1NKP
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CRYSTAL STRUCTURE OF MYC-MAX RECOGNIZING DNA
Descriptor:5'-D(*CP*GP*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*C)-3', Myc proto-oncogene protein, Max protein
Authors:Nair, S.K., Burley, S.K.
Deposit date:2003-01-03
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray structures of Myc-Max and Mad-Max recognizing DNA: Molecular bases of regulation by proto-oncogenic transcription factors
Cell(Cambridge,Mass.), 112, 2003
5I4Z
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STRUCTURE OF APO OMOMYC
Descriptor:Myc proto-oncogene protein, GLYCEROL, CHLORIDE ION, ...
Authors:Koelmel, W., Jung, L.A., Kuper, J., Eilers, M., Kisker, C.
Deposit date:2016-02-13
Release date:2016-10-26
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
Oncogene, 36, 2017
1NLW
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CRYSTAL STRUCTURE OF MAD-MAX RECOGNIZING DNA
Descriptor:5'-D(*GP*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*C)-3', MAD PROTEIN, MAX PROTEIN
Authors:Nair, S.K., Burley, S.K.
Deposit date:2003-01-07
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structures of Myc-Max and Mad-Max recognizing DNA: Molecular bases of regulation by proto-oncogenic transcription factors
Cell(Cambridge,Mass.), 112, 2003
4AYA
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CRYSTAL STRUCTURE OF ID2 HLH HOMODIMER AT 2.1A RESOLUTION
Descriptor:DNA-BINDING PROTEIN INHIBITOR ID-2, POTASSIUM ION, ACETATE ION
Authors:Wong, M.V., Jiang, S., Palasingam, P., Kolatkar, P.R.
Deposit date:2012-06-19
Release date:2012-11-14
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:A Divalent Ion is Crucial in the Structure and Dominant-Negative Function of Id Proteins, a Class of Helix-Loop-Helix Transcription Regulators.
Plos One, 7, 2012
4F3L
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CRYSTAL STRUCTURE OF THE HETERODIMERIC CLOCK:BMAL1 TRANSCRIPTIONAL ACTIVATOR COMPLEX
Descriptor:BMAL1b, Circadian locomoter output cycles protein kaput
Authors:Huang, N., Chelliah, Y., Shan, Y., Taylor, C., Yoo, S., Partch, C., Green, C.B., Zhang, H., Takahashi, J.
Deposit date:2012-05-09
Release date:2012-06-06
Last modified:2012-08-01
Method:X-RAY DIFFRACTION (2.268 Å)
Cite:Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Science, 337, 2012
1AM9
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HUMAN SREBP-1A BOUND TO LDL RECEPTOR PROMOTER
Descriptor:DNA (5'-D(*TP*TP*GP*CP*AP*GP*TP*GP*GP*GP*GP*TP*GP*AP*TP*CP*T )-3'), DNA (5'-D(*CP*AP*TP*GP*AP*GP*AP*TP*CP*AP*CP*CP*CP*CP*AP*CP*T P*GP*CP*AP*A)-3'), PROTEIN (STEROL REGULATORY ELEMENT BINDING PROTEIN 1A), ...
Authors:Parraga, A., Burley, S.K.
Deposit date:1997-06-25
Release date:1998-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution.
Structure, 6, 1998
4ZP4
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
Deposit date:2015-05-07
Release date:2015-08-12
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (2.355 Å)
Cite:Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
5EYO
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THE CRYSTAL STRUCTURE OF THE MAX BHLH DOMAIN IN COMPLEX WITH 5-CARBOXYL CYTOSINE DNA
Descriptor:Protein max, DNA (5'-D(*AP*GP*TP*AP*GP*CP*AP*(1CC)P*GP*TP*GP*CP*TP*AP*CP*T)-3')
Authors:Wang, D., Hashimoto, H., Zhang, X., Cheng, X.
Deposit date:2015-11-25
Release date:2016-12-14
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma.
Nucleic Acids Res., 45, 2017
5Y7Y
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CRYSTAL STRUCTURE OF AHRR/ARNT COMPLEX
Descriptor:Aryl hydrocarbon receptor repressor, Aryl hydrocarbon receptor nuclear translocator, GLYCEROL
Authors:Sakurai, S., Shimizu, T., Ohto, U.
Deposit date:2017-08-18
Release date:2017-09-20
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription.
J. Biol. Chem., 292, 2017
4H10
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INTERMOLECULAR RECOGNITION REVEALED BY THE COMPLEX STRUCTURE OF HUMAN CLOCK-BMAL1 BASIC HELIX-LOOP-HELIX DOMAINS WITH E-BOX DNA
Descriptor:Aryl hydrocarbon receptor nuclear translocator-like protein 1, Circadian locomoter output cycles protein kaput, E-box DNA sense strand, ...
Authors:Wang, Z., Su, X.-D.
Deposit date:2012-09-10
Release date:2012-12-26
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA.
Cell Res., 23, 2013
2QL2
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CRYSTAL STRUCTURE OF THE BASIC-HELIX-LOOP-HELIX DOMAINS OF THE HETERODIMER E47/NEUROD1 BOUND TO DNA
Descriptor:Transcription factor E2-alpha, Neurogenic differentiation factor 1, DNA (5'-D(*DTP*DAP*DGP*DGP*DCP*DCP*DAP*DTP*DCP*DTP*DGP*DGP*DTP*DCP*DCP*DT)-3'), ...
Authors:Rose, R.B., Longo, A., Guanga, G.P.
Deposit date:2007-07-12
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition.
Biochemistry, 47, 2008
4ATI
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MITF:M-BOX COMPLEX
Descriptor:MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR, 5'-D(*GP*TP*TP*AP*GP*CP*AP*CP*AP*TP*GP*AP*CP*CP*CP*T)-3', 5'-D(*AP*GP*GP*GP*TP*CP*AP*TP*GP*TP*GP*CP*TP*AP*AP*C)-3'
Authors:Pogenberg, V., Deineko, V., Wilmanns, M.
Deposit date:2012-05-08
Release date:2012-12-12
Last modified:2012-12-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Restricted Leucine Zipper Dimerization and Specificity of DNA Recognition of the Melanocyte Master Regulator Mitf
Genes Dev., 26, 2012
5GNJ
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STRUCTURE OF A TRANSCRIPTION FACTOR AND DNA COMPLEX
Descriptor:Transcription factor MYC2, DNA (5'-D(*AP*GP*GP*AP*AP*CP*AP*CP*GP*TP*GP*AP*CP*CP*C)-3'), DNA (5'-D(*TP*GP*GP*GP*TP*CP*AP*CP*GP*TP*GP*TP*TP*CP*C)-3')
Authors:Lian, T., Xu, Y., Su, X.
Deposit date:2016-07-21
Release date:2017-05-10
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA.
Cell Rep, 19, 2017
5I50
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STRUCTURE OF OMOMYC BOUND TO DOUBLE-STRANDED DNA
Descriptor:Myc proto-oncogene protein, DNA (5'-D(P*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*CP*TP*AP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*CP*GP*GP*GP*TP*G)-3')
Authors:Koelmel, W., Jung, L.A., Kuper, J., Eilers, M., Kisker, C.
Deposit date:2016-02-13
Release date:2016-10-26
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
Oncogene, 36, 2017
1A0A
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PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4/DNA COMPLEX
Descriptor:DNA (5'-D(*CP*TP*CP*AP*CP*AP*CP*GP*TP*GP*GP*GP*AP*CP*TP*AP*G )-3'), DNA (5'-D(*CP*TP*AP*GP*TP*CP*CP*CP*AP*CP*GP*TP*GP*TP*GP*AP*G )-3'), PROTEIN (PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4)
Authors:Shimizu, T., Toumoto, A., Ihara, K., Shimizu, M., Kyogoku, Y., Ogawa, N., Oshima, Y., Hakoshima, T.
Deposit date:1997-11-27
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition.
EMBO J., 16, 1997
1HLO
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THE CRYSTAL STRUCTURE OF AN INTACT HUMAN MAX-DNA COMPLEX: NEW INSIGHTS INTO MECHANISMS OF TRANSCRIPTIONAL CONTROL
Descriptor:DNA (5'-D(*CP*AP*CP*CP*AP*CP*GP*TP*GP*GP*T)-3'), DNA (5'-D(*AP*CP*CP*AP*CP*GP*TP*GP*GP*TP*G)-3'), PROTEIN (TRANSCRIPTION FACTOR MAX)
Authors:Brownlie, P., Ceska, T.A., Lamers, M., Romier, C., Theo, H., Suck, D.
Deposit date:1997-09-10
Release date:1997-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control.
Structure, 5, 1997
1MDY
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CRYSTAL STRUCTURE OF MYOD BHLH DOMAIN BOUND TO DNA: PERSPECTIVES ON DNA RECOGNITION AND IMPLICATIONS FOR TRANSCRIPTIONAL ACTIVATION
Descriptor:DNA (5'-D(*TP*CP*AP*AP*CP*AP*GP*CP*TP*GP*TP*TP*GP*A)-3'), PROTEIN (MYOD BHLH DOMAIN)
Authors:Ma, P.C.M., Rould, M.A., Weintraub, H., Pabo, C.O.
Deposit date:1994-06-09
Release date:1994-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of MyoD bHLH domain-DNA complex: perspectives on DNA recognition and implications for transcriptional activation.
Cell(Cambridge,Mass.), 77, 1994
2YPA
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STRUCTURE OF THE SCL:E47:LMO2:LDB1 COMPLEX BOUND TO DNA
Descriptor:T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1, TRANSCRIPTION FACTOR E2-ALPHA, RHOMBOTIN-2, ...
Authors:El Omari, K., Hoosdally, S.J., Tuladhar, K., Karia, D., Ponsele, E., Platonova, O., Vyas, P., Patient, R., Porcher, C., Mancini, E.J.
Deposit date:2012-10-30
Release date:2013-07-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets.
Cell Rep., 4, 2013
4ZPH
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH PROFLAVINE
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, PROFLAVIN
Authors:Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
Deposit date:2015-05-07
Release date:2015-08-12
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
2YPB
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STRUCTURE OF THE SCL:E47 COMPLEX BOUND TO DNA
Descriptor:T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1, TRANSCRIPTION FACTOR E2-ALPHA, EBOX FORWARD, ...
Authors:El Omari, K., Hoosdally, S.J., Tuladhar, K., Karia, D., Ponsele, E., Platonova, O., Vyas, P., Patient, R., Porcher, C., Mancini, E.J.
Deposit date:2012-10-30
Release date:2013-07-31
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets.
Cell Rep., 4, 2013
4ZQD
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH THE BENZOXADIAZOLE ANTAGONIST 0X3
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
Authors:Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
Deposit date:2015-05-09
Release date:2015-08-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
1AN2
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RECOGNITION BY MAX OF ITS COGNATE DNA THROUGH A DIMERIC B/HLH/Z DOMAIN
Descriptor:DNA (5'-D(*GP*TP*GP*TP*AP*GP*GP*TP*CP*AP*CP*GP*TP*GP*AP*CP*C P*TP*AP*CP*AP*C)- 3'), PROTEIN (TRANSCRIPTION FACTOR MAX (TF MAX))
Authors:Ferre-D'Amare, A.R., Prendergast, G.C., Ziff, E.B., Burley, S.K.
Deposit date:1996-09-06
Release date:1997-09-17
Last modified:2013-04-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain.
Nature, 363, 1993
1AN4
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STRUCTURE AND FUNCTION OF THE B/HLH/Z DOMAIN OF USF
Descriptor:DNA (5'-D(*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*C P*TP*AP*CP*A)-3'), DNA (5'-D(*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*C P*GP*GP*GP*T)-3'), PROTEIN (UPSTREAM STIMULATORY FACTOR)
Authors:Ferre-D'Amare, A.R., Pognonec, P., Roeder, R.G., Burley, S.K.
Deposit date:1997-03-15
Release date:1997-09-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure and function of the b/HLH/Z domain of USF.
EMBO J., 13, 1994
4ATK
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MITF:E-BOX COMPLEX
Descriptor:MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR, 5'-D(*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*T)-3'
Authors:Pogenberg, V., Deineko, V., Wilmanns, M.
Deposit date:2012-05-08
Release date:2012-12-12
Last modified:2012-12-19
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Restricted Leucine Zipper Dimerization and Specificity of DNA Recognition of the Melanocyte Master Regulator Mitf
Genes Dev., 26, 2012
5SY5
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CRYSTAL STRUCTURE OF THE HETERODIMERIC NPAS1-ARNT COMPLEX
Descriptor:Aryl hydrocarbon receptor nuclear translocator, Neuronal PAS domain-containing protein 1
Authors:Wu, D., Su, X., Potluri, N., Kim, Y., Rastinejad, F.
Deposit date:2016-08-10
Release date:2016-11-09
Method:X-RAY DIFFRACTION (3.201 Å)
Cite:NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Elife, 5, 2016
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