6FAX
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COMPLEX OF HUMAN CD40 ECTODOMAIN WITH LOB 7.4 FAB
Descriptor:Lob 7.4 light chain, Lob 7.4 heavy chain, Tumor necrosis factor receptor superfamily member 5
Authors:Orr, C.M., Tews, I., Pearson, A.R.
Deposit date:2017-12-18
Release date:2018-02-07
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.
Cancer Cell, 33, 2018
6CU0
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CRYSTAL STRUCTURE OF 4-1BBL/4-1BB (C121S) COMPLEX IN P21 SPACE GROUP
Descriptor:Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, N-ACETYL-D-GLUCOSAMINE
Authors:Aruna, B., Zajonc, D.M., Doukov, T.
Deposit date:2018-03-23
Release date:2018-05-09
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier.
J. Biol. Chem., 293, 2018
6CPR
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CRYSTAL STRUCTURE OF 4-1BBL/4-1BB COMPLEX IN C2 SPACE GROUP
Descriptor:Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, GLYCEROL, ...
Authors:Aruna, B., Zajonc, D.M.
Deposit date:2018-03-14
Release date:2018-05-09
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier.
J. Biol. Chem., 293, 2018
6BWV
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CRYSTAL STRUCTURE OF THE 4-1BB/4-1BBL COMPLEX
Descriptor:Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, DI(HYDROXYETHYL)ETHER
Authors:Oganesyan, V., Gilbreth, R.N., Baca, M.
Deposit date:2017-12-15
Release date:2018-05-09
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the human 4-1BB/4-1BBL complex.
J. Biol. Chem., 293, 2018
6A3W
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COMPLEX STRUCTURE OF 4-1BB AND UTOMILUMAB
Descriptor:utomilumab VH, utomilumab VL, Tumor necrosis factor receptor superfamily member 9, ...
Authors:Li, Y., Tan, S., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F.
Deposit date:2018-06-17
Release date:2018-10-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Complex structure of 4-1BB and utomilumab
To Be Published
6A3V
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COMPLEX STRUCTURE OF HUMAN 4-1BB AND 4-1BBL
Descriptor:Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, N-ACETYL-D-GLUCOSAMINE
Authors:Li, Y., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F.
Deposit date:2018-06-17
Release date:2018-10-10
Method:X-RAY DIFFRACTION (3.391 Å)
Cite:Complex structure of human 4-1BB and 4-1BBL
To Be Published
5WJF
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CRYSTAL STRUCTURE OF MURINE 4-1BB FROM HEK293T CELLS IN P21212 SPACE GROUP
Descriptor:Tumor necrosis factor receptor superfamily member 9, N-ACETYL-D-GLUCOSAMINE, 1,2-ETHANEDIOL
Authors:Zajonc, D.M., Doukov, T., Bitra, A.
Deposit date:2017-07-21
Release date:2017-12-20
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.
J. Biol. Chem., 293, 2018
5WIW
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CRYSTAL STRUCTURE OF MURINE 4-1BB N128A MUTANT FROM HEK293T CELLS IN P43 SPACE GROUP
Descriptor:Tumor necrosis factor receptor superfamily member 9, N-ACETYL-D-GLUCOSAMINE, GLYCEROL, ...
Authors:Zajonc, D.M., Bitra, A.
Deposit date:2017-07-20
Release date:2017-12-20
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.
J. Biol. Chem., 293, 2018
5WI8
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CRYSTAL STRUCTURE OF MURINE 4-1BB FROM HEK293T CELLS IN P21 SPACE GROUP
Descriptor:Tumor necrosis factor receptor superfamily member 9, ALPHA-L-FUCOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zajonc, D.M., Bitra, A.
Deposit date:2017-07-18
Release date:2017-12-20
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.
J. Biol. Chem., 293, 2018
5TLK
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COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191
Descriptor:M2177 LIGHT CHAIN, M2177 HEAVY CHAIN, H2191 LIGHT CHAIN, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2016-10-11
Release date:2017-02-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography.
Mol. Immunol., 83, 2017
5TLJ
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COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND M2191
Descriptor:M2177 LIGHT CHAIN, M2177 HEAVY CHAIN, M2191 LIGHT CHAIN, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2016-10-11
Release date:2017-02-08
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography.
Mol. Immunol., 83, 2017
5TL5
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COMPLEX BETWEEN HUMAN CD27 AND ANTIBODY M2177
Descriptor:M2177 LIGHT CHAIN, M2177 HEAVY CHAIN, CD27 antigen, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2016-10-10
Release date:2017-06-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of CD27 in complex with a neutralizing noncompeting antibody.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5T2R
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UNLIGANDED HUMAN HVEM AT 2.1A IN P 21 21 21
Descriptor:Tumor necrosis factor receptor superfamily member 14
Authors:Nemcovicova, I., Zajonc, D.M.
Deposit date:2016-08-24
Release date:2018-10-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Unliganded Human HVEM at 2.1A in P 21 21 21
To Be Published
5T2Q
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UNLIGANDED HUMAN HVEM AT 1.9A IN P 1 21 1
Descriptor:Tumor necrosis factor receptor superfamily member 14
Authors:Nemcovicova, I., Zajonc, D.M.
Deposit date:2016-08-24
Release date:2018-10-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Unliganded Human HVEM at 1.9A in P 1 21 1
To Be Published
5L36
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CRYSTAL STRUCTURE OF A HUMAN FASL MUTANT IN COMPLEX WITH HUMAN DCR3
Descriptor:Tumor necrosis factor receptor superfamily member 6B, Tumor necrosis factor ligand superfamily member 6, SODIUM ION
Authors:Liu, W., Bonanno, J.B., Almo, S.C.
Deposit date:2016-08-03
Release date:2016-09-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.
Structure, 24, 2016
5IHL
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STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB
Descriptor:Tumor necrosis factor receptor superfamily member 5, 3H56-5 domain antibody (dAb), SULFATE ION
Authors:Sheriff, S.
Deposit date:2016-02-29
Release date:2016-06-01
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.
J.Mol.Biol., 428, 2016
5DMJ
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STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB
Descriptor:Tumor necrosis factor receptor superfamily member 5, 3H65-5 domain antibody (dAb), POTASSIUM ION
Authors:Sheriff, S.
Deposit date:2015-09-08
Release date:2016-06-01
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.
J.Mol.Biol., 428, 2016
5DMI
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STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH CHI220 FAB
Descriptor:Tumor necrosis factor receptor superfamily member 5, Chi220 Fab heavy chain, Chi220 Fab light chain, ...
Authors:Sheriff, S.
Deposit date:2015-09-08
Release date:2016-06-01
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (3.69 Å)
Cite:Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.
J.Mol.Biol., 428, 2016
5CIR
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CRYSTAL STRUCTURE OF DEATH RECEPTOR 4 (DR4; TNFFRSF10A) BOUND TO TRAIL (TNFSF10)
Descriptor:Tumor necrosis factor ligand superfamily member 10, Tumor necrosis factor receptor superfamily member 10A, ZINC ION, ...
Authors:Sheriff, S.
Deposit date:2015-07-13
Release date:2017-01-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.
Acta Crystallogr F Struct Biol Commun, 71, 2015
5BNQ
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CRYSTAL STRUCTURE OF HRANKL-MRANK COMPLEX
Descriptor:Tumor necrosis factor ligand superfamily member 11, Tumor necrosis factor receptor superfamily member 11A, PHOSPHATE ION, ...
Authors:Ren, J.
Deposit date:2015-05-26
Release date:2015-10-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis.
Sci Rep, 5, 2015
4YN0
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CRYSTAL STRUCTURE OF APP E2 DOMAIN IN COMPLEX WITH DR6 CRD DOMAIN
Descriptor:Tumor necrosis factor receptor superfamily member 21, Amyloid beta A4 protein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, K., Nikolov, D.
Deposit date:2015-03-08
Release date:2015-04-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation.
Genes Dev., 29, 2015
4RSU
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CRYSTAL STRUCTURE OF THE LIGHT AND HVEM COMPLEX
Descriptor:Tumor necrosis factor ligand superfamily member 14, soluble form, Tumor necrosis factor receptor superfamily member 14, ...
Authors:Liu, W., Ramagoal, U.A., Himmel, D., Bonanno, J.B., Nathenson, S.G., Almo, S.C., Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2014-11-11
Release date:2015-02-04
Last modified:2015-02-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the Light and Hvem Complex
To be Published
4OD2
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF AN ANTI-DR5 ANTIBODY BOUND TO DR5
Descriptor:Fab fragment of drozitumab, light chain, heavy chain, ...
Authors:Hymowitz, S.G., Compaan, D.
Deposit date:2014-01-09
Release date:2014-02-05
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5.
Cell Death Differ., 15, 2008
4N90
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CRYSTAL STRUCTURE OF TERNARY COMPLEX OF TRAIL, DR5, AND FAB FRAGMENT FROM A DR5 AGONIST ANTIBODY
Descriptor:Tumor necrosis factor receptor superfamily member 10B, Tumor necrosis factor ligand superfamily member 10, Fab light chain, ...
Authors:Huang, X.
Deposit date:2013-10-18
Release date:2014-09-03
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity.
Cancer Cell, 26, 2014
4MXW
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STRUCTURE OF HETEROTRIMERIC LYMPHOTOXIN LTA1B2 BOUND TO LYMPHOTOXIN BETA RECEPTOR LTBR AND ANTI-LTA FAB
Descriptor:Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-alpha, Lymphotoxin-beta, ...
Authors:Sudhamsu, J., Yin, J.P., Hymowitz, S.G.
Deposit date:2013-09-26
Release date:2013-11-13
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Dimerization of LT beta R by LT alpha 1 beta 2 is necessary and sufficient for signal transduction.
Proc.Natl.Acad.Sci.USA, 110, 2013
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