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8P6Q
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Racemic structure of TNFR1 cysteine-rich domain
Descriptor: D-TNFR-1 CRD2, SULFATE ION, Tumor necrosis factor-binding protein 1
Authors:Lander, A.J, Jin, Y, Luk, L.Y.P.
Deposit date:2023-05-28
Release date:2024-01-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Deciphering the Synthetic and Refolding Strategy of a Cysteine-Rich Domain in the Tumor Necrosis Factor Receptor (TNF-R) for Racemic Crystallography Analysis and d-Peptide Ligand Discovery.
Acs Bio Med Chem Au, 4, 2024
8OZ3
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BU of 8oz3 by Molmil
Crystal structure of scFv ATOR 1017 bound to human 4-1BB
Descriptor: Single chain Fv, Tumor necrosis factor receptor superfamily member 9
Authors:Hakansson, M, Von Schantz, L, Rose, N.
Deposit date:2023-05-08
Release date:2024-03-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1.
Cancer Immunol.Immunother., 72, 2023
8HLB
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BU of 8hlb by Molmil
Cryo-EM structure of biparatopic antibody Bp109-92 in complex with TNFR2
Descriptor: TR109 heavy chain, TR109 light chain, TR92 heavy chain, ...
Authors:Akiba, H, Fujita, J, Ise, T, Nishiyama, K, Miyata, T, Kato, T, Namba, K, Ohno, H, Kamada, H, Nagata, S, Tsumoto, K.
Deposit date:2022-11-29
Release date:2023-10-04
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection.
Commun Biol, 6, 2023
8GYE
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BU of 8gye by Molmil
Crystal Structure of the 4-1BB in complex with ZG033 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Tumor necrosis factor receptor superfamily member 9, ...
Authors:Zhu, M, Cheng, L.S, Gao, Y.
Deposit date:2022-09-22
Release date:2023-09-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the 4-1BB in complex with ZG033 Fab
To Be Published
8DS5
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BU of 8ds5 by Molmil
X-ray structure of the MK5890 Fab - CD27 antibody-antigen complex
Descriptor: CADMIUM ION, CD27 antigen, MK-5890 Fab heavy chain, ...
Authors:Fischmann, T.O.
Deposit date:2022-07-21
Release date:2022-09-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.926 Å)
Cite:Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy.
J Immunother Cancer, 10, 2022
8DPX
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BU of 8dpx by Molmil
Preligand association structure of DR5
Descriptor: Tumor necrosis factor receptor superfamily member 10B
Authors:Du, G, Zhao, L, Chou, J.J.
Deposit date:2022-07-17
Release date:2023-02-15
Method:SOLUTION NMR
Cite:Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation.
Cell Res., 33, 2023
8AG1
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BU of 8ag1 by Molmil
Crystal structure of a novel OX40 antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Novel OX40 antibody heavy chain, Novel OX40 antibody light chain, ...
Authors:Gao, H, Zhou, A.
Deposit date:2022-07-19
Release date:2023-07-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.303 Å)
Cite:Structural Basis of a Novel Agonistic Anti-OX40 Antibody.
Biomolecules, 12, 2022
7YXU
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BU of 7yxu by Molmil
Crystal structure of agonistic antibody 1618 fab domain bound to human 4-1BB.
Descriptor: MANGANESE (II) ION, Tumor necrosis factor receptor superfamily member 9, heavy chain of Fab, ...
Authors:Hakansson, M, Rose, N, Petersson, J, Enell Smith, K, Thorolfsson, M, von Schantz, L.
Deposit date:2022-02-16
Release date:2023-01-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies.
Mol.Cancer Ther., 22, 2023
7YK4
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BU of 7yk4 by Molmil
ox40-antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor receptor superfamily member 4, antibody-H, ...
Authors:Zhou, A.
Deposit date:2022-07-21
Release date:2023-08-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis of a Novel Agonistic Anti-OX40 Antibody.
Biomolecules, 12, 2022
7P3I
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BU of 7p3i by Molmil
Crystal structure of human CD40/TNFRSF5 in complex with the anti-CD40 DARPin protein
Descriptor: Darpin, SODIUM ION, Tumor necrosis factor receptor superfamily member 5
Authors:Malvezzi, F, Mangold, S, Hospodarsch, T, Reichen, C, Iss, C, Lammens, A, Krapp, S, Domke, C.
Deposit date:2021-07-07
Release date:2022-04-06
Last modified:2022-05-11
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor Regression.
Cancer Immunol Res, 10, 2022
7MSJ
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BU of 7msj by Molmil
The crystal structure of mouse HVEM
Descriptor: SULFATE ION, Tumor necrosis factor receptor superfamily member 14
Authors:Liu, W, Ramagopal, U, Garrett-Thompson, S.C, Fedorov, E, Bonanno, J.B, Almo, S.C.
Deposit date:2021-05-11
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
J.Exp.Med., 218, 2021
7MSG
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BU of 7msg by Molmil
The crystal structure of LIGHT in complex with HVEM and CD160
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD160 antigen, soluble form,Tumor necrosis factor receptor superfamily member 14, ...
Authors:Liu, W, Ramagopal, U, Garrett-Thompson, S.C, Fedorov, E, Bonanno, J.B, Almo, S.C.
Deposit date:2021-05-11
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
J.Exp.Med., 218, 2021
7KX0
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BU of 7kx0 by Molmil
Crystal structure of the CD27:CD70 co-stimulatory complex
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CD27 antigen, ...
Authors:Maben, Z, Liu, W, Mosyak, L, Chaparro-Riggers, J.
Deposit date:2020-12-02
Release date:2021-09-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex.
J.Biol.Chem., 297, 2021
7KPB
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BU of 7kpb by Molmil
Human TNF-alpha TNFR1 complex bound to conformationally selective antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(1-{[2-(difluoromethoxy)phenyl]methyl}-2-{[3-(2-oxopyrrolidin-1-yl)phenoxy]methyl}-1H-benzimidazol-6-yl)pyridin-2(1H)-one, Fab1974 - Heavy Chain, ...
Authors:Fox III, D, Conrady, D.G, Lowe, M, Ceska, T.
Deposit date:2020-11-10
Release date:2021-01-13
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF
Nat Commun, 12, 2021
7KP8
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BU of 7kp8 by Molmil
asymmetric mTNF-alpha hTNFR1 complex
Descriptor: 1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole, Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A
Authors:Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T.
Deposit date:2020-11-10
Release date:2021-01-13
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.
Nat Commun, 12, 2021
7KP7
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BU of 7kp7 by Molmil
asymmetric mTNF-alpha hTNFR1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tumor necrosis factor, ...
Authors:Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T.
Deposit date:2020-11-10
Release date:2021-01-13
Last modified:2021-02-03
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.
Nat Commun, 12, 2021
7D4B
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BU of 7d4b by Molmil
Crystal structure of 4-1BB in complex with a VHH
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Wang, C.
Deposit date:2020-09-23
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer.
J Immunother Cancer, 9, 2021
6Y8K
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BU of 6y8k by Molmil
Crystal structure of CD137 in complex with the cyclic peptide BCY10916
Descriptor: 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Upadhyaya, P, Kublin, J, Dods, R, Kristensson, J, Lahdenranta, J, Kleyman, M, Repash, E, Ma, J, Mudd, G, Van Rietschoten, K, Haines, E, Harrison, H, Beswick, P, Chen, L, McDonnell, K, Battula, S, Hurov, K, Keen, N.
Deposit date:2020-03-05
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist.
J Immunother Cancer, 9, 2021
6T3J
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BU of 6t3j by Molmil
Dual Epitope Targeting by Anti-DR5 Antibodies
Descriptor: IgG1-hDR5-01-Heavy Chain, IgG1-hDR5-01-Light Chain, IgG1-hDR5-05-Heavy Chain, ...
Authors:Tauchert, M.J, Augustin, M, Krapp, S, Overdijk, M.B, Breij, E.C.W, Hibbert, R.G.
Deposit date:2019-10-11
Release date:2020-09-16
Last modified:2020-10-14
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism.
Mol.Cancer Ther., 19, 2020
6PE9
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BU of 6pe9 by Molmil
Crystal Structure of CD40 complexed to FAB516
Descriptor: FAB Heavy chain, FAB Light chain, SULFATE ION, ...
Authors:Argiriadi, M.A.
Deposit date:2019-06-20
Release date:2019-08-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.
BMC Mol Cell Biol, 20, 2019
6PE8
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BU of 6pe8 by Molmil
Crystal structure of CD40/ABBV-323 FAB complex
Descriptor: FAB Heavy chain, FAB Light chain, SULFATE ION, ...
Authors:Argiriadi, M.A.
Deposit date:2019-06-20
Release date:2019-08-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.
BMC Mol Cell Biol, 20, 2019
6OKN
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BU of 6okn by Molmil
OX40R (TNFRSF4) bound to Fab 1A7
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Fab 1A7 heavy chain, Fab 1A7 light chain, ...
Authors:Ultsch, M.H, Boenig, G, Harris, S.F.
Deposit date:2019-04-14
Release date:2019-07-10
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members.
Mabs, 11, 2019
6OKM
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BU of 6okm by Molmil
Human OX40R (TNFRSF4) bound to Fab 3C8
Descriptor: Fab 3C8 Heavy Chain, Fab 3C8 light chain, Tumor necrosis factor receptor superfamily member 4
Authors:Boenig, G, Ultsch, M.H, Harris, S.F.
Deposit date:2019-04-14
Release date:2019-08-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members.
Mabs, 11, 2019
6OGX
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BU of 6ogx by Molmil
Ternary complex of OX40R (TNFRSF4) bound to Fab1 and Fab2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 1 Heavy Chain, Fab1 Light Chain, ...
Authors:Ultsch, M.H, Boenig, G, Harris, S.F.
Deposit date:2019-04-03
Release date:2019-07-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members.
Mabs, 11, 2019
6NG3
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BU of 6ng3 by Molmil
Crystal structure of human CD160 and HVEM complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD160 antigen,Tumor necrosis factor receptor superfamily member 14, MAGNESIUM ION, ...
Authors:Liu, W, Bonanno, J, Almo, S.C.
Deposit date:2018-12-21
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Structural Basis of CD160:HVEM Recognition.
Structure, 27, 2019

 

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