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8PEP
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BU of 8pep by Molmil
H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex - pose 2
Descriptor: Histone H2A, Histone H2B 1.1, Histone H3, ...
Authors:Koutna, E, Kouba, T, Veverka, V.
Deposit date:2023-06-14
Release date:2023-08-16
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
8PEO
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BU of 8peo by Molmil
H3K36me2 nucleosome-LEDGF/p75 PWWP domain complex
Descriptor: (2R)-2-amino-3-(2-dimethylaminoethylsulfanyl)propanoic acid, Histone H2A, Histone H2B 1.1, ...
Authors:Koutna, E, Kouba, T, Veverka, V.
Deposit date:2023-06-14
Release date:2023-08-16
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023
7Y0I
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BU of 7y0i by Molmil
Solution structures of ASH1L PHD domain in complex with H3K4me2 peptide
Descriptor: ALA-ARG-THR-MLY-GLN-THR-ALA-ARG-LYS-SER-THR-GLY-GLY-LYS-ALA, Histone-lysine N-methyltransferase ASH1L, ZINC ION
Authors:Yu, M, Zeng, L.
Deposit date:2022-06-05
Release date:2022-10-12
Method:SOLUTION NMR
Cite:Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer.
Front Oncol, 12, 2022
7MDN
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BU of 7mdn by Molmil
Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a
Descriptor: Histone-lysine N-methyltransferase NSD2, UNKNOWN ATOM OR ION, ~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide
Authors:Lei, M, Freitas, R.F, Dong, A, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2021-04-05
Release date:2021-05-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
Nat.Chem.Biol., 18, 2022
7E8D
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BU of 7e8d by Molmil
NSD2 E1099K mutant bound to nucleosome
Descriptor: DNA (185-MER), Histone H2A type 1, Histone H2B type 1-J, ...
Authors:Sengoku, T, Sato, K, Nishizawa, T, Nureki, O, Ogata, K.
Deposit date:2021-03-01
Release date:2021-11-10
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2.
Nat Commun, 12, 2021
7AT8
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BU of 7at8 by Molmil
Histone H3 recognition by nucleosome-bound PRC2 subunit EZH2.
Descriptor: Histone H2A, Histone H2B 1.1, Histone H3.2, ...
Authors:Finogenova, K, Benda, C, Schaefer, I.B, Poepsel, S, Strauss, M, Mueller, J.
Deposit date:2020-10-29
Release date:2020-12-09
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3.
Elife, 9, 2020
6XCG
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BU of 6xcg by Molmil
Histone-lysine N-methyltransferase NSD2-PWWP1 with compound UNC6934
Descriptor: Histone-lysine N-methyltransferase NSD2, N-cyclopropyl-3-oxo-N-({4-[(pyrimidin-4-yl)carbamoyl]phenyl}methyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carboxamide, UNKNOWN ATOM OR ION
Authors:Zhou, M.Q, Dong, A, Ingerman, L.A, Hanley, R.P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2020-06-08
Release date:2020-07-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
Nat.Chem.Biol., 18, 2022
6UE6
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BU of 6ue6 by Molmil
PWWP1 domain of NSD2 in complex with MR837
Descriptor: 4-cyano-N-cyclopropyl-N-[(thiophen-2-yl)methyl]benzamide, Histone-lysine N-methyltransferase NSD2, UNKNOWN ATOM OR ION
Authors:Liu, Y, Tempel, W, De Freitas, R.F, Schapira, M, Brown, P.J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2019-09-20
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.
J.Med.Chem., 64, 2021
6IIT
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BU of 6iit by Molmil
Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and an H3K36me2-containing histone peptide
Descriptor: 16-bp TA-rich DNA, H3K36me2-containing histone peptide, Hepatoma-derived growth factor-related protein 3
Authors:Wang, Z, Tian, W.
Deposit date:2018-10-07
Release date:2019-04-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and a H3K36me2-containing histone peptide
Nucleic Acids Res., 2019
6IIS
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BU of 6iis by Molmil
Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and an H3K36me3-containing histone peptide
Descriptor: 16-bp TA-rich DNA, H3K36me3 peptide, Hepatoma-derived growth factor-related protein 3
Authors:Wang, Z, Tian, W.
Deposit date:2018-10-07
Release date:2019-04-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.358 Å)
Cite:Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and an H3K36me3-containing histone peptide
Nucleic Acids Res., 2019
6IIR
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BU of 6iir by Molmil
Complex structure of the HRP3 PWWP domain with a 10-bp GC-rich DNA
Descriptor: 10-bp GC-rich DNA, Hepatoma-derived growth factor-related protein 3
Authors:Wang, Z, Tian, W.
Deposit date:2018-10-07
Release date:2019-04-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Complex structure of the HRP3 PWWP domain with a 10-bp GC-rich DNA
Nucleic Acids Res., 2019
6IIQ
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BU of 6iiq by Molmil
Complex structure of the HRP3 PWWP domain with a 16-bp TA-rich DNA
Descriptor: 16-bp TA-rich DNA, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Hepatoma-derived growth factor-related protein 3, ...
Authors:Wang, Z, Tian, W.
Deposit date:2018-10-07
Release date:2019-04-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Complex structure of the HRP3 PWWP domain with a 16-bp TA-rich DNA
Nucleic Acids Res., 2019
6IIP
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BU of 6iip by Molmil
Apo-form structure of the HRP3 PWWP domain
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hepatoma-derived growth factor-related protein 3, SULFATE ION
Authors:Wang, Z, Tian, W.
Deposit date:2018-10-07
Release date:2019-04-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (0.951 Å)
Cite:Apo-form structure of the HRP3 PWWP domain
Nucleic Acids Res., 2019
6AGO
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BU of 6ago by Molmil
Crystal structure of MRG15-ASH1L Histone methyltransferase complex
Descriptor: Histone-lysine N-methyltransferase ASH1L, Mortality factor 4 like 1, S-ADENOSYLMETHIONINE, ...
Authors:Lee, Y, Song, J.
Deposit date:2018-08-13
Release date:2019-03-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (3.103 Å)
Cite:Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop.
Structure, 27, 2019
4QXC
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BU of 4qxc by Molmil
Crystal structure of histone demethylase KDM2A-H3K36ME2 with NOG
Descriptor: Histone H3.2, Lysine-specific demethylase 2A, N-OXALYLGLYCINE, ...
Authors:Cheng, Z.J, Patel, D.J.
Deposit date:2014-07-19
Release date:2014-11-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
Genes Dev., 28, 2014
4QX7
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BU of 4qx7 by Molmil
Crystal structure of histone demethylase kdm2a-h3k36me2 with alpha-kg
Descriptor: 2-OXOGLUTARIC ACID, Histone H3.2, Lysine-specific demethylase 2A, ...
Authors:Cheng, Z.J, Patel, D.J.
Deposit date:2014-07-18
Release date:2014-11-05
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
Genes Dev., 28, 2014
4GJZ
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BU of 4gjz by Molmil
JMJD5 in complex with 2-oxoglutarate
Descriptor: 2-OXOGLUTARIC ACID, BETA-MERCAPTOETHANOL, COBALT (II) ION, ...
Authors:Del Rizzo, P.A, Trievel, R.C.
Deposit date:2012-08-10
Release date:2012-09-05
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (1.0481 Å)
Cite:Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function.
Mol.Cell.Biol., 32, 2012
4GJY
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BU of 4gjy by Molmil
JMJD5 in complex with N-Oxalylglycine
Descriptor: COBALT (II) ION, JmjC domain-containing protein 5, N-OXALYLGLYCINE
Authors:Del Rizzo, P.A, Trievel, R.C.
Deposit date:2012-08-10
Release date:2012-09-05
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (1.2492 Å)
Cite:Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function.
Mol.Cell.Biol., 32, 2012
4BD3
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BU of 4bd3 by Molmil
Phf19 links methylated lysine 36 of histone H3 to regulation of Polycomb activity
Descriptor: HISTONE H3, PHD FINGER PROTEIN 19
Authors:Lapinaite, A, Simon, B, Carlomagno, T.
Deposit date:2012-10-04
Release date:2012-10-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Phf19 Links Methylated Lys36 of Histone H3 to Regulation of Polycomb Activity
Nat.Struct.Mol.Biol., 19, 2012
2YBA
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BU of 2yba by Molmil
Crystal structure of Nurf55 in complex with histone H3
Descriptor: HISTONE H3, PROBABLE HISTONE-BINDING PROTEIN CAF1
Authors:Schmitges, F.W, Prusty, A.B, Faty, M, Stutzer, A, Lingaraju, G.M, Aiwazian, J, Sack, R, Hess, D, Li, L, Zhou, S, Bunker, R.D, Wirth, U, Bouwmeester, T, Bauer, A, Ly-Hartig, N, Zhao, K, Chan, H, Gu, J, Gut, H, Fischle, W, Muller, J, Thoma, N.H.
Deposit date:2011-03-02
Release date:2011-05-11
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Histone Methylation by Prc2 is Inhibited by Active Chromatin Marks
Mol.Cell, 42, 2011
2YB8
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BU of 2yb8 by Molmil
Crystal structure of Nurf55 in complex with Su(z)12
Descriptor: POLYCOMB PROTEIN SU(Z)12, PROBABLE HISTONE-BINDING PROTEIN CAF1, SULFATE ION
Authors:Schmitges, F.W, Prusty, A.B, Faty, M, Stutzer, A, Lingaraju, G.M, Aiwazian, J, Sack, R, Hess, D, Li, L, Zhou, S, Bunker, R.D, Wirth, U, Bouwmeester, T, Bauer, A, Ly-Hartig, N, Zhao, K, Chan, H, Gu, J, Gut, H, Fischle, W, Muller, J, Thoma, N.H.
Deposit date:2011-03-02
Release date:2011-05-18
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Histone Methylation by Prc2 is Inhibited by Active Chromatin Marks.
Mol.Cell, 42, 2011
2Q8E
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BU of 2q8e by Molmil
Specificity and Mechanism of JMJD2A, a Trimethyllysine-Specific Histone Demethylase
Descriptor: JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ...
Authors:Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
2Q8D
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BU of 2q8d by Molmil
Crystal structure of JMJ2D2A in ternary complex with histone H3-K36me2 and succinate
Descriptor: HISTONE 3 peptide, JmjC domain-containing histone demethylation protein 3A, NICKEL (II) ION, ...
Authors:Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
2Q8C
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BU of 2q8c by Molmil
Crystal structure of JMJD2A in ternary complex with an histone H3K9me3 peptide and 2-oxoglutarate
Descriptor: 2-OXOGLUTARIC ACID, HISTONE 3 PEPTIDE, JmjC domain-containing histone demethylation protein 3A, ...
Authors:Couture, J.-F, Collazo, E, Ortiz-Tello, P, Brunzelle, J.S, Trievel, R.C.
Deposit date:2007-06-10
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Nat.Struct.Mol.Biol., 14, 2007
2MWP
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BU of 2mwp by Molmil
Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide
Descriptor: Cellular tumor antigen p53, Tumor suppressor p53-binding protein 1
Authors:Cui, G, Botuyan, M.V, Mer, G.
Deposit date:2014-11-15
Release date:2014-12-10
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:Structural Plasticity of Methyllysine Recognition by the Tandem Tudor Domain of 53BP1.
Structure, 23, 2015

 

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