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4JFL
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Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with 6-({(1S,5R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-2-oxo-3,9-diazabicyclo[3.3.1]non-9-yl}sulfonyl)-1,3-benzothiazol-2(3H)-one
Descriptor: 6-({(1S,5R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-2-oxo-3,9-diazabicyclo[3.3.1]non-9-yl}sulfonyl)-1,3-benzothiazol-2(3H)-one, Peptidyl-prolyl cis-trans isomerase FKBP5
Authors:Wang, Y, Kirschner, A, Fabian, A, Gopalakrishnan, R, Kress, C, Hoogeland, B, Koch, U, Kozany, C, Bracher, A, Hausch, F.
Deposit date:2013-02-28
Release date:2013-08-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.
J.Med.Chem., 56, 2013
4JFI
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Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with compound 1-[(9S,13R,13aR)-1,3-dimethoxy-8-oxo-5,8,9,10,11,12,13,13a-octahydro-6H-9,13-epiminoazocino[2,1-a]isoquinolin-14-yl]-2-(3,4,5-trimethoxyphenyl)ethane-1,2-dione
Descriptor: 1-[(9S,13R,13aR)-1,3-dimethoxy-8-oxo-5,8,9,10,11,12,13,13a-octahydro-6H-9,13-epiminoazocino[2,1-a]isoquinolin-14-yl]-2-(3,4,5-trimethoxyphenyl)ethane-1,2-dione, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Wang, Y, Kirschner, A, Fabian, A, Gopalakrishnan, R, Kress, C, Hoogeland, B, Koch, U, Kozany, C, Bracher, A, Hausch, F.
Deposit date:2013-02-28
Release date:2013-08-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.
J.Med.Chem., 56, 2013
4JFK
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Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with (1S,6R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-10-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)sulfonyl]-3,10-diazabicyclo[4.3.1]decan-2-one
Descriptor: (1S,6R)-3-[2-(3,4-dimethoxyphenoxy)ethyl]-10-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)sulfonyl]-3,10-diazabicyclo[4.3.1]decan-2-one, Peptidyl-prolyl cis-trans isomerase FKBP5
Authors:Wang, Y, Kirschner, A, Fabian, A, Gopalakrishnan, R, Kress, C, Hoogeland, B, Koch, U, Kozany, C, Bracher, A, Hausch, F.
Deposit date:2013-02-28
Release date:2013-08-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.
J.Med.Chem., 56, 2013
4JFM
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Increasing the Efficiency Efficiency of Ligands for the FK506-Binding Protein 51 by Conformational Control: Complex of FKBP51 with 2-(3,4-dimethoxyphenoxy)ethyl (2S)-1-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)sulfonyl]piperidine-2-carboxylate
Descriptor: 2-(3,4-dimethoxyphenoxy)ethyl (2S)-1-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)sulfonyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5
Authors:Wang, Y, Kirschner, A, Fabian, A, Gopalakrishnan, R, Kress, C, Hoogeland, B, Koch, U, Kozany, C, Bracher, A, Hausch, F.
Deposit date:2013-02-28
Release date:2013-08-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.
J.Med.Chem., 56, 2013
4JYS
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Crystal structure of FKBP25 from Plasmodium Vivax
Descriptor: CHLORIDE ION, IMIDAZOLE, Peptidyl-prolyl cis-trans isomerase
Authors:Sreekanth, R, Yoon, H.S.
Deposit date:2013-04-01
Release date:2014-02-12
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Plasmodium vivax FK506-binding protein 25 reveals conformational changes responsible for its noncanonical activity
Proteins, 82, 2014
5HWB
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Aspergillus fumigatus FKBP12 apo protein in P212121 space group
Descriptor: FK506-binding protein 1A, SULFATE ION
Authors:Tonthat, N.K, Schumacher, M.A.
Deposit date:2016-01-28
Release date:2016-09-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Mbio, 7, 2016
5HW6
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Candida albicans FKBP12 apo protein in C2 space group
Descriptor: ACETATE ION, FK506-binding protein 1
Authors:Tonthat, N.K, Schumacher, M.A.
Deposit date:2016-01-28
Release date:2016-09-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Mbio, 7, 2016
5HT1
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Structure of apo C. glabrata FKBP12
Descriptor: FK506-binding protein 1
Authors:Schumacher, M.A.
Deposit date:2016-01-26
Release date:2016-09-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Mbio, 7, 2016
5HW8
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Candida albicans FKBP12 P104G protein bound with FK506 in C2 space group
Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506-binding protein 1
Authors:Tonthat, N.K, Schumacher, M.A.
Deposit date:2016-01-28
Release date:2016-09-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Mbio, 7, 2016
5HKG
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Total chemical synthesis, refolding and crystallographic structure of a fully active immunophilin: calstabin 2 (FKBP12.6).
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ...
Authors:Sirigu, S, Huet, T, Bacchi, M, Jullian, M, Fould, B, Ferry, G, Vuillard, L, Chavas, L, Puget, K, Nosjean, O, Boutin, J.A.
Deposit date:2016-01-14
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2 (FKBP12.6).
Protein Sci., 25, 2016
5HUA
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BU of 5hua by Molmil
Structure of C. glabrata FKBP12-FK506 complex
Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506-binding protein 1
Authors:Schumacher, M.A.
Deposit date:2016-01-27
Release date:2016-09-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Mbio, 7, 2016
5HW7
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Candida albicans FKBP12 apo protein in P21212 space group
Descriptor: FK506-binding protein 1
Authors:Tonthat, N.K, Schumacher, M.A.
Deposit date:2016-01-28
Release date:2016-09-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.291 Å)
Cite:Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Mbio, 7, 2016
5HTG
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BU of 5htg by Molmil
Structure of apo P1 form of Candida albicans FKBP12
Descriptor: FK506-binding protein 1
Authors:Schumacher, M.A.
Deposit date:2016-01-26
Release date:2016-09-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Mbio, 7, 2016
5HWC
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Aspergillus fumigatus FKBP12 P90G protein bound with FK506 in P212121 space group
Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506-binding protein 1A
Authors:Tonthat, N.K, Schumacher, M.A.
Deposit date:2016-01-29
Release date:2016-09-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Mbio, 7, 2016
5I98
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Structure of apo FKBP12(P104G) from C. albicans
Descriptor: FK506-binding protein 1
Authors:Schumacher, M.A.
Deposit date:2016-02-19
Release date:2016-09-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Mbio, 7, 2016
5I7P
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Crystal structure of Fkbp12-IF(SlyD), a chimeric protein of human Fkbp12 and the insert in flap domain of Ecoli SlyD
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A,FKBP-type peptidyl-prolyl cis-trans isomerase SlyD,Peptidyl-prolyl cis-trans isomerase FKBP1A
Authors:Jakob, R.P, Knappe, T.A, Dobbek, H, Schmid, F.X.
Deposit date:2016-02-18
Release date:2017-03-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Structural and Functional Analysis of Chaperone Domain Insertion in Fkbp12
To Be Published
5I7Q
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Crystal structure of Fkbp12-IF(SlpA), a chimeric protein of human Fkbp12 and the insert in flap domain of Ecoli SlpA
Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A,FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase,Peptidyl-prolyl cis-trans isomerase FKBP1A
Authors:Jakob, R.P, Dobbek, H, Schmid, F.X.
Deposit date:2016-02-18
Release date:2017-03-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Analysis of Chaperone Domain Insertion in Fkbp12
To Be Published
5J6E
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Structure of disulfide crosslinked A. fumigatus FKBP12(V91C)
Descriptor: FK506-binding protein 1A
Authors:Schumacher, M.
Deposit date:2016-04-04
Release date:2016-09-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
Mbio, 7, 2016
1D6O
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BU of 1d6o by Molmil
NATIVE FKBP
Descriptor: AMMONIUM ION, PROTEIN (FK506-BINDING PROTEIN), SULFATE ION
Authors:Burkhard, P, Taylor, P, Walkinshaw, M.D.
Deposit date:1999-10-15
Release date:1999-10-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies.
J.Mol.Biol., 295, 2000
1D7H
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FKBP COMPLEXED WITH DMSO
Descriptor: AMMONIUM ION, DIMETHYL SULFOXIDE, PROTEIN (FK506-BINDING PROTEIN), ...
Authors:Burkhard, P, Taylor, P, Walkinshaw, M.D.
Deposit date:1999-10-18
Release date:1999-10-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies.
J.Mol.Biol., 295, 2000
1D7J
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FKBP COMPLEXED WITH 4-HYDROXY-2-BUTANONE
Descriptor: 4-HYDROXY-2-BUTANONE, AMMONIUM ION, PROTEIN (FK506-BINDING PROTEIN), ...
Authors:Burkhard, P, Taylor, P, Walkinshaw, M.D.
Deposit date:1999-10-18
Release date:1999-10-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies.
J.Mol.Biol., 295, 2000
1D7I
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BU of 1d7i by Molmil
FKBP COMPLEXED WITH METHYL METHYLSULFINYLMETHYL SULFIDE (DSS)
Descriptor: AMMONIUM ION, METHYL METHYLSULFINYLMETHYL SULFIDE, PROTEIN (FK506-BINDING PROTEIN), ...
Authors:Burkhard, P, Taylor, P, Walkinshaw, M.D.
Deposit date:1999-10-18
Release date:1999-10-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies.
J.Mol.Biol., 295, 2000
1EYM
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FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX
Descriptor: FK506 BINDING PROTEIN
Authors:Rollins, C.T, Rivera, V.M, Woolfson, D.N, Keenan, T, Hatada, M, Adams, S.E, Andrade, L.J, Yaeger, D, van Schravendijk, M.R, Holt, D.A, Gilman, M, Clackson, T.
Deposit date:2000-05-07
Release date:2000-08-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:A ligand-reversible dimerization system for controlling protein-protein interactions.
Proc.Natl.Acad.Sci.USA, 97, 2000
1F40
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SOLUTION STRUCTURE OF FKBP12 COMPLEXED WITH GPI-1046, A NEUROTROPHIC LIGAND
Descriptor: (2S)-[3-PYRIDYL-1-PROPYL]-1-[3,3-DIMETHYL-1,2-DIOXOPENTYL]-2-PYRROLIDINECARBOXYLATE, FK506 BINDING PROTEIN (FKBP12)
Authors:Sich, C, Improta, S, Cowley, D.J, Guenet, C, Merly, J.P, Teufel, M, Saudek, V.
Deposit date:2000-06-07
Release date:2000-11-08
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structure of a neurotrophic ligand bound to FKBP12 and its effects on protein dynamics.
Eur.J.Biochem., 267, 2000
8PDF
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FKBP12 in complex with PROTAC 6a2
Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[4-[(1~{S})-1-[(1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-ethenyl-2-oxidanylidene-3,10-diazabicyclo[4.3.1]decan-3-yl]ethyl]-1,2,3-triazol-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Peptidyl-prolyl cis-trans isomerase FKBP1A
Authors:Meyners, C, Walz, M, Geiger, T.M, Hausch, F.
Deposit date:2023-06-12
Release date:2023-11-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51).
Angew.Chem.Int.Ed.Engl., 63, 2024

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