2A68
| Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | Authors: | Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-07-01 | Release date: | 2005-09-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell(Cambridge,Mass.), 122, 2005
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2BE5
| Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | Authors: | Vassylyev, D.G, Svetlov, V, Vassylyeva, M.N, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Artsimovitch, I, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-10-22 | Release date: | 2005-11-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for transcription inhibition by tagetitoxin Nat.Struct.Mol.Biol., 12, 2005
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2CW0
| Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | Authors: | Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. | Deposit date: | 2005-06-15 | Release date: | 2005-09-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation Cell(Cambridge,Mass.), 122, 2005
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4G7H
| Crystal structure of Thermus thermophilus transcription initiation complex | Descriptor: | 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... | Authors: | Zhang, Y, Ebright, R.H. | Deposit date: | 2012-07-20 | Release date: | 2012-10-31 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of transcription initiation. Science, 338, 2012
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4G7O
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4G7Z
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7EH0
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7EH2
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7EH1
| Thermus thermophilus transcription initiation complex containing a template-strand purine at position TSS-2, GpG RNA primer, and CMPcPP | Descriptor: | 1,4-BUTANEDIOL, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (27-MER), ... | Authors: | Li, L, Zhang, Y. | Deposit date: | 2021-03-27 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
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7DY6
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7F75
| Cryo-EM structure of Spx-dependent transcription activation complex | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Lin, W, Feng, Y, Shi, J. | Deposit date: | 2021-06-28 | Release date: | 2021-10-13 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis of transcription activation by the global regulator Spx. Nucleic Acids Res., 49, 2021
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7F0R
| Cryo-EM structure of Pseudomonas aeruginosa SutA transcription activation complex | Descriptor: | DNA (70-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | He, D.W, You, L.L, Zhang, Y. | Deposit date: | 2021-06-06 | Release date: | 2022-07-27 | Last modified: | 2023-02-08 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
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7KHE
| Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp | Descriptor: | CHAPSO, DNA (46-MER), DNA (54-MER), ... | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | Deposit date: | 2020-10-21 | Release date: | 2020-12-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
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4JKR
| Crystal Structure of E. coli RNA Polymerase in complex with ppGpp | Descriptor: | DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA', DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Zuo, Y, Wang, Y, Steitz, T.A. | Deposit date: | 2013-03-11 | Release date: | 2013-05-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol.Cell, 50, 2013
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7KHB
| Escherichia coli RNA polymerase and rrnBP1 promoter open complex | Descriptor: | CHAPSO, DNA (60-MER), DNA (64-MER), ... | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | Deposit date: | 2020-10-20 | Release date: | 2020-10-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
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4JK1
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4JK2
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7KHC
| Escherichia coli RNA polymerase and rrnBP1 promoter closed complex | Descriptor: | CHAPSO, DNA (18 MER), DNA (63-MER), ... | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | Deposit date: | 2020-10-20 | Release date: | 2020-10-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.14 Å) | Cite: | Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
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7KHI
| Escherichia coli RNA polymerase and rrnBP1 promoter complex with DksA/ppGpp | Descriptor: | CHAPSO, DNA (28-MER), DNA (36-MER), ... | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | Deposit date: | 2020-10-21 | Release date: | 2020-10-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021
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4KMU
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8GZG
| Cryo-EM structure of Synechocystis sp. PCC 6803 RPitc | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Shen, L.Q, You, L.L, Zhang, Y. | Deposit date: | 2022-09-27 | Release date: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc Proc.Natl.Acad.Sci.USA, 2023
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8GZH
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8HIH
| Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex with transcription factor GlnR | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Lin, W, Shi, J, Xu, J.C. | Deposit date: | 2022-11-20 | Release date: | 2023-06-07 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
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8H3V
| Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC | Descriptor: | DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. | Deposit date: | 2022-10-09 | Release date: | 2023-10-04 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
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8H40
| Cryo-EM structure of the transcription activation complex NtcA-TAC | Descriptor: | DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. | Deposit date: | 2022-10-09 | Release date: | 2023-10-04 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
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