4RBO
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CRYSTAL STRUCTURE OF A NANOG HOMEOBOX (NANOG) FROM HOMO SAPIENS AT 3.30 A RESOLUTION
Descriptor:5'-D(*CP*TP*TP*GP*AP*AP*TP*GP*GP*GP*CP*C)-3', 5'-D(*GP*GP*CP*CP*CP*AP*TP*TP*CP*AP*AP*G)-3', Putative homeobox protein NANOGP8
Authors:Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL)
Deposit date:2014-09-12
Release date:2014-10-01
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Proc.Natl.Acad.Sci.USA, 112, 2015
4RDU
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CRYSTAL STRUCTURE OF A DISTAL-LESS HOMEOBOX PROTEIN 5 (DLX5) FROM HOMO SAPIENS AT 1.85 A RESOLUTION
Descriptor:(DC)(DG)(DA)(DC)(DT)(DA)(DA)(DT)(DT)(DA)(DG)(DT)(DC)(DG), Homeobox protein DLX-5
Authors:Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL)
Deposit date:2014-09-19
Release date:2014-11-19
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of a distal-less homeobox protein 5 (Dlx5) from Homo sapiens at 1.85 A resolution
To be published
1AHD
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DETERMINATION OF THE NMR SOLUTION STRUCTURE OF AN ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX
Descriptor:DNA (5'-D(*CP*TP*CP*TP*AP*AP*TP*GP*GP*CP*TP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*AP*GP*CP*CP*AP*TP*TP*AP*GP*AP*G)-3'), Homeotic protein antennapedia
Authors:Billeter, M., Qian, Y.Q., Otting, G., Muller, M., Gehring, W.J., Wuthrich, K.
Deposit date:1993-04-02
Release date:1993-10-31
Last modified:2016-03-30
Method:SOLUTION NMR
Cite:Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex.
J.Mol.Biol., 234, 1993
1AKH
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MAT A1/ALPHA2/DNA TERNARY COMPLEX
Descriptor:DNA (5'-D(*TP*AP*CP*AP*TP*GP*TP*AP*AP*AP*AP*AP*TP*TP*TP*AP*C P*AP*TP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*GP*AP*TP*GP*TP*AP*AP*AP*TP*TP*TP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MATING-TYPE PROTEIN A-1), ...
Authors:Li, T., Jin, Y., Vershon, A.K., Wolberger, C.
Deposit date:1997-05-19
Release date:1998-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the MATa1/MATalpha2 homeodomain heterodimer in complex with DNA containing an A-tract.
Nucleic Acids Res., 26, 1998
1APL
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CRYSTAL STRUCTURE OF A MAT-ALPHA2 HOMEODOMAIN-OPERATOR COMPLEX SUGGESTS A GENERAL MODEL FOR HOMEODOMAIN-DNA INTERACTIONS
Descriptor:DNA (5'-D(*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*CP*AP*TP*TP*TP*AP*C P*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*GP*TP*AP*AP*AP*TP*GP*AP*AP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MAT-ALPHA2 HOMEODOMAIN)
Authors:Wolberger, C., Vershon, A.K., Liu, B., Johnson, A.D., Pabo, C.O.
Deposit date:1993-10-04
Release date:1993-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions.
Cell(Cambridge,Mass.), 67, 1991
1AU7
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PIT-1 MUTANT/DNA COMPLEX
Descriptor:CONSENSUS DNA 25-MER, DNA (5'-D(*CP*TP*TP*CP*CP*TP*CP*AP*TP*GP*TP*AP*TP*AP*TP*AP*C P*AP*TP*GP*AP*GP* GP*A)-3'), PROTEIN PIT-1
Authors:Jacobson, E.M., Li, P., Leon-Del-Rio, A., Rosenfeld, M.G., Aggarwal, A.K.
Deposit date:1997-09-12
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility.
Genes Dev., 11, 1997
1B72
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PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX
Descriptor:DNA (5'-D(*AP*CP*TP*CP*TP*AP*TP*GP*AP*TP*TP*GP*AP*TP*CP*GP*GP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*CP*CP*GP*AP*TP*CP*AP*AP*TP*CP*AP*TP*AP*GP*AP*G)-3'), PROTEIN (HOMEOBOX PROTEIN HOX-B1), ...
Authors:Piper, D.E., Batchelor, A.H., Chang, C.-P., Cleary, M.L., Wolberger, C.
Deposit date:1999-01-27
Release date:1999-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation.
Cell(Cambridge,Mass.), 96, 1999
1B8I
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STRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX
Descriptor:DNA (5'-D(*AP*CP*GP*TP*GP*AP*TP*TP*TP*AP*TP*GP*GP*CP*G)-3'), DNA (5'-D(*GP*TP*CP*GP*CP*CP*AP*TP*AP*AP*AP*TP*CP*AP*C)-3'), PROTEIN (HOMEOBOX PROTEIN EXTRADENTICLE), ...
Authors:Passner, J.M., Ryoo, H.-D., Shen, L., Mann, R.S., Aggarwal, A.K.
Deposit date:1999-02-01
Release date:1999-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex.
Nature, 397, 1999
1BW5
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THE NMR SOLUTION STRUCTURE OF THE HOMEODOMAIN OF THE RAT INSULIN GENE ENHANCER PROTEIN ISL-1, 50 STRUCTURES
Descriptor:INSULIN GENE ENHANCER PROTEIN ISL-1
Authors:Ippel, J.H., Larsson, G., Behravan, G., Zdunek, J., Lundqvist, M., Schleucher, J., Lycksell, P.-O., Wijmenga, S.S.
Deposit date:1998-09-29
Release date:1999-06-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of the homeodomain of the rat insulin-gene enhancer protein isl-1. Comparison with other homeodomains.
J.Mol.Biol., 288, 1999
1F43
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SOLUTION STRUCTURE OF THE MATA1 HOMEODOMAIN
Descriptor:MATING-TYPE PROTEIN A-1
Authors:Anderson, J.S., Forman, M., Modleski, S., Dahlquist, F.W., Baxter, S.M.
Deposit date:2000-06-07
Release date:2000-07-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Cooperative ordering in homeodomain-DNA recognition: solution structure and dynamics of the MATa1 homeodomain.
Biochemistry, 39, 2000
1FJL
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HOMEODOMAIN FROM THE DROSOPHILA PAIRED PROTEIN BOUND TO A DNA OLIGONUCLEOTIDE
Descriptor:DNA (5'-D(*AP*AP*TP*AP*AP*TP*CP*TP*GP*AP*TP*TP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*AP*AP*TP*CP*AP*GP*AP*TP*TP*AP*T)-3'), DNA (5'-D(*TP*GP*TP*AP*AP*TP*CP*TP*GP*AP*TP*TP*AP*C)-3'), ...
Authors:Wilson, D.S., Guenther, B., Desplan, C., Kuriyan, J.
Deposit date:1995-12-17
Release date:1996-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA.
Cell(Cambridge,Mass.), 82, 1995
1FTT
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THYROID TRANSCRIPTION FACTOR 1 HOMEODOMAIN (RATTUS NORVEGICUS)
Descriptor:THYROID TRANSCRIPTION FACTOR 1 HOMEODOMAIN
Authors:Fogolari, F., Esposito, G., Damante, G., Formisano, S., Di Lauro, R., Viglino, P.
Deposit date:1995-10-03
Release date:1996-01-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Analysis of the solution structure of the homeodomain of rat thyroid transcription factor 1 by 1H-NMR spectroscopy and restrained molecular mechanics.
Eur.J.Biochem., 241, 1996
1FTZ
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NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF THE FUSHI TARAZU HOMEODOMAIN FROM DROSOPHILA AND COMPARISON WITH THE ANTENNAPEDIA HOMEODOMAIN
Descriptor:FUSHI TARAZU PROTEIN
Authors:Qian, Y.Q., Furukubo-Tokunaga, K., Resendez-Perez, D., Muller, M., Gehring, W.J., Wuthrich, K.
Deposit date:1994-01-07
Release date:1994-05-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance solution structure of the fushi tarazu homeodomain from Drosophila and comparison with the Antennapedia homeodomain.
J.Mol.Biol., 238, 1994
1HDD
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CRYSTAL STRUCTURE OF AN ENGRAILED HOMEODOMAIN-DNA COMPLEX AT 2.8 ANGSTROMS RESOLUTION: A FRAMEWORK FOR UNDERSTANDING HOMEODOMAIN-DNA INTERACTIONS
Descriptor:DNA (5'-D(*AP*TP*TP*AP*GP*GP*TP*AP*AP*TP*TP*AP*CP*AP*TP*GP*G P*CP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*TP*AP*C P*CP*TP*AP*A)-3'), PROTEIN (ENGRAILED HOMEODOMAIN)
Authors:Kissinger, C.R., Liu, B., Martin-Blanco, E., Kornberg, T.B., Pabo, C.O.
Deposit date:1991-09-16
Release date:1992-01-15
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions.
Cell(Cambridge,Mass.), 63, 1990
1HDP
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SOLUTION STRUCTURE OF A POU-SPECIFIC HOMEODOMAIN: 3D-NMR STUDIES OF HUMAN B-CELL TRANSCRIPTION FACTOR OCT-2
Descriptor:OCT-2 POU HOMEODOMAIN
Authors:Sivaraja, M., Botfield, M.C., Mueller, M., Jancso, A., Weiss, M.A.
Deposit date:1994-03-08
Release date:1995-01-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a POU-specific homeodomain: 3D-NMR studies of human B-cell transcription factor Oct-2.
Biochemistry, 33, 1994
1HOM
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DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Descriptor:ANTENNAPEDIA PROTEIN
Authors:Qian, Y.-Q., Billeter, M., Otting, G., Muller, M., Gehring, W.J., Wuthrich, K.
Deposit date:1991-10-08
Release date:1993-10-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Determination of the three-dimensional structure of the Antennapedia homeodomain from Drosophila in solution by 1H nuclear magnetic resonance spectroscopy.
J.Mol.Biol., 214, 1990
1IC8
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HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT
Descriptor:5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*GP*A)-3', 5'-D(*TP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*G)-3', HEPATOCYTE NUCLEAR FACTOR 1-ALPHA
Authors:Chi, Y-.I., Frantz, J.D., Oh, B-.C., Hansen, L., Dhe-Paganon, S., Shoelson, S.E.
Deposit date:2001-03-30
Release date:2002-11-27
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Diabetes mutations delineate an atypical POU domains in HNF1-Alpha
Mol.Cell, 10, 2002
1IG7
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MSX-1 HOMEODOMAIN/DNA COMPLEX STRUCTURE
Descriptor:5'-D(*CP*AP*CP*TP*AP*AP*TP*TP*GP*AP*AP*GP*G)-3', 5'-D(P*TP*CP*CP*TP*TP*CP*AP*AP*TP*TP*AP*GP*TP*GP*AP*C)-3', Homeotic protein Msx-1
Authors:Hovde, S., Abate-Shen, C., Geiger, J.H.
Deposit date:2001-04-17
Release date:2001-04-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the Msx-1 homeodomain/DNA complex
Biochemistry, 40, 2001
1JGG
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EVEN-SKIPPED HOMEODOMAIN COMPLEXED TO AT-RICH DNA
Descriptor:5'-D(P*AP*AP*TP*TP*CP*AP*AP*TP*TP*A)-3', 5'-D(P*TP*AP*AP*TP*TP*GP*AP*AP*TP*T)-3', Segmentation Protein Even-Skipped
Authors:Hirsch, J.A., Aggarwal, A.K.
Deposit date:2001-06-25
Release date:2001-07-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity.
EMBO J., 14, 1995
1LE8
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CRYSTAL STRUCTURE OF THE MATA1/MATALPHA2-3A HETERODIMER BOUND TO DNA COMPLEX
Descriptor:5'-D(*AP*CP*AP*TP*GP*TP*AP*AP*AP*AP*AP*TP*TP*TP*AP*CP*AP*TP*CP*A)-3', 5'-D(*TP*TP*GP*AP*TP*GP*TP*AP*AP*AP*TP*TP*TP*TP*TP*AP*CP*AP*TP*G)-3', MATING-TYPE PROTEIN A-1, ...
Authors:Ke, A., Mathias, J.R., Vershon, A.K., Wolberger, C.
Deposit date:2002-04-09
Release date:2002-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Thermodynamic Characterization of the DNA Binding Properties of a Triple Alanine Mutant of MATalpha2
Structure, 10, 2002
1LFB
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THE X-RAY STRUCTURE OF AN ATYPICAL HOMEODOMAIN PRESENT IN THE RAT LIVER TRANSCRIPTION FACTOR LFB1(SLASH)HNF1 AND IMPLICATIONS FOR DNA BINDING
Descriptor:LIVER TRANSCRIPTION FACTOR (LFB1)
Authors:Ceska, T.A., Lamers, M., Monaci, P., Nicosia, A., Cortese, R., Suck, D.
Deposit date:1993-06-28
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The X-ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding.
EMBO J., 12, 1993
1LFU
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NMR SOLUTION STRUCTURE OF THE EXTENDED PBX HOMEODOMAIN BOUND TO DNA
Descriptor:5'-D(*GP*CP*GP*CP*AP*TP*GP*AP*TP*TP*GP*CP*CP*C)-3', 5'-D(*GP*GP*GP*CP*AP*AP*TP*CP*AP*TP*GP*CP*GP*C)-3', homeobox protein PBX1
Authors:Sprules, T., Green, N., Featherstone, M., Gehring, K.
Deposit date:2002-04-12
Release date:2003-01-14
Last modified:2017-02-01
Method:SOLUTION NMR
Cite:Lock and Key Binding of the HOX YPWM Peptide to the PBX Homeodomain
J.Biol.Chem., 278, 2003
1NK2
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VND/NK-2 HOMEODOMAIN/DNA COMPLEX, NMR, 20 STRUCTURES
Descriptor:DNA (5'-D(*AP*CP*AP*GP*CP*CP*AP*CP*TP*TP*GP*AP*CP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*GP*TP*CP*AP*AP*GP*TP*GP*GP*CP*TP*GP*T)-3'), HOMEOBOX PROTEIN VND
Authors:Gruschus, J.M., Tsao, D.H.H., Wang, L.-H., Nirenberg, M., Ferretti, J.A.
Deposit date:1998-05-06
Release date:1999-02-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Interactions of the vnd/NK-2 homeodomain with DNA by nuclear magnetic resonance spectroscopy: basis of binding specificity.
Biochemistry, 36, 1997
1NK3
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VND/NK-2 HOMEODOMAIN/DNA COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:DNA (5'-D(*AP*CP*AP*GP*CP*CP*AP*CP*TP*TP*GP*AP*CP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*GP*TP*CP*AP*AP*GP*TP*GP*GP*CP*TP*GP*T)-3'), HOMEOBOX PROTEIN VND
Authors:Gruschus, J.M., Tsao, D.H.H., Wang, L.-H., Nirenberg, M., Ferretti, J.A.
Deposit date:1998-05-06
Release date:1998-12-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Interactions of the vnd/NK-2 homeodomain with DNA by nuclear magnetic resonance spectroscopy: basis of binding specificity.
Biochemistry, 36, 1997
1OCP
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SOLUTION STRUCTURE OF OCT3 POU-HOMEODOMAIN
Descriptor:OCT-3
Authors:Morita, E.H., Hayashi, F., Shirakawa, M., Kyogoku, Y.
Deposit date:1995-02-21
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the Oct-3 POU-Homeodomain in Solution, as Determined by Triple Resonance Heteronuclear Multidimensional NMR Spectroscopy
Protein Sci., 4, 1995
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