4JSV
  • Download 4jsv
  • View 4jsv
Molmil generated image of 4jsv
MTOR KINASE STRUCTURE, MECHANISM AND REGULATION.
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Pavletich, N.P., Yang, H.
Deposit date:2013-03-22
Release date:2013-05-01
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
4JT6
  • Download 4jt6
  • View 4jt6
Molmil generated image of 4jt6
STRUCTURE OF MTORDELTAN-MLST8-PI-103 COMPLEX
Descriptor:mTOR, mLST8, 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL
Authors:Pavletich, N.P., Yang, H.
Deposit date:2013-03-22
Release date:2013-05-08
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
5ZCS
  • Download 5zcs
  • View 5zcs
Molmil generated image of 5zcs
4.9 ANGSTROM CRYO-EM STRUCTURE OF HUMAN MTOR COMPLEX 2
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Rapamycin-insensitive companion of mTOR, ...
Authors:Chen, X., Liu, M., Tian, Y., Wang, H., Wang, J., Xu, Y.
Deposit date:2018-02-20
Release date:2018-03-21
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Cryo-EM structure of human mTOR complex 2.
Cell Res., 28, 2018
5FLC
  • Download 5flc
  • View 5flc
Molmil generated image of 5flc
ARCHITECTURE OF HUMAN MTOR COMPLEX 1 - 5.9 ANGSTROM RECONSTRUCTION
Descriptor:SERINE/THREONINE-PROTEIN KINASE MTOR, REGULATORY-ASSOCIATED PROTEIN OF MTOR, FKBP, ...
Authors:Aylett, C.H.S., Sauer, E., Imseng, S., Boehringer, D., Hall, M.N., Ban, N., Maier, T.
Deposit date:2015-10-23
Release date:2015-12-30
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Architecture of Human Mtor Complex 1
Science, 351, 2016
4JSN
  • Download 4jsn
  • View 4jsn
Molmil generated image of 4jsn
STRUCTURE OF MTORDELTAN-MLST8 COMPLEX
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
Authors:Pavletich, N.P.
Deposit date:2013-03-22
Release date:2013-05-08
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
4JSP
  • Download 4jsp
  • View 4jsp
Molmil generated image of 4jsp
STRUCTURE OF MTORDELTAN-MLST8-ATPGAMMAS-MG COMPLEX
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Pavletich, N.P., Yang, H.
Deposit date:2013-03-22
Release date:2013-05-01
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
4JSX
  • Download 4jsx
  • View 4jsx
Molmil generated image of 4jsx
STRUCTURE OF MTORDELTAN-MLST8-TORIN2 COMPLEX
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one
Authors:Pavletich, N.P., Yang, H.
Deposit date:2013-03-22
Release date:2013-05-08
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
4JT5
  • Download 4jt5
  • View 4jt5
Molmil generated image of 4jt5
MTORDELTAN-MLST8-PP242 COMPLEX
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, 2-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol
Authors:Pavletich, N.P., Yang, H.
Deposit date:2013-03-22
Release date:2013-05-08
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:mTOR kinase structure, mechanism and regulation.
Nature, 497, 2013
5H64
  • Download 5h64
  • View 5h64
Molmil generated image of 5h64
CRYO-EM STRUCTURE OF MTORC1
Descriptor:Serine/threonine-protein kinase mTOR, Regulatory-associated protein of mTOR, Target of rapamycin complex subunit LST8
Authors:Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M., Wong, C.C.L., Wang, J., Xu, Y., Wang, H.
Deposit date:2016-11-10
Release date:2017-01-25
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1
Protein Cell, 7, 2016
6ZWO
  • Download 6zwo
  • View 6zwo
Molmil generated image of 6zwo
CRYO-EM STRUCTURE OF HUMAN MTOR COMPLEX 2, FOCUSED ON ONE HALF
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Rapamycin-insensitive companion of mTOR, ...
Authors:Scaiola, A., Mangia, F., Imseng, S., Boehringer, D., Ban, N., Maier, T.
Deposit date:2020-07-28
Release date:2020-11-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The 3.2- angstrom resolution structure of human mTORC2.
Sci Adv, 6, 2020
6ZWM
  • Download 6zwm
  • View 6zwm
Molmil generated image of 6zwm
CRYO-EM STRUCTURE OF HUMAN MTOR COMPLEX 2, OVERALL REFINEMENT
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Rapamycin-insensitive companion of mTOR, ...
Authors:Scaiola, A., Mangia, F., Imseng, S., Boehringer, D., Ban, N., Maier, T.
Deposit date:2020-07-28
Release date:2020-11-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:The 3.2- angstrom resolution structure of human mTORC2.
Sci Adv, 6, 2020
3JBZ
  • Download 3jbz
  • View 3jbz
Molmil generated image of 3jbz
CRYSTAL STRUCTURE OF MTOR DOCKED INTO EM MAP OF DIMERIC ATM KINASE
Descriptor:Serine/threonine-protein kinase mTOR, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Lau, W.C.Y.
Deposit date:2015-11-03
Release date:2016-11-16
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (28 Å)
Cite:Structure of the human dimeric ATM kinase.
Cell Cycle, 15, 2016
2NPU
  • Download 2npu
  • View 2npu
Molmil generated image of 2npu
THE SOLUTION STRUCTURE OF THE RAPAMYCIN-BINDING DOMAIN OF MTOR (FRB)
Descriptor:FKBP12-rapamycin complex-associated protein
Authors:Veverka, V., Crabbe, T., Bird, I., Lennie, G., Muskett, F.W., Taylor, R.J., Carr, M.D.
Deposit date:2006-10-30
Release date:2007-09-18
Last modified:2020-02-26
Method:SOLUTION NMR
Cite:Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27, 2008
2RSE
  • Download 2rse
  • View 2rse
Molmil generated image of 2rse
NMR STRUCTURE OF FKBP12-MTOR FRB DOMAIN-RAPAMYCIN COMPLEX STRUCTURE DETERMINED BASED ON PCS
Descriptor:Peptidyl-prolyl cis-trans isomerase FKBP1A, Serine/threonine-protein kinase mTOR, TERBIUM(III) ION
Authors:Kobashigawa, Y., Ushio, M., Saio, T., Inagaki, F.
Deposit date:2012-01-25
Release date:2012-05-30
Method:SOLUTION NMR
Cite:Convenient method for resolving degeneracies due to symmetry of the magnetic susceptibility tensor and its application to pseudo contact shift-based protein-protein complex structure determination.
J.Biomol.Nmr, 53, 2012
4DRH
  • Download 4drh
  • View 4drh
Molmil generated image of 4drh
CO-CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF FKBP51, RAPAMYCIN AND THE FRB FRAGMENT OF MTOR AT LOW PH
Descriptor:Peptidyl-prolyl cis-trans isomerase FKBP5, Serine/threonine-protein kinase mTOR, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ...
Authors:Maerz, A.M., Bracher, A., Hausch, F.
Deposit date:2012-02-17
Release date:2013-02-06
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
Mol.Cell.Biol., 33, 2013
4DRI
  • Download 4dri
  • View 4dri
Molmil generated image of 4dri
CO-CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF FKBP51, RAPAMYCIN AND THE FRB FRAGMENT OF MTOR
Descriptor:Peptidyl-prolyl cis-trans isomerase FKBP5, Serine/threonine-protein kinase mTOR, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
Authors:Maerz, A.M., Bracher, A., Hausch, F.
Deposit date:2012-02-17
Release date:2013-02-06
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
Mol.Cell.Biol., 33, 2013
4DRJ
  • Download 4drj
  • View 4drj
Molmil generated image of 4drj
O-CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF FKBP52, RAPAMYCIN AND THE FRB FRAGMENT OF MTOR
Descriptor:Peptidyl-prolyl cis-trans isomerase FKBP4, Serine/threonine-protein kinase mTOR, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, ...
Authors:Maerz, A.M., Bracher, A., Hausch, F.
Deposit date:2012-02-17
Release date:2013-02-06
Last modified:2013-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin.
Mol.Cell.Biol., 33, 2013
5GPG
  • Download 5gpg
  • View 5gpg
Molmil generated image of 5gpg
CO-CRYSTAL STRUCTURE OF THE FK506 BINDING DOMAIN OF HUMAN FKBP25, RAPAMYCIN AND THE FRB DOMAIN OF HUMAN MTOR
Descriptor:Peptidyl-prolyl cis-trans isomerase FKBP3, Serine/threonine-protein kinase mTOR, RAPAMYCIN IMMUNOSUPPRESSANT DRUG
Authors:Lee, H.B., Lee, S.Y., Rhee, H.W., Lee, C.W.
Deposit date:2016-08-02
Release date:2016-10-12
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells
Acs Cent.Sci., 2, 2016
5WBH
  • Download 5wbh
  • View 5wbh
Molmil generated image of 5wbh
STRUCTURE OF THE FRB DOMAIN OF MTOR BOUND TO A SUBSTRATE RECRUITMENT PEPTIDE OF S6K1
Descriptor:Serine/threonine-protein kinase mTOR, Ribosomal protein S6 kinase beta-1
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBU
  • Download 5wbu
  • View 5wbu
Molmil generated image of 5wbu
CRYSTAL STRUCTURE OF MTOR(DELTAN)-MLST8-PRAS40(ALPHA-HELIX & BETA-STRAND) COMPLEX
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Proline-rich AKT1 substrate 1
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBY
  • Download 5wby
  • View 5wby
Molmil generated image of 5wby
CRYSTAL STRUCTURE OF MTOR(DELTAN)-MLST8-PRAS40(BETA-STRAND) COMPLEX
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Proline-rich AKT1 substrate 1
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
2GAQ
  • Download 2gaq
  • View 2gaq
Molmil generated image of 2gaq
NMR SOLUTION STRUCTURE OF THE FRB DOMAIN OF MTOR
Descriptor:FKBP12-rapamycin complex-associated protein
Authors:Leone, M., Pellecchia, M.
Deposit date:2006-03-09
Release date:2006-08-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The FRB Domain of mTOR: NMR Solution Structure and Inhibitor Design.
Biochemistry, 45, 2006
3L13
  • Download 3l13
  • View 3l13
Molmil generated image of 3l13
CRYSTAL STRUCTURES OF PAN-PI3-KINASE AND DUAL PAN-PI3-KINASE/MTOR INHIBITORS
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, [3-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenyl]methanol
Authors:Murray, J.M., Wiesmann, C.
Deposit date:2009-12-10
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer.
J.Med.Chem., 53, 2010
3L16
  • Download 3l16
  • View 3l16
Molmil generated image of 3l16
DISCOVERY OF (THIENOPYRIMIDIN-2-YL)AMINOPYRIMIDINES AS POTENT, SELECTIVE, AND ORALLY AVAILABLE PAN-PI3-KINASE AND DUAL PAN-PI3-KINASE/MTOR INHIBITORS FOR THE TREATMENT OF CANCER
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)pyridin-2-amine
Authors:Murray, J.M., Wiesmann, C.
Deposit date:2009-12-10
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer.
J.Med.Chem., 53, 2010
3L17
  • Download 3l17
  • View 3l17
Molmil generated image of 3l17
DISCOVERY OF (THIENOPYRIMIDIN-2-YL)AMINOPYRIMIDINES AS POTENT, SELECTIVE, AND ORALLY AVAILABLE PAN-PI3-KINASE AND DUAL PAN-PI3-KINASE/MTOR INHIBITORS FOR THE TREATMENT OF CANCER
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 4-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine
Authors:Murray, J.M., Wiesmann, C.
Deposit date:2009-12-10
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer.
J.Med.Chem., 53, 2010
171916
PDB entries from 2020-12-02