PDB: 250 件ウェブページステータス検索Chemie searchBIRD

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8FYH	G4 RNA-mediated PRC2 dimer 分子名称: G4 RNA, Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, ... 著者 Song, J, Kasinath, V. 登録日 2023-01-26 公開日 2023-10-04 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science, 381, 2023
8GTX	Crystal Structure of human Spindlin1-HBx complex 分子名称: GLYCEROL, HBx, Spindlin-1 著者 Li, H, Liu, W. 登録日 2022-09-09 公開日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of human Spindlin1-HBx complex To be published
8COK	Structural analysis of ING3 protein and its binding to histone H3 分子名称: Inhibitor of growth protein 3 著者 Ferreras-Gutierrez, M, Medrano, F.J, Blanco, F.J. 登録日 2023-02-28 公開日 2023-05-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 Structural analysis of ING3 protein and histone H3 binding. Int.J.Biol.Macromol., 242, 2023
7ZMX	Crystal structure of the Plant Homeodomain (PHD) of human ING3 分子名称: CALCIUM ION, Inhibitor of growth protein 3, ZINC ION 著者 Ferreras, M.O, Medrano, F.J, Blanco, F.J. 登録日 2022-04-20 公開日 2023-05-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structural analysis of ING3 protein and histone H3 binding. Int.J.Biol.Macromol., 242, 2023
8HPO	Cryo-EM structure of a SIN3/HDAC complex from budding yeast 分子名称: Histone deacetylase RPD3, PHOSPHOTHREONINE, POTASSIUM ION, ... 著者 Guo, Z, Zhan, X, Wang, C. 登録日 2022-12-12 公開日 2023-05-03 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structure of a SIN3-HDAC complex from budding yeast. Nat.Struct.Mol.Biol., 30, 2023
8I03	Cryo-EM structure of the SIN3L complex from S. pombe 分子名称: Chromatin modification-related protein png2, Histone deacetylase clr6, POTASSIUM ION, ... 著者 Wang, C, Guo, Z, Zhan, X. 登録日 2023-01-10 公開日 2023-05-03 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Two assembly modes for SIN3 histone deacetylase complexes. Cell Discov, 9, 2023
8F8Y	PHF2 (PHD+JMJ) in Complex with VRK1 N-Terminal Peptide 分子名称: 1,2-ETHANEDIOL, Lysine-specific demethylase PHF2, SULFATE ION, ... 著者 Horton, J.R, Cheng, X. 登録日 2022-11-22 公開日 2023-01-18 最終更新日 2023-02-08 実験手法 X-RAY DIFFRACTION (3.06 Å) 主引用文献 A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. J.Biol.Chem., 299, 2022
8F8Z	PHF2 (PHD+JMJ) in Complex with H3 Histone N-Terminal Peptide 分子名称: 1,2-ETHANEDIOL, H3 N-Terminal Peptide, Lysine-specific demethylase PHF2, ... 著者 Horton, J.R, Cheng, X. 登録日 2022-11-22 公開日 2023-01-18 最終更新日 2023-02-08 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. J.Biol.Chem., 299, 2022
8ESC	Structure of the Yeast NuA4 Histone Acetyltransferase Complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin, Actin-related protein 4, ... 著者 Patel, A.B, Zukin, S.A, Nogales, E. 登録日 2022-10-13 公開日 2022-11-16 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure and flexibility of the yeast NuA4 histone acetyltransferase complex. Elife, 11, 2022
7Y0I	Solution structures of ASH1L PHD domain in complex with H3K4me2 peptide 分子名称: ALA-ARG-THR-MLY-GLN-THR-ALA-ARG-LYS-SER-THR-GLY-GLY-LYS-ALA, Histone-lysine N-methyltransferase ASH1L, ZINC ION 著者 Yu, M, Zeng, L. 登録日 2022-06-05 公開日 2022-10-12 実験手法 SOLUTION NMR 主引用文献 Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer. Front Oncol, 12, 2022
7XE1	Crystal structure of LSD2 in complex with cis-4-Br-PCPA 分子名称: 3-(4-bromophenyl)propanal, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... 著者 Niwa, H, Sato, S, Umehara, T. 登録日 2022-03-29 公開日 2022-09-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 Acs Med.Chem.Lett., 13, 2022
7XE3	Crystal structure of LSD2 in complex with cis-4-Br-2,5-F2-PCPA (S1024) 分子名称: 1,2-ETHANEDIOL, 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal, CITRATE ANION, ... 著者 Niwa, H, Sato, S, Umehara, T. 登録日 2022-03-29 公開日 2022-09-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 Acs Med.Chem.Lett., 13, 2022
7XE2	Crystal structure of LSD2 in complex with trans-4-Br-PCPA 分子名称: 3-(4-bromophenyl)propanal, CITRATE ANION, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Niwa, H, Sato, S, Umehara, T. 登録日 2022-03-29 公開日 2022-09-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 Acs Med.Chem.Lett., 13, 2022
7E9M	Crystal Structure of Spindlin1 bound to SPINDOC Docpep3 分子名称: Peptide from Spindlin interactor and repressor of chromatin-binding protein, Spindlin-1 著者 Zhao, F, Li, H. 登録日 2021-03-04 公開日 2022-06-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published
7EA1	Crystal Structure of Spindlin1 bound to SPINDOC Docpep2 分子名称: Peptide from Spindlin interactor and repressor of chromatin-binding protein, Spindlin-1 著者 Zhao, F, Li, H. 登録日 2021-03-05 公開日 2022-06-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published
7OCB	Crystal structure of Spindlin1 in complex with the inhibitor XY49-92B 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[3-(1,3-dihydroisoindol-2-yl)propoxy]-2N-[2-(dimethylamino)ethyl]-6-methoxy-4N-(1-propan-2-ylpiperidin-4-yl)quinazoline-2,4-diamine, CHLORIDE ION, ... 著者 Johansson, C, Krojer, T, Park, K, Xiong, Y, Jin, J, Oppermann, U. 登録日 2021-04-26 公開日 2022-05-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Crystal structure of Spindlin1 in complex with the inhibitor XY49-92B To Be Published
7ZEX	Complex Cyp33-RRMdelta alpha : UAAUGUCG RNA 分子名称: Isoform 3 of Peptidyl-prolyl cis-trans isomerase E, RNA (5'-R(*UP*AP*AP*UP*GP*UP*CP*G)-3') 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-05-04 最終更新日 2023-05-03 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
7ZEZ	Trimolecular complex Cyp33-RRMdelta alpha : MLL1-PHD3 : H3K4me3 分子名称: Histone H3, Isoform 3 of Peptidyl-prolyl cis-trans isomerase E, MLL cleavage product N320, ... 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-04-13 最終更新日 2023-05-03 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
7ZEW	Complex Cyp33-RRM : AAUAAA RNA 分子名称: Peptidyl-prolyl cis-trans isomerase E, RNA (5'-R(*AP*AP*UP*AP*AP*A)-3') 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-04-13 最終更新日 2023-05-03 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
7ZEV	Free form of extended Cyp33-RRM 分子名称: Peptidyl-prolyl cis-trans isomerase E 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-04-13 最終更新日 2023-05-03 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
7ZEY	Complex Cyp33-RRM : MLL1-PHD3 分子名称: MLL cleavage product N320, Peptidyl-prolyl cis-trans isomerase E, ZINC ION 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-04-13 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
7BCY	X-ray structure of WDR5delta24 bound to the Kaposi's sarcoma herpesvirus LANA win motif peptide 分子名称: ORF 73, WD repeat-containing protein 5 著者 McVey, C.E, Kaye, K.M. 登録日 2020-12-21 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res., 49, 2021
7BED	X-ray structure of WDR5 bound to the WDR5 win motif peptide 分子名称: SULFATE ION, WD repeat-containing protein 5 著者 McVey, C.E, Kaye, K.M. 登録日 2020-12-23 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res., 49, 2021
6TUY	Human LSD1/CoREST bound to the quinazoline inhibitor MC4106 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Mattevi, A, Marrocco, B. 登録日 2020-01-08 公開日 2021-07-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur.J.Med.Chem., 237, 2022
7CFP	Crystal structure of WDR5 in complex with a H3Q5ser peptide 分子名称: H3Q5ser peptide, SEROTONIN, WD repeat-containing protein 5 著者 Zhao, J, Zhang, X, Zang, J. 登録日 2020-06-27 公開日 2021-07-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021

 

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