2HGF
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HAIRPIN LOOP CONTAINING DOMAIN OF HEPATOCYTE GROWTH FACTOR, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:HEPATOCYTE GROWTH FACTOR
Authors:Zhou, H., Mazzulla, M.J., Kaufman, J.D., Stahl, S.J., Wingfield, P.T., Rubin, J.S., Bottaro, D.P., Byrd, R.A.
Deposit date:1997-12-18
Release date:1998-06-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site.
Structure, 6, 1998
2J8J
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SOLUTION STRUCTURE OF THE A4 DOMAIN OF BLOOD COAGULATION FACTOR XI
Descriptor:COAGULATION FACTOR XI
Authors:Samuel, D., Cheng, H., Riley, P.W., Canutescu, A.A., Bu, Z., Walsh, P.N., Roder, H.
Deposit date:2006-10-25
Release date:2007-10-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the A4 Domain of Factor Xi Sheds Light on the Mechanism of Zymogen Activation.
Proc.Natl.Acad.Sci.USA, 104, 2007
2J8L
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FXI APPLE 4 DOMAIN LOOP-OUT CONFORMATION
Descriptor:COAGULATION FACTOR XI
Authors:Samuel, D., Cheng, H., Riley, P.W., Canutescu, A.A., Bu, Z., Walsh, P.N., Roder, H.
Deposit date:2006-10-25
Release date:2007-10-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the A4 Domain of Factor Xi Sheds Light on the Mechanism of Zymogen Activation.
Proc.Natl.Acad.Sci.USA, 104, 2007
3HMR
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CRYSTAL STRUCTURE OF THE N-TERMINAL FRAGMENT (31-127) OF THE MOUSE HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR
Descriptor:Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HMS
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CRYSTAL CRYSTAL STRUCTURE OF THE N-TERMINAL FRAGMENT (28-126) OF THE HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR, ORTHORHOMBIC CRYSTAL FORM
Descriptor:Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HMT
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CRYSTAL STRUCTURE OF THE N-TERMINAL FRAGMENT (28-126) OF THE HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR, TRIGONAL CRYSTAL FORM
Descriptor:Hepatocyte growth factor
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
4A5V
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SOLUTION STRUCTURE ENSEMBLE OF THE TWO N-TERMINAL APPLE DOMAINS (RESIDUES 58-231) OF TOXOPLASMA GONDII MICRONEME PROTEIN 4
Descriptor:MICRONEMAL PROTEIN 4
Authors:Marchant, J., Cowper, B., Liu, Y., Lai, L., Pinzan, C., Marq, J.B., Friedrich, N., Sawmynaden, K., Chai, W., Childs, R.A., Saouros, S., Simpson, P., Barreira, M.C.R., Feizi, T., Soldati-Favre, D., Matthews, S.
Deposit date:2011-10-28
Release date:2012-04-04
Last modified:2012-05-23
Method:SOLUTION NMR
Cite:Galactose Recognition by the Apicomplexan Parasite Toxoplasma Gondii.
J.Biol.Chem., 287, 2012
1BHT
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NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR
Descriptor:HEPATOCYTE GROWTH FACTOR, SULFATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Ultsch, M.H., Lokker, N.A., Godowski, P.J., De Vos, A.M.
Deposit date:1998-06-10
Release date:1998-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution.
Structure, 6, 1998
1GMN
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CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR
Descriptor:HEPATOCYTE GROWTH FACTOR, 2-O-sulfo-alpha-L-idopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ...
Authors:Lietha, D., Chirgadze, D.Y., Mulloy, B., Blundell, T.L., Gherardi, E.
Deposit date:2001-09-19
Release date:2001-10-02
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor
Embo J., 20, 2001
1GMO
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CRYSTAL STRUCTURES OF NK1-HEPARIN COMPLEXES REVEAL THE BASIS FOR NK1 ACTIVITY AND ENABLE ENGINEERING OF POTENT AGONISTS OF THE MET RECEPTOR
Descriptor:HEPATOCYTE GROWTH FACTOR, 2-O-sulfo-alpha-L-idopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ...
Authors:Lietha, D., Chirgadze, D.Y., Mulloy, B., Blundell, T.L., Gherardi, E.
Deposit date:2001-09-20
Release date:2001-10-02
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor
Embo J., 20, 2001
1GP9
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A NEW CRYSTAL FORM OF THE NK1 SPLICE VARIANT OF HGF/SF DEMONSTRATES EXTENSIVE HINGE MOVEMENT AND SUGGESTS THAT THE NK1 DIMER ORIGINATES BY DOMAIN SWAPPING
Descriptor:HEPATOCYTE GROWTH FACTOR, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Watanabe, K., Chirgadze, D.Y., Lietha, D., Gherardi, E., Blundell, T.L.
Deposit date:2001-10-31
Release date:2001-11-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A New Crystal Form of the Nk1 Splice Variant of Hgf/Sf Demonstrates Extensive Hinge Movement and Suggests that the Nk1 Dimer Originates by Domain Swapping
J.Mol.Biol., 319, 2002
1NK1
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NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (HGF/SF) AT 2.5 ANGSTROM RESOLUTION
Descriptor:PROTEIN (HEPATOCYTE GROWTH FACTOR PRECURSOR)
Authors:Chirgadze, D.Y., Hepple, J.P., Zhou, H., Byrd, R.A., Blundell, T.L., Gherardi, E.
Deposit date:1998-08-20
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding.
Nat.Struct.Biol., 6, 1999
2F83
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CRYSTAL STRUCTURE AT 2.9 ANGSTROMS RESOLUTION OF HUMAN PLASMA COAGULATION FACTOR XI ZYMOGEN
Descriptor:Coagulation factor XI, N-ACETYL-D-GLUCOSAMINE, PLATINUM (II) ION
Authors:Papagrigoriou, E., McEwan, P.A., Walsh, P.N., Emsley, J.
Deposit date:2005-12-01
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Crystal structure of the factor XI zymogen reveals a pathway for transactivation.
Nat.Struct.Mol.Biol., 13, 2006
2QJ2
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A MECHANISTIC BASIS FOR CONVERTING A RECEPTOR TYROSINE KINASE AGONIST TO AN ANTAGONIST
Descriptor:Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D., Daugherty, J., Gao, C.-F., Xe, Q., Miranti, C., Gherardi, E., Vande Woude, G., Xu, H.E.
Deposit date:2007-07-06
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QJ4
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A MECHANISTIC BASIS FOR CONVERTING A RECEPTOR TYROSINE KINASE AGONIST TO AN ANTAGONIST
Descriptor:Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D., Daugherty, J., Gao, C.-F., Xe, Q., Miranti, C., Gherardi, E., Vande Woude, G., Xu, H.E.
Deposit date:2007-07-06
Release date:2007-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Proc.Natl.Acad.Sci.Usa, 104, 2007
2YIL
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CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS LECTIN SML-2
Descriptor:MICRONEME ANTIGEN L2, CHLORIDE ION, GLYCEROL, ...
Authors:Mueller, J.J., Weiss, M.S., Heinemann, U.
Deposit date:2011-05-16
Release date:2011-11-02
Last modified:2011-11-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pan-Modular Structure of Microneme Protein Sml-2 from Parasite Sarcocystis Muris at 1.95 A Resolution and its Complex with 1-Thio-Beta-D-Galactose.
Acta Crystallogr.,Sect.D, D67, 2011
2YIO
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CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS MICRONEME PROTEIN SML- 2 IN COMPLEX WITH 1-THIO-BETA-D-GALACTOSE (SPACEGROUP C2221)
Descriptor:MICRONEME ANTIGEN L2, CHLORIDE ION, SULFATE ION, ...
Authors:Mueller, J.J., Heinemann, U.
Deposit date:2011-05-16
Release date:2011-11-02
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Pan-Modular Structure of Microneme Protein Sml-2 from Parasite Sarcocystis Muris at 1.95 A Resolution and its Complex with 1-Thio-Beta-D-Galactose.
Acta Crystallogr.,Sect.D, D67, 2011
2YIP
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CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS MICRONEME PROTEIN SML- 2 IN COMPLEX WITH 1-THIO-BETA-D-GALACTOSE (SPACEGROUP P212121)
Descriptor:MICRONEME ANTIGEN L2, (2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL, CHLORIDE ION, ...
Authors:Mueller, J.J., Heinemann, U.
Deposit date:2011-05-16
Release date:2011-11-02
Last modified:2011-11-30
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Pan-Modular Structure of Microneme Protein Sml-2 from Parasite Sarcocystis Muris at 1.95 A Resolution and its Complex with 1-Thio-Beta-D-Galactose.
Acta Crystallogr.,Sect.D, D67, 2011
3HN4
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CRYSTAL STRUCTURE OF THE NK2 FRAGMENT (28-289) OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR
Descriptor:Hepatocyte growth factor, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MKP
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CRYSTAL STRUCTURE OF 1K1 MUTANT OF HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR FRAGMENT NK1 IN COMPLEX WITH HEPARIN
Descriptor:Hepatocyte growth factor, SULFATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Gherardi, E., Chirgadze, D.Y., Blundell, T.L.
Deposit date:2010-04-15
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Engineering a fragment of Hepatocyte Growth Factor/Scatter Factor for tissue and organ regeneration
To be Published
3SP8
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CRYSTAL STRUCTURE OF NK2 IN COMPLEX WITH FRACTIONATED HEPARIN DP10
Descriptor:Hepatocyte growth factor alpha chain, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Recacha, R., Mulloy, B., Gherardi, E.
Deposit date:2011-07-01
Release date:2012-07-04
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of NK2 in complex with fractionated Heparin DP10
TO BE PUBLISHED
4A5T
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STRUCTURAL BASIS FOR THE CONFORMATIONAL MODULATION
Descriptor:PLASMINOGEN, O-SIALIC ACID, BETA-D-GALACTOSE, ...
Authors:Xue, Y., Bodin, C., Olsson, K.
Deposit date:2011-10-28
Release date:2012-05-23
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Crystal Structure of the Native Plasminogen Reveals an Activation-Resistant Compact Conformation.
J. Thromb. Haemost., 10, 2012
4D3C
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CRYSTAL STRUCTURE OF THE NK1 DOMAIN OF HGF IN COMPLEX WITH ANTI-HGF MONOCLONAL ANTIBODY SFN68.
Descriptor:HEPATOCYTE GROWTH FACTOR, SFN68 FAB
Authors:Kang, Y.J., Kim, K.L., Cho, H.S., Chung, J.H.
Deposit date:2014-10-21
Release date:2016-01-13
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist.
to be published
4DUR
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THE X-RAY CRYSTAL STRUCTURE OF FULL-LENGTH TYPE II HUMAN PLASMINOGEN
Descriptor:Plasminogen, CHLORIDE ION, POTASSIUM ION, ...
Authors:Law, R.H.P., Caradoc-Davies, T., Whisstock, J.C.
Deposit date:2012-02-22
Release date:2012-03-28
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The X-ray crystal structure of full-length human plasminogen
Cell Rep, 1, 2012
4DUU
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THE X-RAY CRYSTAL STRUCTURE OF FULL-LENGTH TYPE I HUMAN PLASMINOGEN
Descriptor:Plasminogen
Authors:Law, R.H.P., Caradoc-Davies, T., Whisstock, J.C.
Deposit date:2012-02-22
Release date:2012-03-28
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (5.2 Å)
Cite:The X-ray crystal structure of full-length human plasminogen
Cell Rep, 1, 2012
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