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5Z6J	High-pressure Crystal Structure Analysis of M20 loop closed DHFR at 220 MPa Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Watanabe, N, Nagae, T, Yamada, H. Deposit date: 2018-01-23 Release date: 2018-09-19 Method: X-RAY DIFFRACTION (1.803 Å) Cite: High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP. Acta Crystallogr D Struct Biol, 74, 2018
5Z6F	High-pressure Crystal Structure Analysis of DHFR(0.1 MPa) Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Watanabe, N, Nagae, T, Yamada, H. Deposit date: 2018-01-22 Release date: 2018-09-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.801 Å) Cite: High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP. Acta Crystallogr D Struct Biol, 74, 2018
5W3Q	L28F E.coli DHFR in complex with NADPH Descriptor: CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Oyen, D, Wright, P.E, Wilson, I.A. Deposit date: 2017-06-08 Release date: 2017-08-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.401 Å) Cite: Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion. J. Am. Chem. Soc., 139, 2017
5UJX	Crystal structure of DHFR in 20% Isopropanol Descriptor: CALCIUM ION, CHLORIDE ION, Dihydrofolate reductase, ... Authors: Cuneo, M.J, Agarwal, P.K. Deposit date: 2017-01-19 Release date: 2017-12-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Modulating Enzyme Activity by Altering Protein Dynamics with Solvent. Biochemistry, 57, 2018
5UJF	Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor Descriptor: 1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2017-01-17 Release date: 2017-02-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor TO BE PUBLISHED
5UIP	structure of DHFR with bound DAP, p-ABG and NADP Descriptor: Dihydrofolate reductase, N-(4-aminobenzene-1-carbonyl)-L-glutamic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-01-14 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
5UIO	structure of DHFR with bound DAP, p-ABG and NADP Descriptor: BETA-MERCAPTOETHANOL, Dihydrofolate reductase, FORMIC ACID, ... Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-01-14 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.929 Å) Cite: A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
5UII	structure of DHFR with bound buformin and NADP Descriptor: CALCIUM ION, Dihydrofolate reductase, N-butyl-N'-(diaminomethylidene)guanidine, ... Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-01-14 Release date: 2018-01-31 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.351 Å) Cite: A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
5UIH	structure of DHFR with bound phenformin and NADP Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Dihydrofolate reductase, ... Authors: Pedersen, L.C, London, R.E. Deposit date: 2017-01-14 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.647 Å) Cite: A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
5U27	Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor Descriptor: 1,2-ETHANEDIOL, 2,4-diamino-6-methyl-5-[3-(2,4,5-trichlorophenoxy)propyloxy]pyrimidine, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-11-29 Release date: 2016-12-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor TO BE PUBLISHED
5U26	Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor Descriptor: 1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2016-11-29 Release date: 2016-12-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor TO BE PUBLISHED
5T7O	Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE Descriptor: (6S)-5,6,7,8-TETRAHYDROFOLATE, 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... Authors: Di Pisa, F, Dello Iacono, L, Bonucci, A, Mangani, S. Deposit date: 2016-09-05 Release date: 2017-09-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE To Be Published
5T0L	Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF and 5-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-15) Descriptor: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-[4-(3,4-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4-diamine, ... Authors: Thomas, S.B, Chen, Z, Lu, H, Li, Y. Deposit date: 2016-08-16 Release date: 2016-09-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.13 Å) Cite: Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design. ACS Med Chem Lett, 7, 2016
5SSW	DHFR:NADP+:FOL complex at 270 K (multi-crystal) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-07-03 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (1.06 Å) Cite: DHFR:NADP+:FOL complex at 270 K To Be Published
5SSV	DHFR:NADP+:FOL complex at 270 K (crystal 4) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-07-03 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (1.08 Å) Cite: DHFR:NADP+:FOL complex at 270 K To Be Published
5SSU	DHFR:NADP+:FOL complex at 270 K (crystal 3) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-07-03 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (1.12 Å) Cite: DHFR:NADP+:FOL complex at 270 K To Be Published
5SST	DHFR:NADP+:FOL complex at 270 K (crystal 2) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-07-03 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (1.07 Å) Cite: DHFR:NADP+:FOL complex at 270 K To Be Published
5SSS	DHFR:NADP+:FOL complex at 270 K (crystal 1) Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. Deposit date: 2022-07-03 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (1.14 Å) Cite: DHFR:NADP+:FOL complex at 270 K To Be Published
5SDB	Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate Descriptor: 1,2-ETHANEDIOL, Dihydrofolate reductase, N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-12-20 Release date: 2022-02-09 Last modified: 2022-03-02 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate to be published
5SDA	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-774 Descriptor: (2R)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-12-20 Release date: 2022-02-09 Last modified: 2022-03-02 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-774 to be published
5SD9	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1096 Descriptor: (2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3-fluoropropanoic acid, 1,2-ETHANEDIOL, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-12-20 Release date: 2022-02-09 Last modified: 2022-03-02 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1096 to be published
5SD8	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture) Descriptor: (2R)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, (2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-12-20 Release date: 2022-02-09 Last modified: 2022-03-02 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture) to be published
5SD7	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-735 Descriptor: (2S)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-12-20 Release date: 2022-02-09 Last modified: 2022-03-02 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-735 to be published
5SD6	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892 Descriptor: 1,2-ETHANEDIOL, 6-ethyl-5-(4-{2-[2-(1H-tetrazol-5-yl)ethyl]phenoxy}butoxy)pyrimidine-2,4-diamine, CHLORIDE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-12-20 Release date: 2022-02-09 Last modified: 2022-03-02 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892 to be published
5SD5	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1230 Descriptor: 1,2-ETHANEDIOL, 1-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}-4-methylphenyl)azetidine-3-carboxylic acid, Dihydrofolate reductase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-12-20 Release date: 2022-02-09 Last modified: 2022-03-02 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1230 to be published

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