PDB: 392 resultsInfo pagesStatus searchChemie searchBIRD

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7AHZ	Crystal structure of Western clawed frog MDM2 RING domain homodimer bound to UbcH5B-Ub Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, ... Authors: Magnussen, H.M, Huang, D.T. Deposit date: 2020-09-25 Release date: 2021-01-20 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
7AI1	Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 2) Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... Authors: Magnussen, H.M, Huang, D.T. Deposit date: 2020-09-25 Release date: 2021-01-20 Last modified: 2021-02-10 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
8ATU	Cryo-EM structure of human BIRC6 Descriptor: Baculoviral IAP repeat-containing protein 6, ZINC ION Authors: Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. Deposit date: 2022-08-24 Release date: 2023-02-15 Last modified: 2023-03-29 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
8AUK	Cryo-EM structure of human BIRC6 in complex with HTRA2. Descriptor: Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial, ... Authors: Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. Deposit date: 2022-08-25 Release date: 2023-02-15 Last modified: 2023-05-24 Method: ELECTRON MICROSCOPY (6.2 Å) Cite: Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
8AUW	Cryo-EM structure of human BIRC6 in complex with SMAC. Descriptor: Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein, ZINC ION Authors: Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. Deposit date: 2022-08-25 Release date: 2023-02-15 Last modified: 2023-05-24 Method: ELECTRON MICROSCOPY (7.2 Å) Cite: Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
8ATX	Cryo-EM structure of human BIRC6 - no substrate Descriptor: Baculoviral IAP repeat-containing protein 6, ZINC ION Authors: Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. Deposit date: 2022-08-24 Release date: 2023-02-15 Last modified: 2023-03-29 Method: ELECTRON MICROSCOPY (7 Å) Cite: Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
8ATO	Structure of the giant inhibitor of apoptosis, BIRC6 bound to the regulator SMAC Descriptor: Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein Authors: Dietz, L, Elliott, P.R. Deposit date: 2022-08-23 Release date: 2023-03-08 Last modified: 2023-03-29 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6. Science, 379, 2023
8ATM	Structure of the giant inhibitor of apoptosis, BIRC6 (composite map) Descriptor: Baculoviral IAP repeat-containing protein 6 Authors: Dietz, L, Elliott, P.R. Deposit date: 2022-08-23 Release date: 2023-03-08 Last modified: 2023-03-29 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6. Science, 379, 2023
5TUT	UbcH5a-Ub isopeptide conjugate Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 D1 Authors: Sanchez, J.G, Wagner, J.M, Pornillos, O. Deposit date: 2016-11-07 Release date: 2017-11-08 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.604 Å) Cite: UbcH5a-Ub isopeptide conjugate To be Published
7BXG	MavC-UBE2N-Ub complex Descriptor: MavC, Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N Authors: Gao, P, Wang, Y. Deposit date: 2020-04-19 Release date: 2020-05-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.705 Å) Cite: Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors. Nat Commun, 11, 2020
7BBF	Crystal structure of ubiquitin charged Ube2N (Ube2N~Ub) in complex with Ube2V2 Descriptor: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2 Authors: Kiss, L, Neuhaus, D, James, L.C. Deposit date: 2020-12-17 Release date: 2021-01-27 Last modified: 2021-03-10 Method: X-RAY DIFFRACTION (2.54 Å) Cite: RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination. Nat Commun, 12, 2021
8B3I	CRL4CSA-E2-Ub (state 2) Descriptor: Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ... Authors: Kokic, G, Cramer, P. Deposit date: 2022-09-16 Release date: 2023-09-27 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: C(N)RL4CSA-E2-Ub (state 2) To Be Published
5ULH	Structure of RNF165 in complex with a UbcH5b~Ub conjugate Descriptor: E3 ubiquitin-protein ligase RNF165, GLYCEROL, THIOCYANATE ION, ... Authors: Middleton, A.J, Day, C.L, Wright, J.D. Deposit date: 2017-01-24 Release date: 2017-06-07 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Discovery of new non-covalent ubiquitin binding sites on UbcH5 To be published
8AMS	Complex of human TRIM2 RING domain, UBCH5C, and Ubiquitin Descriptor: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, Polyubiquitin-C, ... Authors: Perez-Borrajero, C, Kotova, I, Murciano, B, Hennig, J. Deposit date: 2022-08-04 Release date: 2023-11-15 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural and biophysical studies of TRIM2 and TRIM3 To Be Published
5ULF	Crystal Structure of a UbcH5b~Ub conjugate Descriptor: GLYCEROL, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2 Authors: Middleton, A.J, Day, C.L, Wright, J.D. Deposit date: 2017-01-24 Release date: 2017-06-07 Last modified: 2017-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of new non-covalent ubiquitin binding sites on UbcH5 To be published
5ULK	Crystal Structure of RNF165 in complex with a UbcH5b~Ub conjugate Descriptor: E3 ubiquitin-protein ligase RNF165, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2, ... Authors: Middleton, A.J, Day, C.L, Wright, J.D. Deposit date: 2017-01-24 Release date: 2017-06-07 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Discovery of new non-covalent ubiquitin binding sites on UbcH5 To be published
8BTL	Crystal structure of a complex between the E2 conjugating enzyme UBE2A and the E3 ligase module from UBR4 Descriptor: Ubiquitin conjugating enzyme E2 A, ZINC ION, cDNA FLJ12511 fis, ... Authors: Virdee, S, Mabbitt, P.D, Barnsby-Greer, L. Deposit date: 2022-11-29 Release date: 2023-12-13 Last modified: 2024-04-17 Method: X-RAY DIFFRACTION (3.2 Å) Cite: UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4. Nat.Struct.Mol.Biol., 31, 2024
5VZW	TRIM23 RING domain in complex with UbcH5-Ub Descriptor: E3 ubiquitin-protein ligase TRIM23, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2, ... Authors: Pornillos, O, Dawidziak, D. Deposit date: 2017-05-29 Release date: 2017-08-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.278 Å) Cite: Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase. Proteins, 85, 2017
6HPR	Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub Descriptor: Baculoviral IAP repeat-containing protein 2, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ... Authors: Patel, A, Huang, D.T. Deposit date: 2018-09-21 Release date: 2018-12-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex. J. Biol. Chem., 294, 2019
2VRR	Structure of SUMO modified Ubc9 Descriptor: FORMIC ACID, SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, ... Authors: Knipscheer, P, Flotho, A, Klug, H, Olsen, J.V, van Dijk, W.J, Fish, A, Johnson, E.S, Mann, M, Sixma, T.K, Pichler, A. Deposit date: 2008-04-13 Release date: 2008-08-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Ubc9 sumoylation regulates SUMO target discrimination. Mol. Cell, 31, 2008
3SQV	Crystal Structure of E. coli O157:H7 E3 ubiquitin ligase, NleL, with a human E2, UbcH7 Descriptor: GLYCEROL, SULFATE ION, Ubiquitin-conjugating enzyme E2 L3, ... Authors: Lin, D.Y, Chen, J. Deposit date: 2011-07-06 Release date: 2012-01-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions. Proc.Natl.Acad.Sci.USA, 109, 2012
3SY2	Crystal structure of the Salmonella E3 ubiquitin ligase SopA in complex with the human E2 UbcH7 Descriptor: E3 ubiquitin-protein ligase SopA, SULFATE ION, Ubiquitin-conjugating enzyme E2 L3 Authors: Diao, J, Lin, D.Y, Chen, J. Deposit date: 2011-07-15 Release date: 2012-01-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.27 Å) Cite: Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions. Proc.Natl.Acad.Sci.USA, 109, 2012
8EAZ	HOIL-1/E2-Ub/Ub transthiolation complex Descriptor: RanBP-type and C3HC4-type zinc finger-containing protein 1, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ... Authors: Wang, X.S, Cotton, T.R, Lechtenberg, B.C. Deposit date: 2022-08-30 Release date: 2023-01-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.08 Å) Cite: The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family. Nat Commun, 14, 2023
8EB0	RNF216/E2-Ub/Ub transthiolation complex Descriptor: E3 ubiquitin-protein ligase RNF216, SULFATE ION, Ubiquitin, ... Authors: Cotton, T.R, Wang, X.S, Lechtenberg, B.C. Deposit date: 2022-08-30 Release date: 2023-01-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.03 Å) Cite: The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family. Nat Commun, 14, 2023
5ZBU	Crystal Structure of PA-TM-RING E3 ligase RNF13 RING domain in complex with E2~Ub Descriptor: E3 ubiquitin-protein ligase RNF13, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2, ... Authors: Datta, A.B, Sarkar, S. Deposit date: 2018-02-12 Release date: 2019-02-27 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal Structure of PA-TM-RING E3 ligase RNF13 RING domain in complex with E2~Ub To Be Published

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