6QG0
 
 | | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model 1) | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-26 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Nat Commun, 10, 2019
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4ACB
 | | CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS IN COMPLEX WITH THE GTP ANALOGUE GPPNHP | | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, ... | | Authors: | Leibundgut, M, Frick, C, Thanbichler, M, Boeck, A, Ban, N. | | Deposit date: | 2011-12-14 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.34 Å) | | Cite: | Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors.
Embo J., 24, 2005
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6QG3
 | | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model B) | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-26 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (9.4 Å) | | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Nat Commun, 10, 2019
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3ZZT
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6QG5
 | | Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model C) | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Llacer, J.L, Gordiyenko, Y, Ramakrishnan, V. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-26 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (10.1 Å) | | Cite: | Structural basis for the inhibition of translation through eIF2 alpha phosphorylation.
Nat Commun, 10, 2019
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4ACA
 | | CRYSTAL STRUCTURE OF TRANSLATION ELONGATION FACTOR SELB FROM METHANOCOCCUS MARIPALUDIS, APO FORM | | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GUANOSINE-5'-MONOPHOSPHATE, SULFATE ION, ... | | Authors: | Leibundgut, M, Frick, C, Thanbichler, M, Boeck, A, Ban, N. | | Deposit date: | 2011-12-14 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Selenocysteine tRNA-Specific Elongation Factor Selb is a Structural Chimaera of Elongation and Initiation Factors.
Embo J., 24, 2005
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4G5G
 | | ef-tu (Escherichia coli) complexed with nvp-ldu796 | | Descriptor: | Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Palestrant, D. | | Deposit date: | 2012-07-17 | | Release date: | 2012-12-26 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Antibiotic optimization and chemical structure stabilization of thiomuracin A.
J.Med.Chem., 55, 2012
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4FWT
 | | Complex structure of viral RNA polymerase form III | | Descriptor: | CALCIUM ION, Elongation factor Ts, Elongation factor Tu, ... | | Authors: | Takeshita, D, Tomita, K. | | Deposit date: | 2012-07-02 | | Release date: | 2012-08-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Mechanism for template-independent terminal adenylation activity of Q beta replicase
Structure, 20, 2012
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6QW6
 | | Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution. | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | Authors: | Charenton, C, Wilkinson, M.E, Nagai, K. | | Deposit date: | 2019-03-05 | | Release date: | 2019-04-17 | | Last modified: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Mechanism of 5' splice site transfer for human spliceosome activation.
Science, 364, 2019
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6QX9
 | | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, AdML pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Charenton, C, Wilkinson, M.E, Nagai, K. | | Deposit date: | 2019-03-07 | | Release date: | 2019-04-17 | | Last modified: | 2020-10-07 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Mechanism of 5' splice site transfer for human spliceosome activation.
Science, 364, 2019
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6I3M
 | | eIF2B:eIF2 complex, phosphorylated on eIF2 alpha serine 52. | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Adomavicius, T, Roseman, A.M, Pavitt, G.D. | | Deposit date: | 2018-11-06 | | Release date: | 2019-05-22 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (3.93 Å) | | Cite: | The structural basis of translational control by eIF2 phosphorylation.
Nat Commun, 10, 2019
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6ICZ
 | | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | | Deposit date: | 2018-09-07 | | Release date: | 2019-03-13 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
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6ID0
 | | Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | | Deposit date: | 2018-09-07 | | Release date: | 2019-03-13 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
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6I7T
 | | eIF2B:eIF2 complex | | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | Authors: | Adomavicius, T, Guaita, M, Roseman, A.M, Pavitt, G.D. | | Deposit date: | 2018-11-17 | | Release date: | 2019-05-22 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (4.61 Å) | | Cite: | The structural basis of translational control by eIF2 phosphorylation.
Nat Commun, 10, 2019
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6RA9
 | | Novel structural features and post-translational modifications in eukaryotic elongation factor 1A2 from Oryctolagus cuniculus | | Descriptor: | Elongation factor 1-alpha 2, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Carriles, A.A, Hermoso, J, Gago, F. | | Deposit date: | 2019-04-05 | | Release date: | 2020-06-03 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural Cues for Understanding eEF1A2 Moonlighting.
Chembiochem, 22, 2021
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6ID1
 | | Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution | | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | | Deposit date: | 2018-09-07 | | Release date: | 2019-03-13 | | Last modified: | 2020-10-14 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structures of the human spliceosomes before and after release of the ligated exon.
Cell Res., 29, 2019
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4C0S
 | | Mammalian translation elongation factor eEF1A2 | | Descriptor: | ELONGATION FACTOR 1-ALPHA 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Crepin, T, Shalak, V.F, Yaremchuk, A.D, Vlasenko, D.O, McCarthy, A.A, Negrutskii, B.S, Tukalo, M.A, El'skaya, A.V. | | Deposit date: | 2013-08-07 | | Release date: | 2014-08-27 | | Last modified: | 2017-01-25 | | Method: | X-RAY DIFFRACTION (2.703 Å) | | Cite: | Mammalian Translation Elongation Factor Eef1A2: X-Ray Structure and New Features of Gdp/GTP Exchange Mechanism in Higher Eukaryotes
Nucleic Acids Res., 42, 2014
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4H9G
 | | Probing EF-Tu with a very small brominated fragment library identifies the CCA pocket | | Descriptor: | 5-bromofuran-2-carboxylic acid, AMMONIUM ION, Elongation factor Tu-A, ... | | Authors: | Groftehauge, M.K, Therkelsen, M, Taaning, R.H, Skrydstrup, T, Morth, J.P, Nissen, P. | | Deposit date: | 2012-09-24 | | Release date: | 2013-09-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Identifying ligand-binding hot spots in proteins using brominated fragments.
Acta Crystallogr.,Sect.F, 69, 2013
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6JI2
 | | Crystal structure of archaeal ribosomal protein aP1, aPelota, and GTP-bound aEF1A complex | | Descriptor: | Archaeal ribosomal stalk protein aP1, Elongation factor 1-alpha, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Maruyama, K, Imai, H, Kawamura, M, Ishino, S, Ishino, Y, Ito, K, Uchiumi, T. | | Deposit date: | 2019-02-20 | | Release date: | 2019-11-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Switch of the interactions between the ribosomal stalk and EF1A in the GTP- and GDP-bound conformations.
Sci Rep, 9, 2019
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4CXH
 | | Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement | | Descriptor: | 18S RRNA - H44, 18S RRNA - H5-H14, 18S RRNA - H8, ... | | Authors: | Budkevich, T.V, Giesebrecht, J, Behrmann, E, Loerke, J, Ramrath, D.J.F, Mielke, T, Ismer, J, Hildebrand, P, Tung, C.-S, Nierhaus, K.H, Sanbonmatsu, K.Y, Spahn, C.M.T. | | Deposit date: | 2014-04-07 | | Release date: | 2014-07-16 | | Last modified: | 2019-06-26 | | Method: | ELECTRON MICROSCOPY (8.9 Å) | | Cite: | Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome Rearrangement.
Cell(Cambridge,Mass.), 158, 2014
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4CRN
 | | Cryo-EM of a pretermination complex with eRF1 and eRF3 | | Descriptor: | ERF1 IN RIBOSOME-BOUND ERF1-ERF3-GDPNP COMPLEX, ERF3 IN RIBOSOME BOUND ERF1-ERF3-GDPNP COMPLEX, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | Authors: | Preis, A, Heuer, A, Barrio-Garcia, C, Hauser, A, Eyler, D, Berninghausen, O, Green, R, Becker, T, Beckmann, R. | | Deposit date: | 2014-02-28 | | Release date: | 2014-07-23 | | Last modified: | 2017-08-23 | | Method: | ELECTRON MICROSCOPY (9.1 Å) | | Cite: | Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing Erf1-Erf3 or Erf1-Abce1.
Cell Rep., 8, 2014
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4CXG
 | | Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement | | Descriptor: | 18S RRNA - H44, 18S RRNA - H5-H14, 18S RRNA - H8, ... | | Authors: | Budkevich, T.V, Giesebrecht, J, Behrmann, E, Loerke, J, Ramrath, D.J.F, Mielke, T, Ismer, J, Hildebrand, P, Tung, C.-S, Nierhaus, K.H, Sanbonmatsu, K.Y, Spahn, C.M.T. | | Deposit date: | 2014-04-07 | | Release date: | 2014-07-16 | | Last modified: | 2019-06-26 | | Method: | ELECTRON MICROSCOPY (8.7 Å) | | Cite: | Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome Rearrangement.
Cell(Cambridge,Mass.), 158, 2014
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4D61
 | | Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state | | Descriptor: | 18S RRNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ... | | Authors: | Muhs, M, Hilal, T, Mielke, T, Skabkin, M.A, Sanbonmatsu, K.Y, Pestova, T.V, Spahn, C.M.T. | | Deposit date: | 2014-11-07 | | Release date: | 2015-03-04 | | Last modified: | 2017-08-30 | | Method: | ELECTRON MICROSCOPY (9 Å) | | Cite: | Cryo-Em of Ribosomal 80S Complexes with Termination Factors Reveals the Translocated Cricket Paralysis Virus Ires.
Mol.Cell, 57, 2015
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6K72
 | | eIF2(aP) - eIF2B complex | | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | | Authors: | Kashiwagi, K, Yokoyama, T, Ito, T. | | Deposit date: | 2019-06-05 | | Release date: | 2019-07-10 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structural basis for eIF2B inhibition in integrated stress response.
Science, 364, 2019
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6K71
 | | eIF2 - eIF2B complex | | Descriptor: | Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit 3, ... | | Authors: | Kashiwagi, K, Yokoyama, T, Ito, T. | | Deposit date: | 2019-06-05 | | Release date: | 2019-07-10 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structural basis for eIF2B inhibition in integrated stress response.
Science, 364, 2019
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