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4II2
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BU of 4ii2 by Molmil
Crystal structure of Ubiquitin activating enzyme 1 (Uba1) in complex with the Ub E2 Ubc4, ubiquitin, and ATP/Mg
Descriptor: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Olsen, S.K, Lima, C.D.
Deposit date:2012-12-19
Release date:2013-02-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.
Mol.Cell, 49, 2013
4IP3
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BU of 4ip3 by Molmil
Complex structure of OspI and Ubc13
Descriptor: ORF169b, Ubiquitin-conjugating enzyme E2 N
Authors:Fu, P, Jin, M, Zhang, X, Xu, L, Xia, Z, Zhu, Y.
Deposit date:2013-01-09
Release date:2013-03-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure Analysis of Ubc13 Inactivation
To be Published
3PTF
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BU of 3ptf by Molmil
X-ray structure of the non-covalent complex between UbcH5A and Ubiquitin
Descriptor: Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D1
Authors:Bosanac, I, Hymowitz, S.G.
Deposit date:2010-12-02
Release date:2011-05-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Modulation of K11-Linkage Formation by Variable Loop Residues within UbcH5A.
J.Mol.Biol., 408, 2011
4JQU
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BU of 4jqu by Molmil
Crystal structure of Ubc7p in complex with the U7BR of Cue1p
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Coupling of ubiquitin conjugation to ER degradation protein 1, DI(HYDROXYETHYL)ETHER, ...
Authors:Liang, Y.-H, Metzger, M.B, Weissman, A.M, Ji, X.
Deposit date:2013-03-20
Release date:2013-05-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A Structurally Unique E2-Binding Domain Activates Ubiquitination by the ERAD E2, Ubc7p, through Multiple Mechanisms.
Mol.Cell, 50, 2013
3RCZ
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BU of 3rcz by Molmil
Rad60 SLD2 Ubc9 Complex
Descriptor: DNA repair protein rad60, SUMO-conjugating enzyme ubc9
Authors:Perry, J.J.P, Arvai, A.S, Tainer, J.A.
Deposit date:2011-03-31
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.
Mol.Cell.Biol., 31, 2011
3RPG
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BU of 3rpg by Molmil
Bmi1/Ring1b-UbcH5c complex structure
Descriptor: E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, Ubiquitin-conjugating enzyme E2 D3, ...
Authors:Bentley, M.L, Dong, K.C, Cochran, A.G.
Deposit date:2011-04-26
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6485 Å)
Cite:Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.
Embo J., 30, 2011
6GUM
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BU of 6gum by Molmil
Structure of the A.thaliana E1 UFD domain in complex with E2
Descriptor: GLYCEROL, SAE2, SUMO-conjugating enzyme SCE1
Authors:Liu, B, Lois, L.M, Reverter, D.
Deposit date:2018-06-19
Release date:2019-07-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.792 Å)
Cite:Structural insights into SUMO E1-E2 interactions in Arabidopsis uncovers a distinctive platform for securing SUMO conjugation specificity across evolution.
Biochem.J., 476, 2019
6HPR
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BU of 6hpr by Molmil
Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub
Descriptor: Baculoviral IAP repeat-containing protein 2, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ...
Authors:Patel, A, Huang, D.T.
Deposit date:2018-09-21
Release date:2018-12-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex.
J. Biol. Chem., 294, 2019
6IF1
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BU of 6if1 by Molmil
Crystal structure of Ube2K and K48-linked di-ubiquitin complex
Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 K
Authors:Lee, J.-G, Youn, H.-S, Lee, Y, An, J.Y, Park, K.R, Kang, J.Y, Lim, J.J, Eom, S.H.
Deposit date:2018-09-18
Release date:2018-11-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.466 Å)
Cite:Crystal structure of the Ube2K/E2-25K and K48-linked di-ubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis.
Biochem. Biophys. Res. Commun., 506, 2018
6JKY
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BU of 6jky by Molmil
Crystal structure of MvcA-UBE2N-Ub complex from Legionella pneumophila
Descriptor: MvcA, Ub, Ubiquitin-conjugating enzyme E2 N
Authors:Ouyang, S.Y, Guan, H.
Deposit date:2019-03-03
Release date:2019-12-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.454 Å)
Cite:Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination.
Embo J., 39, 2020
6JB6
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BU of 6jb6 by Molmil
Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.7 A resolution
Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 K
Authors:Lee, J.-G, Youn, H.-S, Lee, Y, An, J.Y, Park, K.R, Kang, J.Y, Mun, S.A, Park, J, Park, T, Jin, M.W, Yang, J, Eom, S.H.
Deposit date:2019-01-25
Release date:2019-03-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.7 A resolution
To Be Published
6JB7
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BU of 6jb7 by Molmil
Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution
Descriptor: Ubiquitin, Ubiquitin-conjugating enzyme E2 K
Authors:Lee, J.-G, Youn, H.-S, Lee, Y, An, J.Y, Park, K.R, Kang, J.Y, Mun, S.A, Park, J, Park, T, Jin, M.W, Yang, J, Eom, S.H.
Deposit date:2019-01-25
Release date:2019-03-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of Ub-conjugated Ube2K C92K&K97A mutant (isopeptide linkage), 2.1 A resolution
To Be Published
1KPS
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BU of 1kps by Molmil
Structural Basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin conjugating enzyme Ubc9 and RanGAP1
Descriptor: Ran-GTPase activating protein 1, SULFATE ION, Ubiquitin-like protein SUMO-1 conjugating enzyme
Authors:Bernier-Villamor, V, Sampson, D.A, Matunis, M.J, Lima, C.D.
Deposit date:2002-01-02
Release date:2002-02-13
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1.
Cell(Cambridge,Mass.), 108, 2002
3A33
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BU of 3a33 by Molmil
UbcH5b~Ubiquitin Conjugate
Descriptor: GLYCEROL, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2
Authors:Sakata, E, Satoh, T, Yamamoto, S, Yamaguchi, Y, Yagi-Utsumi, M, Kurimoto, E, Wakatsuki, S, Kato, K.
Deposit date:2009-06-08
Release date:2009-11-24
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of UbcH5b~Ubiquitin Intermediate: Insight into the Formation of the Self-Assembled E2~Ub Conjugates
Structure, 18, 2010
3E46
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BU of 3e46 by Molmil
Crystal structure of ubiquitin-conjugating enzyme E2-25kDa (Huntington interacting protein 2) M172A mutant
Descriptor: CALCIUM ION, Ubiquitin-conjugating enzyme E2-25 kDa
Authors:Hughes, R.C, Wilson, R.C, Flatt, J.W, Meehan, E.J, Ng, J.D, Twigg, P.D.
Deposit date:2008-08-09
Release date:2008-08-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2).
Acta Crystallogr.,Sect.F, 65, 2009
3EB6
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BU of 3eb6 by Molmil
Structure of the cIAP2 RING domain bound to UbcH5b
Descriptor: Baculoviral IAP repeat-containing protein 3, Ubiquitin-conjugating enzyme E2 D2, ZINC ION
Authors:Mace, P.D, Linke, K, Schumacher, F.-R, Smith, C.A, Day, C.L.
Deposit date:2008-08-27
Release date:2008-09-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment.
J.Biol.Chem., 283, 2008
3FN1
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BU of 3fn1 by Molmil
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.
Descriptor: NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F
Authors:Huang, D.T, Ayrault, O, Hunt, H.W, Taherbhoy, A.M, Duda, D.M, Scott, D.C, Borg, L.A, Neale, G, Murray, P.J, Roussel, M.F, Schulman, B.A.
Deposit date:2008-12-22
Release date:2009-03-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Mol.Cell, 33, 2009
3F92
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BU of 3f92 by Molmil
Crystal structure of ubiquitin-conjugating enzyme E2-25kDa (Huntington Interacting Protein 2) M172A mutant crystallized at pH 8.5
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, CALCIUM ION, ...
Authors:Wilson, R.C, Hughes, R.C, Flatt, J.W, Meehan, E.J, Ng, J.D, Twigg, P.D.
Deposit date:2008-11-13
Release date:2008-11-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2).
Acta Crystallogr.,Sect.F, 65, 2009
4WZ3
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BU of 4wz3 by Molmil
Crystal structure of the complex between LubX/LegU2/Lpp2887 U-box 1 and Homo sapiens UBE2D2
Descriptor: E3 ubiquitin-protein ligase LubX, Ubiquitin-conjugating enzyme E2 D2
Authors:Stogios, P.J, Quaile, A.T, Skarina, T, Nocek, B, Di Leo, R, Yim, V, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2014-11-18
Release date:2015-01-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila.
Structure, 23, 2015
5KHR
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BU of 5khr by Molmil
Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C)
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:VanderLinden, R, Yamaguchi, M, Dube, P, Haselbach, D, Stark, H, Schulman, B.A.
Deposit date:2016-06-15
Release date:2016-08-24
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
Mol.Cell, 63, 2016
4X57
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BU of 4x57 by Molmil
Structure of an Arabidopsis E2 / Membrane-anchored Ubiquitin-fold Protein Complex
Descriptor: Membrane-anchored ubiquitin-fold protein 3, SULFATE ION, Ubiquitin-conjugating enzyme E2 8
Authors:Korolev, S, Koroleva, O, Lu, X, Downes, B.
Deposit date:2014-12-04
Release date:2016-01-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of an Arabidopsis E2 / Membrane-anchored Ubiquitin-fold ProteinComplex
To Be Published
5KNL
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BU of 5knl by Molmil
Crystal structure of S. pombe ubiquitin E1 (Uba1) in complex with Ubc15 and ubiquitin
Descriptor: SULFATE ION, Ubiquitin, Ubiquitin-activating enzyme E1 1, ...
Authors:Olsen, S.K, Lv, Z, Yuan, L, Williams, K.
Deposit date:2016-06-28
Release date:2017-02-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
Mol. Cell, 65, 2017
4Y1L
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BU of 4y1l by Molmil
Ubc9 Homodimer The Missing Link in Poly-SUMO Chain Formation
Descriptor: RWD domain-containing protein 3, SUMO-conjugating enzyme UBC9
Authors:Aileen, Y.A, Ambaye, N.D, Li, Y.J, Vega, R, Bzymek, K, Williams, J.C, Hu, W, Chen, Y.
Deposit date:2015-02-08
Release date:2015-05-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:RWD Domain as an E2 (Ubc9)-Interaction Module.
J.Biol.Chem., 290, 2015
5L9U
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BU of 5l9u by Molmil
Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-09-14
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5L9T
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BU of 5l9t by Molmil
Model of human Anaphase-promoting complex/Cyclosome (APC/C-CDH1) with E2 UBE2S poised for polyubiquitination where UBE2S, APC2, and APC11 are modeled into low resolution density
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Brown, N.G, VanderLinden, R, Dube, P, Haselbach, D, Peters, J.M, Stark, H, Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-10-26
Last modified:2016-11-02
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016

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