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7ZJF
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BU of 7zjf by Molmil
R399E, a mutated form of GDF5, for disease modification of osteoarthritis
Descriptor: Growth/differentiation factor 5
Authors:Gigout, A, Wekmann, D, Menges, S, Brenneis, C, Henson, F, Cowan, K.J, Musil, D, Thudium, C, Guehring, H, Michaelis, M, Kleinschmidt-Doerr, K.
Deposit date:2022-04-10
Release date:2022-09-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis.
Arthritis Rheumatol, 75, 2023
7PPA
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BU of 7ppa by Molmil
High resolution structure of bone morphogenetic protein receptor type II (BMPRII) extracellular domain in complex with BMP10
Descriptor: Bone morphogenetic protein 10, Bone morphogenetic protein receptor type-2, GLYCEROL
Authors:Guo, J, Yu, M, Read, R.J, Li, W.
Deposit date:2021-09-13
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.
Nat Commun, 13, 2022
5E4G
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BU of 5e4g by Molmil
Crystal structure of human growth differentiation factor 11 (GDF-11)
Descriptor: Growth/differentiation factor 11, TETRAETHYLENE GLYCOL
Authors:Padyana, A.K, Vaidialingam, B, Hayes, D.B, Gupta, P, Franti, M, Farrow, N.A.
Deposit date:2015-10-06
Release date:2016-03-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of human GDF11.
Acta Crystallogr.,Sect.F, 72, 2016
2ASK
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BU of 2ask by Molmil
Structure of human Artemin
Descriptor: SULFATE ION, artemin
Authors:Silvian, L, Jin, P, Carmillo, P, Boriack-Sjodin, P.A, Pelletier, C, Rushe, M, Gong, B.J, Sah, D, Pepinsky, B, Rossomando, A.
Deposit date:2005-08-23
Release date:2006-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Artemin crystal structure reveals insights into heparan sulfate binding.
Biochemistry, 45, 2006
5NMZ
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BU of 5nmz by Molmil
human Neurturin (97-197)
Descriptor: GLYCEROL, Neurturin
Authors:Bigalke, J.M, Sandmark, J, Roth, R.
Deposit date:2017-04-07
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
6Z3J
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BU of 6z3j by Molmil
Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) (crystal form 1)
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C.
Deposit date:2020-05-20
Release date:2020-07-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
2GYZ
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BU of 2gyz by Molmil
Crystal structure of human artemin
Descriptor: neurotrophic factor artemin isoform 3
Authors:Wang, X.Q, Garcia, K.C.
Deposit date:2006-05-10
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors.
Structure, 14, 2006
5F3B
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BU of 5f3b by Molmil
Structure of myostatin in complex with chimeric RK35 antibody
Descriptor: GLYCEROL, Growth/differentiation factor 8, RK35 Chimeric antibody heavy chain, ...
Authors:Parris, K.D, Mosyak, L.
Deposit date:2015-12-02
Release date:2016-09-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
Mabs, 8, 2016
2TGI
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BU of 2tgi by Molmil
CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA2: AN UNUSUAL FOLD FOR THE SUPERFAMILY
Descriptor: TRANSFORMING GROWTH FACTOR ,BETA 2
Authors:Daopin, S, Davies, D.R.
Deposit date:1993-10-20
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily.
Science, 257, 1992
5TX2
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BU of 5tx2 by Molmil
Miniature TGF-beta2 3-mutant monomer
Descriptor: Transforming growth factor beta-2
Authors:Taylor, A.B, Kim, S.K, Hart, P.J, Hinck, A.P.
Deposit date:2016-11-15
Release date:2017-03-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling.
J. Biol. Chem., 292, 2017
2H62
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BU of 2h62 by Molmil
Crystal structure of a ternary ligand-receptor complex of BMP-2
Descriptor: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Mueller, T.D.
Deposit date:2006-05-30
Release date:2007-04-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
1REW
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BU of 1rew by Molmil
Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor
Descriptor: bone morphogenetic protein 2, bone morphogenetic protein receptor type IA
Authors:Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D.
Deposit date:2003-11-07
Release date:2004-05-04
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.863 Å)
Cite:Molecular recognition of BMP-2 and BMP receptor IA.
Nat.Struct.Mol.Biol., 11, 2004
5I05
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BU of 5i05 by Molmil
Crystal structure of human BMP9 at 1.87 A resolution
Descriptor: GLYCEROL, Growth/differentiation factor 2
Authors:Saito, T, Bokhove, M, Jovine, L.
Deposit date:2016-02-03
Release date:2017-06-07
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.
Cell Rep, 19, 2017
5TX4
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BU of 5tx4 by Molmil
Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130
Descriptor: TGF-beta receptor type-2, Transforming growth factor beta-2
Authors:Hinck, A.P, Kim, S.
Deposit date:2016-11-15
Release date:2017-03-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.876 Å)
Cite:An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling.
J. Biol. Chem., 292, 2017
1AGQ
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BU of 1agq by Molmil
GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT
Descriptor: GLIAL CELL-DERIVED NEUROTROPHIC FACTOR
Authors:Eigenbrot, C, Gerber, N.
Deposit date:1997-03-25
Release date:1997-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding.
Nat.Struct.Biol., 4, 1997
5UHM
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BU of 5uhm by Molmil
Apo-Structure of Mature Growth Differentiation Factor 11
Descriptor: Growth/differentiation factor 11
Authors:Goebel, E, Thompson, T.
Deposit date:2017-01-11
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for potency differences between GDF8 and GDF11.
BMC Biol., 15, 2017
4MPL
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BU of 4mpl by Molmil
Crystal structure of BMP9 at 1.90 Angstrom
Descriptor: Growth/differentiation factor 2
Authors:Li, W, Morrell, N.W, Wei, Z.
Deposit date:2013-09-13
Release date:2014-09-17
Last modified:2021-06-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis.
J.Biol.Chem., 289, 2014
6XM2
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BU of 6xm2 by Molmil
The structure of the 4A11.v7 antibody in complex with human TGFb2
Descriptor: 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized, 4A11.v7 kappa light chain Fab (VL-CL) humanized, Transforming growth factor beta-2
Authors:Lupardus, P.J, Yin, J.P.
Deposit date:2020-06-29
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis.
Sci Transl Med, 13, 2021
4N1D
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BU of 4n1d by Molmil
Nodal/BMP2 chimera NB250
Descriptor: Nodal/BMP2 chimera protein
Authors:Esquivies, L.
Deposit date:2013-10-04
Release date:2013-12-04
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.912 Å)
Cite:Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure.
J.Biol.Chem., 289, 2014
2GH0
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BU of 2gh0 by Molmil
Growth factor/receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GDNF family receptor alpha-3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, X.Q.
Deposit date:2006-03-24
Release date:2006-06-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors.
Structure, 14, 2006
2H64
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BU of 2h64 by Molmil
Crystal structure of a ternary ligand-receptor complex of BMP-2
Descriptor: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Mueller, T.D, Sebald, W, Weber, D.
Deposit date:2006-05-30
Release date:2007-04-10
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
8DC0
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BU of 8dc0 by Molmil
Rat Betaglycan Zona Pellucida Domain (ZPC) in complex with mini monomer TGFb2 (mmTGF-b2-7M2R)
Descriptor: Transforming growth factor beta receptor type 3, Transforming growth factor beta-2
Authors:Wieteska, L, Taylor, A.B, Hinck, A.P.
Deposit date:2022-06-15
Release date:2023-06-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Rat Betaglycan Zona Pellucida Domain (ZPC) in complex with mini monomer TGFb2 (mmTGF-b2-7M2R)
To Be Published
1TFG
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BU of 1tfg by Molmil
AN UNUSUAL FEATURE REVEALED BY THE CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF HUMAN TRANSFORMING GROWTH FACTOR-BETA2
Descriptor: TRANSFORMING GROWTH FACTOR, BETA 2
Authors:Gruetter, M, Schlunegger, M.
Deposit date:1992-11-17
Release date:1993-10-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2.
Nature, 358, 1992
5VZ3
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BU of 5vz3 by Molmil
Growth Factor Crystal Structure at 1.97 Angstrom Resolution
Descriptor: Growth/differentiation factor 15
Authors:Lakshminarasimhan, D, White, A, Suto, R.K.
Deposit date:2017-05-26
Release date:2017-09-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature, 550, 2017
1TGJ
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BU of 1tgj by Molmil
HUMAN TRANSFORMING GROWTH FACTOR-BETA 3, CRYSTALLIZED FROM DIOXANE
Descriptor: 1,4-DIETHYLENE DIOXIDE, TRANSFORMING GROWTH FACTOR-BETA 3
Authors:Mittl, P.R.E, Priestle, J.P, Gruetter, M.G.
Deposit date:1996-07-09
Release date:1997-01-11
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Protein Sci., 5, 1996

217705

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