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3WNS	Allyl isothiocyanate inhibitor complexed with Macrophage Migration Inhibitory Factor Descriptor: CHLORIDE ION, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Spencer, E.S, Dale, E.J, Gommans, A.L, Rutledge, M.T, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A. Deposit date: 2013-12-16 Release date: 2014-03-05 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.658 Å) Cite: Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor Eur.J.Med.Chem., 93, 2015
4NWR	Computationally Designed Two-Component Self-Assembling Tetrahedral Cage T33-28 Descriptor: Macrophage migration inhibitory factor-like protein, integron gene cassette protein Authors: McNamara, D.E, King, N.P, Bale, J.B, Sheffler, W, Baker, D, Yeates, T.O. Deposit date: 2013-12-06 Release date: 2014-05-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Accurate design of co-assembling multi-component protein nanomaterials. Nature, 510, 2014
4P0H	Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with Dimethylformamide Descriptor: DIMETHYLFORMAMIDE, GLYCEROL, Macrophage migration inhibitory factor Authors: Pantouris, G, Lolis, E. Deposit date: 2014-02-21 Release date: 2014-04-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.93 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4OYQ	(6-isothiocyanatohexyl)benzene inhibitor complexed with Macrophage Migration Inhibitory Factor Descriptor: 6-isothiocyanatohexylbenzene, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: Spencer, E.S, Dale, E.J, Gommans, A.L, Vo, C.T, Rutledge, M.T, Nakatani, Y, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A. Deposit date: 2014-02-12 Release date: 2014-03-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: To be published To be published
4OSF	4-(2-isothiocyanatoethyl)phenol inhibitor complexed with Macrophage Migration Inhibitory Factor Descriptor: CHLORIDE ION, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Spencer, E.S, Dale, E.J, Gommans, A.L, Vo, C.T, Rutledge, M.T, Nakatani, Y, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A. Deposit date: 2014-02-12 Release date: 2014-03-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor Eur.J.Med.Chem., 93, 2015
4P01	Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide Descriptor: CHLORIDE ION, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-02-19 Release date: 2014-03-19 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.07 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4P7M	Crystal structure of Plasmodium falciparum MIF in complex with 3-[(2-methyl-6-phenylpyridin-4-yl)oxy]phenol Descriptor: 3-[(2-methyl-6-phenylpyridin-4-yl)oxy]phenol, Macrophage migration inhibitory factor-like protein Authors: Pantouris, G, Lolis, E. Deposit date: 2014-03-27 Release date: 2014-10-15 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.02 Å) Cite: Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors. J.Med.Chem., 57, 2014
4P7S	Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine Descriptor: 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine, Macrophage migration inhibitory factor-like protein Authors: Pantouris, G, Lolis, E. Deposit date: 2014-03-27 Release date: 2014-10-15 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.87 Å) Cite: Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors. J.Med.Chem., 57, 2014
4PKZ	Crystal structure of P1M mutant of Macrophage Migration Inhibitory Factor Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Pantouris, G, Lolis, E. Deposit date: 2014-05-15 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4PLU	Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-05-19 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4PKK	Crystal structure of Macrophage Migration inhibitory factor in complex with furan-2-ylmethyl)imino methanethiol Descriptor: (Z)-[(furan-2-ylmethyl)imino]methanethiol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-05-14 Release date: 2016-05-04 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Crystal structure of Macrophage Migration inhibitory factor with a covalent inhibitor To Be Published
4ETG	Crystal Structure of MIF L46G mutant Descriptor: Macrophage migration inhibitory factor, SULFATE ION Authors: Ashrafi, A, Pojer, F, Lashuel, H. Deposit date: 2012-04-24 Release date: 2012-10-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket. Plos One, 7, 2012
4EVG	Crystal Structure of MIF L46A mutant Descriptor: Macrophage migration inhibitory factor, SULFATE ION Authors: Ashrafi, A, Pojer, F, Lashuel, H. Deposit date: 2012-04-26 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket. Plos One, 7, 2012
5XEJ	Crystal Structure of Macrophage Migration Inhibitory Factor bound to MTX Descriptor: (2~{R})-2-[[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid, Macrophage migration inhibitory factor, SULFATE ION Authors: Takimoto-Kamimura, M, Fukushima, K. Deposit date: 2017-04-05 Release date: 2018-07-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of macrophage migration inhibitory factor in complex with methotrexate. Acta Crystallogr D Struct Biol, 77, 2021
4F2K	Macrophage Migration Inhibitory Factor covalently complexed with phenethylisothiocyanate Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, N-(2-phenylethyl)thioformamide, ... Authors: Tyndall, J.D.A, Bernhagen, J, Hampton, M.B, Wilbanks, S.M, Rutledge, M.T. Deposit date: 2012-05-08 Release date: 2012-06-06 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate Acta Crystallogr.,Sect.F, 68, 2012
4GRR	characterization of N- and C- terminus mutants of human MIF Descriptor: (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, CHLORIDE ION, Macrophage migration inhibitory factor, ... Authors: Fan, C, Lolis, E. Deposit date: 2012-08-26 Release date: 2013-09-25 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Characterization of N- and C- terminus mutants of human MIF To be Published
4GUM	Cystal structure of locked-trimer of human MIF Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor Authors: Fan, C, Lolis, E. Deposit date: 2012-08-29 Release date: 2013-07-03 Last modified: 2020-11-18 Method: X-RAY DIFFRACTION (2.33 Å) Cite: MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc.Natl.Acad.Sci.USA, 110, 2013
4GRU	crystallographic and biological characterization of N- and C- terminus mutants of human MIF Descriptor: 1,4-DIETHYLENE DIOXIDE, CHLORIDE ION, Macrophage migration inhibitory factor, ... Authors: Fan, C, Lolis, E. Deposit date: 2012-08-26 Release date: 2013-09-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.92 Å) Cite: crystallographic and biological characterization of N- and C- terminus mutants of human MIF To be Published
4GRQ	Characterization of N- and C- terminus mutants of human MIF Descriptor: 2-methyl-1-[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, CHLORIDE ION, Macrophage migration inhibitory factor, ... Authors: Fan, C, Lolis, E. Deposit date: 2012-08-26 Release date: 2013-10-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Characterization of N- and C- terminus mutants of human MIF To be Published
4GRO	Crystallographic and biological characterization of N- and C- terminus mutants of human MIF Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor Authors: Fan, C, Lolis, E. Deposit date: 2012-08-26 Release date: 2013-10-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: crystallographic and biological characterization of N- and C- terminus mutants of human MIF To be Published
4GRN	crystal structure of PAAM mutant of human MIF Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SODIUM ION, ... Authors: Fan, C, Lolis, E, Rajesekaran, D. Deposit date: 2012-08-26 Release date: 2013-09-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.25 Å) Cite: crystallographic and biological chacerterization of N- and C-terminus of MIF To be Published
4GRP	Crystallographic and biological characterization of N- and C- terminus mutants of human MIF Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SULFATE ION Authors: Fan, C, Lolis, E. Deposit date: 2012-08-26 Release date: 2013-10-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Crystallographic and biological characterization of N- and C- terminus mutants of human MIF To be Published
6B1C	Macrophage Migration Inhibitory Factor in complex with a Naphthyridinone Inhibitor (4a) Descriptor: 2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-7-methyl-1,7-naphthyridin-8(7H)-one, Macrophage migration inhibitory factor, SULFATE ION Authors: Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. Deposit date: 2017-09-18 Release date: 2018-01-03 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.163 Å) Cite: Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
6B2C	Macrophage Migration Inhibitory Factor in Complex with a Naphthyridinone Inhibitor (4b) Descriptor: Macrophage migration inhibitory factor, SULFATE ION, {2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-8-oxo-1,7-naphthyridin-7(8H)-yl}acetic acid Authors: Krimmer, S.G, Robertson, M.J, Jorgensen, W.L. Deposit date: 2017-09-19 Release date: 2018-01-03 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett, 8, 2017
6BG7	Crystal structure of G107A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2017-10-27 Release date: 2018-06-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74. Angew. Chem. Int. Ed. Engl., 57, 2018

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