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8DS8
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BU of 8ds8 by Molmil
Crystal structure of human TNRC18 BAH domain in complex with H3K9me3 peptide
Descriptor: Histone H3.1, Trinucleotide repeat-containing gene 18 protein
Authors:Song, J.K, Lu, J.W.
Deposit date:2022-07-21
Release date:2023-08-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.
Nature, 623, 2023
7Z36
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BU of 7z36 by Molmil
Crystal structure of the KAP1 tripartite motif in complex with the ZNF93 KRAB domain
Descriptor: Endolysin,Transcription intermediary factor 1-beta,Isoform 2 of Transcription intermediary factor 1-beta, SMARCAD1 CUE1 domain, ZINC ION, ...
Authors:Stoll, G.A, Modis, Y.
Deposit date:2022-03-01
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and functional mapping of the KRAB-KAP1 repressor complex.
Embo J., 41, 2022
7VRF
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BU of 7vrf by Molmil
Crystal structure of Oxpecker chromodomain in complex with H3K9me3
Descriptor: H3K9me3, Oxpecker
Authors:Huang, Y, Jin, Z, Yu, B.
Deposit date:2021-10-22
Release date:2022-10-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural insights into the chromodomain of Oxpecker in complex with histone H3 lysine 9 trimethylation reveal a transposon silencing mechanism by heterodimerization.
Biochem.Biophys.Res.Commun., 652, 2023
7M5U
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BU of 7m5u by Molmil
Crystal structure of human MPP8 chromodomain in complex with peptidomimetic ligand UNC5246
Descriptor: M-phase phosphoprotein 8, UNC5246
Authors:Budziszewski, G.R, McGinty, R.K, Waybright, J.M, Norris, J.L, James, L.I.
Deposit date:2021-03-24
Release date:2021-09-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex.
Acs Chem.Biol., 16, 2021
7EF2
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BU of 7ef2 by Molmil
Crystal structure of maize SHH2 SAWADEE domain in complex with an H3K9me3 peptide
Descriptor: HB transcription factor, Histone H3.2, ZINC ION
Authors:Wang, Y, Du, J.
Deposit date:2021-03-20
Release date:2021-06-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2.
J Integr Plant Biol, 63, 2021
7LMM
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BU of 7lmm by Molmil
Crystal structure of bovine DNMT1 BAH1 domain in complex with H4K20me2
Descriptor: DNA (cytosine-5)-methyltransferase 1,DNA (cytosine-5)-methyltransferase 1, Histone H4, ZINC ION
Authors:Ren, W, Song, J.
Deposit date:2021-02-05
Release date:2021-02-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.
Nat Commun, 12, 2021
7LMK
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BU of 7lmk by Molmil
Crystal structure of bovine DNMT1 BAH1 domain in complex with H4K20me3
Descriptor: DNA (cytosine-5)-methyltransferase 1, Histone H4, ZINC ION
Authors:Ren, W, Song, J.
Deposit date:2021-02-05
Release date:2021-02-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.647 Å)
Cite:DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.
Nat Commun, 12, 2021
7BU9
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BU of 7bu9 by Molmil
Crystal Structure of Spindlin1-H3(K4me3-K9me2) complex
Descriptor: H3(K4me3-K9me2) peptide, Spindlin-1
Authors:Zhao, F, Li, H.
Deposit date:2020-04-05
Release date:2020-10-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.502 Å)
Cite:Molecular basis for histone H3 "K4me3-K9me3/2" methylation pattern readout by Spindlin1.
J.Biol.Chem., 295, 2020
7BQZ
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BU of 7bqz by Molmil
Crystal Structure of Spindlin1 bound to H3(K4me3-K9me3) peptide
Descriptor: H3(K4me3-K9me3) peptide, Spindlin-1
Authors:Zhao, F, Li, H.
Deposit date:2020-03-26
Release date:2020-10-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Molecular basis for histone H3 "K4me3-K9me3/2" methylation pattern readout by Spindlin1.
J.Biol.Chem., 295, 2020
6W92
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BU of 6w92 by Molmil
Human UHRF1 TTD domain
Descriptor: E3 ubiquitin-protein ligase UHRF1
Authors:Campbell, J.C, Chang, L, Sankaran, B, Young, D.W.
Deposit date:2020-03-21
Release date:2021-02-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery.
Sci Rep, 11, 2021
6VYJ
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BU of 6vyj by Molmil
Human UHRF1 TTD domain in complex with a fragment
Descriptor: 2,4-dimethylpyridine, E3 ubiquitin-protein ligase UHRF1, beta-D-glucopyranose
Authors:Campbell, J.C, Chang, L, Young, D.W.
Deposit date:2020-02-26
Release date:2021-01-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery.
Sci Rep, 11, 2021
6LTH
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BU of 6lth by Molmil
Structure of human BAF Base module
Descriptor: AT-rich interactive domain-containing protein 1A, SWI/SNF complex subunit SMARCC2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, ...
Authors:He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y.
Deposit date:2020-01-22
Release date:2020-02-12
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of nucleosome-bound human BAF complex.
Science, 367, 2020
6VFO
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BU of 6vfo by Molmil
Solution structure of the PHD of mouse UHRF1 (NP95)
Descriptor: E3 ubiquitin-protein ligase UHRF1, ZINC ION
Authors:Lemak, A, Houliston, S, Duan, S, Arrowsmith, C.H.
Deposit date:2020-01-06
Release date:2020-06-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1.
Nucleic Acids Res., 48, 2020
6VED
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BU of 6ved by Molmil
Solution structure of the TTD and linker region of UHRF1
Descriptor: E3 ubiquitin-protein ligase UHRF1
Authors:Lemak, A, Houliston, S, Duan, S, Ong, M.S, Arrowsmith, C.H.
Deposit date:2019-12-31
Release date:2020-06-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1.
Nucleic Acids Res., 48, 2020
6VEE
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BU of 6vee by Molmil
Solution structure of the TTD and linker region of mouse UHRF1 (NP95)
Descriptor: E3 ubiquitin-protein ligase UHRF1
Authors:Lemak, A, Houliston, S, Duan, S, Arrowsmith, C.H.
Deposit date:2019-12-31
Release date:2020-06-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1.
Nucleic Acids Res., 48, 2020
6V8W
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BU of 6v8w by Molmil
CDYL2 chromodomain in complex with a synthetic peptide
Descriptor: Chromodomain Y-like protein 2, IVA-PHE-ALA-PHE-5T3-SER-NH2, UNKNOWN ATOM OR ION
Authors:Dong, C, Tempel, W, James, L.I, Lamb, K.N, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-12-12
Release date:2020-01-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6TL1
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BU of 6tl1 by Molmil
Crystal structure of the TASOR pseudo-PARP domain
Descriptor: GLYCEROL, Protein TASOR
Authors:Douse, C.H, Timms, R.T, Freund, S.M.V, Modis, Y.
Deposit date:2019-11-29
Release date:2020-09-16
Last modified:2020-10-14
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
Nat Commun, 11, 2020
6V41
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BU of 6v41 by Molmil
crystal structure of CDY1 chromodomain bound to H3K9me3
Descriptor: Histone H3.1 Peptide, Testis-specific chromodomain protein Y 1, UNKNOWN ATOM OR ION
Authors:Qin, S, Tempel, W, Walker, J.R, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-11-27
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.603 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V3N
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BU of 6v3n by Molmil
Crystal structure of CDYL2 in complex with H3K27me3
Descriptor: ACE-GLN-LEU-ALA-THR-LYS-ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA-THR-TYR-NH2, Chromodomain Y-like protein 2, UNKNOWN ATOM OR ION
Authors:Qin, S, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-11-26
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V2S
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BU of 6v2s by Molmil
Crystal Structure of chromodomain of MPP8 in complex with inhibitor UNC3866
Descriptor: M-phase phosphoprotein 8, UNC3866, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2019-11-25
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V2R
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BU of 6v2r by Molmil
Crystal Structure of chromodomain of CBX7 mutant V13A in complex with inhibitor UNC3866
Descriptor: Chromobox protein homolog 7, UNC3866, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Walker, J.R, Stuckey, J.I, Dickson, B.M, James, L.I, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2019-11-25
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V2H
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BU of 6v2h by Molmil
Crystal structure of CDYL2 in complex with H3tK27me3
Descriptor: Chromodomain Y-like protein 2, H3tK27me3, NICKEL (II) ION, ...
Authors:Dong, C, Tempel, W, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2019-11-22
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V2D
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BU of 6v2d by Molmil
Crystal Structure of chromodomain of CDYL2 in complex with inhibitor UNC3866
Descriptor: Chromodomain Y-like protein 2, UNC3866, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2019-11-22
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6SWG
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BU of 6swg by Molmil
Crystal structure of the TASOR-Periphilin core complex
Descriptor: Periphilin-1, Protein TASOR, SULFATE ION
Authors:Prigozhin, D.M, Freund, S.M.V, Modis, Y.
Deposit date:2019-09-20
Release date:2020-08-05
Last modified:2020-10-21
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Periphilin self-association underpins epigenetic silencing by the HUSH complex.
Nucleic Acids Res., 48, 2020
6PZV
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BU of 6pzv by Molmil
Crystal Structure of Bovine DNMT1 RFTS domain in complex with H3K9me3 and Ubiquitin
Descriptor: CITRATE ANION, DNA (cytosine-5)-methyltransferase 1, Histone H3.3, ...
Authors:Ren, W, Song, J.
Deposit date:2019-08-01
Release date:2020-07-15
Last modified:2020-08-12
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation.
Proc.Natl.Acad.Sci.USA, 117, 2020

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PDB entries from 2024-03-27

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