6N4B
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CANNABINOID RECEPTOR 1-G PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Krishna Kumar, K., Shalev-Benami, M., Hu, H., Weis, W.I., Kobilka, B.K., Skiniotis, G.
Deposit date:2018-11-18
Release date:2019-01-30
Last modified:2019-02-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell, 176, 2019
6MXT
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CRYSTAL STRUCTURE OF HUMAN BETA2 ADRENERGIC RECEPTOR BOUND TO SALMETEROL AND NB71
Descriptor:Endolysin, Beta-2 adrenergic receptor chimera, nanobody Nb71, ...
Authors:Masureel, M., Zou, Y., Picard, L.P., van der Westhuizen, E., Mahoney, J.P., Rodrigues, J.P.G.L.M., Mildorf, T.J., Dror, R.O., Shaw, D.E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R.K., Weis, W.I., Zhang, C., Kobilka, B.K.
Deposit date:2018-10-31
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.959342 Å)
Cite:Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
Nat. Chem. Biol., 14, 2018
6MET
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STRUCTURAL BASIS OF CORECEPTOR RECOGNITION BY HIV-1 ENVELOPE SPIKE
Descriptor:Envelope glycoprotein gp160, T-cell surface glycoprotein CD4, C-C chemokine receptor type 5, ...
Authors:Shaik, M.M., Chen, B.
Deposit date:2018-09-07
Release date:2018-12-12
Last modified:2019-01-16
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural basis of coreceptor recognition by HIV-1 envelope spike.
Nature, 565, 2018
6MEO
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STRUCTURAL BASIS OF CORECEPTOR RECOGNITION BY HIV-1 ENVELOPE SPIKE
Descriptor:Envelope glycoprotein gp160, T-cell surface glycoprotein CD4, C-C chemokine receptor type 5, ...
Authors:Shaik, M.M., Chen, B.
Deposit date:2018-09-06
Release date:2018-12-12
Last modified:2019-01-16
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of coreceptor recognition by HIV-1 envelope spike.
Nature, 565, 2018
6M9T
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CRYSTAL STRUCTURE OF EP3 RECEPTOR BOUND TO MISOPROSTOL-FA
Descriptor:Prostaglandin E2 receptor EP3 subtype, Endolysin chimera, (11alpha,12alpha,13E,16S)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid, ...
Authors:Audet, M., White, K.L., Breton, B., Zarzycka, B., Han, G.W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katrich, V., Cherezov, V., Hanson, M.A., Stevens, R.C.
Deposit date:2018-08-24
Release date:2018-12-05
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor.
Nat. Chem. Biol., 15, 2019
6IIV
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO DALTROBAN
Descriptor:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 2-[4-[2-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]ethanoic acid, ZINC ION, ...
Authors:Fan, H., Zhao, Q., Wu, B.
Deposit date:2018-10-07
Release date:2018-12-19
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6IIU
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO RAMATROBAN
Descriptor:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid, ZINC ION, ...
Authors:Fan, H., Zhao, Q., Wu, B.
Deposit date:2018-10-07
Release date:2018-12-19
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6IGL
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CRYSTAL STRUCTURE OF HUMAN ETB RECEPTOR IN COMPLEX WITH IRL1620
Descriptor:Endothelin receptor type B,Endolysin,Endothelin receptor type B, IRL1620, CITRIC ACID, ...
Authors:Shihoya, W., Izume, T., Inoue, A., Yamashita, K., kadji, F.M.N., Hirata, K., Aoki, J., Nishizawa, T., Nureki, O.
Deposit date:2018-09-25
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.
Nat Commun, 9, 2018
6IGK
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CRYSTAL STRUCTURE OF HUMAN ETB RECEPTOR IN COMPLEX WITH ENDOTHELIN-3
Descriptor:Endothelin receptor type B,Endolysin,Endothelin receptor type B, Endothelin-3, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Shihoya, W., Izume, T., Inoue, A., Yamashita, K., Kadji, F.M.N., Hirata, K., Aoki, J., Nishizawa, T., Nureki, O.
Deposit date:2018-09-25
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.
Nat Commun, 9, 2018
6IBL
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY NB80
Descriptor:Thioredoxin 1,Beta-1 adrenergic receptor, Camelid antibody fragment Nb80, ~{N}-[5-[(1~{R})-2-[[(2~{R})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Deposit date:2018-11-30
Release date:2019-01-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
To Be Published
6HLP
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CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST NETUPITANT
Descriptor:Substance-P receptor,Substance-P receptor, 2-[3,5-bis(trifluoromethyl)phenyl]-~{N},2-dimethyl-~{N}-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide, CITRIC ACID, ...
Authors:Schoppe, J., Ehrenmann, J., Klenk, C., Rucktooa, P., Schutz, M., Dore, A.S., Pluckthun, A.
Deposit date:2018-09-11
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.
Nat Commun, 10, 2019
6HLO
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CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST APREPITANT
Descriptor:Substance-P receptor,GlgA glycogen synthase,Substance-P receptor, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, CITRIC ACID, ...
Authors:Schoppe, J., Ehrenmann, J., Klenk, C., Rucktooa, P., Schutz, M., Dore, A.S., Pluckthun, A.
Deposit date:2018-09-11
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.
Nat Commun, 10, 2019
6HLL
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CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST CP-99,994
Descriptor:Substance-P receptor,GlgA glycogen synthase,Substance-P receptor, (2~{S},3~{S})-~{N}-[(2-methoxyphenyl)methyl]-2-phenyl-piperidin-3-amine
Authors:Schoppe, J., Ehrenmann, J., Klenk, C., Rucktooa, P., Schutz, M., Dore, A.S., Pluckthun, A.
Deposit date:2018-09-11
Release date:2019-01-16
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.
Nat Commun, 10, 2019
6H7O
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND WEAK PARTIAL AGONIST CYANOPINDOLOL AND NANOBODY NB6B9
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6H7N
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST XAMOTEROL AND NANOBODY NB6B9
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6H7M
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY NB6B9
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6H7L
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST DOBUTAMINE AND NANOBODY NB6B9
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6H7J
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY NB80
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb80, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6GPX
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CRYSTAL STRUCTURE OF CCR2A IN COMPLEX WITH MK-0812
Descriptor:C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2, ZINC ION, OLEIC ACID, ...
Authors:Pautsch, A., Schnapp, G., Cheng, R., Apel, A.
Deposit date:2018-06-07
Release date:2019-01-02
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.
Structure, 2018
6GPS
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CRYSTAL STRUCTURE OF CCR2A IN COMPLEX WITH MK-0812
Descriptor:C-C chemokine receptor type 2,Rubredoxin,C-C chemokine receptor type 2, ZINC ION, [(3~{S},4~{S})-3-methoxyoxan-4-yl]-[(1~{R},3~{S})-3-propan-2-yl-3-[[3-(trifluoromethyl)-7,8-dihydro-5~{H}-1,6-naphthyridin-6-yl]carbonyl]cyclopentyl]azanium
Authors:Pautsch, A., Schnapp, G.
Deposit date:2018-06-07
Release date:2019-01-02
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists.
Structure, 2018
6GDG
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CRYO-EM STRUCTURE OF THE ADENOSINE A2A RECEPTOR BOUND TO A MINIGS HETEROTRIMER
Descriptor:TrxA,Adenosine receptor A2a, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Garcia-Nafria, J., Lee, Y.
Deposit date:2018-04-23
Release date:2018-05-16
Method:ELECTRON MICROSCOPY (4.11 Å)
Cite:Cryo-EM structure of the adenosine A2Areceptor coupled to an engineered heterotrimeric G protein.
Elife, 7, 2018
6G79
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COUPLING SPECIFICITY OF HETEROTRIMERIC GO TO THE SEROTONIN 5-HT1B RECEPTOR
Descriptor:Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(o) subunit alpha, ...
Authors:Garcia-Nafria, J., Nehme, R., Edwards, P., Tate, C.G.
Deposit date:2018-04-05
Release date:2018-06-20
Last modified:2018-09-19
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Cryo-EM structure of the serotonin 5-HT1Breceptor coupled to heterotrimeric Go.
Nature, 558, 2018
6FUF
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CRYSTAL STRUCTURE OF THE RHODOPSIN-MINI-GO COMPLEX
Descriptor:Rhodopsin, Guanine nucleotide-binding protein G(o) subunit alpha, RETINAL, ...
Authors:Tsai, C.-J., Weinert, T., Muehle, J., Pamula, F., Nehme, R., Flock, T., Nogly, P., Edwards, P.C., Carpenter, B., Gruhl, T., Ma, P., Deupi, X., Standfuss, J., Tate, C.G., Schertler, G.F.X.
Deposit date:2018-02-27
Release date:2018-10-03
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (3.117 Å)
Cite:Crystal structure of rhodopsin in complex with a mini-Gosheds light on the principles of G protein selectivity.
Sci Adv, 4, 2018
6FKD
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CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS16
Descriptor:Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mattle, D., Standfuss, J., Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FKC
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CRYSTAL STRUCTURE OF N2C/D282C STABILIZED OPSIN BOUND TO RS15
Descriptor:Rhodopsin, PALMITIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Mattle, D., Standfuss, J., Dawson, R.
Deposit date:2018-01-23
Release date:2018-04-04
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Ligand channel in pharmacologically stabilized rhodopsin.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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