5FYI
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CRYSTAL STRUCTURE OF HUMAN JMJD2A IN COMPLEX WITH PYRUVATE
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, NICKEL (II) ION, PYRUVIC ACID, ...
Authors:Nowak, R., Kopec, J., Johansson, C., Szykowska, A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
Deposit date:2016-03-07
Release date:2016-03-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Crystal Structure of Human Jmjd2A in Complex with Pyruvate
To be Published
5H6Y
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THE BPTF BROMODOMAIN RECOGNISING H4K12CR PEPTIDE
Descriptor:Nucleosome-remodeling factor subunit BPTF, GLY-KCR-GLY
Authors:Wang, Y., Hao, Q.
Deposit date:2016-11-15
Release date:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:The BPTF Bromodomain Recognising H4K12Cr peptide
To Be Published
5J9Q
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
Descriptor:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
Authors:Chen, Z.C., Xu, P.
Deposit date:2016-04-11
Release date:2016-10-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
5J9T
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
Descriptor:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
Authors:Chen, Z.C., Xu, P.
Deposit date:2016-04-11
Release date:2016-10-26
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
5J9U
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
Descriptor:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
Authors:Chen, Z.C., Xu, P.
Deposit date:2016-04-11
Release date:2016-10-26
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
5J9W
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CRYSTAL STRUCTURE OF THE NUA4 CORE COMPLEX
Descriptor:Histone acetyltransferase ESA1, Chromatin modification-related protein EAF6, Enhancer of polycomb-like protein 1, ...
Authors:Chen, Z.C., Xu, P.
Deposit date:2016-04-11
Release date:2016-10-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism
Mol.Cell, 63, 2016
5JSG
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CRYSTAL STRUCTURE OF SPINDLIN1 BOUND TO COMPOUND EML405
Descriptor:Spindlin-1, [2-(phenylamino)-1,4-phenylene]bis({4-[2-(pyrrolidin-1-yl)ethyl]piperidin-1-yl}methanone), MAGNESIUM ION, ...
Authors:Su, X., Li, H.
Deposit date:2016-05-08
Release date:2017-05-10
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Nat. Chem. Biol., 13, 2017
5JSJ
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CRYSTAL STRUCTURE OF SPINDLIN1 BOUND TO COMPOUND EML631
Descriptor:Spindlin-1, [4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]-[4-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl-3-[[4-(pyrrolidin-1-ylmethoxy)phenyl]amino]phenyl]methanone, MAGNESIUM ION, ...
Authors:Su, X., Li, H.
Deposit date:2016-05-08
Release date:2017-05-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.348 Å)
Cite:Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Nat. Chem. Biol., 13, 2017
5LY1
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JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND MACROCYCLIC PEPTIDE INHIBITOR CP2 (13-MER)
Descriptor:Lysine-specific demethylase 4A, CP2, NICKEL (II) ION, ...
Authors:King, O.N.F., Chowdhury, R., Kawamura, A., Schofield, C.J.
Deposit date:2016-09-23
Release date:2017-04-12
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
5LY2
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JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND MACROCYCLIC PEPTIDE INHIBITOR CP2_R6KME3 (13-MER)
Descriptor:Lysine-specific demethylase 4A, CP2_R6Kme3, NICKEL (II) ION, ...
Authors:CHOWDHURY, R., Madden, S.K., Hopkinson, R., SCHOFIELD, C.J.
Deposit date:2016-09-23
Release date:2017-04-12
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
5MTO
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N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5 C19S MUTANT
Descriptor:Inhibitor of growth protein 5, SODIUM ION, SULFATE ION
Authors:Ormaza, G., Buitrago, J.A.R., Roversi, P., Rojas, A.L., Blanco, F.J.
Deposit date:2017-01-10
Release date:2018-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:N-terminal domain of the human tumor suppressor ING5 C19S mutant
To Be Published
5TVR
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JMJD2A IN COMPLEX WITH NI(II) AND ALPHA-KETOGLUTARATE
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:Cascella, B., Lee, S.G., Jez, J.M.
Deposit date:2016-11-09
Release date:2017-02-01
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53, 2017
5TVS
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JMJD2A IN COMPLEX WITH NI(II)
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION
Authors:Cascella, B., Lee, S.G., Jez, J.M.
Deposit date:2016-11-09
Release date:2017-02-01
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.745 Å)
Cite:The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53, 2017
5VGI
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CRYSTAL STRUCTURE OF KDM4 WITH THE SMALL MOLECULE INHIBITOR QC6352
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J.
Deposit date:2017-04-11
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
ACS Med Chem Lett, 8, 2017
5VMP
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CRYSTAL STRUCTURE OF HUMAN KDM4 WITH SMALL MOLECULE INHIBITOR QC5714
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J.
Deposit date:2017-04-28
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
ACS Med Chem Lett, 8, 2017
5WLF
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CRYSTAL STRUCTURE OF THE APO PPS PHD FINGER
Descriptor:Protein partner of snf, isoform A, GLYCEROL, ...
Authors:Klein, B.J., Kutateladze, T.G.
Deposit date:2017-07-26
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.
Structure, 25, 2017
5XMY
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CRYSTAL STRUCTURE OF TAF3 PHD FINGER BOUND TO H3K4ME3Q5SER
Descriptor:Transcription initiation factor TFIID subunit 3, Histone peptide H3(1-15)K4me3Q5ser, ZINC ION
Authors:Zhao, S., Zhang, B., Li, H.
Deposit date:2017-05-16
Release date:2018-11-28
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Crystal structure of TAF3 PHD finger bound to H3K4me3Q5ser
to be published
5Y5W
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CRYSTAL STRUCTURE OF HUMAN SPINDLIN1 IN COMPLEX WITH A HISTONE H4K20(ME3) PEPTIDE
Descriptor:Spindlin-1, Histone peptide H4K20(me3)
Authors:Wang, C.L., Zang, J.Y.
Deposit date:2017-08-10
Release date:2017-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of human Spindlin1 in complex with a histone H4K20(me3) peptide
To Be Published
6CG1
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CRYSTAL STRUCTURE OF KDM4A WITH COMPOUND 14
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J., Nie, Z.
Deposit date:2018-02-19
Release date:2018-04-18
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structure-based design and discovery of potent and selective KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
6CG2
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CRYSTAL STRUCTURE OF KDM4A WITH COMPOUND 8
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J., Nie, Z.
Deposit date:2018-02-19
Release date:2018-04-18
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structure-based design and discovery of potent and selective KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
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