6KVG
| The solution structure of human Orc6 | Descriptor: | Origin recognition complex subunit 6 | Authors: | Liu, C, Xu, N, You, Y, Zhu, G. | Deposit date: | 2019-09-04 | Release date: | 2020-09-09 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA. Nucleic Acids Res., 48, 2020
|
|
3M03
| Crystal structure of human Orc6 fragment | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Origin recognition complex subunit 6, SULFATE ION | Authors: | Liu, S.X, Wu, L.J, Sun, J, Wang, H.F, Liu, Y.F. | Deposit date: | 2010-03-02 | Release date: | 2011-03-09 | Last modified: | 2014-03-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
7TJK
| S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with docked Orc6 N-terminal domain | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | Authors: | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | Deposit date: | 2022-01-16 | Release date: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
|
|
7TJJ
| S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with docked Orc6 N-terminal domain | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | Authors: | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | Deposit date: | 2022-01-16 | Release date: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
|
|
7TJH
| S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 1) with flexible Orc6 N-terminal domain | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | Authors: | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | Deposit date: | 2022-01-16 | Release date: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
|
|
7TJI
| S. cerevisiae ORC bound to 84 bp ARS1 DNA and Cdc6 (state 2) with flexible Orc6 N-terminal domain | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6, DNA, ... | Authors: | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | Deposit date: | 2022-01-16 | Release date: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
|
|
7TJF
| S. cerevisiae ORC bound to 84 bp ARS1 DNA | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA, 84 bp ARS1, ... | Authors: | Schmidt, J.M, Yang, R, Kumar, A, Hunker, O, Bleichert, F. | Deposit date: | 2022-01-16 | Release date: | 2023-01-18 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6. Nat Commun, 13, 2022
|
|
4XGC
| Crystal structure of the eukaryotic origin recognition complex | Descriptor: | CHLORIDE ION, Origin recognition complex subunit 1, Origin recognition complex subunit 2, ... | Authors: | Bleichert, F, Botchan, M.R, Berger, J.M. | Deposit date: | 2014-12-30 | Release date: | 2015-04-01 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structure of the eukaryotic origin recognition complex. Nature, 519, 2015
|
|
7MCA
| |
6RQC
| Cryo-EM structure of an MCM loading intermediate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (88-MER), ... | Authors: | Miller, T.C.R, Locke, J, Costa, A. | Deposit date: | 2019-05-15 | Release date: | 2019-11-20 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM. Nature, 575, 2019
|
|
5ZR1
| Saccharomyces Cerevisiae Origin Recognition Complex Bound to a 72-bp Origin DNA containing ACS and B1 element | Descriptor: | 72bp-oring DNA, ACS305, A-rich, ... | Authors: | Li, N, Lam, W.H, Zhai, Y, Cheng, J, Cheng, E, Zhao, Y, Gao, N, Tye, B.K. | Deposit date: | 2018-04-21 | Release date: | 2018-07-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of the origin recognition complex bound to DNA replication origin. Nature, 559, 2018
|
|
5V8F
| Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ... | Authors: | Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H. | Deposit date: | 2017-03-21 | Release date: | 2017-05-10 | Last modified: | 2020-04-22 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat. Struct. Mol. Biol., 24, 2017
|
|
6WGI
| Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at 10.5 A resolution | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (34-MER), ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6WGG
| Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | Descriptor: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (41-MER), ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (8.1 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6WGC
| Atomic model of semi-attached mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) | Descriptor: | Cell division control protein 6, DNA (41-MER), DNA replication licensing factor MCM3, ... | Authors: | Yuan, Z, Schneider, S, Dodd, T, Riera, A, Bai, L, Yan, C, Magdalou, I, Ivanov, I, Stillman, B, Li, H, Speck, C. | Deposit date: | 2020-04-05 | Release date: | 2020-07-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
7JK4
| Structure of Drosophila ORC bound to AT-rich DNA and Cdc6 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (34-MER), ... | Authors: | Schmidt, J.M, Bleichert, F. | Deposit date: | 2020-07-27 | Release date: | 2020-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
|
|
7JK6
| Structure of Drosophila ORC in the active conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... | Authors: | Schmidt, J.M, Bleichert, F. | Deposit date: | 2020-07-27 | Release date: | 2020-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
|
|
7JK2
| |
7JK3
| Structure of Drosophila ORC bound to GC-rich DNA and Cdc6 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein, DNA (33-MER), ... | Authors: | Schmidt, J.M, Bleichert, F. | Deposit date: | 2020-07-27 | Release date: | 2020-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
|
|
7JK5
| Structure of Drosophila ORC bound to DNA | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (32-MER), MAGNESIUM ION, ... | Authors: | Schmidt, J.M, Bleichert, F. | Deposit date: | 2020-07-27 | Release date: | 2020-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
|
|
7JGS
| |
7JGR
| Structure of Drosophila ORC bound to DNA (84 bp) and Cdc6 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, AT22044p1, Cell division control protein, ... | Authors: | Schmidt, J.M, Bleichert, F. | Deposit date: | 2020-07-19 | Release date: | 2020-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6. Nat Commun, 11, 2020
|
|
2LE8
| The protein complex for DNA replication | Descriptor: | DNA replication factor Cdt1, DNA replication licensing factor MCM6 | Authors: | Liu, C, Wei, Z, Zhu, G. | Deposit date: | 2011-06-14 | Release date: | 2012-12-19 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural insights into the Cdt1-mediated MCM2-7 chromatin loading Nucleic Acids Res., 40, 2012
|
|