5ZNR
  • Download 5znr
  • View 5znr
Molmil generated image of 5znr
CRYSTAL STRUCTURE OF PTSHL IN COMPLEX WITH AN H3K27ME3 PEPTIDE
Descriptor:SHORT LIFE family protein, 17-mer peptide from Histone H3.2, ZINC ION, ...
Authors:Lv, X., Du, J.
Deposit date:2018-04-10
Release date:2018-07-18
Method:X-RAY DIFFRACTION (3.202 Å)
Cite:Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.
Nat Commun, 9, 2018
6IP4
  • Download 6ip4
  • View 6ip4
Molmil generated image of 6ip4
CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA JMJ13 CATALYTIC DOMAIN IN COMPLEX WITH NOG AND AN H3K27ME3 PEPTIDE
Descriptor:Arabidopsis JMJ13, Histone H3.2, NICKEL (II) ION, ...
Authors:Hu, H., Du, J.
Deposit date:2018-11-02
Release date:2019-04-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor.
Nat Commun, 10, 2019
4X3K
  • Download 4x3k
  • View 4x3k
Molmil generated image of 4x3k
CRYSTAL STRUCTURE OF CHROMOBOX HOMOLOG 7 (CBX7) CHROMODOMAIN WITH H3K27ME3 PEPTIDE
Descriptor:Chromobox protein homolog 7, H3K27me3 peptide, NICKEL (II) ION, ...
Authors:Ren, C., Zhou, M.M.
Deposit date:2014-12-01
Release date:2015-03-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain.
Chem.Biol., 22, 2015
5Z8L
  • Download 5z8l
  • View 5z8l
Molmil generated image of 5z8l
CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA EBS IN COMPLEX WITH AN H3K27ME3 PEPTIDE
Descriptor:Chromatin remodeling protein EBS, H3K27me3 peptide, ZINC ION
Authors:Yang, Z., Du, J.
Deposit date:2018-01-31
Release date:2018-07-25
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.
Nat. Genet., 50, 2018
6IP0
  • Download 6ip0
  • View 6ip0
Molmil generated image of 6ip0
CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA JMJ13 CATALYTIC DOMAIN IN COMPLEX WITH AKG
Descriptor:Transcription factor jumonji (Jmj) family protein, 2-OXOGLUTARIC ACID, NICKEL (II) ION, ...
Authors:Hu, H., Du, J.
Deposit date:2018-11-01
Release date:2019-04-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor.
Nat Commun, 10, 2019
4X3E
  • Download 4x3e
  • View 4x3e
Molmil generated image of 4x3e
CRYSTAL STRUCTURE OF EED IN COMPLEX WITH A TRIMETHYLATED JARID2 PEPTIDE
Descriptor:Polycomb protein EED, ALA-GLN-ARG-M3L-PHE-ALA-GLN-SER
Authors:Justin, N., Gamblin, S.J., Margueron, R.
Deposit date:2014-11-28
Release date:2015-01-21
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
Mol.Cell, 57, 2015
5GSA
  • Download 5gsa
  • View 5gsa
Molmil generated image of 5gsa
EED IN COMPLEX WITH AN ALLOSTERIC PRC2 INHIBITOR
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
Authors:Zhao, K., Zhao, M., Luo, X., Zhang, H.
Deposit date:2016-08-15
Release date:2017-02-01
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Nat. Chem. Biol., 13, 2017
5WP3
  • Download 5wp3
  • View 5wp3
Molmil generated image of 5wp3
CRYSTAL STRUCTURE OF EED IN COMPLEX WITH EB22
Descriptor:Polycomb protein EED, EB22, UNKNOWN ATOM OR ION
Authors:Dong, C., Tempel, W., Zhu, L., Moody, J.D., Baker, D., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2017-08-03
Release date:2017-09-13
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5ZNP
  • Download 5znp
  • View 5znp
Molmil generated image of 5znp
CRYSTAL STRUCTURE OF PTSHL IN COMPLEX WITH AN H3K4ME3 PEPTIDE
Descriptor:SHORT LIFE family protein, 15-mer peptide from Histone H3.2, ZINC ION
Authors:Lv, X., Du, J.
Deposit date:2018-04-10
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.
Nat Commun, 9, 2018
4V2V
  • Download 4v2v
  • View 4v2v
Molmil generated image of 4v2v
JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27ME3 PEPTIDE (25-29) ARK(ME3)SA
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, HISTONE H3.1T, N-OXALYLGLYCINE, ...
Authors:Chowdhury, R., Madden, S.K., Schofield, C.J.
Deposit date:2014-10-15
Release date:2014-11-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates.
Epigenetics, 9, 2014
4V2W
  • Download 4v2w
  • View 4v2w
Molmil generated image of 4v2w
JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27ME3 PEPTIDE (16-35)
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, HISTONE H3.1T, NICKEL (II) ION, ...
Authors:Chowdhury, R., Zafred, D., Schofield, C.J.
Deposit date:2014-10-15
Release date:2014-11-26
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates.
Epigenetics, 9, 2014
2L1B
  • Download 2l1b
  • View 2l1b
Molmil generated image of 2l1b
SOLUTION NMR STRUCTURE OF THE CHROMOBOX PROTEIN CBX7 WITH H3K27ME3
Descriptor:Chromobox protein homolog 7, Histone H3
Authors:Kaustov, L., Lemak, A., Fares, C., Gutmanas, A., Muhandiram, R., Quang, H., Loppnau, P., Min, J., Edwards, A., Arrowsmith, C., Structural Genomics Consortium (SGC)
Deposit date:2010-07-27
Release date:2010-08-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Recognition and specificity determinants of the human cbx chromodomains.
J.Biol.Chem., 286, 2011
3AVR
  • Download 3avr
  • View 3avr
Molmil generated image of 3avr
CATALYTIC FRAGMENT OF UTX/KDM6A BOUND WITH HISTONE H3K27ME3 PEPTIDE, N-OXYALYLGLYCINE, AND NI(II)
Descriptor:Lysine-specific demethylase 6A, Histone H3, N-OXALYLGLYCINE, ...
Authors:Sengoku, T., Yokoyama, S.
Deposit date:2011-03-07
Release date:2011-10-19
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A
Genes Dev., 25, 2011
3JZG
  • Download 3jzg
  • View 3jzg
Molmil generated image of 3jzg
STRUCTURE OF EED IN COMPLEX WITH H3K27ME3
Descriptor:Polycomb protein EED, HISTONE PEPTIDE
Authors:Xu, C., Bian, C.B., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2009-09-23
Release date:2009-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
Proc.Natl.Acad.Sci.USA, 107, 2010
4EZH
  • Download 4ezh
  • View 4ezh
Molmil generated image of 4ezh
THE CRYSTAL STRUCTURE OF KDM6B BOUND WITH H3K27ME3 PEPTIDE
Descriptor:Lysine-specific demethylase 6B, SYNTHESIZED methylation peptide, NICKEL (II) ION, ...
Authors:Cheng, Z.J., Patel, D.J.
Deposit date:2012-05-02
Release date:2012-08-08
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Nature, 488, 2012
5KJH
  • Download 5kjh
  • View 5kjh
Molmil generated image of 5kjh
CRYSTAL STRUCTURE OF AN ACTIVE POLYCOMB REPRESSIVE COMPLEX 2 IN THE STIMULATED STATE
Descriptor:putative polycomb protein Eed, Putative uncharacterized protein,Zinc finger domain-containing protein, Peptide H3K27me3, ...
Authors:Jiao, L., Liu, X.
Deposit date:2016-06-20
Release date:2017-04-19
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354, 2016
5KKL
  • Download 5kkl
  • View 5kkl
Molmil generated image of 5kkl
STRUCTURE OF CTPRC2 IN COMPLEX WITH H3K27ME3 AND H3K27M
Descriptor:putative polycomb protein Eed, Putative uncharacterized protein,Histone H3.1 peptide,Zinc finger domain-containing protein, ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA, ...
Authors:Jiao, L., Liu, X.
Deposit date:2016-06-21
Release date:2017-04-19
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354, 2016
5U5T
  • Download 5u5t
  • View 5u5t
Molmil generated image of 5u5t
CRYSTAL STRUCTURE OF EED IN COMPLEX WITH H3K27ME3 PEPTIDE AND 3-(BENZO[D][1,3]DIOXOL-4-YLMETHYL)PIPERIDINE-1-CARBOXIMIDAMIDE
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, (3R)-3-[(2H-1,3-benzodioxol-4-yl)methyl]piperidine-1-carboximidamide, ...
Authors:Bussiere, D., Shu, W.
Deposit date:2016-12-07
Release date:2017-01-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
J. Med. Chem., 60, 2017
5U62
  • Download 5u62
  • View 5u62
Molmil generated image of 5u62
CRYSTAL STRUCTURE OF EED IN COMPLEX WITH H3K27ME3 PEPTIDE AND 6-(BENZO[D][1,3]DIOXOL-4-YLMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,5-A]PYRIDIN-3-AMINE
Descriptor:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, GLYCEROL, ...
Authors:Bussiere, D., Shu, W.
Deposit date:2016-12-07
Release date:2017-01-11
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
J. Med. Chem., 60, 2017
2N4Q
  • Download 2n4q
  • View 2n4q
Molmil generated image of 2n4q
SOLUTION NMR STRUCTURE OF CBX8 IN COMPLEX WITH AF9 (CBX8-AF9)
Descriptor:Chromobox protein homolog 8, Protein AF-9
Authors:Kuntimaddi, A., Leach, B.I., Bushweller, J.H.
Deposit date:2015-06-30
Release date:2016-07-20
Method:SOLUTION NMR
Cite:Solution NMR Structure of CBX8 in complex with AF9 (CBX8-AF9)
To be Published
5YUG
  • Download 5yug
  • View 5yug
Molmil generated image of 5yug
ATVAL1 PHD-LIKE DOMAIN IN THE P31 SPACE GROUP
Descriptor:B3 domain-containing transcription repressor VAL1, ZINC ION, GLYCEROL
Authors:Zhang, M.M., Wu, B.X.
Deposit date:2017-11-22
Release date:2018-05-02
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:AtVAL1 PHD-Like domain in the P31 space group
To Be Published