1AGQ
 
 | | GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT | | Descriptor: | GLIAL CELL-DERIVED NEUROTROPHIC FACTOR | | Authors: | Eigenbrot, C, Gerber, N. | | Deposit date: | 1997-03-25 | | Release date: | 1997-06-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding.
Nat.Struct.Biol., 4, 1997
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1BMP
 | | BONE MORPHOGENETIC PROTEIN-7 | | Descriptor: | BONE MORPHOGENETIC PROTEIN-7 | | Authors: | Griffith, D.L, Scott, D.L. | | Deposit date: | 1995-12-14 | | Release date: | 1997-07-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.
Proc.Natl.Acad.Sci.USA, 93, 1996
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7L0J
 | | Structure of AMH bound to AMHR2-ECD | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-Muellerian hormone type-2 receptor, Muellerian-inhibiting factor, ... | | Authors: | Hart, K.N, Thompson, T.B. | | Deposit date: | 2020-12-11 | | Release date: | 2021-06-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-beta family.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6I9J
 | | Human transforming growth factor beta2 in a tetragonal crystal form | | Descriptor: | Transforming growth factor beta-2 proprotein | | Authors: | Gomis-Ruth, F.X, Marino-Puertas, L, del Amo-Maestro, L, Goulas, T. | | Deposit date: | 2018-11-23 | | Release date: | 2019-07-03 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor beta 2 in a new conformation.
Sci Rep, 9, 2019
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7ZJF
 | | R399E, a mutated form of GDF5, for disease modification of osteoarthritis | | Descriptor: | Growth/differentiation factor 5 | | Authors: | Gigout, A, Wekmann, D, Menges, S, Brenneis, C, Henson, F, Cowan, K.J, Musil, D, Thudium, C, Guehring, H, Michaelis, M, Kleinschmidt-Doerr, K. | | Deposit date: | 2022-04-10 | | Release date: | 2022-09-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis.
Arthritis Rheumatol, 75, 2023
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8E3G
 | | BMP2/GDF5 heterodimer | | Descriptor: | Bone morphogenetic protein 2, GLYCEROL, Growth/differentiation factor 5 | | Authors: | Gipson, G.R, Nolan, K.T, Thompson, T.B. | | Deposit date: | 2022-08-17 | | Release date: | 2023-02-15 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers.
Bmc Biol., 21, 2023
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1TGK
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1TFG
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1TGJ
 | | HUMAN TRANSFORMING GROWTH FACTOR-BETA 3, CRYSTALLIZED FROM DIOXANE | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, TRANSFORMING GROWTH FACTOR-BETA 3 | | Authors: | Mittl, P.R.E, Priestle, J.P, Gruetter, M.G. | | Deposit date: | 1996-07-09 | | Release date: | 1997-01-11 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Protein Sci., 5, 1996
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6SF3
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6SF1
 | | Bone morphogenetic protein 10 (BMP10) complexed with extracellular domain of activin receptor-like kinase 1 (ALK1). | | Descriptor: | Bone morphogenetic protein 10, NICKEL (II) ION, Serine/threonine-protein kinase receptor R3 | | Authors: | Salmon, R.M, Guo, J, Yu, M, Li, W. | | Deposit date: | 2019-07-30 | | Release date: | 2020-04-08 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms.
Nat Commun, 11, 2020
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5MR9
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5E4G
 | | Crystal structure of human growth differentiation factor 11 (GDF-11) | | Descriptor: | Growth/differentiation factor 11, TETRAETHYLENE GLYCOL | | Authors: | Padyana, A.K, Vaidialingam, B, Hayes, D.B, Gupta, P, Franti, M, Farrow, N.A. | | Deposit date: | 2015-10-06 | | Release date: | 2016-03-09 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of human GDF11.
Acta Crystallogr.,Sect.F, 72, 2016
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5NMZ
 | | human Neurturin (97-197) | | Descriptor: | GLYCEROL, Neurturin | | Authors: | Bigalke, J.M, Sandmark, J, Roth, R. | | Deposit date: | 2017-04-07 | | Release date: | 2018-02-14 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
J. Biol. Chem., 293, 2018
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1WAQ
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5F3H
 | | Structure of myostatin in complex with humanized RK35 antibody | | Descriptor: | Growth/differentiation factor 8, humanized RK35 antibody heavy chain, humanized RK35 antibody light chain | | Authors: | Parris, K.D, Mosyak, L. | | Deposit date: | 2015-12-02 | | Release date: | 2016-09-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
Mabs, 8, 2016
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5F3B
 | | Structure of myostatin in complex with chimeric RK35 antibody | | Descriptor: | GLYCEROL, Growth/differentiation factor 8, RK35 Chimeric antibody heavy chain, ... | | Authors: | Parris, K.D, Mosyak, L. | | Deposit date: | 2015-12-02 | | Release date: | 2016-09-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody.
Mabs, 8, 2016
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4KV5
 | | scFv GC1009 in complex with TGF-beta1. | | Descriptor: | Single-chain variable fragment GC1009, Transforming growth factor beta-1 proprotein | | Authors: | Wei, R, Moulin, A.G, Mathieu, M. | | Deposit date: | 2013-05-22 | | Release date: | 2014-09-24 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
Protein Sci., 23, 2014
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4KXZ
 | | crystal structure of tgfb2 in complex with GC2008. | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, GC1008 Heavy Chain, ... | | Authors: | Mathieu, M, Moulin, A.G, Wei, R. | | Deposit date: | 2013-05-28 | | Release date: | 2014-09-24 | | Last modified: | 2014-12-03 | | Method: | X-RAY DIFFRACTION (2.83 Å) | | Cite: | Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
Protein Sci., 23, 2014
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3BMP
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3BK3
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4MID
 | | Crystal Structure of Activin A/BMP2 chimera | | Descriptor: | AB204 Activin A/BMP2 chimera | | Authors: | Esquivies, L. | | Deposit date: | 2013-08-30 | | Release date: | 2014-05-07 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (2.139 Å) | | Cite: | An Activin A/BMP2 Chimera, AB204, Displays Bone-Healing Properties Superior to Those of BMP2.
J.Bone Miner.Res., 29, 2014
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4MPL
 | | Crystal structure of BMP9 at 1.90 Angstrom | | Descriptor: | Growth/differentiation factor 2 | | Authors: | Li, W, Morrell, N.W, Wei, Z. | | Deposit date: | 2013-09-13 | | Release date: | 2014-09-17 | | Last modified: | 2021-06-02 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis.
J.Biol.Chem., 289, 2014
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4N1D
 | | Nodal/BMP2 chimera NB250 | | Descriptor: | Nodal/BMP2 chimera protein | | Authors: | Esquivies, L. | | Deposit date: | 2013-10-04 | | Release date: | 2013-12-04 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (1.912 Å) | | Cite: | Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure.
J.Biol.Chem., 289, 2014
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1REU
 | | Structure of the bone morphogenetic protein 2 mutant L51P | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, bone morphogenetic protein 2 | | Authors: | Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D. | | Deposit date: | 2003-11-07 | | Release date: | 2004-05-04 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Molecular recognition of BMP-2 and BMP receptor IA.
Nat.Struct.Mol.Biol., 11, 2004
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