
Last modified:2010-07-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo.
Mol.Cancer Ther., 9, 2010
3LRI
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SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF LONG-[ARG(3)]INSULIN-LIKE GROWTH FACTOR-I
Descriptor:INSULIN-LIKE GROWTH FACTOR-1 IGF-I
Authors:Laajoki, L.G., Francis, G.L., Wallace, J.C., Carver, J.A., Keniry, M.A.
Deposit date:1999-04-13
Release date:2000-05-23
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I
J.Biol.Chem., 275, 2000
5L3L
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D11 BOUND IGF-II
Descriptor:Insulin-like growth factor II
Authors:Hexnerova, R.
Deposit date:2016-05-23
Release date:2016-08-10
Last modified:2016-10-19
Method:SOLUTION NMR
Cite:Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.
J.Biol.Chem., 291, 2016
5L3M
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D11 BOUND [S39_PQ]-IGF-II
Descriptor:Insulin-like growth factor II
Authors:Hexnerova, R.
Deposit date:2016-05-23
Release date:2016-08-10
Last modified:2016-10-19
Method:SOLUTION NMR
Cite:Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.
J.Biol.Chem., 291, 2016
5L3N
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D11 BOUND [N29, S39_PQ]-IGF-II
Descriptor:Insulin-like growth factor II
Authors:Hexnerova, R.
Deposit date:2016-05-23
Release date:2016-08-10
Last modified:2016-10-19
Method:SOLUTION NMR
Cite:Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain.
J.Biol.Chem., 291, 2016
4XSS
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INSULIN-LIKE GROWTH FACTOR I IN COMPLEX WITH SITE 1 OF A HYBRID INSULIN RECEPTOR / TYPE 1 INSULIN-LIKE GROWTH FACTOR RECEPTOR
Descriptor:Insulin-like growth factor I, Insulin receptor domains L1-CR, Insulin-like growth factor receptor alpha-CT peptide
Authors:Lawrence, C., Kong, G.K.-W., Menting, J.G., Lawrence, M.C.
Deposit date:2015-01-22
Release date:2015-06-10
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.
Structure, 23, 2015
1WQJ
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STRUCTURAL BASIS FOR THE REGULATION OF INSULIN-LIKE GROWTH FACTORS (IGFS) BY IGF BINDING PROTEINS (IGFBPS)
Descriptor:Insulin-like growth factor binding protein 4, Insulin-like growth factor IB
Authors:Siwanowicz, I., Popowicz, G.M., Wisniewska, M., Huber, R., Kuenkele, K.P., Lang, K., Engh, R.A., Holak, T.A.
Deposit date:2004-09-29
Release date:2005-03-01
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for the regulation of insulin-like growth factors by IGF binding proteins
Structure, 13, 2005
2DSP
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STRUCTURAL BASIS FOR THE INHIBITION OF INSULIN-LIKE GROWTH FACTORS BY IGF BINDING PROTEINS
Descriptor:Insulin-like growth factor-binding protein 4, Insulin-like growth factor IB
Authors:Sitar, T., Popowicz, G.M., Siwanowicz, I., Huber, R., Holak, T.A.
Deposit date:2006-07-05
Release date:2006-08-22
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2DSQ
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STRUCTURAL BASIS FOR THE INHIBITION OF INSULIN-LIKE GROWTH FACTORS BY IGF BINDING PROTEINS
Descriptor:Insulin-like growth factor-binding protein 4, Insulin-like growth factor IB, Insulin-like growth factor-binding protein 1
Authors:Sitar, T., Popowicz, G.M., Siwanowicz, I., Huber, R., Holak, T.A.
Deposit date:2006-07-05
Release date:2006-08-22
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2DSR
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STRUCTURAL BASIS FOR THE INHIBITION OF INSULIN-LIKE GROWTH FACTORS BY IGF BINDING PROTEINS
Descriptor:Insulin-like growth factor-binding protein 4, Insulin-like growth factor IB
Authors:Sitar, T., Popowicz, G.M., Siwanowicz, I., Huber, R., Holak, T.A.
Deposit date:2006-07-05
Release date:2006-08-22
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2V5P
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COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II
Descriptor:CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, INSULIN-LIKE GROWTH FACTOR II
Authors:Brown, J., Delaine, C., Zaccheo, O.J., Siebold, C., Gilbert, R.J., Van Boxel, G., Denley, A., Wallace, J.C., Hassan, A.B., Forbes, B.E., Jones, E.Y.
Deposit date:2007-07-06
Release date:2007-12-11
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structure and Functional Analysis of the Igf-II/Igf2R Interaction
Embo J., 27, 2008
3E4Z
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH INSULIN-LIKE GROWTH FACTOR II
Descriptor:Insulin-degrading enzyme, Insulin Growth Factor II
Authors:Guo, Q., Manolopoulou, M., Tang, W.-J.
Deposit date:2008-08-12
Release date:2009-08-18
Last modified:2010-02-09
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
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