6MV4 | | CRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR IXA | | Descriptor: | Coagulation factor IX, SULFATE ION, 1,2-ETHANEDIOL, ... | | Authors: | Vadivel, K., Schreuder, H.A., Liesum, A., Bajaj, S.P. | | Deposit date: | 2018-10-24 | | Release date: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (1.37 Å) | | Cite: | Sodium-site in serine protease domain of human coagulation factor IXa: evidence from the crystal structure and molecular dynamics simulations study.
J. Thromb. Haemost., 2019
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6N2D | |
6N2Y | | BACILLUS PS3 ATP SYNTHASE CLASS 1 | | Descriptor: | ATP synthase subunit alpha, ATP synthase subunit beta, ATP synthase gamma chain, ... | | Authors: | Guo, H., Rubinstein, J.L. | | Deposit date: | 2018-11-14 | | Release date: | 2019-02-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure of a bacterial ATP synthase.
Elife, 8, 2019
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6N2Z | | BACILLUS PS3 ATP SYNTHASE CLASS 2 | | Descriptor: | Bacillus PS3 ATP synthase subunit b, Bacillus PS3 ATP synthase subunit a, ATP synthase subunit c, ... | | Authors: | Guo, H., Rubinstein, J.L. | | Deposit date: | 2018-11-14 | | Release date: | 2019-02-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure of a bacterial ATP synthase.
Elife, 8, 2019
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6N30 | | BACILLUS PS3 ATP SYNTHASE CLASS 3 | | Descriptor: | Bacillus PS3 ATP synthase subunit b, Bacillus PS3 ATP synthase subunit a, ATP synthase subunit c, ... | | Authors: | Guo, H., Rubinstein, J.L. | | Deposit date: | 2018-11-14 | | Release date: | 2019-02-20 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of a bacterial ATP synthase.
Elife, 8, 2019
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6NCW | |
6NCX | |
6NCY | |
6NCZ | |
6ND6 | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ERYTHROMYCIN AND BOUND TO MRNA AND A-, P-, AND E-SITE TRNAS AT 2.85A RESOLUTION | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Svetlov, M.S., Plessa, E., Chen, C.-W., Bougas, A., Krokidis, M.G., Dinos, G.P., Polikanov, Y.S. | | Deposit date: | 2018-12-13 | | Release date: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition.
RNA, 2019
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6NEO | |
6NJ9 | | ACTIVE STATE DOT1L BOUND TO THE H2B-UBIQUITINATED NUCLEOSOME, 2-TO-1 COMPLEX | | Descriptor: | Histone H4, Histone H2A type 1, Histone H2B 1.1, ... | | Authors: | Worden, E.J., Hoffmann, N.A., Wolberger, C. | | Deposit date: | 2019-01-02 | | Release date: | 2019-02-20 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L
Cell(Cambridge,Mass.), 2019
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6NJO | | STRUCTURE OF THE ASSEMBLED ATPASE ESCN FROM THE ENTEROPATHOGENIC E. COLI (EPEC) TYPE III SECRETION SYSTEM | | Descriptor: | Translocator EscN, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Majewski, D.D., Worrall, L.J., Hong, C., Atkinson, C.E., Vuckovic, M., Watanabe, N., Yu, Z., Strynadka, N.C.J. | | Deposit date: | 2019-01-03 | | Release date: | 2019-02-20 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry.
Nat Commun, 10, 2019
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6NJP | | STRUCTURE OF THE ASSEMBLED ATPASE ESCN IN COMPLEX WITH ITS CENTRAL STALK ESCO FROM THE ENTEROPATHOGENIC E. COLI (EPEC) TYPE III SECRETION SYSTEM | | Descriptor: | Translocator EscN, EscO, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Majewski, D.D., Worrall, L.J., Hong, C., Atkinson, C.E., Vuckovic, M., Watanabe, N., Yu, Z., Strynadka, N.C.J. | | Deposit date: | 2019-01-03 | | Release date: | 2019-02-20 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry.
Nat Commun, 10, 2019
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6NM7 | | PD-L1 IGV DOMAIN BOUND TO FRAGMENT | | Descriptor: | Programmed cell death 1 ligand 1, 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one | | Authors: | Perry, E., Zhao, B. | | Deposit date: | 2019-01-10 | | Release date: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.426 Å) | | Cite: | Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 2019
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6NM8 | | IGV-V76T BMS COMPOUND 105 | | Descriptor: | Programmed cell death 1 ligand 1, N-({2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl}methyl)-D-alanine | | Authors: | Perry, E., Zhao, B., Fesik, S. | | Deposit date: | 2019-01-10 | | Release date: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.792 Å) | | Cite: | Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 2019
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6NNA | | HUMAN FATTY ACID SYNTHASE PSI/KR TRI-DOMAIN WITH NADPH AND COMPOUND 22 | | Descriptor: | Fatty acid synthase,Fatty acid synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {4-[4-(1,3-benzoxazol-2-yl)benzene-1-carbonyl]piperazin-1-yl}(1-hydroxycyclopropyl)methanone, ... | | Authors: | Toms, A.V., Martin, M.W. | | Deposit date: | 2019-01-14 | | Release date: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Discovery and Optimization of Novel Piperazines as Potent Inhibitors of Fatty Acid Synthase (FASN)
Bioorg.Med.Chem.Lett., 2019
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6NNV | |
6NOG | | POISED-STATE DOT1L BOUND TO THE H2B-UBIQUITINATED NUCLEOSOME | | Descriptor: | Histone H3.2, Histone H4, Histone H2A type 1, ... | | Authors: | Worden, E.J., Hoffmann, N.A., Wolberger, C. | | Deposit date: | 2019-01-16 | | Release date: | 2019-02-20 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L
Cell(Cambridge,Mass.), 2019
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6NOJ | | PD-L1 IGV DOMAIN V76T WITH FRAGMENT | | Descriptor: | Programmed cell death 1 ligand 1, methyl 3-amino-4-(2-fluorophenyl)-1H-pyrrole-2-carboxylate | | Authors: | Zhao, B., Perry, E. | | Deposit date: | 2019-01-16 | | Release date: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 2019
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6NOS | | PD-L1 IGV DOMAIN V76T WITH FRAGMENT | | Descriptor: | Programmed cell death 1 ligand 1, 1-[5-(3,5-dichlorophenyl)furan-2-yl]-N-methylmethanamine | | Authors: | Zhao, B., Perry, E. | | Deposit date: | 2019-01-16 | | Release date: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.701 Å) | | Cite: | Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 2019
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6NP9 | | PD-L1 IGV DOMAIN V76T WITH FRAGMENT | | Descriptor: | Programmed cell death 1 ligand 1, SULFATE ION | | Authors: | Zhao, B., Perry, E. | | Deposit date: | 2019-01-17 | | Release date: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (1.27 Å) | | Cite: | Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 2019
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6NPN | | CRYSTAL STRUCTURE OF THE HUMAN VACCINIA-RELATED KINASE BOUND TO A N,N-DIPROPYNYL-DIHYDROPTERIDINE-3-HYDROXYINDAZOLE INHIBITOR | | Descriptor: | Serine/threonine-protein kinase VRK1, (7R)-7-methyl-2-[(3-oxo-2,3-dihydro-1H-indazol-6-yl)amino]-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one, SULFATE ION, ... | | Authors: | Counago, R.M., dos Reis, C.V., Takarada, J.E., Azevedo, A., Guimaraes, C., Mascarello, A., Gama, F., Ferreira, M., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, J.M., Structural Genomics Consortium (SGC) | | Deposit date: | 2019-01-18 | | Release date: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal Structure of the Human vaccinia-related kinase bound to a N,N-dipropynyl-dihydropteridine-3-hydroxyindazole inhibitor
To Be Published
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6NQA | | ACTIVE STATE DOT1L BOUND TO THE H2B-UBIQUITINATED NUCLEOSOME, 1-TO-1 COMPLEX | | Descriptor: | 601 DNA Strand 1, 601 DNA Strand 2, Histone H4, ... | | Authors: | Worden, E.J., Hoffmann, N.A., Wolberger, C. | | Deposit date: | 2019-01-19 | | Release date: | 2019-02-20 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L
Cell(Cambridge,Mass.), 2019
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6NR2 | | CRYO-EM STRUCTURE OF THE TRPM8 ION CHANNEL IN COMPLEX WITH THE MENTHOL ANALOG WS-12 AND PI(4,5)P2 | | Descriptor: | Transient receptor potential cation channel subfamily M member 8, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide | | Authors: | Yin, Y., Le, S.C., Hsu, A.L., Borgnia, M.J., Yang, H., Lee, S.-Y. | | Deposit date: | 2019-01-22 | | Release date: | 2019-02-20 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 2019
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