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8FGX
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BU of 8fgx by Molmil
Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasma kallikrein light chain, STAR-0215 Heavy chain, ...
Authors:Fuller, J.R, Biris, N, Bista, P.
Deposit date:2022-12-13
Release date:2023-09-06
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (2.62 Å)
Cite:STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema.
J.Pharmacol.Exp.Ther., 387, 2023
7QOX
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BU of 7qox by Molmil
Factor XI and Plasma Kallikrein apple domain structures reveals different kininogen bound complexes
Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
Authors:Li, C, Awital, B, Wong, S, Dreveny, I, Meijers, J, Emsley, J.
Deposit date:2021-12-29
Release date:2023-01-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.
J Thromb Haemost, 17, 2019
7QOT
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BU of 7qot by Molmil
Factor XI and Plasma Kallikrein apple domain structures reveals different kininogen bound complexes
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XIa heavy chain, Kininogen-1 light chain, ...
Authors:Li, C, Awital, B, Wong, S, Dreveny, I, Meijers, J, Emsley, J.
Deposit date:2021-12-28
Release date:2023-01-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.
J Thromb Haemost, 17, 2019
7MOA
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BU of 7moa by Molmil
Cryo-EM structure of the c-MET II/HGF I complex bound with HGF II in a rigid conformation
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C.
Deposit date:2021-05-01
Release date:2021-06-09
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
7MOB
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BU of 7mob by Molmil
Cryo-EM structure of 2:2 c-MET/NK1 complex
Descriptor: Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C.
Deposit date:2021-05-01
Release date:2021-06-09
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
7MO8
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BU of 7mo8 by Molmil
Cryo-EM structure of 1:1 c-MET I/HGF I complex after focused 3D refinement of holo-complex
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C.
Deposit date:2021-05-01
Release date:2021-06-09
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
7MO7
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BU of 7mo7 by Molmil
Cryo-EM structure of 2:2 c-MET/HGF holo-complex
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C.
Deposit date:2021-05-01
Release date:2021-06-09
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
7MO9
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BU of 7mo9 by Molmil
Cryo-EM map of the c-MET II/HGF I/HGF II (K4 and SPH) sub-complex
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor
Authors:Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C.
Deposit date:2021-05-01
Release date:2021-06-09
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
6STX
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BU of 6stx by Molmil
Copper oxidase from Colletotrichum graminicola
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Kelch domain-containing protein, ...
Authors:Offen, W.A, Henrissat, B, Davies, G.J.
Deposit date:2019-09-12
Release date:2019-11-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of a Fungal Copper Radical Oxidase with High Catalytic Efficiency toward 5-Hydroxymethylfurfural and Benzyl Alcohols for Bioprocessing
Acs Catalysis, 2020
6RYV
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BU of 6ryv by Molmil
Copper oxidase from Colletotrichum graminicola
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, Kelch domain-containing protein, ...
Authors:Offen, W.A, Henrissat, B, Davies, G.J.
Deposit date:2019-06-12
Release date:2019-11-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a Fungal Copper Radical Oxidase with High Catalytic Efficiency toward 5-Hydroxymethylfurfural and Benzyl Alcohols for Bioprocessing
Acs Catalysis, 2020
6RYX
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BU of 6ryx by Molmil
Copper oxidase from Colletotrichum graminicola
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Offen, W.A, Henrissat, B, Davies, G.J.
Deposit date:2019-06-12
Release date:2019-11-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Discovery of a Fungal Copper Radical Oxidase with High Catalytic Efficiency toward 5-Hydroxymethylfurfural and Benzyl Alcohols for Bioprocessing
Acs Catalysis, 2020
6RYW
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BU of 6ryw by Molmil
Copper oxidase from Colletotrichum graminicola
Descriptor: COPPER (II) ION, Kelch domain-containing protein, TRIETHYLENE GLYCOL
Authors:Offen, W.A, Henrissat, B, Davies, G.J.
Deposit date:2019-06-12
Release date:2019-11-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of a Fungal Copper Radical Oxidase with High Catalytic Efficiency toward 5-Hydroxymethylfurfural and Benzyl Alcohols for Bioprocessing
Acs Catalysis, 2020
6O1G
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BU of 6o1g by Molmil
Full length human plasma kallikrein with inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(6-amino-2,4-dimethylpyridin-3-yl)methyl]-1-({4-[(1H-pyrazol-1-yl)methyl]phenyl}methyl)-1H-pyrazole-4-carboxamide, Plasma kallikrein
Authors:Partridge, J.R, Choy, R.M.
Deposit date:2019-02-19
Release date:2019-03-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition.
J.Struct.Biol., 206, 2019
6I58
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BU of 6i58 by Molmil
Allosteric activation of human prekallikrein by apple domain disc rotation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Li, C, Pathak, M, McCrae, K, Dreveny, I, Emsley, J.
Deposit date:2018-11-13
Release date:2019-03-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.
J.Thromb.Haemost., 17, 2019
6I44
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BU of 6i44 by Molmil
Allosteric activation of human prekallikrein by apple domain disc rotation
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
Authors:Li, C, Pathak, M, MaCrae, K, Dreveny, I, Emsley, J.
Deposit date:2018-11-09
Release date:2019-03-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.
J.Thromb.Haemost., 17, 2019
5I25
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BU of 5i25 by Molmil
human recombinant coagulation FXI in complex with a peptide derived from human high molecular weight kininogen (HKP)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ASN-PRO-ILE-SER-ASP-PHE-PRO-ASP, Coagulation factor XI
Authors:Hall, G.A.F, Wong, S.S, Emsley, J.
Deposit date:2016-02-08
Release date:2016-04-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.
Blood, 127, 2016
5EOD
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BU of 5eod by Molmil
Human Plasma Coagulation FXI with peptide LP2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XI, LP2
Authors:Wong, S.S, Ostergaard, S, Hall, G, Li, C, Williams, P.M, Stennicke, H, Emsley, J.
Deposit date:2015-11-10
Release date:2016-04-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.
Blood, 127, 2016
5EOK
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BU of 5eok by Molmil
Human Plasma Coagulation Factor XI in complex with peptide P39
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XI, ...
Authors:Wong, S.S, Ostergaard, S, Hall, G, Li, C, Williams, P.M, Stennicke, H, Emsley, J.
Deposit date:2015-11-10
Release date:2016-04-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.
Blood, 127, 2016
5CSQ
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BU of 5csq by Molmil
The structure of the NK1 fragment of HGF/SF complexed with MOPS
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Hepatocyte growth factor
Authors:Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E.
Deposit date:2015-07-23
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015
5CS9
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BU of 5cs9 by Molmil
The structure of the NK1 fragment of HGF/SF complexed with MES
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hepatocyte growth factor
Authors:Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E.
Deposit date:2015-07-23
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015
5CT1
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BU of 5ct1 by Molmil
The structure of the NK1 fragment of HGF/SF complexed with CHES
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Hepatocyte growth factor
Authors:Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E.
Deposit date:2015-07-23
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015
5CS1
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BU of 5cs1 by Molmil
The structure of the NK1 fragment of HGF/SF
Descriptor: Hepatocyte growth factor
Authors:Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E.
Deposit date:2015-07-23
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015
5CS5
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BU of 5cs5 by Molmil
The structure of the NK1 fragment of HGF/SF complexed with PIPES
Descriptor: Hepatocyte growth factor, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID)
Authors:Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E.
Deposit date:2015-07-23
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015
5CT2
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BU of 5ct2 by Molmil
The structure of the NK1 fragment of HGF/SF complexed with CAPS
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Hepatocyte growth factor
Authors:Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E.
Deposit date:2015-07-23
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015
5CT3
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BU of 5ct3 by Molmil
The structure of the NK1 fragment of HGF/SF complexed with 2FA
Descriptor: 3-hydroxypropane-1-sulfonic acid, Hepatocyte growth factor
Authors:Sigurdardottir, A.G, Winter, A, Sobkowicz, A, Fragai, M, Chirgadze, D.Y, Ascher, D.B, Blundell, T.L, Gherardi, E.
Deposit date:2015-07-23
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
Chem Sci, 6, 2015

 

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